-
公开(公告)号：US11154548B2
公开(公告)日：2021-10-26
申请号：US15769789
申请日：2016-10-21
发明人： Pengfei Wang , Jiasheng Wu , Weimin Liu , Ying Gu , Jiechao Ge , Xiuli Zheng , Hongyan Zhang
IPC分类号： C07C217/12 , C07C221/00 , C07C225/22 , C07C225/32 , C07C229/18 , C07C237/08 , C07C239/14 , C07C243/22 , C07C249/02 , C07C251/24 , C07C251/56 , C07C251/86 , C07C309/69 , A61K31/122 , A61K31/135 , A61K31/473 , A61K41/00 , A61K47/54 , A61K47/60 , A61P35/00 , C07C323/25 , C07C319/18 , C07D279/14 , C07D487/08 , C07D513/06 , C07D513/16 , C07D241/38 , C07C50/36 , C07D221/02
摘要： The invention discloses a monosubstituted or polysubstituted amphiphilic hypocrellin derivative, and a preparation method and application thereof. The amphiphilic hypocrellin derivative substituted by a group containing PEG, a quaternary ammonium salt or the like prepared according to the invention has an obvious red shift in its absorption spectrum and a significantly enhanced molar extinction coefficient, compared with the parent hypocrellin, can efficiently produce singlet state oxygen and other reactive oxygen species under photosensitive conditions; has different amphiphilicities and increased biocompatibility with cells or tissues by regulating its hydrophilicity and hydrophobicity; can meet the requirements of different clinical drugs, and solves the requirements of different drug delivery methods for different drug hydrophilicity and lipophilicity. Under identical conditions, the amphiphilic hypocrellin derivative photosensitizer according to the invention has higher ability to photodynamically inactivate tumor cells than the first and second generation commercial photosensitizers.
-
公开(公告)号：US5391749A
公开(公告)日：1995-02-21
申请号：US843656
申请日：1992-02-28
申请人： Walter Fischer , Marcus Baumann , Jurgen Finter , Vratislav Kvita , Carl W. Mayer , Wolfgang Wernet
发明人： Walter Fischer , Marcus Baumann , Jurgen Finter , Vratislav Kvita , Carl W. Mayer , Wolfgang Wernet
IPC分类号： G03F7/028 , B05D1/20 , C07C45/00 , C07C50/24 , C07C50/36 , C07C66/00 , C07C67/00 , C07C69/00 , C07C69/738 , C07C201/00 , C07C205/46 , C07C205/48 , C07C211/61 , C07C225/32 , C07C235/40 , C07C255/40 , C07C255/41 , C07C255/56 , C07C255/57 , C07C317/24 , C07C323/20 , C07C323/22 , C07D295/10 , C07D295/116 , C07D307/12 , C07F7/08 , C08F2/50 , C08G61/12 , C08K5/08 , C08K5/10 , C08K5/13 , C08K5/36 , C09B3/58 , H01B1/12 , C07D211/06
CPC分类号： C07D295/116 , B05D1/202 , B82Y30/00 , B82Y40/00 , C07C205/48 , C07C225/32 , C07C255/40 , C07C255/41 , C07C255/56 , C07C323/20 , C07C323/22 , C07C50/24 , C07C50/36 , C07C69/00 , C07D307/12 , C07F7/0818 , C08F2/50 , C08G61/123 , H01B1/121 , C07C2101/02 , C07C2103/00 , C07C2103/44
摘要： Substituted naphthacenediones of the formula I ##STR1## in which R.sup.1 to R.sup.8 are H and at least one of R.sup.1 to R.sup.8, for example R.sup.2 and R.sup.3 or R.sup.2 and R.sup.6, are, for example, C.sub.1 -C.sub.20 alkoxy, C.sub.1 -C.sub.20 alkenoxy, C.sub.1 -C.sub.20 -alkylsulfinyl, --CN, --CF.sub.3, --NO.sub.2, --Si(CH.sub.3).sub.3 or --COO(C.sub.1 -C.sub.12 alkyl), are suitable, when incorporated into polymers having hydroxyalkyl groups, for currentless deposition of metals onto the polymer surface. They are in some cases suitable as photoinitiators.
