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公开(公告)号：US11439642B2
公开(公告)日：2022-09-13
申请号：US16919385
申请日：2020-07-02
申请人： Adverio Pharma GmbH
发明人： Markus Follmann , Johannes-Peter Stasch , Gorden Redlich , Jens Ackerstaff , Nils Griebenow , Walter Kroh , Andreas Knorr , Eva-Maria Becker , Frank Wunder , Volkhart Min-Jian Li , Elke Hartmann , Joachim Mittendorf , Karl-Heinz Schlemmer , Rolf Jautelat , Donald Bierer
IPC分类号： A61K31/506 , A61K45/06 , C07D471/04 , C07C57/145 , C07C309/04 , C07C309/05
摘要： The present application relates to novel substituted 5-fluoro-1H-pyrazolopyridines, to processes for their preparation, to their use alone or in combinations for the treatment and/or prophylaxis of diseases, and to their use for producing medicaments for the treatment and/or prophylaxis of diseases, in particular for the treatment and/or prophylaxis of cardiovascular disorders.
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公开(公告)号：US11009790B2
公开(公告)日：2021-05-18
申请号：US15662677
申请日：2017-07-28
发明人： Suk-koo Hong , Kyoung-yong Cho , Hyo-sung Lee , Gum-hye Jeon , Mi-yeong Kang , Gun-woo Park
IPC分类号： G03F7/004 , G03F7/26 , C07C309/05 , C07C309/06 , C07C309/19 , C07C309/32 , C07C309/39 , C07C309/65 , C07C309/73 , C07C303/32 , G03F7/027 , G03F7/038 , G03F7/11 , G03F7/20 , G03F7/039 , C07C309/12 , C07C309/17 , C07C381/12 , C07D333/46
摘要： A photoacid generator (PAG) and a photoresist composition, the PAG being represented by the following Chemical Formula (I): wherein, in Chemical Formula (I), L is sulfur (S) or iodine (I), R3 being omitted when L is I; R1, R2, and R3 are each independently a C1 to C10 alkyl, alkenyl, alkynyl, or alkoxy group that is unsubstituted or substituted with a heteroatom such that the heteroatom is pendant or is between the group and L, or a C6 to C18 aryl, arylalkyl, or alkylaryl group that is unsubstituted or substituted with a heteroatom such that the heteroatom is pendant or is between the group and L; AL is an acid-labile group; m is 1 to 4; and M is a C1 to C30 hydrocarbon group that is unsubstituted or substituted with a heteroatom such that the heteroatom is pendant or is between the group and a sulfur atom.
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公开(公告)号：US20180354897A1
公开(公告)日：2018-12-13
申请号：US15778802
申请日：2016-11-30
申请人： Evonik Degussa GmbH
发明人： Benjamin FONFE , Nadine DUERR , Harald JAKOB , Chiu Kee CHEUNG , Andreas DOERFLEIN , Sebastian FUSS
IPC分类号： C07C303/16 , C07C309/04 , C07C309/05 , B01J19/00
CPC分类号： C07C303/16 , B01J19/0006 , B01J2219/0004 , B01J2219/00707 , C07C309/04 , C07C309/05
摘要： The present invention relates to a process for preparing alkanesulphonic acid by oxidizing an alkyl mercaptan, a dialkyl disulphide and/or a dialkyl polysulphide having three to nine sulphur atoms with an oxidizing agent, wherein additional oxidizing agentis fed into the oxidation if as yet unoxidized alkyl mercaptan and/or unoxidized dialkyl disulphide and/or at least one intermediate from the oxidation of the dialkyl disulphide and/or of the dialkyl polysulphide is present in the reaction output, and a corresponding apparatus for performance of oxidation reactions.
