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    Purification Platform for Bispecific Antibodies
    2.
    发明申请
    Purification Platform for Bispecific Antibodies 审中-公开
    双特异性抗体纯化平台

    公开(公告)号：US20160024147A1

    公开(公告)日：2016-01-28

    申请号：US14808171

    申请日：2015-07-24

    Applicant: REGENERON PHARMACEUTICALS, INC.

    Inventor： Andrew TUSTIAN ,  Christine ENDICOTT ,  Benjamin ADAMS ,  John MATTILA ,  Hanne BAK

    IPC: C07K1/22 ,  B01D15/38 ,  B01J39/08 ,  B01J39/26 ,  C07K16/12 ,  C07K1/16

    CPC classification number: C07K1/22 ,  B01D15/3819 ,  B01D15/3828 ,  B01J39/08 ,  B01J39/26 ,  C07K16/065 ,  C07K2317/14 ,  C07K2317/31 ,  C07K2317/526

    Abstract: High resolution protein A chromatography employing a chaotropic agent and pH gradient or pH step elution buffer results in improved peak resolution between closely related molecular species. Bispecific antibodies containing a protein A-binding-ablating substitution CH3 domain paired with a protein A-binding CH3 domain are separated with high peak resolution from monospecific antibodies containing a protein A-binding-ablating substituted CH3 domain paired with the protein A-binding-ablating substituted CH3 domain and monospecific antibodies containing a protein A-binding CH3 domain paired with the protein A-binding CH3 domain. Useful chaotropic agents include magnesium chloride and calcium chloride.

    Abstract translation: 使用离液剂和pH梯度或pH步骤洗脱缓冲液的高分辨率蛋白质A层析结果提高了密切相关的分子物质之间的峰分辨率。 将含有与蛋白质A结合的CH3结构域配对的蛋白质A结合消融的取代的CH3结构域的双特异性抗体与来自含有蛋白质A结合消融的取代的CH3结构域的单特异性抗体以高蛋白A-结合 - 消融取代的CH3结构域和含有与蛋白A结合CH3结构域配对的蛋白A结合CH3结构域的单特异性抗体。 有用的离液剂包括氯化镁和氯化钙。

    Preparation Method for Titanium-Based Lithium Ion Exchanger
    6.
    发明公开
    Preparation Method for Titanium-Based Lithium Ion Exchanger 审中-公开

    公开(公告)号：US20240307862A1

    公开(公告)日：2024-09-19

    申请号：US18576146

    申请日：2022-11-02

    Applicant: CHENGDU CHEMPHYS CHEMICAL INDUSTRY CO., LTD. ,  SINOLITHIUM MATERIALS LIMITED

    Inventor： Qiang MENG ,  Yihua DAI ,  Lei ZHANG ,  Jinfeng YANG ,  Wenjun BAN ,  Rongfu CAI

    IPC: B01J39/08

    CPC classification number: B01J39/08

    Abstract: A preparation method for a titanium-based lithium ion exchanger includes the following steps: step 1, preparation of lithium metatitanate precursor, namely, uniformly mixing titanium source, lithium source and water in proportion by ball milling, adding an adjuvant, and allowing reaction by ultrasonic heating and stirring, so as to obtain the lithium metatitanate precursor powder; step 2, preparation of lithium metatitanate powder, including spray drying and microwave calcination with the lithium metatitanate precursor to obtain the lithium metatitanate powder; and step 3, elution and replacement, namely, leaching out Li with an eluent to obtain lithium ion exchanger. The preparation method is a solid-liquid phase contact reaction so that the ratio of raw materials can be accurately controlled. The synthesis reaction is strengthened by ultrasound. Titanium is controlled at a relatively excessive proportion to prepare the lithium metatitanate powder with high porosity and good filterability.

    WATER SOFTENING DEVICE
    10.
    发明申请
    WATER SOFTENING DEVICE 审中-公开
    水冷装置

    公开(公告)号：US20140138321A1

    公开(公告)日：2014-05-22

    申请号：US14083611

    申请日：2013-11-19

    Applicant: Kenneth A. Koch

    Inventor： Kenneth A. Koch

    IPC: C02F1/42

    CPC classification number: C02F1/42 ,  B01J39/02 ,  B01J39/08 ,  B01J49/06 ,  B01J49/53 ,  C02F1/001 ,  C02F1/281 ,  C02F2001/425 ,  C02F2201/005 ,  C02F2201/006 ,  C02F2201/009 ,  C02F2301/043 ,  C02F2303/16 ,  C02F2305/14 ,  C02F2307/06 ,  Y02A20/212

    Abstract: A system comprises an input, a brine chamber, a water softening chamber, and an output. One or more valves are configured to selectively prevent fluid communication of water from the input into the brine chamber; and to selectively permit communication of brine from the brine chamber to the water softening chamber when water is not being communicated through the input. The output is configured to output water softened in the water softening chamber. The one or more valves may include a first valve and a second valve. The first valve may be responsive to water being communicated through the input. The second valve may be responsive to either manual actuation or a fluid level in the brine chamber. The system may further include a cartridge that is removably coupled with the water softening chamber. The cartridge may contain salt and may further define the brine chamber.

    Abstract translation: 系统包括输入，盐水室，水软化室和输出。 一个或多个阀构造成选择性地防止水从输入端进入盐水室的流体连通; 并且当水没有通过输入通过时，选择性地允许盐水从盐水室通向水软化室。 输出被配置为输出在软化水中软化的水。 一个或多个阀可以包括第一阀和第二阀。 第一阀可以响应于通过输入端传递的水。 第二阀可以响应手动致动或盐水室中的液位。 该系统还可以包括可拆卸地与水软化室耦合的盒。 墨盒可能含有盐，并可进一步限定盐水室。

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