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公开(公告)号：US20240009352A1
公开(公告)日：2024-01-11
申请号：US18470838
申请日：2023-09-20
申请人： LifeNet Health
发明人： Silvia Chen , Grant Cleavenger , Dennis Phelps , Breanne Gjurich , Evans Wralstad , Austin Johnson , Alana Sampson , Adam Entsminger , Jingsong Chen
CPC分类号： A61L27/3608 , A61L27/3687 , A61L27/365 , A61L27/54 , A61L2430/02
摘要： The present invention provides demineralized bone fibers exhibiting optimal handling properties (e.g., high moldability and low elastic modulus) and biological activities (e.g., osteoinductivity) as well as non-demineralized bone fibers useful for preparing the demineralized bone fibers. A well-controlled demineralization process for preparing the demineralized bone of fibers is also provided. Products comprising the demineralized bone fibers and uses thereof are further provided.
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公开(公告)号：US11655448B2
公开(公告)日：2023-05-23
申请号：US15576954
申请日：2016-05-27
申请人： LIFENET HEALTH
发明人： Michael Francis , Silvia Chen , Erick Breathwaite , Rudy Rodriguez , Alan Smith , Alexander Huber , Jung Bok Lee
CPC分类号： C12N5/0068 , C12N5/0605 , C12N2501/11 , C12N2501/113 , C12N2501/115 , C12N2501/119 , C12N2501/305 , C12N2501/31 , C12N2509/00 , C12N2533/52 , C12N2533/54 , C12N2533/90
摘要： The invention relates to placenta-derived matrix, methods of preparing, and methods of use thereof. The invention also relates to methods of culturing cells, delivering cells, promoting differentiation of stem cells or tissue-specific progenitor cells, and repairing, replacing, regenerating, filling, reducing or inhibiting scarring of defects using the same. The invention further relates to methods of coating placenta-derived matrix on a surface or injecting the placenta-derived matrix into a site of interest.
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公开(公告)号：US11576999B2
公开(公告)日：2023-02-14
申请号：US16988078
申请日：2020-08-07
申请人： LifeNet Health
发明人： Michael Francis , Rudy Rodriquez , Nathan Kemper , Silvia Chen
摘要： The present disclosure relates to compressed bone compositions, bone implants, and variants thereof. The present disclosure also relates to methods of preparing compressed bone compositions, bone implants, and variants thereof. The present disclosure also relates to methods of using the bone compositions, bone implants and variants thereof.
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公开(公告)号：US11078248B2
公开(公告)日：2021-08-03
申请号：US16218979
申请日：2018-12-13
申请人： LifeNet Health
发明人： Xiaofei Qin , Silvia Chen , Jingsong Chen , James Clagett
摘要： The invention relates to truncated growth factors and variants thereof. The invention also relates to methods of making and using the truncated growth factors. The invention further relates to compositions including a protease and a growth factor comprising a bone morphogenic protein (BMP) or a variant thereof. The invention also relates to methods of using the composition.
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公开(公告)号：US20180361026A1
公开(公告)日：2018-12-20
申请号：US16063357
申请日：2016-12-23
申请人： LifeNet Health
发明人： Xiaofei QIN , Silvia Chen , Lindsey Aschenbach , Jiingsong Chen
摘要： A method of preparing a decellularized placental membrane is provided. The method comprises removing cells from a pre-decellularized placental membrane comprising an amnion layer and a chorion layer to produce a decellularized placental membrane without separating the amnion layer from the chorion layer. The pre-decellularized placental membrane is obtained from an amniotic sac, and the decellularized placental membrane comprises the amnion layer and the chorion layer. Also provided is a decellularized placental membrane and a placenta-derived graft comprising the decellularized placental membrane. Further provided are the uses of the decellularized placental membrane or the placenta-derived graft.
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公开(公告)号：US20230363374A1
公开(公告)日：2023-11-16
申请号：US18225923
申请日：2023-07-25
申请人： LifeNet Health
发明人： Silvia Chen , Austin Johnson , Roberto Bracone
CPC分类号： A01N1/021 , A01N1/0263 , A01N1/0268 , A61J1/10 , A61M5/002 , B65D39/0052 , B65D39/08
摘要： An improved packaging assembly for storing, distributing, treating, mixing, and dispensing tissue and/or cellular material and/or implantable material. The packaging assembly may include pouches, tubes, and a bag made of a sealable, flexible polymeric material that is open at one end and a needle-free swabable connector attached to the pouch at the other end and acting as a port to allow for the introduction or discharge of biological solutions, rinsing solution, and/or preservation solutions into the packaging assembly. The designed thickness of the wall of the packaging assembly facilitates efficient heat/cold transfer, which is useful for successful controlled rate freezing, quick thawing, and resuscitation of viable cells or tissue. The packaging assembly is also useful for combining additional biological fluids with the cellular material or tissue, and for efficient mixing of the biological fluids with the tissue and/or cellular material in the assembly.
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公开(公告)号：US11533906B2
公开(公告)日：2022-12-27
申请号：US17101294
申请日：2020-11-23
申请人： LifeNet Health
发明人： Roberto Bracone , Jingsong Chen , Marilyn Gatin , Silvia Chen , James A. Clagett , Daniel Osborne
摘要： The present invention is directed to methods for collecting and processing autografts, processed autografts, kits for collecting and transporting autografts, and tools for preparing autografts. It is also directed to autologous bone grafts, and methods of preparing them.
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公开(公告)号：US20220372438A1
公开(公告)日：2022-11-24
申请号：US17871149
申请日：2022-07-22
申请人： LifeNet Health
发明人： Xiaofei Qin , Silvia Chen
摘要： The invention relates to biologically functional scaffolds having a porous structure, methods of preparing, and methods of use thereof. The invention also relates to methods of repairing a defect, methods of culturing cells and promoting differentiation of stem cells using the same.
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公开(公告)号：US11033656B2
公开(公告)日：2021-06-15
申请号：US16309505
申请日：2017-06-13
申请人： LifeNet Health
发明人： Silvia Chen , Grant Cleavenger , Dennis Phelps , Evans Wralstad , Breanne Gjurich , Austin Johnson , Alana Sampson , Adam Entsminger , Jingsong Chen
摘要： The present invention provides demineralized bone fibers exhibiting optimal handling properties (e.g., high moldability and low elastic modulus) and biological activities (e.g., osteoinductivity) as well as non-demineralized bone fibers useful for preparing the demineralized bone fibers. A well-controlled demineralization process for preparing the demineralized bone of fibers is also provided. Products comprising the demineralized bone fibers and uses thereof are further provided.
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公开(公告)号：US11434469B2
公开(公告)日：2022-09-06
申请号：US15549771
申请日：2016-02-09
申请人： LifeNet Health
发明人： Xiaofei Qin , Silvia Chen
摘要： The invention relates to biologically functional scaffolds having a porous structure, methods of preparing, and methods of use thereof. The invention also relates to methods of repairing a defect, methods of culturing cells and promoting differentiation of stem cells using the same.
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