公开(公告)号：US11731952B2

公开(公告)日：2023-08-22

申请号：US16633464

申请日：2018-08-29

Applicant: MUSC FOUNDATION FOR RESEARCH DEVELOPMENT ,  LEUKOGENE THERAPEUTICS INCORPORATED

Inventor： Nathan G. Dolloff ,  Reeder M. Robinson ,  Allen B. Reitz ,  Haiyan Bian

IPC: C07C39/38 ,  C07C43/225 ,  C07C61/29 ,  C07C69/708 ,  C07C233/02 ,  C07C233/58 ,  C07D317/70 ,  C07D317/52 ,  C07D319/14 ,  C07D263/52 ,  C07C69/712 ,  A61P35/00 ,  C07C62/32 ,  C07C69/757 ,  C07C235/40 ,  C07C235/34 ,  C07C49/255 ,  C07C59/72 ,  C07C65/11

CPC classification number: C07D317/70 ,  A61P35/00 ,  C07C39/38 ,  C07C43/225 ,  C07C49/255 ,  C07C59/72 ,  C07C61/29 ,  C07C62/32 ,  C07C65/11 ,  C07C69/708 ,  C07C69/712 ,  C07C69/757 ,  C07C233/02 ,  C07C233/58 ,  C07C235/34 ,  C07C235/40 ,  C07D263/52 ,  C07D317/52 ,  C07D319/14 ,  C07C2601/14 ,  C07C2602/08

Abstract: The present invention relates to compounds of formula (I): including any stereochemically isomeric form thereof, or pharmaceutically acceptable salts thereof, for the treatment of, for example, cancer.

公开(公告)号：US11654102B2

公开(公告)日：2023-05-23

申请号：US16968267

申请日：2019-03-11

Applicant: GIVAUDAN SA

Inventor： Amandine Scandolera ,  Carole Lambert ,  Romain Reynaud

IPC: A61K36/00 ,  A61K8/9794 ,  A61Q19/00 ,  A61Q19/08 ,  C07C49/733 ,  C07C49/743 ,  C07C49/747 ,  C07C61/35 ,  C07C62/32 ,  C07D303/32 ,  C07D303/38

CPC classification number: A61K8/9794 ,  A61Q19/007 ,  A61Q19/08 ,  C07C49/733 ,  C07C49/743 ,  C07C49/747 ,  C07C61/35 ,  C07C62/32 ,  C07D303/32 ,  C07D303/38 ,  A61K2236/331 ,  C07C2602/32

Abstract: A cosmetic composition is provided, which comprises a carrier and a Vetiver root extract, in particular an extract from exhausted Vetiver root. This composition provides a stimulation of sebum production, stimulation of sebum antimicrobial, lipids production, activation of adipocytes volume increase, skin hydration, skin tonicity booster, skin fatigue reduction, perilabial wrinkles reduction, skin replumping, and fragrance long-lastingness enhancement.

公开(公告)号：US10934251B2

公开(公告)日：2021-03-02

申请号：US16797498

申请日：2020-02-21

Applicant: Hetero Research Foundation

Inventor： Bandi Parthasaradhi Reddy ,  Kura Rathnakar Reddy ,  Bandi Vamsi Krishna ,  Jambula Mukunda Reddy

IPC: C07C231/02 ,  C07D211/58 ,  C07C231/12 ,  C07C67/293 ,  C07C69/157 ,  C07C51/367 ,  C07C62/32

Abstract: The present invention relates to a process for preparing Lomitapide or its pharmaceutically acceptable salt thereof having high purity with acceptable levels of impurities.

公开(公告)号：US10800730B2

公开(公告)日：2020-10-13

申请号：US16136830

申请日：2018-09-20

Applicant: The Board of Trustees of the University of Illinois

Inventor： Paul J. Hergenrother ,  Robert W. Huigens, III ,  Karen C. Morrison ,  Robert W. Hicklin, II ,  Timothy A. Flood, Jr.

IPC: C07C69/757 ,  C07J21/00 ,  C07J69/00 ,  C07J71/00 ,  C07J73/00 ,  C07J75/00 ,  C07D401/14 ,  C07D311/94 ,  C07D313/06 ,  C07D223/14 ,  C07D401/04 ,  C07D471/04 ,  C07D471/08 ,  C07D493/08 ,  C07D513/04 ,  C07D519/00 ,  C07C59/205 ,  C07C62/32 ,  C07C62/38 ,  C07D303/10 ,  C07B37/06 ,  C07B37/08 ,  C07D307/93 ,  C07D313/08 ,  C07D405/06 ,  C07D405/12 ,  C07D413/06

Abstract: The invention provides a novel, general, and facile strategy for the creation of small molecules with high structural and stereochemical complexity. Aspects of the methods include ring system distortion reactions that are systematically applied to rapidly convert readily available natural products to structurally complex compounds with diverse molecular architectures. Through evaluation of chemical properties including fraction of sp3 carbons, ClogP, and the number of stereogenic centers, these compounds are shown to be significantly more complex and diverse than those in standard screening collections. This approach is demonstrated with natural products (gibberellic acid, adrenosterone, and quinine) from three different structural classes, and methods are described for the application of this strategy to any suitable natural product.

