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    Bio-implantable devices having super-hydrophobic surface and method for manufacturing thereof
    1.
    发明授权
    Bio-implantable devices having super-hydrophobic surface and method for manufacturing thereof 有权
    具有超疏水表面的生物植入装置及其制造方法

    公开(公告)号：US09358093B2

    公开(公告)日：2016-06-07

    申请号：US13713414

    申请日：2012-12-13

    申请人： Korea Institute of Science and Technology

    发明人： Soo Hyun Kim ,  Jin Ik Lim ,  Youngmee Jung

    IPC分类号： A61F2/01 ,  A61L33/02

    CPC分类号： A61F2/01 ,  A61L33/022 ,  A61L2400/12

    摘要： The present disclosure relates to a bioimplantable device having a superhydrophobic surface and a method for manufacturing the same. The bioimplantable device, which includes a biocompatible substrate and a superhydrophobic nanostructure formed on the surface of the biocompatible substrate, is capable of preventing blood clot formation by blocking contact with proteins, water, blood platelets, etc. when used for blood vessels.

    摘要翻译： 本公开涉及具有超疏水表面的生物可​​植入装置及其制造方法。 生物可植入装置，其包括生物相容性底物和形成在生物相容性底物表面上的超疏水性纳米结构，能够通过与用于血管的蛋白质，水，血小板等阻断接触来防止血块形成。

    Coated implantable medical device
    10.
    发明授权
    Coated implantable medical device 失效
    涂层可植入医疗器械

    公开(公告)号：US5609629A

    公开(公告)日：1997-03-11

    申请号：US484532

    申请日：1995-06-07

    申请人： Neal E. Fearnot ,  Thomas G. Kozma ,  Anthony O. Ragheb ,  William D. Voorhees

    发明人： Neal E. Fearnot ,  Thomas G. Kozma ,  Anthony O. Ragheb ,  William D. Voorhees

    IPC分类号： A61B17/00 ,  A61F2/00 ,  A61K9/00 ,  A61K51/12 ,  A61L27/30 ,  A61L27/54 ,  A61L29/08 ,  A61L29/10 ,  A61L29/16 ,  A61L31/00 ,  A61L31/08 ,  A61L31/10 ,  A61L31/16 ,  A61L33/02 ,  A61M37/00 ,  A61N5/10 ,  A61F2/06

    CPC分类号： A61L31/088 ,  A61K51/1282 ,  A61L27/306 ,  A61L27/54 ,  A61L29/085 ,  A61L29/106 ,  A61L29/16 ,  A61L31/10 ,  A61L31/16 ,  A61L33/022 ,  A61F2250/0068 ,  A61L2300/42 ,  A61L2300/602 ,  A61L2300/608 ,  A61N5/1002

    摘要： A coated implantable medical device 10 includes a structure 12 adapted for introduction into the vascular system, esophagus, trachea, colon, biliary tract, or urinary tract; at least one layer 18 of a bioactive material positioned over the structure 12; and at least one porous layer 20 positioned over the bioactive material layer 18. Preferably, the structure 12 is a coronary stent, and the bioactive material is at least one of heparin, dexamethasone or a dexamethasone derivative. The device 10 includes layers 18 and 22 of heparin and dexamethasone, the layer 22 of dexamethasone being positioned above the layer 18 of heparin. The layers of bioactive material also can be individual materials or a combination of different materials. Unexpectedly, the more soluble heparin markedly promotes the release of the less soluble dexamethasone above it. The porous layer 20 is composed of a polymer applied by vapor or plasma deposition and provides a controlled release of the bioactive material. It is particularly preferred that the polymer is a polyimide, parylene or a parylene derivative, which is deposited without solvents, heat or catalysts, merely by condensation of a monomer vapor.

    摘要翻译： 涂覆的可植入医疗装置10包括适于引入到血管系统，食道，气管，结肠，胆道或尿道中的结构12; 位于结构12上方的生物活性材料的至少一层18; 以及位于生物活性材料层18上方的至少一个多孔层20.优选地，结构12是冠状动脉支架，生物活性材料是肝素，地塞米松或地塞米松衍生物中的至少一种。 装置10包括肝素和地塞米松的层18和22，地塞米松的层22位于肝素层18之上。 生物活性材料的层也可以是单独的材料或不同材料的组合。 意外的是，较易溶解的肝素显着促进了较低溶解度的地塞米松释放。 多孔层20由通过蒸汽或等离子体沉积施加的聚合物组成，并提供生物活性材料的受控释放。 特别优选的是，聚合物是聚酰亚胺，聚对二甲苯或聚对二甲苯衍生物，它们仅通过单体蒸气的冷凝而无溶剂，热或催化剂沉积。