公开(公告)号：US09322071B2

公开(公告)日：2016-04-26

申请号：US14499801

申请日：2014-09-29

Applicant: Korea Basic Science Institute ,  Industry Foundation of Chonnam National University

Inventor： Joseph Kwon ,  Jong-Soon Choi ,  Duwoon Kim ,  Hee-Min Lee

IPC: C12Q1/70 ,  C12N7/00

CPC classification number: C12Q1/701 ,  C12N7/02 ,  C12N2770/16011 ,  C12N2770/32411 ,  C12Q1/706 ,  Y02A50/54

Abstract: Disclosed is an economic method for concentrating virus and detecting virus, such that virus in a sample solution having low virus concentration can be concentrated with high efficiency within a short time. Particularly, the method comprising the steps of: (A) adding Concanavalin A (Con A) to a sample solution containing a virus, and reacting the added Concanavalin A with the virus in the sample solution to form a virus-Concanavalin A conjugate; and (B) separating the virus-Concanavalin A conjugate from the sample solution.

Abstract translation: 公开了一种用于浓缩病毒和检测病毒的经济方法，使得可以在短时间内以高效率浓缩具有低病毒浓度的样品溶液中的病毒。 特别地，该方法包括以下步骤：（A）将伴刀豆球蛋白A（Con A）加入到含有病毒的样品溶液中，并将加入的伴刀豆球蛋白A与病毒在样品溶液中反应，形成病毒 - 伴刀豆球蛋白A缀合物; 和（B）从样品溶液中分离病毒 - 伴刀豆球蛋白A缀合物。

公开(公告)号：US5298023A

公开(公告)日：1994-03-29

申请号：US949265

申请日：1992-09-22

Applicant: Terry M. Haber ,  William H. Smedley ,  Clark B. Foster

Inventor： Terry M. Haber ,  William H. Smedley ,  Clark B. Foster

IPC: A61M39/00 ,  A61M5/178 ,  A61M5/19 ,  A61M5/24 ,  A61M5/31 ,  A61M5/315 ,  A61M5/32 ,  A61M5/34 ,  A61M37/00 ,  A61M5/00

CPC classification number: A61M5/19 ,  A61M5/2448 ,  A61M5/3129 ,  A61M5/315 ,  A61M5/31525 ,  A61M5/322 ,  A61M5/34 ,  A61M2005/3125 ,  A61M2005/3126 ,  A61M2005/3128 ,  A61M2005/3131 ,  A61M2005/3227 ,  A61M2005/3228 ,  A61M2005/341 ,  A61M5/1782 ,  A61M5/204 ,  A61M5/2425 ,  A61M5/31535 ,  A61M5/31543 ,  A61M5/31551 ,  A61M5/31553 ,  A61M5/31555 ,  A61M5/31561 ,  A61M5/3158 ,  A61M5/3202 ,  C12N2770/32411

Abstract: A multiple pharmaceutical syringe (2, 160, 402), especially useful for use in dispensing insulin, includes a body (4, 162, 404) housing first and second pharmaceutical-filled cartridges (30, 32; 182, 184; 478, 480). The cartridges are of the type with a septum (36, 190, 484) at one end and a piston (42, 48; 224, 225; 562, 564) at the other end with the liquid pharmaceutical (46, 48; 226, 228; 534, 536) between the two. The body also defines an accumulator chamber (10, 202, 654) within which an accumulator piston (26, 238, 464) is slidably mounted. The cartridge interiors are connected by a flow path (70, 752) to the accumulator chamber. Pressing on the cartridge pistons forces desired amounts of the liquids from the cartridge into the accumulator chamber. The mixed pharmaceutical is dispensed by driving the accumulator piston.

Abstract translation: 特别适用于分配胰岛素的多药物注射器（2,160,402）包括容纳第一和第二药物填充药筒（30,32; 182,184; 478,480）的主体（4,162,404） ）。 药筒的一端为隔膜（36,190,484），另一端为活塞（42,48; 224,225; 562,564），液体药物（46,48; 226， 228; 534,536）之间。 所述主体还限定蓄能器室（10,202,654），蓄能器活塞（26,238,464）可滑动地安装在该蓄能器室内。 墨盒内部通过流路（70,752）连接到储存室。 按压墨盒活塞将所需量的液体从墨盒推入蓄能器室。 通过驱动蓄能器活塞来分配混合药物。

公开(公告)号：US07785773B1

公开(公告)日：2010-08-31

申请号：US11604169

申请日：2006-11-22

Applicant: David Andrew Anderson ,  Teresa Sylvia Howard ,  Anne Healy ,  Katherine Anders ,  Mary Louise Garcia

Inventor： David Andrew Anderson ,  Teresa Sylvia Howard ,  Anne Healy ,  Katherine Anders ,  Mary Louise Garcia

IPC: C12Q1/70 ,  C12N7/00 ,  G01N33/563 ,  G01N33/533

CPC classification number: G01N33/5768 ,  C12N2770/32411 ,  G01N33/6857

Abstract: This invention is directed to diagnostic methods detecting the presence of an antibody to a virus in a sample from a subject and kits for using the methods.

