公开(公告)号：US3734913A

公开(公告)日：1973-05-22

申请号：US3734913D

申请日：1970-10-12

Applicant: SHIONOGI & CO

Inventor： TAKAMIZAWA A ,  HIRAI K

IPC: C07D277/22 ,  C07D277/26 ,  C07D99/12

CPC classification number: C07D277/22 ,  C07D277/26

Abstract: THIAZOLIUM SALTS REPRESENTED BY THE FORMULA:

(-C(-NH2)=N-C(-CH3)=N-CH=)>C-CH2-N
S(=O)-R)=C(-CH3)-)

WHEREIN R REPRESENTS A LOWER ALKYL GROUP, AN ARYL GROUP, OR AN AR(LOWER)ALKYL GROUP, AND X REPRESENTS AN ACID RESIDUE OR ITS ACID ADDITION SALT, BEING USEFUL AS POULTRY ANTI-COCCIDIAL AGENTS, ARE PREPARED BY TWO ROUTES.

公开(公告)号：US3824308A

公开(公告)日：1974-07-16

申请号：US27980972

申请日：1972-08-11

Applicant: SHIONOGI & CO

Inventor： TAKAMIZAWA A ,  HIRAI K

IPC: C07D277/22 ,  C07D277/26 ,  A61K27/00

CPC classification number: C07D277/22 ,  C07D277/26

Abstract: THIAZOLIUM SALTS REPRESENTED BY THE FORMULA:

3-((2-(H3C-),6-(H2N-)-PYRIMIDIN-5-YL)-CH2-),4-(H3C-),

5-(R-SO-CH2-CH2-)-THIAZOLIUM X(-)

WHEREIN R REPRESENTS A LOWER ALKYL GROUP, AN ARYL GROUP, OR AN AR(LOWER)ALKYL GROUP, AND X REPRESENTS AN ACID RESIDUE OR ITS ACID ADDITION SALT, BEING USEFUL AS POULTRY ANTICOCCIDIAL AGENTS, ARE PREPARED BY TWO ROUTES.

公开(公告)号：US3808297A

公开(公告)日：1974-04-30

申请号：US24924372

申请日：1972-05-01

Applicant: SHIONOGI & CO

Inventor： TAKAMIZAWA A ,  IWATA T

IPC: C07F9/24 ,  C07F9/6584 ,  C07D105/04

CPC classification number: C07F9/65846 ,  C07F9/2412 ,  C07F9/65844

Abstract: CYCLIC PHOSPHAMIDE DERIVATIVES OF THE GENERAL FORMULA:

R1-N(-R2)-P(=O)
(WHEREIN R1 AND R2 ARE THE SAME OR DIFFERENT REPRESENTING HYDROGEN ATOMS, LOWER ALKYL GROUPS, HALOGENATED LOWER ALKYL GROUPS OR ARYL GROUPS, OR TAKEN TOGETHER WITH THE NITROGEN ATOM, A 3- TO 6-MEMBERED HETEROCYCLIC RING; R3 IS A HYDROGEN ATOM, LOWER ALKYL GROUP, HALOGENATED LOWER ALKYL GROUP OR ARYL GROUP; R4 AND R5 ARE THE SAME OR DIFFERENT REPRESENTING HYDROGEN ATOMS OR LOWER ALKYL GROUPS; N REPRESENTS A NUMERICAL 0 OR 1) BEING USEFUL AS MEDICAOENTS SHOWING ANTIMICROBIAL, IMMUNOSUPPRESIVE AND/OR ANTITUMOR ACTIVITIES.