Silicone hydrogel lens with a crosslinked hydrophilic coating
    7.
    发明授权
    Silicone hydrogel lens with a crosslinked hydrophilic coating 有权
    硅胶水凝胶透镜与交联的亲水涂层

    公开(公告)号:US09505184B2

    公开(公告)日:2016-11-29

    申请号:US13675805

    申请日:2012-11-13

    申请人: Novartis AG

    摘要: The invention is related to a cost-effective method for making a silicone hydrogel contact lens having a crosslinked hydrophilic coating thereon. A method of the invention involves autoclaving, in a sealed lens package, a silicone hydrogel contact lens having a base coating of polyacrylic acid thereon in an aqueous solution in the presence of a water-soluble, crosslinkable hydrophilic polymeric material having epoxide groups, for a period of time sufficient to covalently attach the crosslinkable hydrophilic polymeric material onto the surface of the silicone hydrogel contact lens through covalent linkages each formed between one epoxide group and one of the carboxyl groups on and/or near the surface of the silicone hydrogel contact lens.

    摘要翻译: 本发明涉及制备其上具有交联亲水性涂层的硅氧水凝胶隐形眼镜的成本有效的方法。 本发明的方法包括在密封的镜片包装中,在具有环氧基团的水溶性,可交联的亲水性聚合物材料存在下,在水溶液中具有聚丙烯酸基底涂层的硅酮水凝胶隐形眼镜进行高压灭菌,用于 足以将可交联亲水性聚合物材料共价连接到硅酮水凝胶隐形眼镜的表面上,通过在硅氧烷水凝胶隐形眼镜的表面上和/或附近的一个环氧基和一个羧基之间形成的共价键。