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公开(公告)号：US20090124034A1
公开(公告)日：2009-05-14
申请号：US12121008
申请日：2008-05-15
IPC分类号： H01L21/30
CPC分类号： A61L27/303 , A61L31/122 , H01J49/0418 , Y10S977/701 , Y10T428/12736 , Y10T428/12743
摘要： The present invention generally discloses the use of a nanostructured non-silicon thin film (such as an alumina or aluminum thin film) on a supporting substrate which is subsequently coated with an active layer of a material such as silicon or tungsten. The base, underlying non-silicon material generates enhanced surface area while the active layer assists in incorporating and transferring energy to one or more analytes adsorbed on the active layer when irradiated with a laser during laser desorption of the analyte(s). The present invention provides substrate surfaces that can be produced by relatively straightforward and inexpensive manufacturing processes and which can be used for a variety of applications such as mass spectrometry, hydrophobic or hydrophilic coatings, medical device applications, electronics, catalysis, protection, data storage, optics, and sensors.
摘要翻译： 本发明一般公开了在支撑衬底上使用纳米结构非硅薄膜（例如氧化铝或铝薄膜），随后用诸如硅或钨的材料的活性层涂覆。 底层的非硅材料产生增强的表面积，而活性层有助于在分析物的激光解吸附中用激光照射时，将能量并入和转移到吸附在活性层上的一种或多种分析物。 本发明提供了可以通过相对直接和廉价的制造方法制造的衬底表面，其可用于各种应用，例如质谱，疏水或亲水涂层，医疗器械应用，电子学，催化，保护，数据存储， 光学和传感器。
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2.发明申请MEDICAL DRAINAGE DEVICES WITH CARBON-BASED STRUCTURES FOR INHIBITING GROWTH OF FIBROBLASTS 审中-公开具有碳基结构的医用排水装置，用于抑制FIBROBLASTS的生长公开(公告)号：US20140248454A1
公开(公告)日：2014-09-04
申请号：US14275466
申请日：2014-05-12
发明人： Khalid Lafdi , Edward J. Timm
CPC分类号： A61L31/122 , A61F9/00781 , A61L29/02 , A61L29/123 , A61L29/126 , A61L31/125 , A61L31/14 , A61L2400/12 , A61M1/008 , A61M1/3653 , A61M1/3655 , A61M25/0009 , A61M25/001 , A61M25/0012 , A61M25/0026 , A61M25/0043 , A61M27/002 , A61M27/006 , A61M2025/0037 , A61M2025/006 , A61M2210/101 , B82Y5/00 , Y10T428/1369 , Y10T428/23993
摘要： Drainage devices for draining a fluid from a patient during treatment of a medical condition body are disclosed. The drainage devices comprise a body defining at least one conduit through the body from a distal end of the body to a proximal end of the body. The body comprises at least one carbon-based structure configured to inhibit growth of fibroblasts in the conduit when the fluid flows through the conduit. Example embodiments of the drainage device may include an ophthalmic shunt, a hydrocephalus shunt, an artificial mesh, an arteriovenous shunt, a thoracic catheter, and a central venous access device.