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公开(公告)号：US09879038B2
公开(公告)日：2018-01-30
申请号：US15325988
申请日：2015-07-09
发明人： Do-Kyu Pyun , Won-Kyoung Lee , Su-Ha Park
IPC分类号： C07F9/6561 , C07C309/05
CPC分类号： C07F9/65616 , A61K31/675 , C07C309/05
摘要： Disclosed is a novel tenofovir disoproxil edisylate salt having the structure of Chemical Formula 1.
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5.发明授权Salts of 2-amino-1-hydroxyethyl-8-hydroxyquinolin-2(1H)-one derivatives having both β2 adrenergic receptor agonist and M3 muscarinic receptor antagonist activities 有权具有β2肾上腺素能受体激动剂和M3毒蕈碱受体拮抗剂活性的2-氨基-1-羟乙基-8-羟基喹啉-2（1H） - 酮衍生物的盐公开(公告)号：US09562039B2
公开(公告)日：2017-02-07
申请号：US14770206
申请日：2014-02-27
申请人： ALMIRALL, S.A.
发明人： Montserrat Julia Jane , Francesc Carrera Carrera , Maria Prat Quiñones , Carlos Puig Duran , Francesca Pajuelo Lorenzo , Juan Antonio Perez Andres
IPC分类号： C07D409/14 , A61K31/4709 , A61K45/06 , A61K9/00 , C07C59/255 , C07C309/05 , C07D275/06
CPC分类号： C07D409/14 , A61K9/0073 , A61K9/0075 , A61K31/4709 , A61K45/06 , C07B2200/13 , C07C59/255 , C07C309/05 , C07D275/06 , A61K2300/00
摘要： The present invention is directed to crystalline addition salts of (i) 8-hydroxyquinolin-2(1H)-one derivatives and (ii) a hydroxycarboxylic acid, a sulfonic acid or a sulfimide, or a pharmaceutically acceptable solvates thereof.
摘要翻译： 本发明涉及（i）8-羟基喹啉-2（1H） - 酮衍生物和（ii）羟基羧酸，磺酸或硫酰亚胺或其药学上可接受的溶剂合物的结晶加成盐。
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6.发明申请SALTS AND SOLID FORMS OF ISOQUINOLINONES AND COMPOSITION COMPRISING AND METHODS OF USING THE SAME 审中-公开异喹啉的盐和固体形式及其组合物及其使用方法公开(公告)号：US20160024051A1
公开(公告)日：2016-01-28
申请号：US14776604
申请日：2014-03-13
发明人： Daniel G. GENOV , Louis GRENIER , Andrew B. HAGUE , Alexander Redvers EBERLIN , Ludovic Sylvain Marc RENOU , Susana DEL RIO GANCEDO
IPC分类号： C07D401/14 , C07C309/05 , C07C57/145
CPC分类号： C07D401/14 , A61K31/506 , C07B2200/13 , C07C57/145 , C07C309/05 , C07D401/12
摘要： Solid forms of chemical compounds that modulate kinase activity, including PI3 kinase activity, and compounds, pharmaceutical compositions, and methods of treatment of diseases and conditions associated with kinase activity, including PI3 kinase activity, are described herein. Also provided herein are processes for preparing compounds, solid forms thereof, and pharmaceutical compositions thereof.
摘要翻译： 本文描述了调节激酶活性（包括PI3激酶活性）的化合物的固体形式，以及化合物，药物组合物和治疗与激酶活性（包括PI3激酶活性）相关的疾病和病症的方法。 本文还提供了制备化合物，其固体形式及其药物组合物的方法。
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7.发明申请SALTS OF 2-AMINO-1-HYDROXYETHYL-8-HYDROXYQUINOLIN-2(1H)-ONE DERIVATIVES HAVING BOTH β2 ADRENERGIC RECEPTOR AGONIST AND M3 MUSCARINIC RECEPTOR ANTAGONIST ACTIVITIES 有权2-氨基-1-羟基乙基-8-羟基喹啉-2（1H） - 酮衍生物，具有两种和两种ADRENERGIC受体激动剂和M3MUSCARINIC受体拮抗剂活性公开(公告)号：US20160009698A1
公开(公告)日：2016-01-14
申请号：US14770206
申请日：2014-02-27
申请人： ALMIRALL S.A.
