公开(公告)号：US09695109B2

公开(公告)日：2017-07-04

申请号：US14926135

申请日：2015-10-29

Applicant: Noxell Corporation

Inventor： Heike Gertrud Abel ,  Armin Osan ,  Markus Speckbacher ,  Ingo Reinhold Weber ,  Garry Steven Garrett

IPC: C07C209/24 ,  C07C213/02 ,  C07C245/08 ,  C07C245/20 ,  C07C245/24

CPC classification number: C07C209/24 ,  C07C213/02 ,  C07C245/08 ,  C07C245/20 ,  C07C245/24 ,  Y02P20/582 ,  C07C217/76

Abstract: A telescoping process for the preparation of 2-methoxymethyl-p-phenylenediamine, a cosmetically acceptable salt thereof, or mixture thereof. The process according to the present invention is a particularly cost effective process in that it avoids sophisticated chemical steps which requires special equipment or expensive catalysts and in that it comprises a recycling step of one of the starting materials, namely 2-methoxymethylaniline.

公开(公告)号：US09078933B2

公开(公告)日：2015-07-14

申请号：US14154498

申请日：2014-01-14

Applicant: Suzhou Zelgen Biopharmaceutical Co., Ltd.

Inventor： Weidong Feng ,  Xiaoyong Gao ,  Xiaojun Dai

IPC: A61K51/04 ,  C07B59/00 ,  C07D213/81 ,  C07C209/24 ,  C07D209/48 ,  C07D213/68

CPC classification number: A61K51/0455 ,  C07B59/002 ,  C07C209/24 ,  C07D209/48 ,  C07D213/68 ,  C07D213/81

Abstract: Methods and processes for preparation and production of deuterated ω-diphenylurea are disclosed. Especially, a kind of deuterated ω-diphenylurea compounds which can inhibit phosphokinase and the preparation method of N-(4-chloro-3-(trifluoromethyl)phenyl)-N′-(4-(2-(N-d3-methylcarbamoyl)-4-pridinyloxy)phenyl)urea are disclosed. The said deuterated diphenylurea compounds can be used for treating or preventing tumors and relative diseases.

Abstract translation: 公开了制备和生产氘代ω-二苯脲的方法和方法。 特别是可抑制磷酸激酶的一种氘代ω-二苯基脲化合物及N-（4-氯-3-（三氟甲基）苯基）-N' - （4-（2-（N-d 3 - 甲基氨基甲酰基） -4-吡啶基氧基）苯基）脲。 所述氘化二苯脲化合物可用于治疗或预防肿瘤和相关疾病。

公开(公告)号：US20140128612A1

公开(公告)日：2014-05-08

申请号：US14154498

申请日：2014-01-14

Applicant: Suzhou Zelgen Biopharmaceutical Co., Ltd.

Inventor： Weidong FENG ,  Xiaoyong GAO ,  Xiaojun DAI

IPC: A61K51/04 ,  C07B59/00 ,  C07D213/81

CPC classification number: A61K51/0455 ,  C07B59/002 ,  C07C209/24 ,  C07D209/48 ,  C07D213/68 ,  C07D213/81

Abstract: Methods and processes for preparation and production of deuterated ω-diphenylurea are disclosed. Especially, a kind of deuterated ω-diphenylurea compounds which can inhibit phosphokinase and the preparation method of N-(4-chloro-3-(trifluoromethyl)phenyl)-N′-(4-(2-(N-d3-methylcarbamoyl)-4-pridinyloxy)phenyl)urea are disclosed. The said deuterated diphenylurea compounds can be used for treating or preventing tumors and relative diseases.

Abstract translation: 公开了制备和生产氘代ω-二苯脲的方法和方法。 特别是可抑制磷酸激酶的一种氘代ω-二苯基脲化合物及N-（4-氯-3-（三氟甲基）苯基）-N' - （4-（2-（N-d 3 - 甲基氨基甲酰基） -4-吡啶基氧基）苯基）脲。 所述氘化二苯脲化合物可用于治疗或预防肿瘤和相关疾病。

公开(公告)号：US08664442B2

公开(公告)日：2014-03-04

申请号：US12283170

申请日：2008-09-09

Applicant: Theodore E. Nalesnik

Inventor： Theodore E. Nalesnik

IPC: C07C211/00 ,  C10M141/06 ,  C10M171/00 ,  C01G39/06 ,  C07C211/58 ,  C07F7/22 ,  C10M135/36 ,  C10M137/10 ,  C10M105/34 ,  C10M173/02 ,  C10M141/10

