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    PREPARATION OF PURIFIED PHOSPHORODIAMIDITE
    1.
    发明申请
    PREPARATION OF PURIFIED PHOSPHORODIAMIDITE 有权
    纯化磷酸二钙的制备

    公开(公告)号：US20160333034A1

    公开(公告)日：2016-11-17

    申请号：US15110971

    申请日：2015-01-15

    Applicant: RHODIA OPERATIONS

    Inventor： Gary WOODWARD

    IPC: C07F9/24

    CPC classification number: C07F9/2412 ,  C07F9/2408 ,  C07F9/2458

    Abstract: The instant invention relates to a method of phosphorodiamidite production that comprises: (E1) preparing a purified solution of a dialkylamine in a polar solvent as follows:—the dialkylamine dissolved in a polar solvent is contacted with a quantity of phosphorus trihalide that is sufficient to react with the alcohol impurities contained in the dialkylamine but sufficiently low to leave a major part of the dialkylamine unreacted, whereby a mixture is obtained that contains the dialkylamine in the polar solvent and reaction products of the impurities with the phosphorous trihalide;—the unreacted dialkylamine and polar solvent present in the mixture obtained in step (E1.1.) are extracted from the solution S by their difference of volatility, typically by distillation, whereby the purified solution of the dialkylamine in the polar solvent is obtained; (E2) the purified solution of dialkylamine in a polar solvent as obtained in step (E1) is reacted with a phosphorus trihalide, whereby an intermediate compound is formed; (E3) the intermediate compound obtained in step (E2) is reacted with a hydroxyalkyl compound in the presence of a non-polar co-solvent.

    Abstract translation: 本发明涉及一种磷二亚胺生产方法，其包括：（E1）如下制备极性溶剂中的二烷基胺纯化溶液： - 将溶解在极性溶剂中的二烷基胺与一定量的三卤化磷接触， 与二烷基胺中所含的醇杂质反应，但足够低以留下未反应的二烷基胺的主要部分，由此得到在极性溶剂中含有二烷基胺的混合物和杂质与三卤化磷的反应产物; - 未反应的二烷基胺 通过挥发性的差异从溶液S中提取存在于步骤（E1.1。）中获得的混合物中的极性溶剂，通常通过蒸馏提取，得到二烷基胺在极性溶剂中的纯化溶液; （E2）将步骤（E1）中得到的极性溶剂中的二烷基胺的纯化溶液与三卤化磷反应，形成中间体化合物; （E3）中，将步骤（E2）中得到的中间体化合物与羟烷基化合物在非极性助溶剂的存在下反应。

    Purification of synthetic oligomers
    2.
    发明授权
    Purification of synthetic oligomers 有权
    合成低聚物的纯化

    公开(公告)号：US07850949B2

    公开(公告)日：2010-12-14

    申请号：US11865499

    申请日：2007-10-01

    Applicant: Shiyue Fang

    Inventor： Shiyue Fang

    IPC: A61K8/55

    CPC classification number: C07H1/06 ,  C07D207/404 ,  C07D491/16 ,  C07F9/146 ,  C07F9/2408 ,  C07F9/2412 ,  C07F9/572 ,  C07F9/5728 ,  C07F9/6561 ,  C07K1/02 ,  C07K1/04 ,  C07K1/14

    Abstract: This invention provides a novel method for purifying synthetic oligomers comprising capping, polymerizing and separating any failure sequences produced during oligomer synthesis. Either the failure sequence or the full-length oligomer may be polymerized. Optionally, small molecule impurities may also be incorporated into the polymerized material. The invention provides novel capping agents having a polymerizable functional group. The invention also provides kits comprising at least one composition of the present invention.

    Abstract translation: 本发明提供了一种纯化合成低聚物的新方法，其包括封端，聚合和分离寡聚物合成中产生的任何破坏序列。 故障序列或全长低聚物可以聚合。 任选地，也可以将小分子杂质掺入到聚合材料中。 本发明提供具有可聚合官能团的新型封端剂。 本发明还提供包含至少一种本发明组合物的试剂盒。

    Polymeric bromine-containing phosphoramidate polyols
    5.
    发明授权
    Polymeric bromine-containing phosphoramidate polyols 失效
    聚合物含溴氨基磷酸酯多元醇

    公开(公告)号：US3932565A

    公开(公告)日：1976-01-13

    申请号：US430995

    申请日：1973-12-26

    Applicant: Wadim Batorewicz

    Inventor： Wadim Batorewicz

    IPC: C07F9/24 ,  C08G18/38 ,  C08G18/64 ,  C08G79/04 ,  C08L85/02 ,  C08G18/83

    CPC classification number: C08L85/02 ,  C07F9/2408 ,  C07F9/2412 ,  C08G18/3889 ,  C08G18/6461 ,  C08G79/04

    Abstract: Polymeric bromine-containing phosphoramidate polyols are obtained by reacting bromine with spirocyclic phosphoramidites and thereafter reacting the brominated products with a polyol, in the presence of an acid acceptor. The novel viscous polymers thus produced react with polyisocyanates to produce polyurethanes. Polyurethanes so made are characterized by improved flame-retardant properties compared with conventional polyurethanes.

