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公开(公告)号：US12121631B2
公开(公告)日：2024-10-22
申请号：US17527679
申请日：2021-11-16
CPC分类号： A61L27/50 , A61L27/24 , A61L27/3604 , A61L27/3633 , A61L27/3808 , A61L27/3826 , C12M21/08 , C12M23/06 , C12M23/34 , C12M25/14 , C12N5/0062 , A61L2430/02 , A61L2430/06 , A61L2430/26 , A61L2430/28 , A61L2430/30 , A61L2430/32 , A61L2430/34 , C12N2533/54
摘要： Described are methods, cell growth substrates, and devices that are useful in preparing cell-containing graft materials for administration to patients. Tubular passages can be defined in cell growth substrates to promote distribution of cells into the substrates. Also described are methods and devices for preparing cell-seeded graft compositions, methods and devices for preconditioning cell growth substrates prior to application of cells, and cell seeded grafts having novel substrates, and uses thereof.
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公开(公告)号：US12121434B2
公开(公告)日：2024-10-22
申请号：US17930661
申请日：2022-09-08
CPC分类号： A61F2/2412 , A61F2/2409 , A61F2/2418 , A61F2/2427 , A61L27/34 , A61L27/3625 , A61L27/3629 , A61L33/0011 , C08L67/04 , A61B17/0401 , A61B2017/0404 , A61B17/064 , A61B17/0644 , A61F2/2436 , A61F2/2457 , A61F2210/0004 , A61F2210/0014 , A61F2220/0008 , A61F2220/005 , A61F2220/0058 , A61F2220/0091 , A61F2230/0013 , A61F2230/0034 , A61F2230/005 , A61F2230/0054 , A61F2230/0067 , A61F2230/0091 , A61F2310/00023 , A61F2310/00077 , A61L2400/16 , A61L2430/20 , A61L27/34 , C08L67/04
摘要： This invention relates to the design and function of a compressible valve replacement prosthesis, collared or uncollared, which can be deployed into a beating heart without extracorporeal circulation using a transcatheter delivery system. The design as discussed focuses on the deployment of a device via a minimally invasive fashion and by way of example considers a minimally invasive surgical procedure preferably utilizing the intercostal or subxyphoid space for valve introduction. In order to accomplish this, the valve is formed in such a manner that it can be compressed to fit within a delivery system and secondarily ejected from the delivery system into the annulus of a target valve such as a mitral valve or tricuspid valve.
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公开(公告)号：US12121288B2
公开(公告)日：2024-10-22
申请号：US17204150
申请日：2021-03-17
发明人： Bruce R. Forsyth , Chun Wang , Samuel Hanson
CPC分类号： A61B18/1477 , A61B18/1485 , A61L27/3641 , A61B2018/00154 , A61B2018/00333 , A61B2018/00345 , A61B2018/00452 , A61B2018/00494 , A61B2018/00511 , A61B2018/00529 , A61B2018/00541 , A61B2018/00547 , A61B2018/00559 , A61B2018/00613 , A61L2400/06
摘要： In some aspects, the present disclosure pertains to methods of treating a tissue volume comprising (a) administering an implantable composition comprising a releasable membrane-active agent to a target site such that the membrane-active agent is locally released to the tissue volume and (b) performing irreversible, reversible and/or thermal treatment by application of a pulsed electric field to the tissue volume. In other aspects, the present disclosure pertains to embolic compositions that comprise releasable membrane-active agents.
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4.发明授权公开(公告)号：US12115280B2
公开(公告)日：2024-10-15
申请号：US17127281
申请日：2020-12-18
发明人： Jeffrey S. Dove , Tara J. Tod
CPC分类号： A61L27/3687 , A61L27/50 , A61L27/54 , A61L2430/20 , A61L2430/40
摘要： Methods are provided herein for modifying antigenic carbohydrate epitopes within a xenographic bioprosthetic tissue by oxidation of vicinal diols to form aldehydes or acids and subsequence reductive amination of aldehydes to form stable secondary amines, or amidation or esterification of acids to form stable amides or esters. Advantageously, methods provided herein mitigate the antigenicity of the bioprosthetic tissue while leaving the overall tissue structure substantially undisturbed, and thereby enhance the durability, safety and performance of the bioprosthetic implant.
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公开(公告)号：US20240335590A1
公开(公告)日：2024-10-10
申请号：US18225482
申请日：2023-07-24
发明人： Keng-Liang Ou , Hsu-An Pan , En-Kai Chang
CPC分类号： A61L27/3687 , A61L27/3633 , C12N5/0075 , C12N2531/00 , C12N2533/74
摘要： A method for manufacturing an extracellular matrix composition includes providing a gel, carrying out a crosslinking treatment, carrying out a single type cell culture, carrying out a decrosslinking treatment, and carrying out an extraction treatment. The crosslinking treatment includes adding a crosslinking agent to the gel to obtain a crosslinked gel. The cell culture includes implanting cells of a singular type on the crosslinked gel and incubating the cells by adding a culture solution. The decrosslinking treatment includes adding a decrosslinking agent to the crosslinked gel to obtain a decrosslinked mixture that contains an extracellular matrix. The extraction treatment includes filtering the decrosslinked mixture to obtain the extracellular matrix composition that is in a liquid state.