公开(公告)号：US20190226000A1

公开(公告)日：2019-07-25

申请号：US16299960

申请日：2019-03-12

Applicant: DSM IP ASSETS B.V.

Inventor： Nicolette Jasmijn BROERS ,  Viktor Marius BOER ,  Adam G. LAWRENCE

IPC: C12P19/56 ,  C12P15/00 ,  C12N9/02 ,  C12N9/10 ,  C07H15/256 ,  C07C62/32 ,  A23L27/30 ,  A23L2/60 ,  C12N15/52 ,  C12N9/90 ,  C12N9/88

Abstract: The present invention relates to a method for the production of a diterpene or a glycosylated diterpene, which method comprises: a. fermenting a recombinant microorganism of the genus Yarrowia in a suitable fermentation medium at a temperature of about 29° C. or higher, wherein the microorganism comprises one or more nucleotide sequence(s) encoding: a polypeptide having ent-copalyl pyrophosphate synthase activity; a polypeptide having ent-Kaurene synthase activity; a polypeptide having ent-Kaurene oxidase activity; and a polypeptide having kaurenoic acid 13-hydroxylase activity and whereby expression of the nucleotide sequence(s) confer(s) on the microorganism the ability to produce at least steviol; and b. recovering the diterpene or glycosylated diterpene.

公开(公告)号：US10351504B1

公开(公告)日：2019-07-16

申请号：US16126386

申请日：2018-09-10

Applicant: Naga Bhushan Mandava

Inventor： Naga Bhushan Mandava

IPC: C07C46/00 ,  C07C51/00 ,  C07C67/00 ,  C07C46/04 ,  C07C67/08 ,  C07C62/32 ,  C07C69/757 ,  C07C46/10 ,  C07C50/16

Abstract: Methods of synthesizing phenanthrenequinone, 9-hydroxyfluorene-9-5 carboxylic acid (“HFCA”), methyl-9-hydroxyfluorene-carboxylate (“HFCA methyl ester”) and methyl-2-chloro-9-hydroxyfluorenecarboxylate, (“Chlorflurenol”) starting from preferred embodiment are disclosed. Several reaction products of phenanthrene are useful in industry, and are valuable plant growth regulators.

公开(公告)号：US10273519B2

公开(公告)日：2019-04-30

申请号：US14906497

申请日：2014-07-23

Applicant: DSM IP ASSETS B.V.

Inventor： Nicolette Jasmijn Broers ,  Viktor Marius Boer ,  Adam G. Lawrence

IPC: C12P19/56 ,  A23L2/60 ,  C12N9/00 ,  C12N15/52 ,  C12N9/88 ,  C12N9/90 ,  C12N15/00 ,  C07C62/32 ,  C07H15/256 ,  C12N9/02 ,  C12N9/10 ,  C12P15/00 ,  A23L27/30

Abstract: The present invention relates to a method for the production of a diterpene or a glycosylated diterpene, which method comprises: a. fermenting a recombinant microorganism of the genus Yarrowia in a suitable fermentation medium at a temperature of about 29° C. or higher, wherein the microorganism comprises one or more nucleotide sequence(s) encoding: a polypeptide having ent-copalyl pyrophosphate synthase activity; a polypeptide having ent-Kaurene synthase activity; a polypeptide having ent-Kaurene oxidase activity; and a polypeptide having kaurenoic acid 13-hydroxylase activity and whereby expression of the nucleotide sequence(s) confer(s) on the microorganism the ability to produce at least steviol; and b. recovering the diterpene or glycosylated diterpene.

公开(公告)号：US20190062298A1

公开(公告)日：2019-02-28

申请号：US16115780

申请日：2018-08-29

Applicant: MUSC FOUNDATION FOR RESEARCH DEVELOPMENT

Inventor： Nathan G. Dolloff ,  Reeder M. Robinson ,  Allen B. Reitz ,  Haiyan Bian

IPC: C07D317/70 ,  C07C39/38 ,  C07D319/14 ,  C07D263/52 ,  C07C69/712 ,  C07C59/72 ,  C07C62/32 ,  C07C69/757 ,  C07C235/40 ,  C07C235/34 ,  C07C49/255 ,  A61P35/00

CPC classification number: C07D317/70 ,  A61P35/00 ,  C07C39/38 ,  C07C43/225 ,  C07C49/255 ,  C07C59/72 ,  C07C62/32 ,  C07C65/11 ,  C07C69/708 ,  C07C69/712 ,  C07C69/757 ,  C07C235/34 ,  C07C235/40 ,  C07C2601/14 ,  C07C2602/08 ,  C07D263/52 ,  C07D319/14

Abstract: The present invention relates to compounds of formula (I): including any stereochemically isomeric form thereof, or pharmaceutically acceptable salts thereof, for the treatment of, for example, cancer.

