公开(公告)号：US20210204582A1

公开(公告)日：2021-07-08

申请号：US17196500

申请日：2021-03-09

Applicant: Dennis Wysocki

Inventor： Dennis Wysocki

IPC: A23L33/105 ,  C07B37/06 ,  A61L9/014 ,  A23D9/04 ,  B01D46/00

Abstract: A system for decarboxylating and infusing an organic material includes a decarboxylation and infusion apparatus is provided. The apparatus includes a heated reservoir in operable communication with a user interface whereon a user selects decarboxylation and infusion settings. The heated reservoir has a mixing element to agitate an organic material and solvent disposed therein as well as a filter to filter the organic material following the infusion.

公开(公告)号：US10081592B2

公开(公告)日：2018-09-25

申请号：US14387028

申请日：2013-03-25

Applicant: THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS ,  Paul J. Hergenrother ,  Robert W. Huigens, III ,  Karen C. Morrison ,  Robert W. Hicklin, II ,  Timothy A. Flood, Jr.

Inventor： Paul J. Hergenrother ,  Robert W. Huigens, III ,  Karen C. Morrison ,  Robert W. Hicklin, II ,  Timothy A. Flood, Jr.

IPC: C07D401/14 ,  C07C69/757 ,  C07D311/94 ,  C07D313/06 ,  C07D223/14 ,  C07D401/04 ,  C07D471/04 ,  C07D471/08 ,  C07D493/08 ,  C07D513/04 ,  C07D519/00 ,  C07D303/10 ,  C07C59/205 ,  C07C62/32 ,  C07C62/38 ,  C07B37/06 ,  C07B37/08 ,  C07D307/93 ,  C07D313/08 ,  C07D405/06 ,  C07D405/12 ,  C07D413/06 ,  C07J21/00 ,  C07J69/00 ,  C07J71/00 ,  C07J73/00 ,  C07J75/00

CPC classification number: C07C69/757 ,  C07B37/06 ,  C07B37/08 ,  C07C59/205 ,  C07C62/32 ,  C07C62/38 ,  C07C2601/16 ,  C07C2602/44 ,  C07C2603/86 ,  C07D223/14 ,  C07D303/10 ,  C07D307/93 ,  C07D311/94 ,  C07D313/06 ,  C07D313/08 ,  C07D401/04 ,  C07D401/14 ,  C07D405/06 ,  C07D405/12 ,  C07D413/06 ,  C07D471/04 ,  C07D471/08 ,  C07D493/08 ,  C07D513/04 ,  C07D519/00 ,  C07J21/008 ,  C07J69/00 ,  C07J71/001 ,  C07J71/0031 ,  C07J73/005 ,  C07J73/008 ,  C07J75/005

Abstract: The invention a novel, general, and facile strategy for the creation of small molecules with high structural and stereochemical complexity. Aspects of the methods include ring system distortion reactions that are systematically applied to rapidly convert readily available natural products to structurally complex compounds with diverse molecular architectures. Through evaluation of chemical properties including fraction of sp3 carbons, ClogP, and the number of stereogenic centers, these compounds are shown to be significantly more complex and diverse than those in standard screening collections. This approach is demonstrated with natural products (gibberellic acid, adrenosterone, and quinine) from three different structural classes, and methods are described for the application of this strategy to any suitable natural product.

公开(公告)号：US09637422B2

公开(公告)日：2017-05-02

申请号：US14000095

申请日：2012-02-17

Applicant: Myeong-Seok Kim ,  Jae-Hoon Uhm ,  Min-Sup Park ,  Hyoung-Jae Seo ,  Kyoung-Tae Min

Inventor： Myeong-Seok Kim ,  Jae-Hoon Uhm ,  Min-Sup Park ,  Hyoung-Jae Seo ,  Kyoung-Tae Min

IPC: C07C1/22 ,  C07B37/06 ,  C07C1/20 ,  C07C41/06

CPC classification number: C07C1/22 ,  C07B37/06 ,  C07C1/20 ,  C07C41/06 ,  C07C2531/10 ,  Y02P20/582 ,  C07C11/09 ,  C07C43/10

Abstract: Disclosed is a method of preparing isobutene in which high-purity isobutene is separated (prepared) from a C4 mixture by cracking glycol ether prepared from a C4 mixture (in particular, C4 raffinate-1) containing isobutene and a glycol. The method includes cracking glycol ether into isobutene and glycol at a temperature between 50° C. and 300° C. in the presence of a strongly acidic catalyst. The glycol ether may be prepared by reaction between a C4 mixture containing isobutene and glycol in the presence of an acid catalyst.

