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    Ophthalmic drug delivery system
    5.
    发明申请
    Ophthalmic drug delivery system 有权
    眼科药物输送系统

    公开(公告)号：US20040241207A1

    公开(公告)日：2004-12-02

    申请号：US10802058

    申请日：2004-03-17

    Inventor： Anuj Chauhan ,  Derya Gulsen

    IPC: A61K009/00 ,  A61K009/24

    CPC classification number: A61K9/0048 ,  A61F2250/0067 ,  A61K9/1075 ,  A61K9/5115 ,  A61K9/5138 ,  A61K9/5192 ,  A61K31/41 ,  G02C7/04

    Abstract: A drug delivery system comprising a contact lens having dispersed therein as nanoparticles having a particle size less than about 200 nm, an ophthalmic drug nanoencapsulated in a material from which said ophthalmic drug is capable of diffusion into and migration through said contact lens and into the post-lens tear film when said contact lens is placed on the eye.

    Abstract translation: 一种药物递送系统，其包含其中分散有粒径小于约200nm的纳米颗粒的隐形眼镜，纳米胶囊化的药物，所述眼科药物纳入到所述眼药物能够扩散入所述隐形眼镜并通过所述隐形眼镜迁移到所述柱中的材料中 当所述隐形眼镜放置在眼睛上时，将其撕开。

    Dosage form for treatment of diabetes mellitus
    6.
    发明申请
    Dosage form for treatment of diabetes mellitus 审中-公开
    用于治疗糖尿病的剂型

    公开(公告)号：US20040202718A1

    公开(公告)日：2004-10-14

    申请号：US10491305

    申请日：2004-03-29

    Inventor： Ziauddin Z. Tyebji ,  Harivardhan L Reddy

    IPC: A61K009/24

    CPC classification number: A61K9/2886 ,  A61K9/2009 ,  A61K9/2027 ,  A61K9/205 ,  A61K9/2054 ,  A61K9/2059 ,  A61K9/2846 ,  A61K9/2866 ,  A61K31/155

    Abstract: A dosage form for the treatment of diabetes mellitus and conditions associated with it comprising a biguanide such as metformin or its pharmaceutically acceptable salt wherein the metformin is released in a controlled manner. A dosage form for the treatment of diabetes mellitus and conditions associated with it comprising an immediate release composition comprising a long-acting sulfonyl urea and a controlled release composition comprising a biguanide.

    Abstract translation: 用于治疗糖尿病的剂型和与其相关的病症包括双胍，例如二甲双胍或其药学上可接受的盐，其中二甲双胍以受控的方式释放。 用于治疗糖尿病的剂型及与其相关的病症包括立即释放组合物，其包含长效磺酰脲和包含双胍的控释组合物。

    Direct compression polymer tablet core
    8.
    发明申请
    Direct compression polymer tablet core 审中-公开
    直接压缩聚合物片芯

    公开(公告)号：US20040166156A1

    公开(公告)日：2004-08-26

    申请号：US10785322

    申请日：2004-02-24

    Applicant: Genzyme Corporation

    Inventor： Joseph Tyler ,  John S. Petersen

    IPC: A61K009/20 ,  A61K009/24

    CPC classification number: A61K31/785 ,  A61K9/2009 ,  A61K9/2013 ,  A61K9/2027 ,  A61K9/28 ,  A61K9/282 ,  A61K9/2866

    Abstract: The present invention provides a tablet core which comprises at least about 95% by weight of an aliphatic amine polymer. The invention also provides a method of producing a tablet core comprising at least about 95% by weight of an aliphatic amine polymer resin The method comprises the step of compressing the aliphatic amine polymer to form the tablet core. The tablet core can further include one or more excipients. In this embodiment, the method of producing the tablet core comprises the steps of: (1) hydrating the aliphatic amine polymer to the desired moisture level; (2) blending the aliphatic amine polymer with the excipients in amounts such that the polymer comprises at least about 95% by weight of the resulting blend; and (3) compressing the blend to form the tablet core. The present invention further relates to a coated tablet comprising an aliphatic amine polymer core wherein the coating is a water based coating.