    Abstract translation: 聚合的含溴氨基磷酸酯多元醇通过溴与螺环亚磷酰胺反应，然后在酸受体的存在下使溴化产物与多元醇反应而获得。 由此产生的新型粘性聚合物与多异氰酸酯反应生成聚氨酯。 如此制成的聚氨酯的特征在于与常规聚氨酯相比具有改进的阻燃性能。

    Hydroperoxy substituted cyclic phosphamides
    6.
    发明授权
    Hydroperoxy substituted cyclic phosphamides 失效
    羟基取代的环磷酰胺

    公开(公告)号：US3808297A

    公开(公告)日：1974-04-30

    申请号：US24924372

    申请日：1972-05-01

    Applicant: SHIONOGI & CO

    Inventor： TAKAMIZAWA A ,  IWATA T

    IPC: C07F9/24 ,  C07F9/6584 ,  C07D105/04

    CPC classification number: C07F9/65846 ,  C07F9/2412 ,  C07F9/65844

    Abstract: CYCLIC PHOSPHAMIDE DERIVATIVES OF THE GENERAL FORMULA:

    R1-N(-R2)-P(=O)
    (WHEREIN R1 AND R2 ARE THE SAME OR DIFFERENT REPRESENTING HYDROGEN ATOMS, LOWER ALKYL GROUPS, HALOGENATED LOWER ALKYL GROUPS OR ARYL GROUPS, OR TAKEN TOGETHER WITH THE NITROGEN ATOM, A 3- TO 6-MEMBERED HETEROCYCLIC RING; R3 IS A HYDROGEN ATOM, LOWER ALKYL GROUP, HALOGENATED LOWER ALKYL GROUP OR ARYL GROUP; R4 AND R5 ARE THE SAME OR DIFFERENT REPRESENTING HYDROGEN ATOMS OR LOWER ALKYL GROUPS; N REPRESENTS A NUMERICAL 0 OR 1) BEING USEFUL AS MEDICAOENTS SHOWING ANTIMICROBIAL, IMMUNOSUPPRESIVE AND/OR ANTITUMOR ACTIVITIES.

    O-loweralkyl-o-(2-alkoxylcarbonylmethyl)vinyl-monoalkylamido phosphates
    7.
    发明授权
    O-loweralkyl-o-(2-alkoxylcarbonylmethyl)vinyl-monoalkylamido phosphates 失效
    O-低级烷基-O-（2-烷氧基羰基甲基）乙烯基 - 单甲基氨基磷酸酯

    公开(公告)号：US3709960A

    公开(公告)日：1973-01-09

    申请号：US3709960D

    申请日：1969-11-12

    Applicant: SANDOZ LTD

    Inventor： LUTZ K ,  SCHULER M

    IPC: C07F9/24 ,  A01N9/36

    CPC classification number: C07F9/2412

    Abstract: NOVEL INSECTICIDALLY ACTIVE PHOSPHORIC ACID AMIDE ESTERS OF THE FORMULA I

    R1-O-P(=O)(-NH-R2)-O-(CH3-)C=CH-COO-R3

    IN WHICH EACH OF R1, R2 AND R3 REPRESENTS AN ALKYL RADICAL WITH FROM 1 TO 5 CARBON ATOMS INCLUSIVE, ARE PRODUCED BY REACTING A COMPOUND OF THE FORMULA IV

    R1-O-P(=O)(-CL)2

    WITH AN ALKYLAMINE IN THE PRESENCE OF AN ACID ACCEPTOR, AND THEN REACTING THE RESULTING REACTION PRODUCT WITH THE ENOL FORM OF AN ACETIC ACID ALKYL ESTER OF THE FORMULA LA III

    M-O-(H3C-)C=CH-COO-R3

    IN WHICH M IS A SALT FORMING AROM OR RADICAL. PREPARATIONS CONTAINING VARYING AMOUNTS OF THE COMPOUNDS OF FORMULA I AND ONE OR MORE DILUENTS (E.G. ISOC TY OCTAGLYCOL ETHER AND/OR A HIGH BOILING PETROLEUM FRACTION AND/OR XYLENE, DIISOHEXYL/HEPTYLPHENYLHEXAGLYCOL ETHER AND ACTONE, AND LAURYLHEXAGLYCOL ETHER AND SO-PROPYL ALCOHOL) ARE USED TO SHOW THE PRESTICIDAL EFFECT OF THE SAID ACTIVE AGENTS BY MEANS OF CONTACT TESTS ON BRUCHIDIUS OBTECTUS AND EPHESTIA (ANAGESTA) KEUNHIELLA, FEED EFFECT ON CARAUSIUS MOROSUS AND ACARICIDAL CONTACT EFFECT ON TETRANYCHUS TELARIUS. SOME COMPARATIVE TESTS ARE ALSO GIVEN TO DEMONSTRATE SUPERIORITY OVER KNOWN COMPOUNDS HAVING PESTICIDAL ACTIVITY, INCLUDING LESSER TOXICITY TOWARDS WARM-BLOODED ANIMALS.

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