公开(公告)号：US20110005916A1

公开(公告)日：2011-01-13

申请号：US12736209

申请日：2009-03-19

Applicant: Kazuhito Hashimoto ,  Hiroshi Irie ,  Syuhei Miura ,  Kazuhide Kamiya ,  Shinichiro Miki ,  Koichi Takahama ,  Mitsuo Yaguchi

Inventor： Kazuhito Hashimoto ,  Hiroshi Irie ,  Syuhei Miura ,  Kazuhide Kamiya ,  Shinichiro Miki ,  Koichi Takahama ,  Mitsuo Yaguchi

IPC: C07B37/06 ,  B01J23/888

CPC classification number: A61L9/18 ,  A61L9/205 ,  B01J23/72 ,  B01J23/888 ,  B01J35/004 ,  B01J37/0072 ,  B01J37/009 ,  B01J37/0211 ,  B01J37/0234 ,  B01J37/04

Abstract: The present invention provides a tungsten trioxide microparticle carrying on its surface divalent copper salt. The divalent copper salt is utilized to perform a multi-electron reduction of oxygen. The tungsten trioxide exhibits a high oxidative decomposition activity when exposed to visible light.

Abstract translation: 本发明提供了在其表面上具有二价铜盐的三氧化钨微粒。 二价铜盐用于进行氧的多电子还原。 当暴露于可见光时，三氧化钨显示出高的氧化分解活性。

公开(公告)号：US5922906A

公开(公告)日：1999-07-13

申请号：US128141

申请日：1998-08-03

Applicant: Joseph E. Lynch ,  Yao-Jun Shi ,  Kenneth M. Wells

Inventor： Joseph E. Lynch ,  Yao-Jun Shi ,  Kenneth M. Wells

IPC: C07C51/353 ,  C07B37/06

CPC classification number: C07C51/353

Abstract: The present invention is directed to an improved process for preparing the phenylacetic acid side chain of the compound of the formula ##STR1## This compound exhibits utility as a Class III antiarrhythmic agent.

Abstract translation: 本发明涉及一种制备下式化合物的苯乙酸侧链的改进方法。该化合物显示出作为III类抗心律失常药物的用途。

公开(公告)号：US5264094A

公开(公告)日：1993-11-23

申请号：US849059

申请日：1992-04-24

Applicant: Frank P. Sistig ,  Ernst I. Leupold ,  Heinz Litterer

Inventor： Frank P. Sistig ,  Ernst I. Leupold ,  Heinz Litterer

IPC: B01J31/24 ,  C07B37/06 ,  C07B61/00 ,  C07C17/361 ,  C07C25/13 ,  C07C37/62 ,  C07C201/12 ,  C07C205/11 ,  C07C205/12 ,  C07C17/33 ,  C07G13/00

CPC classification number: C07C201/12 ,  C07C17/361

Abstract: Process for the preparation of fluorobenzenes having at least one hydrogen atom as ring substituent and, optionally, further substituents, which, independently of each other, can be chlorine, bromine, nitro, hydroxyl, C.sub.1 -C.sub.3 -alkoxy or C.sub.1 -C.sub.3 -alkyl, the number of nitro groups being not more than 2 and the number of hydroxyl groups and alkoxy groups being not more than 3 in each case, by heating the corresponding benzaldehydes, substituted by at least one flourine atom, in the presence of a catalyst, characterized in that the reaction product is immediately removed from the reaction zone.

Abstract translation: PCT No.PCT / EP90 / 01762 Sec。 371日期：1992年4月24日 102（e）日期1992年4月24日PCT 1990年10月18日PCT PCT。 公开号WO91 / 06518 日期：1991年5月16日。具有至少一个氢原子作为环取代基的氟苯的制备方法和任选的另外的取代基，其彼此独立地可以是氯，溴，硝基，羟基，C 1 -C 3 - 烷氧基 或C 1 -C 3 - 烷基，硝基数不超过2，羟基和烷氧基的数目在每种情况下不超过3，通过加热相应的由至少一个亮原子取代的苯甲醛，在 催化剂的存在，其特征在于反应产物立即从反应区除去。

公开(公告)号：US4482502A

公开(公告)日：1984-11-13

申请号：US488192

申请日：1983-04-25

Applicant: Venkataraman Ramachandran

Inventor： Venkataraman Ramachandran

IPC: C07B37/04 ,  B01J27/00 ,  B01J27/122 ,  B01J31/00 ,  C07B31/00 ,  C07B37/06 ,  C07B61/00 ,  C07C67/00 ,  C07C69/616 ,  C07C69/65 ,  C07C253/00 ,  C07C255/32 ,  C07C255/33 ,  C07C255/35 ,  C07C255/58 ,  C07C121/66

CPC classification number: C07C255/00

Abstract: Biaryl compounds are prepared by coupling an arylamine with an aromatic compound in the presence of an alkyl nitrite and about 0.04-0.6 mol of an acid having a dissociation constant of at least about 1.7.times.10.sup.-5 at 25.degree. C. and about 0.08-1.3 mols of a cuprous halide catalyst per mol of the arylamine. The invention has particular utility in the coupling with aromatic compounds of arylamines having acid-sensitive ar-substituents, e.g. flurbiprofen intermediates, such as 2-(4-amino-3-fluorobenzene)propionitrile and alkyl 2-(4-amino-3-fluorobenzene)propionates.