摘要翻译： 公开了用于在治疗医疗状况体内从患者排出流体的排水装置。 引流装置包括：主体，其限定穿过主体的至少一个导管，其从主体的远端到主体的近端。 身体包括至少一个碳基结构，其被配置为当流体流过导管时抑制导管中成纤维细胞的生长。 排水装置的示例性实施例可以包括眼科分流术，脑积水分流术，人造网，动静脉分流术，胸导管和中心静脉通路装置。
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3.发明申请METAL ALLOY MONO AND POLY-FILAMENT WIRE REINFORCED CARBON FIBER PLATING SYSTEM WITH ELECTROMAGNETIC BONE STIMULATION 审中-公开金属合金单层和多层玻璃纤维增强碳纤维布线系统与电磁波刺激公开(公告)号：US20170000536A1
公开(公告)日：2017-01-05
申请号：US15198725
申请日：2016-06-30
发明人： JORDAN TACKTILL
CPC分类号： A61N1/36 , A61B17/72 , A61B17/80 , A61B2017/00221 , A61B2017/00734 , A61F2002/2821 , A61L31/122 , A61L2430/02 , A61N1/326 , H01M10/0525 , H01M2220/30
摘要： The invention entails metal alloy mono and poly-filament wire reinforced carbon fiber plating system for the fixation of skeletal fractures and osteotomies with electrical bone stimulation. For example, in some embodiments, systems and methods comprise a bone stimulation device by generating an electrical current from an implanted power pack, which travels through wire wrapped in the transverse/perpendicular plane around the mono-poly filament wires within the carbon fiber plate, creating an electromagnetic field. Such systems and methods find use in delayed or non-union events of bone and also in patients with acute bone fractures whom also suffer from other comorbidities predisposing the osteotomy or fracture to a non-union event.
摘要翻译： 本发明涉及用于骨骼骨折和截骨术用电骨刺激固定的金属合金单丝和聚丝丝增强碳纤维电镀系统。 例如，在一些实施例中，系统和方法包括骨刺激装置，其通过从植入的动力装置产生电流，所述植入的动力装置穿过围绕碳纤维板内的单聚丝细丝的横向/垂直平面中缠绕的线， 创造一个电磁场。 这种系统和方法可用于骨骼的延迟或非联合事件，并且也用于急性骨折的患者，其也患有将截骨或骨折倾向于非联合事件的其他并发症。
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公开(公告)号：US09271853B2
公开(公告)日：2016-03-01
申请号：US14533979
申请日：2014-11-05
CPC分类号： A61F2/915 , A61F2/82 , A61F2/844 , A61F2/86 , A61F2002/91558 , A61F2002/91575 , A61F2002/91583 , A61F2210/0014 , A61F2250/0036 , A61L31/122 , A61L31/146 , A61L2400/12 , B29C59/007 , B82Y40/00
摘要： A vascular stent assembly includes at least a first and a second strut, each including a thickness and a depth. The assembly includes a pair of end radii, with each of the first and second struts extending from one of the pair of end radii. A thickness of at least one of the first and second struts includes a tapering profile extending from one of the end radii to another of the end radii, the tapering profile following a continuously increasing or decreasing function through at least half a length of the at least one strut.
摘要翻译： 血管支架组件包括至少第一和第二支柱，每个支柱包括厚度和深度。 组件包括一对端部半径，第一和第二支柱中的每一个从一对端部半径中的一个延伸。 所述第一和第二支柱中的至少一个的厚度包括从所述端部半径之一延伸到所述端部半径中的另一个的锥形轮廓，所述锥形轮廓沿连续增加或减小的功能通过所述至少一半的长度 一个支柱
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5.发明申请MEDICAL DRAINAGE DEVICES WITH CARBON-BASED STRUCTURES FOR INHIBITING GROWTH OF FIBROBLASTS 有权具有碳基结构的医用排水装置，用于抑制FIBROBLASTS的生长公开(公告)号：US20110144559A1
公开(公告)日：2011-06-16
申请号：US12816840
申请日：2010-06-16
申请人： Khalid Lafdi , Edward J. Timm
发明人： Khalid Lafdi , Edward J. Timm
CPC分类号： A61L31/122 , A61F9/00781 , A61L29/02 , A61L29/123 , A61L29/126 , A61L31/125 , A61L31/14 , A61L2400/12 , A61M1/008 , A61M1/3653 , A61M1/3655 , A61M25/0009 , A61M25/001 , A61M25/0012 , A61M25/0026 , A61M25/0043 , A61M27/002 , A61M27/006 , A61M2025/0037 , A61M2025/006 , A61M2210/101 , B82Y5/00 , Y10T428/1369 , Y10T428/23993
摘要： Drainage devices for draining a fluid from a patient during treatment of a medical condition body are disclosed. The drainage devices comprise a body defining at least one conduit through the body from a distal end of the body to a proximal end of the body. The body comprises at least one carbon-based structure configured to inhibit growth of fibroblasts in the conduit when the fluid flows through the conduit. Example embodiments of the drainage device may include an ophthalmic shunt, a hydrocephalus shunt, an artificial mesh, an arteriovenous shunt, a thoracic catheter, and a central venous access device.