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公开(公告)号：US12109330B2
公开(公告)日：2024-10-08
申请号：US17570549
申请日：2022-01-07
发明人： Amelie Barbara Hildegarde Beduer , Thomas Braschler , Philippe Renaud , Giorgio Pietramaggiori , Saja Scherer
CPC分类号： A61L27/56 , A61L27/227 , A61L27/3616 , A61L27/38 , A61L27/50 , A61L27/52 , A61L27/505
摘要： The invention relates to a scaffold material comprising a plurality of particles of a highly porous polymeric material, characterized in that said scaffold material becomes a shapeable paste once hydrated. The specific features of the particle material impart a special behavior to the scaffold, which can be easily shaped and even highly reversibly compressed, so that in certain aspects it can, if needed, be injected, said capacity to be shaped being maintained over a high range of hydration conditions. A particular aspect of the invention relates, therefore, to the use of such scaffold material for the manufacturing of shapeable body implants, such as breast implants, to the shapeable body implants themselves as well as to non-invasive methods for using thereof in creating or reconstructing a three-dimensional volume in a subject's body part.
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公开(公告)号：US20240325605A1
公开(公告)日：2024-10-03
申请号：US18623287
申请日：2024-04-01
申请人： BVW Holding AG
发明人： Lukas Bluecher , Michael Milbocker
CPC分类号： A61L27/50 , A61L27/3633 , A61L27/3886 , A61L2420/02 , G03F7/2002
摘要： Provided herein is a tissue scaffold that may include microstructure patterns on one or more surfaces that can modify the physical properties of the tissue scaffold. The microstructure patterns may be cell-directing across a larger spatial range than the prior art which uses chemically modified substrates. The present disclosure further includes tissue scaffold configured such that cells may infiltrate the tissue scaffold by responding to patterns of surface energy gradients on the tissue scaffold and the cells may not be constrained into patterns by physical means. As the cells proliferate, they associate and orient in response to long-range patterns to form confluent monolayers of cells while constructing functional macro-structure across the tissue scaffold surface.
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公开(公告)号：US20240315835A1
公开(公告)日：2024-09-26
申请号：US18731039
申请日：2024-05-31
发明人： Travis Zenyo Oba , Matthew A. Peterson , Glen T. Rabito , Alexander H. Cooper , David Robert Landon , Jeremy Brent (aka J. Brent) Ratz , Seung-Beom Yi
CPC分类号： A61F2/2409 , A61F2/2418 , A61L27/04 , A61L27/3625 , A61F2/2412 , A61F2/2436 , A61F2220/0008 , A61F2220/0075 , A61F2230/0093 , A61F2250/0018 , A61F2250/0039 , A61F2250/0063 , A61L2430/20
摘要： A self-expanding prosthetic heart valve includes an inner frame and an outer sealing frame. A lower region of the outer sealing frame is coupled to a lower region of the inner frame. At least a portion of the outer frame has a D-shape cross-section for conforming to a shape of a native heart valve annulus. Elongate anchors are positioned outwardly from the outer sealing frame for anchoring to native leaflets. Preferably, the native leaflets are secured between the anchors and an outer surface of the outer sealing frame. A valve body is positioned within an interior lumen of the inner frame and provides a one-way valve mechanism for replacing the function of the native leaflets. For additional stability, a further anchoring mechanism may extend from the inner frame for attachment to a heart wall. The prosthetic heart valve is well-suited for replacing the function of a native tricuspid valve.
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公开(公告)号：US12097301B2
公开(公告)日：2024-09-24
申请号：US16619256
申请日：2018-06-07
发明人： Sheila Macneil , Christopher Reginald Chapple , Sabiniano Roman Regueros , Christopher James Hillary , Anthony James Bullock
CPC分类号： A61L27/18 , A61F2/0036 , A61L27/3604 , A61L27/3834 , A61L27/56 , A61F2240/001 , A61L2430/22 , D01D5/003 , D10B2331/10 , D10B2509/00
摘要： The present invention relates to a scaffold for the treatment of stress urinary incontinence, wherein the scaffold comprises three layers of polyurethane: a first layer and a third layer in which the polyurethane fibres are randomly orientated and a second layer between said first and third layers in which the fibres are aligned longitudinally; methods of making such scaffolds and uses thereof.
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公开(公告)号：US12090250B2
公开(公告)日：2024-09-17
申请号：US17321904
申请日：2021-05-17
申请人： LifeNet Health
发明人： Silvia Chen , Grant Cleavenger , Dennis Phelps , Evans Wralstad , Breanne Gjurich , Austin Johnson , Alana Sampson , Adam Entsminger , Jingsong Chen
CPC分类号： A61L27/3608 , A61K35/32 , A61L27/365 , A61L27/3687 , A61L2430/02
摘要： The present invention provides demineralized bone fibers exhibiting optimal handling properties (e.g., high moldability and low elastic modulus) and biological activities (e.g., osteoinductivity) as well as non-demineralized bone fibers useful for preparing the demineralized bone fibers. A well-controlled demineralization process for preparing the demineralized bone of fibers is also provided. Products comprising the demineralized bone fibers and uses thereof are further provided.
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