摘要翻译： 其中R 1至R 8为H并且R 1至R 8中的至少一个，例如R 2和R 3或R 2和R 6的取代的对映体萘并吖啶为例如C 1 -C 20烷氧基，C 1 -C 20链烯氧基 ，当C 1 -C 20烷基亚磺酰基，-CN，-CF 3，-NO 2，-Si（CH 3）3或-COO（C 1 -C 12烷基）掺入到具有羟烷基的聚合物中时，适用于金属在聚合物上无电沉积 表面。 在某些情况下，它们适合作为光引发剂。
-
3.发明申请公开(公告)号：US20200155609A1
公开(公告)日：2020-05-21
申请号：US16615389
申请日：2018-05-18
发明人： Timothy Webb , Zhan Wang
IPC分类号： A61K35/28 , C12N5/0789 , C07C233/65 , C07C225/32 , C07C233/43 , C07C233/33 , C07C50/34 , C07C233/25 , C07C233/29
摘要： This invention is directed to, inter alia, compounds, methods, systems, and compositions for the maintenance, enhancement, and expansion of hematopoietic stem cells derived from sources of non-mobilized peripheral blood. Also provided herein are compounds of Formula I which are useful in maintaining, enhancing, and expanding of hematopoietic stem cells.
-
4.发明申请ELECTRODE ACTIVE MATERIAL FOR ELECTRICITY STORAGE DEVICE, AND ELECTRICITY STORAGE DEVICE USING SAME 有权用于电力存储装置的电极活性材料和使用其的电力存储装置公开(公告)号：US20130004836A1
公开(公告)日：2013-01-03
申请号：US13583880
申请日：2011-03-11
IPC分类号： H01M4/60 , C07C50/22 , C07C50/24 , C07C205/46 , C08G16/00 , C07C69/95 , C07C66/00 , C07C235/84 , C08G6/00 , H01M10/056 , C07C225/32
CPC分类号： H01M4/60 , H01G11/30 , H01G11/48 , H01G11/50 , H01M4/137 , H01M4/606 , H01M10/052 , H01M10/0566 , Y02E60/122 , Y02E60/13
摘要： The present invention provides an electrode active material for an electricity storage device, having a structure represented by following formula (1). In the formula (1), R1 to R6 each denote independently a hydrogen atom (except for a case where all of R1 to R6 denote hydrogen atoms), a halogen atom, an optionally substituted phenyl group, an optionally substituted heterocyclic group, or an optionally substituted hydrocarbon group having 1 to 4 carbon atoms.
摘要翻译： 本发明提供一种具有由下式（1）表示的结构的蓄电装置用电极活性物质。 式（1）中，R 1〜R 6各自独立地表示氢原子（除了所有R 1至R 6表示氢原子的情况），卤素原子，任选取代的苯基，任选取代的杂环基或 任选取代的具有1至4个碳原子的烃基。
-
公开(公告)号：US6096888A
公开(公告)日：2000-08-01
申请号：US395202
申请日：1999-09-14
IPC分类号： C07D309/10 , A61K31/12 , A61K31/122 , A61K31/135 , A61K31/165 , A61K31/35 , A61K31/351 , A61K31/445 , A61K31/495 , A61K31/535 , A61K31/5375 , A61K31/65 , A61P3/00 , A61P25/00 , A61P25/28 , C07C46/00 , C07C50/36 , C07C50/38 , C07C66/00 , C07C225/32 , C07C225/34 , C07C225/36 , C07C233/31 , C07C233/36 , C07C309/65 , C07C309/73 , C07D295/108 , C07D295/112 , C07D317/26
CPC分类号： C07D295/112 , A61K31/12 , A61K31/135 , A61K31/445 , A61K31/495 , A61K31/535 , C07C225/32 , C07C225/34 , C07D295/108 , C07D317/26 , C07C2103/44
摘要： The present invention provides the new use in the treatment of amyloidosis with the anthracyclinone of formula (A) wherein R1, R2, R3, R4, and R5, are appropriate substituents. Some compounds of formula (A) are novel. Processes for their preparation and pharmaceutical composition containing them are also described.
