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    NUCLEIC ACID FUNCTIONALIZED METAL NANOPROBE AND PREPARATION METHOD THEREFOR
    1.
    发明公开
    NUCLEIC ACID FUNCTIONALIZED METAL NANOPROBE AND PREPARATION METHOD THEREFOR 审中-公开

    公开(公告)号：US20240240078A1

    公开(公告)日：2024-07-18

    申请号：US18013928

    申请日：2021-11-10

    Applicant: SOUTHEAST UNIVERSITY

    Inventor： Xuemei WANG ,  Zengchao GUO ,  Jiayu ZENG ,  Hui JIANG

    IPC: C09K11/58 ,  B82Y20/00 ,  B82Y40/00 ,  G01N21/64

    CPC classification number: C09K11/58 ,  G01N21/6458 ,  B82Y20/00 ,  B82Y40/00 ,  G01N2021/6439

    Abstract: Disclosed are a nucleic acid functionalized metal nanoprobe and a preparation method therefor; according to the probe, metal cations with desirable biocompatibility are mixed with exogenous deoxyribonucleic acid (DNA) or ribonucleic acid (RNA) molecules to generate a DNA or RNA composite nanostructure; co-incubating is performed with a pathogenic microorganism, the composite nanostructure enters pathogenic microorganism cells through electrostatic adsorption, and unique microenvironment of high-level oxidizing and reducing substances possessed by the pathogenic microorganism is used to promote in-situ synthesis of the intelligent biological probe; accurate targeted labeling and real-time rapid detection of the pathogenic microorganism are achieved, and the probe is used for targeted intervention of infectious diseases such as lung infection, intestinal infection and influenza; combined with physical interventions such as photoelectricity, magnetocaloric effect, near infrared, multi-modal real-time dynamic and high-specificity rapid and accurate tracing and accurate killing of related lesions can be achieved.

    NEAR-INFRARED-II FLUORESCENT COMPOSITE, ITS PREPARATION METHOD AND USES THEREOF
    2.
    发明公开
    NEAR-INFRARED-II FLUORESCENT COMPOSITE, ITS PREPARATION METHOD AND USES THEREOF 审中-公开

    公开(公告)号：US20240173438A1

    公开(公告)日：2024-05-30

    申请号：US18071647

    申请日：2022-11-30

    Applicant: Chung Yuan Christian University

    Inventor： Cheng-An LIN ,  Yi-Tang SUN ,  Min-Hua CHEN

    IPC: A61K49/00 ,  C09K11/02 ,  C09K11/58

    CPC classification number: A61K49/0065 ,  C09K11/025 ,  C09K11/58 ,  B82Y20/00

    Abstract: Disclosed herein are second near-infrared (NIR-II) fluorescent composite and its production method. The method mainly includes the steps of, mixing a gold nanocluster having a plurality of a thiol-based compound on its outer surface and alpha-glycerylphosphorylcholine (alpha-GPC) in a solvent to form a mixture; replacing the solvent with an inert gas; and heating the mixture at a temperature about 100-200° C. in the presence of the inert gas until at least a portion of the gold nanocluster is encapsulated by a capping layer consisting of alpha-GPC, thereby producing the NIR-II fluorescent composite. The thus-produced NIR-II fluorescent composite is characterized by having an emission wavelength covering NIR-II region detectable by specialized camera. Also encompassed in the present disclosure is a method for conducting in vivo bioimaging of a target area in a subject. The method includes administering the present NIR-II fluorescent composite to the target area; and detecting the fluorescence emitted therefrom at a wavelength between 900 to 1700 nm.

    LUMINESCENT NANOCOMPOUNDS
    7.
    发明申请
    LUMINESCENT NANOCOMPOUNDS 有权
    发光纳米微粒

    公开(公告)号：US20150321252A1

    公开(公告)日：2015-11-12

    申请号：US14650522

    申请日：2013-12-11

    Applicant: NANOGAP SUB NM POWDER, S.A.

    Inventor： Manuel Arturo Lopez Quintela

    IPC: B22F1/00 ,  G01N21/64 ,  C09K11/58

    CPC classification number: B22F1/0044 ,  B22F1/0088 ,  B82Y20/00 ,  C09K11/58 ,  G01N21/6428 ,  G01N2201/068 ,  Y10S977/95

    Abstract: The present invention relates to nanocompounds comprising a charge-transfer complex of at least two different size metal atomic quantum clusters (AQCs) and the use thereof as luminescent nanocompounds, particularly for the use thereof as fluorescent nanocompounds; as well as the method for obtaining and detecting them.

    Abstract translation: 本发明涉及包含至少两种不同尺寸的金属原子量子簇（AQC）的电荷转移络合物及其作为发光纳米化合物的用途的纳米化合物，特别是其用作荧光纳米化合物; 以及获取和检测它们的方法。

    LUMINESCENT NANOSYSTEMS
    9.
    发明申请
    LUMINESCENT NANOSYSTEMS 有权

    公开(公告)号：US20140106465A1

    公开(公告)日：2014-04-17

    申请号：US14123149

    申请日：2012-06-14

    Applicant: Manuel Arturo Lopez Quintela

    Inventor： Manuel Arturo Lopez Quintela

    IPC: G01N21/64

    CPC classification number: G01N21/6428 ,  B82Y15/00 ,  C09K11/025 ,  C09K11/58 ,  G01N33/542 ,  G01N33/5432 ,  G01N33/582

    Abstract: The present invention relates to nanosystems comprising metal atomic quantum clusters (AQCs) of at least two different sizes encapsulated in a cavity with an inner diameter less than or equal to 10 nm for the use thereof as luminescent nanosystems, particularly for the use thereof as fluorescent nanosystems; as well as the method for obtaining and detecting them. The invention also relates to the use of said luminescent nanosystems as a fluorescent probe, biomarker or contrasting agent.

    Abstract translation: 本发明涉及包含至少两种不同尺寸的金属原子量子簇（AQC）的纳米系统，其包封在具有小于或等于10nm的内径的空腔中，以用于其作为发光纳米系统，特别是其用作荧光 纳米系统 以及获取和检测它们的方法。 本发明还涉及所述发光纳米系统作为荧光探针，生物标志物或对比剂的用途。

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