发明人： Montserrat JULIA JANE , Francesc CARRERA CARRERA , Maria PRAT QUIÑONES , Carlos PUIG DURAN , Francesca PAJUELO LORENZO , Juan Antonio PEREZ ANDRES
IPC分类号： C07D409/14 , C07C309/05 , A61K9/00 , C07C59/255 , A61K31/4709 , A61K45/06 , C07D275/06
CPC分类号： C07D409/14 , A61K9/0073 , A61K9/0075 , A61K31/4709 , A61K45/06 , C07B2200/13 , C07C59/255 , C07C309/05 , C07D275/06 , A61K2300/00
摘要： The present invention is directed to crystalline addition salts of (i) 8-hydroxyquinolin-2(1H)-one derivatives and (ii) a hydroxycarboxylic acid, a sulfonic acid or a sulfimide, or a pharmaceutically acceptable solvates thereof.
摘要翻译： 本发明涉及（i）8-羟基喹啉-2（1H） - 酮衍生物和（ii）羟基羧酸，磺酸或硫酰亚胺或其药学上可接受的溶剂合物的结晶加成盐。
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公开(公告)号：US20110021813A1
公开(公告)日：2011-01-27
申请号：US12842990
申请日：2010-07-23
申请人： Xianqi Kong , David Migneault , Xinfu Wu
发明人： Xianqi Kong , David Migneault , Xinfu Wu
IPC分类号： C07C309/05
CPC分类号： C07C309/05 , C07C309/14 , C07C2602/10 , C07C2602/42 , C07C2603/74 , C07D211/32 , C07D211/52 , C07D211/64 , C07D211/70 , C07D217/04
摘要： The present invention is directed to methods of preparation of sulfonate derivatized compounds, e.g., 3-amino-1-propanesulfonic acid and 1,3-propanedisulfonic acid disodium salt with increased purity, with reduced potential for toxic by-products, and that are pharmaceutically useful, e.g., for the treatment of amyloidosis.
摘要翻译： 本发明涉及制备磺酸衍生化合物的方法，例如3-氨基-1-丙磺酸和1,3-丙烷二磺酸二钠盐，其纯度提高，有毒副产物的潜力降低，且为药学上 有用的，例如用于治疗淀粉样变性。
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9.发明授权Process for preparing sulfonated paraffins with a larger content of polysulfonated species 失效制备具有较大含量的多磺化物质的磺化石蜡的方法
公开(公告)号：US5364960A
公开(公告)日：1994-11-15
申请号：US152704
申请日：1993-11-16
IPC分类号： C07C303/14 , C07C303/32 , C07C309/05 , C09K8/38 , C09K8/94 , C07C143/02
CPC分类号： C09K8/94 , C07C303/14 , C07C303/32 , C09K8/38
摘要： Process for obtaining sulfonated paraffins containing more than 50% of polysulfonates, by weight, by causing essentially linear C.sub.12 -C.sub.20 paraffins to react with SO.sub.2 and O.sub.2, at a temperature comprised within the range of from 55 to 100.degree. C. and in the presence of a peroxide belonging to the class of peroxy dicarbonates.
摘要翻译： 通过使基本上线性的C 12 -C 20链烷烃与SO 2和O 2反应，得到含有超过50％的聚磺酸盐的磺化石蜡的方法，该温度为55-100℃， 的过氧化物，属于过氧化二碳酸酯类。
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公开(公告)号：US2842589A
公开(公告)日：1958-07-08
申请号：US56168756
申请日：1956-01-26
申请人： ALLIED CHEM
发明人： CROWDER JOHN A , GILBERT EVERETT E
IPC分类号： C07C303/06 , C07C309/05
CPC分类号： C07C303/06 , C07C309/05
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