    Abstract translation: 本发明提供一种片芯，其包含至少约95重量％的脂族胺聚合物。 本发明还提供一种生产包含至少约95重量％的脂族胺聚合物树脂的片芯的方法。该方法包括压缩脂族胺聚合物以形成片芯的步骤。 片芯可进一步包括一种或多种赋形剂。 在该实施方案中，制备片芯的方法包括以下步骤：（1）将脂族胺聚合物水合至期望的水分含量; （2）将脂族胺聚合物与赋形剂混合，使得聚合物包含至少约95重量％的所得共混物; 和（3）压缩混合物以形成片芯。 本发明还涉及一种包含脂族胺聚合物核心的包衣片剂，其中该涂料是水基涂料。

    Extended release pharmaceutical tablet of metformin
    9.
    发明申请
    Extended release pharmaceutical tablet of metformin 审中-公开
    延长释放二甲双胍药物片剂

    公开(公告)号：US20040161461A1

    公开(公告)日：2004-08-19

    申请号：US10771987

    申请日：2004-02-04

    Inventor： Pawan Seth ,  Benoit Schmitt

    IPC: A61K009/24

    CPC classification number: A61K9/284 ,  A61K9/145 ,  A61K9/2027 ,  A61K9/2866 ,  A61K31/155

    Abstract: The invention provides an extended release pharmaceutical tablet containing: (i) a core comprising by weight, based on the core weight, about 70% to about 99% metformin and pharmaceutically acceptable excipients; and (ii) a coating surrounding said core, wherein said coating is permeable to metformin. The extended release tablets of the invention exhibit a dissolution profile such that after about 2 hours, from about 7% to about 60% of the metformin is released; after about 4 hours, from about 15% to about 90% of the metformin is released; after about 8 hours, from about 50% to about 100% of the metformin is released; after about 12 hours, more than about 75% of the metformin is released.

    Abstract translation: 本发明提供了一种延长释放的药物片剂，其包含：（i）核心重量，基于核心重量的核心，约70％至约99％的二甲双胍和药学上可接受的赋形剂; 和（ii）围绕所述芯的涂层，其中所述涂层可渗透二甲双胍。 本发明的延长释放片剂显示溶出曲线，使得在约2小时后，释放约7％至约60％的二甲双胍; 约4小时后，约15％至约90％的二甲双胍释放; 约8小时后，约50％至约100％的二甲双胍释放; 约12小时后，超过约75％的二甲双胍释放。

    Use of a mixture of two or more enteric materials to regulate drug release via membrane or matrix for systemic therapeutics
    10.
    发明申请
    Use of a mixture of two or more enteric materials to regulate drug release via membrane or matrix for systemic therapeutics 有权
    使用两种或多种肠溶性物质的混合物来调节药物释放通过膜或基质进行全身治疗

    公开(公告)号：US20040142035A1

    公开(公告)日：2004-07-22

    申请号：US10751766

    申请日：2004-01-05

    Inventor： Rong-Kun Chang ,  Niraj Shah

    IPC: A61K009/24

    CPC classification number: A61K31/65 ,  A61K9/2027 ,  A61K9/2054 ,  A61K9/5026 ,  A61K9/5042 ,  A61K9/5078

    Abstract: Disclosed are pharmaceutical compositions, particularly oral dosage forms, which comprise two or more enteric coating materials, either as a coating or as part of a matrix dosage form, and methods of making and using the same. The compositions are characterized by having a sustained release profile at lower pH and an accelerated dissolution profile at higher pH.

    Abstract translation: 公开了药物组合物，特别是口服剂型，其包含两种或多种肠溶包衣材料，作为包衣或基质剂型的一部分，以及制备和使用它们的方法。 该组合物的特征在于在较低pH下具有持续释放曲线，并且在较高pH下具有加速的溶解曲线。

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