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    NANOPARTICLE / NANOTUBE-BASED NANOELECTRONIC DEVICES AND CHEMICALLY-DIRECTED ASSEMBLY THEREOF
    2.
    发明申请
    NANOPARTICLE / NANOTUBE-BASED NANOELECTRONIC DEVICES AND CHEMICALLY-DIRECTED ASSEMBLY THEREOF 有权
    基于纳米基/纳米管的纳米电子器件及其化学成分

    公开(公告)号：US20100133513A1

    公开(公告)日：2010-06-03

    申请号：US11910521

    申请日：2007-02-02

    申请人： Howard K. Schmidt

    发明人： Howard K. Schmidt

    IPC分类号： H01L31/0352 ,  H01L31/18

    CPC分类号： B82Y20/00 ,  B82Y10/00 ,  B82Y30/00 ,  B82Y40/00 ,  C01B32/15 ,  H01L31/035227 ,  H01L31/1085 ,  H01L51/0049 ,  H01L51/0595 ,  Y10S977/712 ,  Y10S977/743 ,  Y10S977/806

    摘要： According to some embodiments, the present invention provides a nanoelectronic device based on a nanostructure that may include a nanotube with first and second ends, a metallic nanoparticle attached to the first end, and an insulating nanoparticle attached to the second end. The nanoelectronic device may include additional nanostructures so a to form a plurality of nanostructures comprising the first nanostructure and the additional nanostructures. The plurality of nanostructures may arranged in a network comprising a plurality of edges and a plurality of vertices, wherein each edge comprises a nanotube and each vertex comprises at least one insulating nanoparticle and at least one metallic nanoparticle adjacent the insulating nanoparticle. The combination of at least one edge and at least one vertex comprises a diode. The device may be an optical rectenna.

    摘要翻译： 根据一些实施方案，本发明提供了一种基于纳米结构的纳米电子器件，其可以包括具有第一和第二末端的纳米管，附着到第一端的金属纳米颗粒和附着到第二末端的绝缘纳米颗粒。 纳米电子器件可以包括另外的纳米结构，从而形成包含第一纳米结构和另外的纳米结构的多个纳米结构。 多个纳米结构可以布置在包括多个边缘和多个顶点的网络中，其中每个边缘包括纳米管，并且每个顶点包括至少一个绝缘纳米颗粒和与绝缘纳米颗粒相邻的至少一个金属纳米颗粒。 至少一个边缘和至少一个顶点的组合包括二极管。 该装置可以是光学整流天线。

    Method of delivery of a medicament to a cancer cell using a pathway of plasminogen activator material
    4.
    发明授权
    Method of delivery of a medicament to a cancer cell using a pathway of plasminogen activator material 失效
    使用纤溶酶原激活剂材料的途径将药物递送至癌细胞的方法

    公开(公告)号：US5679350A

    公开(公告)日：1997-10-21

    申请号：US646561

    申请日：1996-05-08

    申请人： Jerzy Jankun ,  Richard Hart

    发明人： Jerzy Jankun ,  Richard Hart

    IPC分类号： A61K47/48 ,  C07K14/81 ,  A61K39/385

    CPC分类号： C07K14/81 ,  A61K47/48238 ,  Y10S977/806 ,  Y10S977/906 ,  Y10S977/911 ,  Y10S977/912 ,  Y10S977/915 ,  Y10S977/92

    摘要： A method of delivering a medicament to the surface of a cancer cell and transferring the medicament into the cancer cell using an activated plasminogen activator material such as a plasminogen activator inhibitor type-1 or type-2 (PAI-1, PAI-2). The medicament is coupled to PAI-1 or PAI-2 to form a reaction product that is coupled with the urokinase plasminogen activator (uPA) that is bound to the cell surface by the uPA receptor (uPAR). The medicament is coupled to PAI-1 or PAI-2 (for example, using a preserving agent such as saporin) in such a way that the medicament does not interfere with active sites responsible for binding to uPA or LRP proteins responsible for the internalization of the plasminogen activator material/conjugated medicament. The conjugated medicament prevents the conversion of the plasminogen activator inhibitor material into its latent inactive form. The resulting complex is internalized into the cancer cell to deliver the medicament within the cell.

    摘要翻译： 将药物递送到癌细胞的表面并使用活化的纤溶酶原激活剂材料例如纤溶酶原激活物抑制剂1型或2型（PAI-1，PAI-2）将药物转运到癌细胞中的方法。 药物与PAI-1或PAI-2偶联以形成与uPA受体（uPAR）结合于细胞表面的尿激酶纤溶酶原激活物（uPA）偶联的反应产物。 药物与PAI-1或PAI-2（例如，使用防腐剂，例如皂草素）偶联，使得药物不干扰负责结合负责内在化的uPA或LRP蛋白的活性位点 纤溶酶原激活物质/共轭药物。 缀合的药物防止纤溶酶原激活物抑制剂材料转化为其非活性形式。 所得的复合物被内化到癌细胞中以将细胞内的药物输送到细胞内。

    Nanoparticle/nanotube-based nanoelectronic devices and chemically-directed assembly thereof
    8.
    发明授权
    Nanoparticle/nanotube-based nanoelectronic devices and chemically-directed assembly thereof 有权
    基于纳米颗粒/纳米管的纳米电子器件及其化学指向的组装

    公开(公告)号：US07893513B2

    公开(公告)日：2011-02-22

    申请号：US11910521

    申请日：2007-02-02

    申请人： Howard K. Schmidt

    发明人： Howard K. Schmidt

    IPC分类号： H01L27/14

    CPC分类号： B82Y20/00 ,  B82Y10/00 ,  B82Y30/00 ,  B82Y40/00 ,  C01B32/15 ,  H01L31/035227 ,  H01L31/1085 ,  H01L51/0049 ,  H01L51/0595 ,  Y10S977/712 ,  Y10S977/743 ,  Y10S977/806

    摘要： According to some embodiments, the present invention provides a nanoelectronic device based on a nanostructure that may include a nanotube with first and second ends, a metallic nanoparticle attached to the first end, and an insulating nanoparticle attached to the second end. The nanoelectronic device may include additional nanostructures so a to form a plurality of nanostructures comprising the first nanostructure and the additional nanostructures. The plurality of nanostructures may arranged in a network comprising a plurality of edges and a plurality of vertices, wherein each edge comprises a nanotube and each vertex comprises at least one insulating nanoparticle and at least one metallic nanoparticle adjacent the insulating nanoparticle. The combination of at least one edge and at least one vertex comprises a diode. The device may be an optical rectenna.

    摘要翻译： 根据一些实施方案，本发明提供了一种基于纳米结构的纳米电子器件，其可以包括具有第一和第二末端的纳米管，附着到第一端的金属纳米颗粒和附着到第二末端的绝缘纳米颗粒。 纳米电子器件可以包括另外的纳米结构，从而形成包含第一纳米结构和另外的纳米结构的多个纳米结构。 多个纳米结构可以布置在包括多个边缘和多个顶点的网络中，其中每个边缘包括纳米管，并且每个顶点包括至少一个绝缘纳米颗粒和与绝缘纳米颗粒相邻的至少一个金属纳米颗粒。 至少一个边缘和至少一个顶点的组合包括二极管。 该装置可以是光学整流天线。