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1.发明授权公开(公告)号：US12123876B2
公开(公告)日：2024-10-22
申请号：US16077911
申请日：2017-01-16
发明人： Shoutaro Tsuji , Taihei Kageyama , Kota Washimi , Makiko Tsuji , Rieko Matsuura , Mitsuyo Yoshihara , Kohzoh Imai
IPC分类号： G01N33/574 , A61K39/395 , A61K49/00 , A61K49/16 , A61P35/00 , C07K14/705 , C07K16/30 , C07K16/46 , C12N15/09 , C12N15/62 , G01N33/577 , G01N33/68
CPC分类号： G01N33/574 , A61K39/395 , A61K49/00 , A61K49/0058 , A61K49/16 , A61P35/00 , C07K14/705 , C07K16/30 , C07K16/3092 , C07K16/46 , C12N15/09 , C12N15/62 , G01N33/57423 , G01N33/68
摘要： The present invention provides an antibody for detecting mesothelioma and an antibody having high specificity to mesothelioma and high sensitivity thereto. The present invention also provides a method of diagnosis of mesothelioma by using the antibody, a reagent containing the antibody for use in diagnosis of mesothelioma, and a kit comprising the antibody for use in diagnosis of mesothelioma. Further, the present invention provides a marker for use in diagnosis of mesothelioma. Furthermore, the present invention provides a pharmaceutical composition containing the antibody according to the present invention or an antigen-binding fragment thereof for use in treatment of mesothelioma. An antibody that binds to a glycosylated HEG1 protein obtained from mesothelioma.
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公开(公告)号：US20240261441A1
公开(公告)日：2024-08-08
申请号：US18620709
申请日：2024-03-28
申请人： NANOMEDTRIX, LLC
发明人： Joe G. ASSOULINE , Sean K. SWEENEY
CPC分类号： A61K49/1824 , A61K49/0089 , A61K49/16
摘要： Mesoporous silica nanoparticles (MSNs) that may be useful as ultrasound contrast agents for detecting and treating bladder cancer are described herein. The MSNs include a lanthanide, a fluorophore, and an agent detectable by ultrasound.
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公开(公告)号：US20240115740A1
公开(公告)日：2024-04-11
申请号：US18254851
申请日：2021-11-30
发明人： Andrew TSOURKAS , Feifan YU
CPC分类号： A61K49/0032 , A61K49/0056 , A61K49/16 , C07K16/2863 , C07K16/32 , A61K2123/00
摘要： This invention relates to the compositions and methods for labeling antibodies and other proteins and targeting agents with a helical bundle protein that is functionalized with cargo. Cargos can include but are not limited to fluorescent dyes, haptens (e.g. biotin), contrast agents (e.g. gadolinium, radionuclides), chelated metals, therapeutic agents, sensitizers, or other small molecules. Specifically, provided herein are compositions having a helical bundle, that has been labeled at precisely defined locations with cargo, and that can be conjugated, attached or fused to an antibody or other targeting agent.
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公开(公告)号：US11642418B2
公开(公告)日：2023-05-09
申请号：US16647467
申请日：2018-09-13
发明人： Hong Hoi Ting , Chung Lim Wong
CPC分类号： A61K47/6849 , A61K47/6803 , A61K49/16 , A61K51/088 , G01N33/6872
摘要： Disclosed is the use of a radiolabeled anti-nanobody in the prognosis and diagnosis of cancers. In particular, disclosed is an immunoconjugate for detecting a PD-L1 molecule. The immunoconjugate comprises the VHH chain of a specific anti-PD-L1 nanobody and a radionuclide, and can be used for non-invasive detecting of expression of the object PD-L1 to be detected. The immunoconjugate of the invention has small size and high specificity, and is suitable for systemic detection which simultaneously targets primary and metastatic tumors, and has high accuracy and low radiation dose.
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公开(公告)号：US20230066723A1
公开(公告)日：2023-03-02
申请号：US17823236
申请日：2022-08-30
申请人： James Shue-Min YEH
发明人： James Shue-Min YEH
IPC分类号： A61K49/22 , A61B8/06 , G01R33/56 , A61K49/00 , A61K49/16 , A61K49/18 , A61B6/00 , A61B8/08 , G06T7/00
摘要： There is provided a microparticle composition suitable for molecular imaging, the composition comprising microparticles, wherein the microparticles comprise: a core microparticle structure having a central area and a shell, and wherein the core microparticle structure comprises (i) a phosphatidylcholine lipid: (ii) a phosphatidylethanolamine lipid comprising at least one maleimide moiety; and (iii) an alkoxylated fatty acid.