CPC classification number: C07C209/24 ,  C07C211/50 ,  C08K5/17 ,  C09K15/18 ,  C10L1/223 ,  C10L10/00 ,  C10M133/12 ,  C10M141/06 ,  C10M141/08 ,  C10M141/10 ,  C10M2201/065 ,  C10M2201/066 ,  C10M2207/026 ,  C10M2207/281 ,  C10M2215/06 ,  C10M2215/064 ,  C10M2215/066 ,  C10M2215/08 ,  C10M2219/022 ,  C10M2219/066 ,  C10M2219/087 ,  C10M2219/108 ,  C10M2223/045 ,  C10M2223/047 ,  C10N2220/022 ,  C10N2230/10 ,  C10N2230/42 ,  C10N2240/04 ,  C10N2240/08 ,  C10N2240/10 ,  C10N2240/30 ,  C10N2270/02 ,  C08L21/00 ,  C10N2210/06 ,  C10N2210/02

Abstract: A dialkylanilino-cyclohexane compound useful as an antioxidant has the following formula I or formula II: wherein Ar1 and Ar2 can be the same or different and each is an alkylaromatic group; each of R1, R2, R3, and R4 is independently selected from hydrogen or CR7R8; each of R5, R6, and R7 is independently selected from hydrogen and a substituted or unsubstituted C1 to C32 hydrocarbyl group; and each R8 is independently selected from hydrogen and a C1 to C2 alkyl group, provided that when, each of R1 and R2 is CR7R8 and each such R8 is other than hydrogen, R1 and R2 may be joined to form a five or six-membered ring, and provided further that when, each of R3 and R4 is an adjacent CR7R8 and each such R8 is other than hydrogen, R3 and R4 may be joined to form a five or six-membered ring.

Abstract translation: 可用作抗氧化剂的二烷基苯胺基 - 环己烷化合物具有下式I或式II：其中Ar 1和Ar 2可以相同或不同，并且各自为烷基芳族基团; R 1，R 2，R 3和R 4各自独立地选自氢或CR 7 R 8; R5，R6和R7各自独立地选自氢和取代或未取代的C1至C32烃基; 并且每个R 8独立地选自氢和C 1至C 2烷基，条件是当R 1和R 2各自为CR 7 R 8且每个R 8不为氢时，R 1和R 2可以连接形成五或六元 并且进一步提供当R 3和R 4各自为相邻的CR 7 R 8且每个这样的R 8不是氢时，R 3和R 4可以连接形成五元或六元环。

公开(公告)号：US20130060043A1

公开(公告)日：2013-03-07

申请号：US13635808

申请日：2011-03-17

Applicant: Weidong Feng ,  Xiaoyong Gao ,  Xiaojun Dai

Inventor： Weidong Feng ,  Xiaoyong Gao ,  Xiaojun Dai

IPC: C07C273/18 ,  C07C275/34 ,  C07D213/81

CPC classification number: A61K51/0455 ,  C07B59/002 ,  C07C209/24 ,  C07D209/48 ,  C07D213/68 ,  C07D213/81

Abstract: A fluoro-substituted deuterated diphenylurea compound, especially 4-(4-(3-(4-chloro-3-(trifluoromethyl)phenyl)ureido)-3-fluorophenoxy)-2-(N-(methyl-d3))picolinamide, preparing method and use for treating or preventing tumor and relative diseases thereof.

Abstract translation: 氟取代的氘化二苯脲化合物，特别是4-（4-（3-（4-氯-3-（三氟甲基）苯基）脲基）-3-氟苯氧基）-2-（N-（甲基-d 3））吡啶甲酰胺， 制备方法和用于治疗或预防肿瘤及其相关疾病的用途。

公开(公告)号：US20070232832A1

公开(公告)日：2007-10-04

申请号：US11759897

申请日：2007-06-07

Applicant: Xiaogen Feng ,  Nongyue Wang ,  Xiaohui Mao ,  Ruibiao Yu ,  Qianwen Cheng

Inventor： Xiaogen Feng ,  Nongyue Wang ,  Xiaohui Mao ,  Ruibiao Yu ,  Qianwen Cheng

IPC: C07C209/36

CPC classification number: C07C209/24 ,  B01D1/065 ,  C07C209/02 ,  C07C209/36 ,  C07C209/38 ,  C07C209/86 ,  Y02P20/584 ,  C07C211/56 ,  C07C211/54

Abstract: A complex base catalyst comprising tetraalkyl ammonium hydroxide and tetraalkyl ammonium salt for the condensation reaction of aniline and nitrobenzene.

Abstract translation: 一种复合碱催化剂，包括四烷基氢氧化铵和四烷基铵盐，用于苯胺和硝基苯的缩合反应。

公开(公告)号：US20060247473A1

公开(公告)日：2006-11-02

申请号：US11477954

申请日：2006-06-30

Applicant: Xiaogen Feng ,  Nongyue Wang ,  Xiaohui Mao ,  Ruibiao Yu ,  Qianwen Cheng

Inventor： Xiaogen Feng ,  Nongyue Wang ,  Xiaohui Mao ,  Ruibiao Yu ,  Qianwen Cheng

IPC: C07C209/04

CPC classification number: C07C209/24 ,  B01D1/065 ,  C07C209/02 ,  C07C209/36 ,  C07C209/38 ,  C07C209/86 ,  Y02P20/584 ,  C07C211/56 ,  C07C211/54

Abstract: A process for preparing 4-aminodiphenylamine having the steps of reacting nitrobenzene and aniline in the presence of a complex base catalyst, hydrogenating the reaction mixture with hydrogen, a powdery composite catalyst, and a hydrogenation solvent; separating, recovering, and reusing the complex base catalyst and the powdery composite catalyst from the reaction mixture; separating, recovering, and reusing aniline, and optionally water, from the the reaction mixture; refining the reaction mixture to obtain 4-aminodiphenylamine. The complex base catalyst comprises tetraalkyl ammonium hydroxide, and tetraalkyl ammonium salt.

