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1.发明申请Mixed Cell Diagnostic Systems For Detection Of Respiratory, Herpes and Enteric Viruses 有权用于检测呼吸道，疱疹和肠道病毒的混合细胞诊断系统公开(公告)号：US20150031016A1
公开(公告)日：2015-01-29
申请号：US14450673
申请日：2014-08-04
Inventor： David R. Scholl , Yung T Huang , Patricia Gail Ray Goodrum
CPC classification number: C12Q1/02 , C12N7/00 , C12N2710/16611 , C12N2760/16051 , C12N2770/20011 , C12N2770/32311 , C12Q1/04 , C12Q1/18 , G01N2333/11 , G01N2333/29 , G01N2333/295
Abstract: The present invention generally relates to the field of diagnostic microbiology, and, more particularly, to compositions and methods for detecting and differentiating one or more viruses or other intracellular parasites present in a specimen. The present invention also provides compositions and methods to evaluate the susceptibility of organisms to antimicrobial agents.
Abstract translation: 本发明一般涉及诊断微生物领域，更具体地，涉及用于检测和分化存在于样品中的一种或多种病毒或其它细胞内寄生虫的组合物和方法。 本发明还提供了评估生物体对抗微生物剂的敏感性的组合物和方法。
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公开(公告)号：US20100111873A1
公开(公告)日：2010-05-06
申请号：US12528047
申请日：2008-02-20
Applicant: Stephen J. Russell , Elizabeth J. Kelly , Elizabeth M. Hadac
Inventor： Stephen J. Russell , Elizabeth J. Kelly , Elizabeth M. Hadac
IPC: A61K49/00 , A61K31/7052 , C07H21/00 , A61P35/00
CPC classification number: C07K14/005 , A61K35/768 , C12N7/00 , C12N2770/32311 , C12N2770/32332 , C12N2770/32611 , C12N2770/32632 , C12N2840/102 , Y02A50/465
Abstract: This document provides methods and materials related to the use of nucleic acid coding for viruses to reduce the number of viable cancer cells within a mammal. For example, methods for using infectious nucleic acid to treat cancer, engineered viral nucleic acid, methods for making engineered viral nucleic acid, methods for identifying infectious nucleic acid for treating cancer, methods and materials for controlling virus-mediated cell lysis, and methods and materials for assessing the control of virus-mediated cell lysis are provided.
Abstract translation: 本文件提供了与使用编码病毒的核酸相关的方法和材料，以减少哺乳动物内活细胞的数量。 例如，使用感染性核酸治疗癌症的方法，工程化病毒核酸，制备工程化病毒核酸的方法，用于鉴定用于治疗癌症的感染性核酸的方法，用于控制病毒介导的细胞裂解的方法和材料，以及方法和 提供了评估病毒介导的细胞裂解控制的材料。
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公开(公告)号：US20100034848A1
公开(公告)日：2010-02-11
申请号：US12523328
申请日：2008-01-31
Applicant: Hanna Viskari , Mikael Knip , Tapio Seiskari , Heikki Hyöty , Laura Kummola , Anita Kondrashova
Inventor： Hanna Viskari , Mikael Knip , Tapio Seiskari , Heikki Hyöty , Laura Kummola , Anita Kondrashova
IPC: A61K39/00
CPC classification number: A61K39/35 , A61K35/76 , C12N2770/32311 , C12N2770/32332
Abstract: The present invention relates to prevention and treatment of allergic sensitization and diseases associated therewith by treatment with an enterovirus vaccine, wherein the enterovirus does not contain an exogenous nucleic acid sequence that is integrated into the viral genome and that encodes an allergen that induces said allergic sensitization.