公开(公告)号：US20160207869A1

公开(公告)日：2016-07-21

申请号：US14839810

申请日：2015-08-28

Applicant: Huya Bioscience International LLC

Inventor： Andreas KYAS ,  Ernst FREUND ,  Oliver SCHLÖRKE ,  Joerg LILL ,  Lars ROGALL ,  Dario MENIA ,  Gary ELLIOTT ,  James PATERNITI

IPC: C07C62/32 ,  C07H15/24

CPC classification number: C07C62/32 ,  A61K36/73 ,  A61K2236/333 ,  C07H1/08 ,  C07H13/08 ,  C07H15/24 ,  C07J63/008

Abstract: A cardiogenin major isomer is obtained from a methanol extract of Geum japonicum and separated from its minor isomer. The separation of the two isomers can be achieved by chiral phase chromatography, e.g., using a Chiralpak® IC™ column. The purity of the isolated cardiogenin major isomer can be further increased by crystallization, yielding isolated cardiogenin major isomer having HPLC purity as high as 98.97% (a/a) at 210 nm and a potency of 95.50%) (w/w).

Abstract translation: 从天竺葵的甲醇提取物获得心脏发生素主要异构体，并从其次要的异构体中分离。 两种异构体的分离可以通过手性相色谱法来实现，例如使用Chiralpak IC TM柱。 通过结晶可以进一步提高分离的心脏生长素主要异构体的纯度，产生在210nm处具有高达98.97％（a / a）的HPLC纯度的分离的心脏生长素主要异构体，效能为95.50％）（w / w）。

公开(公告)号：US09205113B2

公开(公告)日：2015-12-08

申请号：US14395157

申请日：2013-05-07

Applicant: Trustees of Dartmouth College

Inventor： Gordon W. Gribble ,  Liangfeng Fu ,  Michael B. Sporn ,  Karen T. Liby

IPC: A61K31/56 ,  A61K35/44 ,  C07C61/29 ,  C07J63/00 ,  C07C62/38 ,  C07C229/50 ,  C07C235/78 ,  C07C255/47 ,  C07C291/10 ,  C07C317/44 ,  C07C323/55 ,  A61K35/12 ,  C07C62/32

CPC classification number: A61K35/44 ,  A61K31/56 ,  A61K35/12 ,  C07C61/29 ,  C07C62/32 ,  C07C62/38 ,  C07C229/50 ,  C07C235/78 ,  C07C255/47 ,  C07C291/10 ,  C07C317/44 ,  C07C323/55 ,  C07C2603/52 ,  C07J63/008 ,  C07J71/0005

Abstract: Synthetic triterpenoids and methods of using the same to induce gene expression and differentiation of stem or progenitor cells are provided. Furthermore, the present invention provides methods for producing a cell, such as a stem or progenitor cell, with induced gene expression by contacting a stem or progenitor cell with an effective amount of a synthetic triterpenoid to induce the expression of one or more of SOX9 (Sex determining region Y-box 9), COL2A1 (Type II Collagen (alpha1)), TGF-βI, TGF-p2, TGF-33, BMP2, BMP4, BMPRII (Bone Morphogenic Protein Receptor II), SMAD (Small Mothers Against Decapentaplegic) 3, SMAD4, SMAD6, SMAD7, TIMP (Tissue Inhibitor of Metalloproteinase)-1 or TIMP-2 in the stem or progenitor cell, wherein the stem or progenitor cell is not a mesenchymal stem cell, periosteium cell or osteoprogenitor cell. In one embodiment, the stem or progenitor cell is multipotent.

Abstract translation: 提供合成三萜类化合物及其使用方法诱导干细胞或祖细胞的基因表达和分化。 此外，本发明提供了通过使干细胞或祖细胞与有效量的合成三萜化合物接触以诱导一种或多种SOX9的表达来生产具有诱导的基因表达的细胞例如干细胞或祖细胞的方法（ 性别确定区域Y盒9），COL2A1（II型胶原（α1）），TGF-和bgr I，TGF-p2，TGF-β3，BMP2，BMP4，BMPRII（骨形态发生蛋白受体II），SMAD 针对剔除性皮炎）3，SMAD4，SMAD6，SMAD7，TIMP（金属蛋白酶组织抑制剂）-1或TIMP-2在茎或​​祖细胞中，其中干细胞或祖细胞不是间充质干细胞，骨膜细胞或骨祖细胞。 在一个实施方案中，干细胞或祖细胞是多能的。