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公开(公告)号：US11305023B2
公开(公告)日：2022-04-19
申请号：US13675306
申请日：2012-11-13
申请人： Sam Popinchalk
发明人： Sam Popinchalk
摘要： An improved method for diagnosing and characterizing peripheral nerve lesions to permit early identification and characterization of peripheral nerve injuries that will require surgical intervention.
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公开(公告)号：US20220105194A1
公开(公告)日：2022-04-07
申请号：US17420692
申请日：2020-01-06
申请人： ASTELLAS PHARMA INC.
发明人： Michinori Akaiwa , Junya Ishida , Hiroki Toya , Toru Asano , Tomoaki Yoshikawa , Yorikata Sano , Yukihito Sugano
摘要： Provided is a conjugate comprising a ligand, a spacer, and a peptide linker useful for an in-vivo diagnostic drug and internal radiation therapy, using an anti-human MUC1 antibody Fab fragment whose binding activity is not attenuated even by labeling with a metal, a fluorescent dye, or the like. A conjugate comprising 3arm DOTA, a specific spacer, a specific peptide linker, and a biomolecule including an anti-human MUC1 antibody Fab fragment, wherein the binding activity thereof is not attenuated even by labeling with a metal, a fluorescent dye, or the like, can be used as a diagnostic composition and/or a pharmaceutical composition.
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公开(公告)号：US11124563B2
公开(公告)日：2021-09-21
申请号：US16700788
申请日：2019-12-02
申请人： F. HOFFMANN-LA ROCHE AG , INSTITUT PASTEUR , COMMISSARIAT A L'ENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVES , CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS)
发明人： Pierre Lafaye , Sylvie Bay , Benoit Delatour , Marc Dhenain , Charles Duyckaerts , Tengfei Li , Matthias Vandesquille , Christian Czech , Fiona Grueninger
摘要： The present invention relates to variable domains of a camelid heavy-chain antibodies directed against a phosphorylated tau protein and conjugates thereof. The present invention also relates to the use of these domains or conjugates for treating or diagnosing disorders mediated by neurofibrillary tangles, neuropil threads or dystrophic neurites, such as tauopathies.
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9.发明授权公开(公告)号：US11072651B2
公开(公告)日：2021-07-27
申请号：US16332900
申请日：2017-09-08
发明人： Nanmeng Song , Jiawang Liu , Yaping Yang , Yang Yang , Dongge Yang , Hongjuan Zhang , Mengxie Jin
IPC分类号： A61K39/395 , C07K16/24 , A61K47/68 , A61K49/00 , A61K49/16 , A61K49/22 , A61K51/10 , A61P19/08 , A61P43/00 , A61P27/02 , A61P11/00 , A61P11/06 , A61P17/06 , A61P37/08 , A61P19/02 , A61P1/12 , A61P17/14 , A61P17/00 , A61P25/00 , A61P31/04 , A61P1/04 , A61P37/06 , A61P7/06 , A61P29/00 , A61P13/12 , A61P9/02 , A61P37/02 , A61P1/00 , A61K39/00
摘要： An antibody specifically binding to IL-17A or a functional fragment thereof. The antibody or functional fragment thereof includes an IL-17A chimeric antibody and a functional fragment thereof, and an IL-17A humanized antibody and a functional fragment thereof.
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公开(公告)号：US10941203B2
公开(公告)日：2021-03-09
申请号：US16492954
申请日：2018-03-15
申请人： TSINGHUA UNIVERSITY
发明人： Bai Lu , Wei Guo , Hongyang Yao
IPC分类号： A61K39/395 , A61K39/00 , C12P21/08 , G01N33/53 , A61K49/00 , A61K49/16 , C07K14/00 , A61K38/00 , C07K16/28 , A61P25/28 , A61K38/18 , A61P25/00 , A61P25/02 , A61P27/00 , A61P27/06 , A61P27/02 , C07K16/00 , C07K14/48 , A61P9/10 , C07K16/18 , A61P25/14 , A61K9/00 , A61K38/17 , C07K14/705 , C07K14/47 , A61P25/16 , C12N5/0793 , A61P21/00 , A61L27/38
摘要： Provided is an isolated TrkB agonist antibody that binds to an epitope contained in one of the extracellular domains of TrkB and is capable of activating TrkB, wherein the extracellular domains comprises extracellular D1, D2, D3, D4, D5 domains and juxtamembrane domain of TrkB. Methods of using the TrkB agonist antibody in treating or reducing the risk of a TrkB associated conditions in a subject, wherein said condition is selected from cell differentiation, synaptic development, neural injury repairing and/or neurite branching.
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