公开(公告)号：US20220409618A1

公开(公告)日：2022-12-29

申请号：US17820667

申请日：2022-08-18

申请人： Adverio Pharma GmbH

发明人： Markus Follmann ,  Johannes-Peter Stasch ,  Gorden Redlich ,  Jens Ackerstaff ,  Nils Griebenow ,  Walter Kroh ,  Andreas Knorr ,  Eva-Maria Becker ,  Frank Wunder ,  Volkhart Min-Jian Li ,  Elke Hartmann ,  Joachim Mittendorf ,  Karl-Heinz Schlemmer ,  Rolf Jautelat ,  Donald Bierer

IPC分类号： A61K31/506 ,  A61K45/06 ,  C07D471/04 ,  C07C57/145 ,  C07C309/04 ,  C07C309/05

摘要： The present application relates to novel substituted 5-fluoro-1H-pyrazolopyridines, to processes for their preparation, to their use alone or in combinations for the treatment and/or prophylaxis of diseases, and to their use for producing medicaments for the treatment and/or prophylaxis of diseases, in particular for the treatment and/or prophylaxis of cardiovascular disorders.

公开(公告)号：US12064429B2

公开(公告)日：2024-08-20

申请号：US17820667

申请日：2022-08-18

申请人： Adverio Pharma GmbH

发明人： Markus Follmann ,  Johannes-Peter Stasch ,  Gorden Redlich ,  Jens Ackerstaff ,  Nils Griebenow ,  Walter Kroh ,  Andreas Knorr ,  Eva-Maria Becker ,  Frank Wunder ,  Volkhart Min-Jian Li ,  Elke Hartmann ,  Joachim Mittendorf ,  Karl-Heinz Schlemmer ,  Rolf Jautelat ,  Donald Bierer

IPC分类号： A61K31/506 ,  A61K45/06 ,  C07C57/145 ,  C07C309/04 ,  C07C309/05 ,  C07D471/04

CPC分类号： A61K31/506 ,  A61K45/06 ,  C07C57/145 ,  C07C309/04 ,  C07C309/05 ,  C07D471/04

摘要： The present application relates to novel substituted 5-fluoro-1H-pyrazolopyridines, to processes for their preparation, to their use alone or in combinations for the treatment and/or prophylaxis of diseases, and to their use for producing medicaments for the treatment and/or prophylaxis of diseases, in particular for the treatment and/or prophylaxis of cardiovascular disorders.

公开(公告)号：US09993476B2

公开(公告)日：2018-06-12

申请号：US15348545

申请日：2016-11-10

申请人： ADVERIO PHARMA GMBH

发明人： Markus Follmann ,  Johannes-Peter Stasch ,  Gorden Redlich ,  Jens Ackerstaff ,  Nils Griebenow ,  Walter Kroh ,  Andreas Knorr ,  Eva-Maria Becker ,  Frank Wunder ,  Volkhart Min-Jian Li ,  Elke Hartmann ,  Joachim Mittendorf ,  Karl-Heinz Schlemmer ,  Rolf Jautelat ,  Donald Bierer

IPC分类号： A61K31/506 ,  A61K45/06 ,  C07D471/04 ,  C07C57/145 ,  C07C309/04 ,  C07C309/05

CPC分类号： A61K31/506 ,  A61K45/06 ,  C07C57/145 ,  C07C309/04 ,  C07C309/05 ,  C07D471/04

摘要： The present application relates to novel substituted 5-fluoro-1H-pyrazolopyridines, to processes for their preparation, to their use alone or in combinations for the treatment and/or prophylaxis of diseases, and to their use for producing medicaments for the treatment and/or prophylaxis of diseases, in particular for the treatment and/or prophylaxis of cardiovascular disorders.

公开(公告)号：US10736896B2

公开(公告)日：2020-08-11

申请号：US15981598

申请日：2018-05-16

申请人： ADVERIO PHARMA GMBH

发明人： Markus Follmann ,  Johannes-Peter Stasch ,  Gorden Redlich ,  Jens Ackerstaff ,  Nils Griebenow ,  Walter Kroh ,  Andreas Knorr ,  Eva-Maria Becker ,  Frank Wunder ,  Volkhart Min-Jian Li ,  Elke Hartmann ,  Joachim Mittendorf ,  Karl-Heinz Schlemmer ,  Rolf Jautelat ,  Donald Bierer

IPC分类号： C07D471/04 ,  A61K31/506 ,  A61K45/06 ,  C07C57/145 ,  C07C309/04 ,  C07C309/05

摘要： The present application relates to novel substituted 5-fluoro-1H-pyrazolopyridines, to processes for their preparation, to their use alone or in combinations for the treatment and/or prophylaxis of diseases, and to their use for producing medicaments for the treatment and/or prophylaxis of diseases, in particular for the treatment and/or prophylaxis of cardiovascular disorders.

公开(公告)号：US11439642B2

公开(公告)日：2022-09-13

申请号：US16919385

申请日：2020-07-02

申请人： Adverio Pharma GmbH

发明人： Markus Follmann ,  Johannes-Peter Stasch ,  Gorden Redlich ,  Jens Ackerstaff ,  Nils Griebenow ,  Walter Kroh ,  Andreas Knorr ,  Eva-Maria Becker ,  Frank Wunder ,  Volkhart Min-Jian Li ,  Elke Hartmann ,  Joachim Mittendorf ,  Karl-Heinz Schlemmer ,  Rolf Jautelat ,  Donald Bierer

IPC分类号： A61K31/506 ,  A61K45/06 ,  C07D471/04 ,  C07C57/145 ,  C07C309/04 ,  C07C309/05

摘要： The present application relates to novel substituted 5-fluoro-1H-pyrazolopyridines, to processes for their preparation, to their use alone or in combinations for the treatment and/or prophylaxis of diseases, and to their use for producing medicaments for the treatment and/or prophylaxis of diseases, in particular for the treatment and/or prophylaxis of cardiovascular disorders.