Abstract translation: 本发明涉及检测来自受试者的样品中病毒的抗体的存在的诊断方法和使用该方法的试剂盒。

公开(公告)号：US3313706A

公开(公告)日：1967-04-11

申请号：US46239165

申请日：1965-06-08

Applicant: JOHNSON & JOHNSON

Inventor： ANDREAS LEMBKE ,  SIEGFRIED SCHLECHT

IPC: A61K39/29 ,  C12Q1/70 ,  G01N33/576

CPC classification number: G01N33/576 ,  A61K39/12 ,  A61K39/29 ,  C12N2770/32411 ,  C12N2770/32434 ,  C12Q1/70 ,  Y10S436/811 ,  Y10S436/82

公开(公告)号：US09474759B2

公开(公告)日：2016-10-25

申请号：US14347756

申请日：2012-09-27

Applicant: Kansas State University Research Foundation ,  The Ohio State University ,  Wichita State University

Inventor： Kyeong-Ok Chang ,  Yunjeong Kim ,  William C. Groutas ,  Duy Hua ,  Linda J. Saif

IPC: A61K38/06 ,  A61K31/5377 ,  A61K31/4015 ,  A61K31/422 ,  A61K31/427 ,  A61K45/06 ,  C07D207/27

CPC classification number: A61K31/5377 ,  A61K31/4015 ,  A61K31/422 ,  A61K31/427 ,  A61K38/06 ,  A61K45/06 ,  C07D207/27 ,  C12N2770/16011 ,  C12N2770/20011 ,  C12N2770/32111 ,  C12N2770/32311 ,  C12N2770/32411 ,  C12N2770/32611 ,  Y02A50/463

Abstract: Antiviral protease inhibitors, including peptidyl aldehydes, peptidyl α-ketoamides, peptidyl bisulfate salts, and peptidyl heterocycles, are disclosed, along with related antiviral compounds, and methods of using the same to treat or prevent viral infection and disease. The compounds possess broad-spectrum activity against viruses that belong to the picornavirus-like supercluster, which include important human and animal pathogens including noroviruses, enteroviruses, poliovirus, foot-and-mouth disease virus, hepatitis A virus, human rhinovirus (cause of common cold), human coronavirus (another cause of common cold), transmissible gastroenteritis virus, murine hepatitis virus, feline infectious peritonitis virus, and severe acute respiratory syndrome coronavirus.

Abstract translation: 公开了抗病毒蛋白酶抑制剂，包括肽基醛，肽基α-酮酰胺，硫酸氢酯盐和肽基杂环，以及相关的抗病毒化合物，以及使用它们来治疗或预防病毒感染和疾病的方法。 该化合物对属于小核糖核酸病毒超级群集的病毒具有广谱活性，其包括重要的人和动物病原体，包括诺维病毒，肠道病毒，脊髓灰质炎病毒，口蹄疫病毒，甲型肝炎病毒，人类鼻病毒（常见病因 感冒），人类冠状病毒（普通感冒的另一原因），传染性胃肠炎病毒，鼠肝炎病毒，猫感染性腹膜炎病毒和严重急性呼吸综合征冠状病毒。

公开(公告)号：US20160090640A1

公开(公告)日：2016-03-31

申请号：US14499801

申请日：2014-09-29

Applicant: KOREA BASIC SCIENCE INSTITUTE ,  INDUSTRY FOUNDATION OF CHONNAM NATIONAL UNIVERSITY

Inventor： Joseph Kwon ,  Jong-Soon Choi ,  Duwoon Kim ,  Hee-Min Lee

IPC: C12Q1/70 ,  C12N7/00

CPC classification number: C12Q1/701 ,  C12N7/02 ,  C12N2770/16011 ,  C12N2770/32411 ,  C12Q1/706 ,  Y02A50/54

Abstract: Disclosed is an economic method for concentrating virus and detecting virus, such that virus in a sample solution having low virus concentration can be concentrated with high efficiency within a short time. Particularly, the method comprising the steps of: (A) adding Concanavalin A (Con A) to a sample solution containing a virus, and reacting the added Concanavalin A with the virus in the sample solution to form a virus-Concanavalin A conjugate; and (B) separating the virus-Concanavalin A conjugate from the sample solution.

