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公开(公告)号：US20170304421A1
公开(公告)日：2017-10-26
申请号：US15528813
申请日：2015-11-24
申请人： The United States of America, as represented by the Secretary, Dep. of Health and Human Services
发明人： Qiong J. WANG , Zhiya YU , James C. YANG
IPC分类号： A61K39/00 , G01N33/574 , C07K14/725
CPC分类号： A61K39/0011 , A61K38/00 , A61K2039/5152 , C07K14/7051 , C07K14/82 , C12Y306/00 , G01N33/5748 , G01N2333/914
摘要： Disclosed is an isolated or purified T cell receptor (TCR) having antigenic specificity for an HLA-A11-restricted epitope of mutated Kirsten rat sarcoma viral oncogene homolog (KRAS) (KRAS7-16), Neuroblastoma RAS Viral (V-Ras) Oncogene Homolog (NRAS), or Harvey Rat Sarcoma Viral Oncogene Homolog (HRAS). Related polypeptides and proteins, as well as related nucleic acids, recombinant expression vectors, host cells, populations of cells, and pharmaceutical compositions are also provided. Also disclosed are methods of detecting the presence of cancer in a mammal and methods of treating or preventing cancer in a mammal.
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公开(公告)号：US20150045284A1
公开(公告)日：2015-02-12
申请号：US13980626
申请日：2012-01-20
IPC分类号： C12N9/99 , G01N33/573 , G06F19/16 , C12N9/14
CPC分类号： C12N9/99 , C12N9/14 , C12Y306/00 , C12Y306/03004 , G01N33/573 , G01N2500/04 , G16B15/00
摘要： The present invention relates to crystals of a type IB P-type ATPase having the space group P1 and methods for purification and growing said crystals. The invention also presents methods for identifying an inhibitor of a type IB P-type ATPase for example by determining binding interactions between an inhibitor and a set of binding interaction sites in said type IB P-type ATPase.
摘要翻译： 本发明涉及具有空间群P1的IB型P型ATP酶的晶体和用于纯化和生长所述晶体的方法。 本发明还提供了用于鉴定IB型P型ATP酶的抑制剂的方法，例如通过测定抑制剂与所述IB型P型ATP酶中的一组结合相互作用位点之间的结合相互作用。
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3.发明申请公开(公告)号：US20170183704A1
公开(公告)日：2017-06-29
申请号：US15409137
申请日：2017-01-18
CPC分类号： C12P21/02 , C12N9/14 , C12N15/70 , C12N15/72 , C12Y306/00
摘要： The present invention is concerned with a method of production of authentic human epidermal growth factor (EGF) and hyper-production of authentic basic fibroblast growth factor (bFGF) without any modification at either C- or N-terminal of the bFGF.
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4.发明申请HIGH EFFICIENCY FLP SITE-SPECIFIC RECOMBINATION IN MAMMALIAN CELLS USING AN OPTIMIZED FLP GENE 审中-公开使用优化的FLP基因在马马里亚细胞中的高效FLP位点特异性重组公开(公告)号：US20160083699A1
公开(公告)日：2016-03-24
申请号：US14959247
申请日：2015-12-04
IPC分类号： C12N9/14
CPC分类号： C12N9/14 , C07H21/04 , C12N9/00 , C12N15/63 , C12N15/79 , C12N2510/00 , C12N2800/30 , C12Y306/00
摘要： The present invention provides an optimized FLP site-specific recombinase coding sequence and methods for its use. This genetically engineered FLP gene displays a marked increase in recombination efficiency compared to the native FLP gene and is therefore useful in a wide array of molecular applications.
摘要翻译： 本发明提供了优化的FLP位点特异性重组酶编码序列及其使用方法。 与天然FLP基因相比，这种基因工程FLP基因显示出重组效率的显着增加，因此可用于广泛的分子应用。
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5.发明申请公开(公告)号：US20180171305A1
公开(公告)日：2018-06-21
申请号：US15849069
申请日：2017-12-20
发明人： Axel Nimmerjahn , Charles L. Clark
IPC分类号： C12N7/00 , A61P37/06 , A61P29/00 , C12N15/113 , A61K31/713 , A61K38/46
CPC分类号： C12N7/00 , A61K31/713 , A61K38/46 , A61K48/0008 , A61P29/00 , A61P37/06 , C12N15/1137 , C12N15/86 , C12N2310/11 , C12N2310/122 , C12N2310/14 , C12N2310/531 , C12N2320/31 , C12N2710/10041 , C12N2710/10043 , C12N2710/10071 , C12N2710/10343 , C12N2710/16641 , C12N2710/16643 , C12N2710/16671 , C12Y306/00
摘要： The finding that phosphatidylserine (PtdSer) exposure on the outer leaflet of virally transduced cells triggers their engulfment by resident immune cells is described. It is demonstrated that inhibition of phospholipid scramblase 1 (PLSCR1) activity prevents PtdSer externalization and enables prolonged protection of vector-transduced cells from phagocytosis. Methods of inhibiting a virus vector-induced inflammatory response in tissue, methods of prolonging virus vector encoded transgene expression, and methods of modulating an inflammatory response in tissue of a subject, by administering an inhibitor of PLSCR1 are described.
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6.发明授权High efficiency FLP site-specific recombination in mammalian cells using an optimized FLP gene 有权使用优化的FLP基因在哺乳动物细胞中高效率FLP位点特异性重组公开(公告)号：US09206397B2
公开(公告)日：2015-12-08
申请号：US12307418
申请日：2007-06-21
CPC分类号： C12N9/14 , C07H21/04 , C12N9/00 , C12N15/63 , C12N15/79 , C12N2510/00 , C12N2800/30 , C12Y306/00
摘要： The present invention provides an optimized FLP site-specific recombinase coding sequence and methods for its use. This genetically engineered FLP gene displays a marked increase in recombination efficiency compared to the native FLP gene and is therefore useful in a wide array of molecular applications.
摘要翻译： 本发明提供了优化的FLP位点特异性重组酶编码序列及其使用方法。 与天然FLP基因相比，这种基因工程FLP基因显示出重组效率的显着增加，因此可用于广泛的分子应用。
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7.发明申请HIGH EFFICIENCY FLP SITE-SPECIFIC RECOMBINATION IN MAMMALIAN CELLS USING AN OPTIMIZED FLP GENE 有权使用优化的FLP基因在马马里亚细胞中的高效FLP位点特异性重组公开(公告)号：US20100050279A1
公开(公告)日：2010-02-25
申请号：US12307418
申请日：2007-06-21
IPC分类号： A01K67/027 , A01K67/033 , C07H21/00 , C12N5/00 , C12N5/07 , C12N15/63
CPC分类号： C12N9/14 , C07H21/04 , C12N9/00 , C12N15/63 , C12N15/79 , C12N2510/00 , C12N2800/30 , C12Y306/00
摘要： The present invention provides an optimized FLP site-specific recombinase coding sequence and methods for its use. This genetically engineered FLP gene displays a marked increase in recombination efficiency compared to the native FLP gene and is therefore useful in a wide array of molecular applications.
摘要翻译： 本发明提供了优化的FLP位点特异性重组酶编码序列及其使用方法。 与天然FLP基因相比，这种基因工程FLP基因显示出重组效率的显着增加，因此可用于广泛的分子应用。
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