Abstract translation: 一种制备4-氨基二苯胺的方法，其步骤是在复合碱催化剂存在下使硝基苯和苯胺反应，用氢氢化反应混合物，粉末复合催化剂和氢化溶剂; 从反应混合物中分离，回收和再利用复合碱催化剂和粉末复合催化剂; 从反应混合物中分离，回收和再利用苯胺和任选的水; 精制反应混合物得到4-氨基二苯胺。 复合碱催化剂包括四烷基氢氧化铵和四烷基铵盐。

公开(公告)号：US4384142A

公开(公告)日：1983-05-17

申请号：US271869

申请日：1981-06-09

Applicant: Helmut L. Merten ,  Gene R. Wilder

Inventor： Helmut L. Merten ,  Gene R. Wilder

IPC: C07B61/00 ,  B01J20060101 ,  B01J23/00 ,  B01J23/46 ,  C07C20060101 ,  C07C67/00 ,  C07C209/00 ,  C07C209/24 ,  C07C209/72 ,  C07C211/26 ,  C07C211/35 ,  C07C85/24

CPC classification number: C07C209/72 ,  B01J21/18 ,  B01J23/462 ,  B01J38/04 ,  C07C209/00 ,  C07C209/24 ,  C07C211/26 ,  C07C211/35 ,  C07C2101/08 ,  C07C2101/14 ,  Y02P20/584

Abstract: Cyclohexylamine is produced by the catalytic hydrogenation of aniline. In contact with a ruthenium catalyst and in the presence of from about one to about 8 parts by weight of ammonia, aniline is hydrogenated under an absolute pressure of from about 2 to about 5 MPa at a temperature of from about 160.degree. to about 180.degree. C. High yields and a minimum of byproducts result. The catalyst can be recycled.

Abstract translation: 环己胺通过苯胺的催化氢化生产。 在与钌催化剂接触并且在约1至约8重量份氨存在下，苯胺在约2至约5MPa的绝对压力下在约160至约180℃的温度下氢化 C.产量高，副产物最少。 催化剂可以回收利用。

公开(公告)号：US20240286993A1

公开(公告)日：2024-08-29

申请号：US18113047

申请日：2023-02-22

Applicant: PHARMAPOTHECA A, INC.

Inventor： Harold MECKLER ,  Darryl CLEARY ,  Karl POPP ,  Heidi SCHLAGER ,  Mozhgan NAVIDI ,  Joshua MALONE

IPC: C07C231/14 ,  C07C209/24

CPC classification number: C07C231/14 ,  C07C209/24 ,  C07B2200/07

Abstract: The invention provides a non-distillative process for manufacturing amphetamine and substituted amphetamines, comprising obtaining a highly pure phosphoramidate compound, converting the highly pure phosphoramidate compound to an amphetamine sulfate compound, concentrating the amphetamine sulfate compound in isopropanol, and then salting out the amphetamine compound directly to obtain an amphetamine salt, the amphetamine salt selected from amphetamine saccharate, amphetamine sulfate, amphetamine aspartate, alkyl-amphetamine saccharate, alkyl-amphetamine sulfate, alkyl-amphetamine aspartate, aryl-amphetamine saccharate, aryl-amphetamine sulfate, aryl-amphetamine aspartate, and mixtures thereof.

公开(公告)号：US20170313657A1

公开(公告)日：2017-11-02

申请号：US15520256

申请日：2015-10-22

Applicant: LABORATORIO CHIMICO INTERNAZIONALE S.P.A.

Inventor： Giorgio BERTOLINI ,  Corrado COLLI ,  Aldo BIANCHI ,  Federica COLOMBO ,  Stefano MAIORANA ,  Filippo NISIC

IPC: C07D211/62 ,  C07D211/06 ,  C07C209/24 ,  C07F13/00 ,  C07C22/00

CPC classification number: C07D211/62 ,  C07C22/00 ,  C07C209/24 ,  C07D211/06 ,  C07D211/52 ,  C07F13/00

Abstract: The present invention refers to a process for the preparation of 1-(2-halogen-ethyl)-4-piperidinecarboxylic acid ethyl esters, in particular of 1-(2-chloroethyl)-4 piperidinecarboxylic acid ethyl ester, a versatile synthesis intermediate, particularly useful as an intermediate compound in the synthesis of umeclidinium.