Abstract translation: 公开了一种用于浓缩病毒和检测病毒的经济方法，使得可以在短时间内以高效率浓缩具有低病毒浓度的样品溶液中的病毒。 特别地，该方法包括以下步骤：（A）将伴刀豆球蛋白A（Con A）加入到含有病毒的样品溶液中，并将加入的伴刀豆球蛋白A与病毒在样品溶液中反应，形成病毒 - 伴刀豆球蛋白A缀合物; 和（B）从样品溶液中分离病毒 - 伴刀豆球蛋白A缀合物。

公开(公告)号：US20140243341A1

公开(公告)日：2014-08-28

申请号：US14347756

申请日：2012-09-27

Applicant: Kansas State University Research Foundation ,  Wichita State University ,  The Ohio State University

Inventor： Kyeong-Ok Chang ,  Yunjeong Kim ,  William C. Groutas ,  Duy Hua ,  Linda J. Saif

IPC: A61K31/5377 ,  A61K31/4015 ,  A61K45/06 ,  C07D207/27

CPC classification number: A61K31/5377 ,  A61K31/4015 ,  A61K31/422 ,  A61K31/427 ,  A61K38/06 ,  A61K45/06 ,  C07D207/27 ,  C12N2770/16011 ,  C12N2770/20011 ,  C12N2770/32111 ,  C12N2770/32311 ,  C12N2770/32411 ,  C12N2770/32611 ,  Y02A50/463

Abstract: Antiviral protease inhibitors, including peptidyl aldehydes, peptidyl α-ketoamides, peptidyl bisulfite salts, and peptidyl heterocycles, are disclosed, along with related antiviral compounds, and methods of using the same to treat or prevent viral infection and disease. The compounds possess broad-spectrum activity against viruses that belong to the picornavirus-like supercluster, which include important human and animal pathogens including noroviruses, enteroviruses, poliovirus, foot-and-mouth disease virus, hepatitis A virus, human rhinovirus (cause of common cold), human coronavirus (another cause of common cold), transmissible gastroenteritis virus, murine hepatitis virus, feline infectious peritonitis virus, and severe acute respiratory syndrome coronavirus.

Abstract translation: 公开了抗病毒蛋白酶抑制剂，包括肽基醛，肽基α-酮酰胺，亚硫酸氢盐和肽基杂环，以及相关的抗病毒化合物，以及使用它们来治疗或预防病毒感染和疾病的方法。 该化合物对属于小核糖核酸病毒超集群的病毒具有广谱活性，其包括重要的人和动物病原体，包括诺维病毒，肠道病毒，脊髓灰质炎病毒，口蹄疫病毒，甲型肝炎病毒，人类鼻病毒（常见病因 感冒），人类冠状病毒（普通感冒的另一原因），传染性胃肠炎病毒，鼠肝炎病毒，猫感染性腹膜炎病毒和严重急性呼吸综合征冠状病毒。

公开(公告)号：US5199949A

公开(公告)日：1993-04-06

申请号：US718398

申请日：1991-06-21

Applicant: Terry M. Haber ,  William H. Smedley ,  Clark B. Foster

Inventor： Terry M. Haber ,  William H. Smedley ,  Clark B. Foster

IPC: A61M5/19 ,  A61M5/24 ,  A61M5/31 ,  A61M5/315 ,  A61M5/32 ,  A61M5/34

CPC classification number: A61M5/34 ,  A61M5/19 ,  A61M5/2448 ,  A61M5/3129 ,  A61M5/315 ,  A61M5/31525 ,  A61M5/322 ,  A61M2005/3126 ,  A61M2005/3128 ,  A61M2005/3131 ,  A61M2005/3227 ,  A61M2005/3228 ,  A61M2005/341 ,  A61M5/204 ,  A61M5/2425 ,  A61M5/31543 ,  A61M5/31553 ,  A61M5/31555 ,  A61M5/3158 ,  A61M5/3202 ,  C12N2770/32411

Abstract: A multiple pharmaceutical syringe (160), especially useful for use in dispensing insulin, includes a body (162) housing first and second pharmaceutical-filled cartridges (182, 184). The cartridges are of the type with a septum (190) at one end and a piston (224, 225) at the other end with the liquid pharmaceutical (226, 228) between the two. The body also defines an accumulator chamber (202) within which an accumulator piston (238) is slidably mounted. When the cartridges are mounted within the body, the septums are pierced by hollow spikes (188) which are connected to a flow path opening into the accumulator chamber. Check valves (230) are used at the distal ends of the spikes to prevent liquid flow back into the cartridges. Pressing on the cartridge pistons forces the liquids into the accumulator chamber. Once the desired amounts of both liquids are in the accumulator chamber, the needle assembly is mounted to the replaceable fluid path assembly which fluidly couples the needle to the accumulator chamber. The injection is given by driving the accumulators piston using the accumulator stem.

Abstract translation: 特别用于分配胰岛素的多药物注射器（160）包括容纳第一和第二药物填充药筒（182,184）的主体（162）。 药筒是一端具有隔膜（190）的类型，另一端的活塞（224,225）在两者之间具有液体药物（226,228）。 该主体还限定蓄能器室（202），蓄能器活塞（238）可滑动地安装在该蓄能器室内。 当墨盒安装在主体内时，隔膜被中空尖钉（188）穿透，空心尖钉（188）连接到通向蓄能器室的流动路径。 止回阀（230）用于尖钉的末端，以防止液体回流到墨盒中。 在墨盒活塞上按压迫使液体进入蓄能器室。 一旦所需量的两种液体都在蓄能器室中，针组件安装到可更换的流体路径组件上，该流体路径组件将针流动地连接到蓄能器室。 注射通过使用蓄能器杆驱动蓄能器活塞来给出。