摘要翻译： 本发明提供了用式（A）的蒽环类抗生素治疗淀粉样变性的新用途，其中R1，R2，R3，R4和R5是适当的取代基。 一些式（A）的化合物是新的。 还描述了其制备方法和含有它们的药物组合物。
-
6.发明申请COMPOUNDS AND THEIR USE IN MEDICINE, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM 失效化合物及其在医药中的应用，其制备方法和含有它们的药物组合物公开(公告)号：US20070142470A1
公开(公告)日：2007-06-21
申请号：US11674465
申请日：2007-02-13
申请人： Bhuniya Debnath , Saibal Das , Gurram Madhaven , Javed Iqbal , Ranjan Chakrabarti , Reeba Vikramadithyan
发明人： Bhuniya Debnath , Saibal Das , Gurram Madhaven , Javed Iqbal , Ranjan Chakrabarti , Reeba Vikramadithyan
IPC分类号： A61K31/195 , C07C229/54 , C07C225/32
CPC分类号： A61K31/353 , A61K31/4439 , A61K31/454 , A61K31/4709 , A61K31/496 , A61K31/5377 , A61K31/541 , C07C309/66 , C07C309/73 , C07C311/53
摘要： The present invention relates to novel antidiabetic, hypolipidemic, antiobesity and hypocholesterolemic compounds of formula (I), their derivatives, their analogs, their tautomeric forms, their stereoisomers, their polymorphs, their pharmaceutically acceptable salts, their pharmaceutically acceptable solvates and pharmaceutically acceptable compositions containing them.
摘要翻译： 本发明涉及式（I）的新型抗糖尿病，降血脂，抗胆固醇和低胆固醇血症化合物，其衍生物，其类似物，其互变异构形式，其立体异构体，其多晶型物，其药学上可接受的盐，其药学上可接受的溶剂合物和药学上可接受的组合物，其含有 他们。
-
7.发明授权公开(公告)号：US07157477B2
公开(公告)日：2007-01-02
申请号：US10415249
申请日：2001-10-24
申请人： Manhua Zhang , Shangjie Xu , Tao Wu , Shen Chen , Tao Shen
发明人： Manhua Zhang , Shangjie Xu , Tao Wu , Shen Chen , Tao Shen
IPC分类号： C07D213/38 , C07C225/32 , A61K31/135 , A61K31/44
CPC分类号： A61K41/0057 , C07C225/32 , C07C2601/08 , C07C2601/14 , C07C2603/54 , C07D213/38
摘要： The invention involves a methods and compositions for use in photodynamic therapy. Novel perylenequinone derivatives, conjugates comprising perylenequinone derivatives and a binding agent, and methods of treatment using these compositions are disclosed. The present invention relates to the field of photosensitizers possessing photodynamic activities. They possess high photodynamic activities and low dark toxicities, which makes them as more potent photodynamic agents than HPD against cancer and AIDS virus.
