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公开(公告)号：US11666868B2
公开(公告)日：2023-06-06
申请号：US17590085
申请日：2022-02-01
Applicant: GAMBRO LUNDIA AB
Inventor： Adriana Boschetti-De-Fierro , Manuel Voigt , Bernd Krause , Markus Hornung , Markus Storr , Heinrich Behr , Werner Beck , Carina Zweigart , Reinhold Buck , Philipp Herbst , Joachim Loercher , Arnd Wochner
CPC classification number: B01D71/68 , A61M1/1621 , A61M1/3413 , B01D61/243 , B01D63/021 , B01D69/081 , B01D69/084 , B01D69/087 , B01D71/38 , B01D71/44 , A61M1/16 , B01D2323/06 , B01D2323/12 , B01D2325/022 , B01D2325/025 , B01D2325/026 , B01D2325/04 , B01D2325/20
Abstract: The present disclosure relates to semipermeable membranes which are suitable for blood purification, e.g. by hemodialysis, which have an increased ability to remove larger molecules while at the same time effectively retaining albumin. The membranes are characterized by a molecular retention onset (MWRO) of between 9.0 kD and 14.5 kD and a molecular weight cut-off (MWCO) of between 55 kD and 130 kD as determined by dextran sieving curves and can be prepared by industrially feasible processes excluding a treatment with salt before drying. The invention therefore also relates to a process for the production of the membranes and to their use in medical applications.
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公开(公告)号：US11413384B2
公开(公告)日：2022-08-16
申请号：US16762623
申请日：2018-12-10
Applicant: GAMBRO LUNDIA AB
Inventor： Joachim Loercher , Juergen Eichinger , Reinhold Buck , Arnd Wochner
Abstract: The present disclosure relates to capillary dialyzers for blood purification, in particular, capillary dialyzers suitable for home hemodialysis systems.
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公开(公告)号：US09028740B2
公开(公告)日：2015-05-12
申请号：US13926045
申请日：2013-06-25
Applicant: Gambro Lundia AB
Inventor： Hermann Gohl , Reinhold Buck
CPC classification number: B29D99/005 , A61M1/16 , A61M1/34 , A61M1/3403 , A61M2205/3368 , B01D67/0009 , B01D67/0011 , B01D67/0013 , B01D69/02 , B01D69/08 , B01D71/68 , B01D2323/08 , B01D2323/12 , B01D2323/36 , B01D2323/38 , B01D2325/022 , D01D5/24 , Y10T428/2975 , Y10T442/3106 , Y10T442/3325 , Y10T442/612 , Y10T442/647
Abstract: A method for preparing by solvent phase inversion spinning a hollow fiber membrane suitable for dialysis. The membrane includes at least one hydrophobic polymer and at least one hydrophilic polymer. An outer surface of the membrane is characterized by pores having sizes in the range of 0.5-3 μm, with the density of the pores on the outer surface of the membrane being in the range of 10,000 to 150,000 pores per mm2. The method includes dissolving the at least one hydrophobic polymer and the at least one hydrophilic polymer in at least one solvent to form a polymer solution, extruding the thus-formed polymer solution through an outer ring slit of a nozzle with two concentric openings, extruding a center fluid through the inner opening of the nozzle, and wishing said membrane. The polymer solution coming out through the outer slit opening on the outside of the precipitating fiber is exposed to a humid steam/air mixture including a solvent content of between 0.5 and 10% by weight related to the water content.
Abstract translation: 通过溶剂相转化制备适合于透析的中空纤维膜的方法。 膜包括至少一种疏水性聚合物和至少一种亲水性聚合物。 膜的外表面的特征在于具有0.5-3μm范围内的尺寸的孔，膜的外表面上的孔的密度在每平方毫米10,000至150,000个孔的范围内。 该方法包括将至少一种疏水性聚合物和至少一种亲水性聚合物溶解在至少一种溶剂中以形成聚合物溶液，将由此形成的聚合物溶液通过具有两个同心开口的喷嘴的外环狭缝挤出，挤出 中心流体通过喷嘴的内部开口，并希望所述膜。 通过沉淀纤维外部的外部狭缝开口出来的聚合物溶液暴露于包含与含水量相关的0.5至10重量％的溶剂含量的湿蒸汽/空气混合物。
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公开(公告)号：US12059657B2
公开(公告)日：2024-08-13
申请号：US18143324
申请日：2023-05-04
Applicant: GAMBRO LUNDIA AB
Inventor： Markus Hornung , Bernd Krause , Markus Storr , Philipp Herbst , Arnd Wochner , Adriana Boschetti-De-Fierro , Manuel Voigt , Carina Zweigart , Joachim Loercher , Reinhold Buck , Heinrich Behr , Werner Beck
CPC classification number: B01D71/68 , A61M1/3479 , B01D61/243 , B01D63/0233 , B01D69/084 , B01D69/087 , B01D71/381 , B01D71/441 , B01D2323/06 , B01D2323/12 , B01D2325/022 , B01D2325/20
Abstract: The present disclosure relates to a dialyzer comprising a bundle of semipermeable hollow fiber membranes which is suitable for blood purification, wherein the dialyzer has an increased ability to remove larger molecules while at the same time it is able to effectively remove small uremic toxins and efficiently retain albumin and larger proteins. The invention also relates to using said dialyzer in hemodialysis.