Abstract translation: 二芳基化合物是通过在亚烷基烷基酯存在下将芳基胺与芳族化合物偶合而制备的，约0.04-0.6摩尔的解离常数在25℃和约0.08-1.3的解离常数至少约为1.7×10-5 每摩尔芳基胺的卤化亚铜催化剂的摩尔数。 本发明在与具有酸敏感的芳取代基的芳基胺的芳族化合物的偶联中具有特别的用途， 氟比洛芬中间体，如2-（4-氨基-3-氟苯）丙腈和2-（4-氨基-3-氟苯）丙酸烷基酯。

公开(公告)号：US20230102045A1

公开(公告)日：2023-03-30

申请号：US17394680

申请日：2021-08-05

Applicant: WALKER CANCER RESEARCH INSTITUTE, INC

Inventor： Eduardo Palomino

IPC: C07B35/04 ,  C07B37/06 ,  C07B41/02 ,  C07B37/10

Abstract: Embodiments of the present invention provide for syntheses of pattern-specific compounds using hypohalites, such as hypochlorous acid, sodium hypochlorite and potassium hypoiodite, as dual-radical generators, wherein the synthesis can be implemented by a cyclization reaction, a dehydrogenation reaction, a hydroxylation reaction, a decarboxylation reaction, or any combination of the above four.

公开(公告)号：US20200339487A1

公开(公告)日：2020-10-29

申请号：US16858690

申请日：2020-04-26

Applicant: Reno R. Rolle

Inventor： Reno R. Rolle

IPC: C07B37/06 ,  B01J31/02 ,  A23L33/105 ,  A23L29/00 ,  A23L33/135 ,  A23L33/175 ,  A23L2/52 ,  A23L2/39

Abstract: A composition for the activation (decarboxylation) and improved bioavailability of acid-form cannabinoids is provided. The composition includes dried Cannabis sativa L, such as dried hemp flower, dried food powder, and at least one catalyst, selected from dried citrus juice, lemon juice or composition thereof. The dried Cannabis sativa L is combined with the dried food powder including at least one catalyst for cold decarboxylation and improved bioavailability of cannabinoids. Preferably the catalyst becomes immediately effective when the composition is mixed into an aqueous solution for consumption. The composition is also endowed with a cytochrome p450 enzyme inhibitor in the form of dried food powder having an ascorbic acid content, or other enzyme inhibitor, in sufficient amount to inhibit hepatic enzymes in vivo and improve the bio-effects of the cannabinoids.

公开(公告)号：US20190152891A1

公开(公告)日：2019-05-23

申请号：US16136830

申请日：2018-09-20

Applicant: The Board of Trustees of the University of Illinois

Inventor： Paul J. Hergenrother ,  Robert W. Huigens, III ,  Karen C. Morrison ,  Robert W. Hicklin, II ,  Timothy A. Flood

IPC: C07C69/757 ,  C07J69/00 ,  C07C62/32 ,  C07C62/38 ,  C07B37/08 ,  C07D405/06 ,  C07D405/12 ,  C07D413/06 ,  C07B37/06 ,  C07D307/93 ,  C07D313/08 ,  C07J75/00 ,  C07J73/00 ,  C07J71/00 ,  C07C59/205 ,  C07J21/00 ,  C07D303/10 ,  C07D519/00 ,  C07D513/04 ,  C07D493/08 ,  C07D471/08 ,  C07D471/04 ,  C07D401/04 ,  C07D223/14 ,  C07D313/06 ,  C07D311/94 ,  C07D401/14

Abstract: The invention provides a novel, general, and facile strategy for the creation of small molecules with high structural and stereochemical complexity. Aspects of the methods include ring system distortion reactions that are systematically applied to rapidly convert readily available natural products to structurally complex compounds with diverse molecular architectures. Through evaluation of chemical properties including fraction of sp3 carbons, ClogP, and the number of stereogenic centers, these compounds are shown to be significantly more complex and diverse than those in standard screening collections. This approach is demonstrated with natural products (gibberellic acid, adrenosterone, and quinine) from three different structural classes, and methods are described for the application of this strategy to any suitable natural product.