Abstract translation: 本发明涉及通过肠道病毒疫苗的治疗来预防和治疗过敏性致敏及其相关疾病，其中肠道病毒不含有整合到病毒基因组中并编码诱导所述过敏致敏的变应原的外源性核酸序列 。
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公开(公告)号：US20040259243A1
公开(公告)日：2004-12-23
申请号：US10861724
申请日：2004-06-03
Inventor： Yung T. Huang
IPC: C12N005/06
CPC classification number: C12N5/0686 , C07K14/70596 , C12N7/00 , C12N2503/00 , C12N2510/02 , C12N2770/32311 , C12N2770/32611 , G01N33/56983
Abstract: The invention provides cell lines which are useful for the rapid detection of enteroviruses. In particular, the invention provides transgenic African green monkey kidney cell lines and buffalo green monkey kidney cell lines. The invention provides cell lines which have increased sensitivity to infection by enteroviruses in single-cell type and mixed-cell type cultures compared to other cell types which are currently used for enterovirus detection. The cells of the invention also are permissive to infection by a larger number of enteroviruses as compared to the cell type from which they were derived.
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公开(公告)号：US09957302B2
公开(公告)日：2018-05-01
申请号：US14792178
申请日：2015-07-06
Inventor： Stephen James Russell , Elizabeth J. Kelly , Elizabeth M. Hadac
IPC: C07K14/005 , C12N7/00 , A61K35/768
CPC classification number: C07K14/005 , A61K35/768 , C12N7/00 , C12N2770/32311 , C12N2770/32332 , C12N2770/32611 , C12N2770/32632 , C12N2840/102 , Y02A50/465
Abstract: This document provides methods and materials related to the use of nucleic acid coding for viruses to reduce the number of viable cancer cells within a mammal. For example, methods for using infectious nucleic acid to treat cancer, engineered viral nucleic acid, methods for making engineered viral nucleic acid, methods for identifying infectious nucleic acid for treating cancer, methods and materials for controlling virus-mediated cell lysis, and methods and materials for assessing the control of virus-mediated cell lysis are provided.
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Patent Agency Ranking
公开(公告)号：US20130067609A1
公开(公告)日：2013-03-14
申请号：US13377815
申请日：2010-06-14
Applicant: Donald Rubin , Robert Gilmore , Thomas Hodge , Natalie McDonald
Inventor： Donald Rubin , Robert Gilmore , Thomas Hodge , Natalie McDonald
IPC: A61K31/713 , A01K67/027 , C12N5/071
CPC classification number: C12N15/113 , C07K14/4702 , C12N9/1051 , C12N9/2402 , C12N15/1137 , C12N2310/11 , C12N2310/14 , C12N2310/16 , C12N2710/16611 , C12N2710/24111 , C12N2760/16111 , C12N2760/18511 , C12N2770/24111 , C12N2770/32311
Abstract: The present invention relates to nucleic acid sequences and cellular proteins encoded by these sequences that are involved in infection or are otherwise associated with the life cycle of one or more pathogens.
Abstract translation: 本发明涉及由这些序列编码的涉及感染或以其它方式与一种或多种病原体的生命周期相关的核酸序列和细胞蛋白质。
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7.发明申请USE OF ENTEROVIRUS FOR DIAGNOSTICS, TREATMENT AND PREVENTION OF DISEASE 审中-公开使用EnterioVIRUS进行诊断，治疗和预防疾病公开(公告)号：US20110002943A1
公开(公告)日：2011-01-06
申请号：US12743903
申请日：2008-11-28
Applicant: Heikki Hyöty , Sisko Tauriainen , Sami Oikarinen , Maarit Oikarinen , Markku Mäki , Katri Kaukinen , Teemu Honkanen , Immo Rantala
Inventor： Heikki Hyöty , Sisko Tauriainen , Sami Oikarinen , Maarit Oikarinen , Markku Mäki , Katri Kaukinen , Teemu Honkanen , Immo Rantala
IPC: A61K39/42 , C12Q1/70 , A61K39/12 , A61K35/76 , C12N7/00 , C07K16/08 , A61P3/00 , A61P37/04 , A61P31/12
CPC classification number: G01N33/56983 , A61K39/12 , A61K39/125 , C12N2770/32311 , C12N2770/32332 , C12N2770/32334 , G01N2800/02 , G01N2800/04 , G01N2800/06
Abstract: The invention is based on the finding that enterovirus is present in body samples of patients with celiac disease. The invention opens up the possibility for using enteroviruses in diagnosing, preventing, treating and monitoring the treatment of celiac-related diseases. The invention relates to a method for diagnosing, treating and monitoring the treatment of a celiac-related disease. The invention also relates to the use of enteroviruses or components or antibodies thereof for producing a vaccine, and the use of anti-enterovirus compositions for preparing a pharmaceutical against said disease.