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公开(公告)号：US10661231B2
公开(公告)日：2020-05-26
申请号：US15116031
申请日：2015-02-05
Applicant: GAMBRO LUNDIA AB
Inventor： Adriana Boschetti-De-Fierro , Manuel Voigt , Bernd Krause , Markus Hornung , Markus Storr , Heinrich Behr , Werner Beck , Carina Zweigart , Reinhold Buck , Philipp Herbst , Joachim Loercher , Arnd Wochner
Abstract: The present disclosure relates to semipermeable membranes which are suitable for blood purification, e.g. by hemodialysis, which have an increased ability to remove larger molecules while at the same time effectively retaining albumin. The membranes are characterized by a molecular retention onset (MWRO) of between 9.0 kD and 14.5 kD and a molecular weight cut-off (MWCO) of between 55 kD and 130 kD as determined by dextran sieving curves and can be prepared by industrially feasible processes excluding a treatment with salt before drying. The invention therefore also relates to a process for the production of the membranes and to their use in medical applications.
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Patent Agency Ranking
公开(公告)号：US10661230B2
公开(公告)日：2020-05-26
申请号：US15115951
申请日：2015-02-05
Applicant: GAMBRO LUNDIA AB
Inventor： Markus Hornung , Bernd Krause , Markus Storr , Philipp Herbst , Arnd Wochner , Adriana Boschetti-De-Fierro , Manuel Voigt , Carina Zweigart , Joachim Loercher , Reinhold Buck , Heinrich Behr , Werner Beck
Abstract: The present disclosure relates to a dialyzer comprising a bundle of semipermeable hollow fiber membranes which is suitable for blood purification, wherein the dialyzer has an increased ability to remove larger molecules while at the same time it is able to effectively remove small uremic toxins and efficiently retain albumin and larger proteins. The invention also relates to using said dialyzer in hemodialysis.
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公开(公告)号：US11273417B2
公开(公告)日：2022-03-15
申请号：US16851439
申请日：2020-04-17
Applicant: GAMBRO LUNDIA AB
Inventor： Markus Hornung , Bernd Krause , Markus Storr , Philipp Herbst , Arnd Wochner , Adriana Boschetti-De-Fierro , Manuel Voigt , Carina Zweigart , Joachim Loercher , Reinhold Buck , Heinrich Behr , Werner Beck
Abstract: The present disclosure relates to a dialyzer comprising a bundle of semipermeable hollow fiber membranes which is suitable for blood purification, wherein the dialyzer has an increased ability to remove larger molecules while at the same time it is able to effectively remove small uremic toxins and efficiently retain albumin and larger proteins. The invention also relates to using said dialyzer in hemodialysis.
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公开(公告)号：US11154820B2
公开(公告)日：2021-10-26
申请号：US15538533
申请日：2015-12-21
Applicant: GAMBRO LUNDIA AB
Inventor： Ulrich Bauer , Reinhold Buck , Juergen Graf , Helmut Hildwein , Bernd Krause , Markus Storr , Arnd Wochner
Abstract: The present invention relates to a continuous process for preparing permselective hollow fiber membranes being suitable e.g. for hemodialysis, hemodiafiltration and hemofiltration of blood which comprises a two-stage drying and tempering treatment of the hollow fiber membranes. According to a further aspect, the invention relates to a continuous process for drying permselective hollow fiber membranes on-line. The invention also relates to devices for on-line drying of permselective hollow fiber membranes.
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公开(公告)号：US12145108B2
公开(公告)日：2024-11-19
申请号：US17786685
申请日：2020-12-21
Applicant: GAMBRO LUNDIA AB
Inventor： Reinhold Buck , Evelyn Grossmann , Markus Hornung , Markus Loeffler , Heinrich Behr , Arnd Wochner , Carl-Philipp Scheuermann
IPC: B01D69/08 , B01D71/44 , B01D71/68 , B29C48/00 , B29C48/05 , B29C48/09 , B29C48/32 , B29C48/345 , B29K81/00 , B29L31/00 , D01D5/06 , D01D5/24 , D01F6/76
Abstract: The present disclosure relates to a spinneret for producing hollow fiber membranes in a phase inversion process.
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公开(公告)号：US11666869B2
公开(公告)日：2023-06-06
申请号：US17590097
申请日：2022-02-01
Applicant: GAMBRO LUNDIA AB
Inventor： Markus Hornung , Bernd Krause , Markus Storr , Philipp Herbst , Arnd Wochner , Adriana Boschetti-De-Fierro , Manuel Voigt , Carina Zweigart , Joachim Loercher , Reinhold Buck , Heinrich Behr , Werner Beck
CPC classification number: B01D71/68 , A61M1/3479 , B01D61/243 , B01D63/021 , B01D69/084 , B01D69/087 , B01D71/38 , B01D71/44 , B01D2323/06 , B01D2323/12 , B01D2325/022 , B01D2325/20
Abstract: The present disclosure relates to a dialyzer comprising a bundle of semipermeable hollow fiber membranes which is suitable for blood purification, wherein the dialyzer has an increased ability to remove larger molecules while at the same time it is able to effectively remove small uremic toxins and efficiently retain albumin and larger proteins. The invention also relates to using said dialyzer in hemodialysis.
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