摘要翻译： 本发明涉及用于光动力疗法的方法和组合物。 公开了新型苝醌衍生物，包含苝醌衍生物和结合剂的共轭物，以及使用这些组合物的处理方法。 本发明涉及具有光动力学活性的光敏剂领域。 它们具有高光动力学活性和低暗毒性，这使得它们比HPD对抗癌症和艾滋病病毒更有效的光动力学剂。
-
公开(公告)号：US5912386A
公开(公告)日：1999-06-15
申请号：US19571
申请日：1998-02-06
IPC分类号： C07C225/32 , C07C233/80 , C08K5/00 , C09B1/16 , C09B1/26 , C09B1/28 , C09B1/42 , D06P1/24 , D06P3/00 , D06P5/00 , C07C209/38
CPC分类号： C09B1/42 , C08K5/0041 , C09B1/262 , C09B1/285
摘要： The present invention relates to compounds of the formula (I)R.sup.1 --NH--B--NH--R.sup.2 (I),whereinR.sup.1 and R.sup.2 independently of one another denote an unsubstituted or substituted radical of the formula ##STR1## and B represents an unsubstituted or substituted cycloalkylene-containing bridge member, which are suitable for bulk dyeing of plastics.
摘要翻译： 本发明涉及式（I）R 1 -NH-B-NH-R 2（I）的化合物，其中R 1和R 2彼此独立地表示下式的未取代或取代的基团，B表示未取代或取代的亚环烷基 适用于塑料的大量染色。
-
公开(公告)号：US11439707B2
公开(公告)日：2022-09-13
申请号：US16645301
申请日：2018-09-05
发明人： Pengfei Wang , Jiasheng Wu , Weimin Liu , Xiuli Zheng , Ying Gu
IPC分类号： A61K47/10 , A61K41/00 , C07C221/00 , C07C225/32 , C07C227/28 , C07C229/16 , C07C229/28 , C07C241/02 , C07C243/20 , C07C323/30 , C07C323/38 , C07D295/13 , C07D295/205 , C07D401/12 , C07D403/12 , C07D519/00
摘要： The present invention discloses a hypocrellin derivative substituted both in a pen-position and in a 2-position by an amino, and a preparation method and use thereof. A general structural formula of the derivative is as represented by formulas I-a to I-d: The hypocrellin derivative substituted both in a peri-position and in a 2-position by an amino prepared in the present invention has a maximum absorption wavelength of 600-650 nm and a molar extinction coefficient reaching about 20000-40000 M−1cm−1. Compared with unmodified hypocrellin or hypocrellin having only a 2-position modified, an absorption spectrum of the derivative is significantly red-shifted and the molar extinction coefficient is greatly improved, and the derivative can efficiently produce reactive oxygen species such as singlet oxygen in a photosensitive condition. In the same condition, the hypocrellin derivative substituted both in a pen-position and in a 2-position by an amino involved in the present invention, when used as a photosensitizer, has a stronger ability to photo-dynamically inactivate tumor cells than the first and second generation commercial photosensitizers.
-
10.发明申请公开(公告)号：US20180338965A1
公开(公告)日：2018-11-29
申请号：US15769789
申请日：2016-10-21
发明人： Pengfei Wang , Jiasheng Wu , Weimin Liu , Ying Gu , Jiechao Ge , Xiuli Zheng , Hongyan Zhang
IPC分类号： A61K31/473 , C07D221/02 , C07C225/32 , A61K31/122 , A61K31/135 , C07C50/36
摘要： The invention discloses a monosubstituted or polysubstituted amphiphilic hypocrellin derivative, and a preparation method and application thereof. The amphiphilic hypocrellin derivative substituted by a group containing PEG, a quaternary ammonium salt or the like prepared according to the invention has an obvious red shift in its absorption spectrum and a significantly enhanced molar extinction coefficient, compared with the parent hypocrellin, can efficiently produce singlet state oxygen and other reactive oxygen species under photosensitive conditions; has different amphiphilicities and increased biocompatibility with cells or tissues by regulating its hydrophilicity and hydrophobicity; can meet the requirements of different clinical drugs, and solves the requirements of different drug delivery methods for different drug hydrophilicity and lipophilicity. Under identical conditions, the amphiphilic hypocrellin derivative photosensitizer according to the invention has higher ability to photodynamically inactivate tumor cells than the first and second generation commercial photosensitizers.
-
-
-
-
-
-
-
-
-
搜索结果
17 条记录 (耗时 0.019 秒)