Abstract translation: 本发明是基于肠道病毒存在于乳糜泻患者的身体样品中的发现。 本发明开辟了使用肠道病毒诊断，预防，治疗和监测乳糜泻相关疾病治疗的可能性。 本发明涉及诊断，治疗和监测乳糜泻相关疾病的治疗方法。 本发明还涉及肠道病毒或其组分或其抗体用于生产疫苗的用途，以及使用抗肠道病毒组合物制备抗所述疾病的药物。
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公开(公告)号：US20070134791A1
公开(公告)日：2007-06-14
申请号：US11657822
申请日：2007-01-23
Applicant: Yung Huang
Inventor： Yung Huang
CPC classification number: C12N5/0686 , C07K14/70596 , C12N7/00 , C12N2503/00 , C12N2510/02 , C12N2770/32311 , C12N2770/32611 , G01N33/56983
Abstract: The invention provides cell lines which are useful for the rapid detection of enteroviruses. In particular, the invention provides transgenic African green monkey kidney cell lines and buffalo green monkey kidney cell lines. The invention provides cell lines which have increased sensitivity to infection by enteroviruses in single-cell type and mixed-cell type cultures compared to other cell types which are currently used for enterovirus detection. The cells of the invention also are permissive to infection by a larger number of enteroviruses as compared to the cell type from which they were derived.
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公开(公告)号：US07186504B2
公开(公告)日：2007-03-06
申请号：US10861724
申请日：2004-06-03
Applicant: Yung T. Huang
Inventor： Yung T. Huang
CPC classification number: C12N5/0686 , C07K14/70596 , C12N7/00 , C12N2503/00 , C12N2510/02 , C12N2770/32311 , C12N2770/32611 , G01N33/56983
Abstract: The invention provides cell lines which are useful for the rapid detection of enteroviruses. In particular, the invention provides transgenic African green monkey kidney cell lines and buffalo green monkey kidney cell lines. The invention provides cell lines which have increased sensitivity to infection by enteroviruses in single-cell type and mixed-cell type cultures compared to other cell types which are currently used for enterovirus detection. The cells of the invention also are permissive to infection by a larger number of enteroviruses as compared to the cell type from which they were derived.
Abstract translation: 本发明提供可用于快速检测肠道病毒的细胞系。 特别地，本发明提供转基因非洲绿猴肾细胞系和水牛绿猴肾细胞系。 本发明提供了与目前用于肠道病毒检测的其它细胞类型相比，对单细胞型和混合细胞型培养物中肠道病毒感染具有增加的敏感性的细胞系。 与其衍生的细胞类型相比，本发明的细胞也可以容忍更多数量的肠道病毒的感染。
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公开(公告)号：US20180215794A1
公开(公告)日：2018-08-02
申请号：US15937567
申请日：2018-03-27
Inventor： Stephen James Russell , Elizabeth J. Kelly , Elizabeth M. Hadac
IPC: C07K14/005 , C12N7/00 , A61K35/768
CPC classification number: C07K14/005 , A61K35/768 , C12N7/00 , C12N2770/32311 , C12N2770/32332 , C12N2770/32611 , C12N2770/32632 , C12N2840/102 , Y02A50/465
Abstract: This document provides methods and materials related to the use of nucleic acid coding for viruses to reduce the number of viable cancer cells within a mammal. For example, methods for using infectious nucleic acid to treat cancer, engineered viral nucleic acid, methods for making engineered viral nucleic acid, methods for identifying infectious nucleic acid for treating cancer, methods and materials for controlling virus-mediated cell lysis, and methods and materials for assessing the control of virus-mediated cell lysis are provided.
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