摘要翻译： 公开了用于在治疗医疗状况体内从患者排出流体的排水装置。 引流装置包括：主体，其限定穿过主体的至少一个导管，其从主体的远端到主体的近端。 身体包括至少一个碳基结构，其被配置为当流体流过导管时抑制导管中成纤维细胞的生长。 排水装置的示例性实施例可以包括眼科分流术，脑积水分流术，人造网，动静脉分流术，胸导管和中心静脉通路装置。
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公开(公告)号：US07755038B2
公开(公告)日：2010-07-13
申请号：US12121008
申请日：2008-05-15
IPC分类号： H01J49/04
CPC分类号： A61L27/303 , A61L31/122 , H01J49/0418 , Y10S977/701 , Y10T428/12736 , Y10T428/12743
摘要： The present invention generally discloses the use of a nanostructured non-silicon thin film (such as an alumina or aluminum thin film) on a supporting substrate which is subsequently coated with an active layer of a material such as silicon or tungsten. The base, underlying non-silicon material generates enhanced surface area while the active layer assists in incorporating and transferring energy to one or more analytes adsorbed on the active layer when irradiated with a laser during laser desorption of the analyte(s). The present invention provides substrate surfaces that can be produced by relatively straightforward and inexpensive manufacturing processes and which can be used for a variety of applications such as mass spectrometry, hydrophobic or hydrophilic coatings, medical device applications, electronics, catalysis, protection, data storage, optics, and sensors.
摘要翻译： 本发明一般公开了在支撑衬底上使用纳米结构非硅薄膜（例如氧化铝或铝薄膜），随后用诸如硅或钨的材料的活性层涂覆。 底层的非硅材料产生增强的表面积，而活性层有助于在分析物的激光解吸附中用激光照射时，将能量并入和转移到吸附在活性层上的一种或多种分析物。 本发明提供了可以通过相对直接和廉价的制造方法制造的衬底表面，其可用于各种应用，例如质谱，疏水或亲水涂层，医疗器械应用，电子学，催化，保护，数据存储， 光学和传感器。
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公开(公告)号：US20170035943A1
公开(公告)日：2017-02-09
申请号：US15099193
申请日：2016-04-14
CPC分类号： A61L31/024 , A61L31/084 , A61L31/122 , A61L31/146 , A61L31/16 , A61L2300/62 , A61L2300/64 , A61L2420/04 , A61L2420/08
摘要： Two-dimensional materials can be formed into enclosures for various substances and a substrate layer can be provided on an outside and/or on an inside of the enclosure, wherein the enclosure is not cytotoxic. The enclosures can be exposed to an environment, such as a biological environment (in vivo or in vitro), where the fibrous layer can promote vascular ingrowth. One or more substances within the enclosure can be released into the environment, one or more selected substances from the environment can enter the enclosure, one or more selected substances from the environment can be prevented from entering the enclosure, one or more selected substances can be retained within the enclosure, or combinations thereof. The enclosure can, for example, allow a sense-response paradigm to be realized. The enclosure can, for example, provide immunoisolation for materials, such as living cells, retained therein.
摘要翻译： 二维材料可以形成为各种物质的外壳，并且可以在外壳的外部和/或内部提供基底层，其中外壳不是细胞毒性的。 外壳可以暴露于诸如生物环境（体内或体外）的环境中，其中纤维层可以促进血管向内生长。 外壳内的一种或多种物质可以释放到环境中，来自环境的一种或多种选择的物质可以进入外壳，可以防止来自环境的一种或多种选择的物质进入外壳，一种或多种选择的物质可以是 保持在外壳内，或其组合。 例如，外壳可以允许实现感应响应范例。 外壳可以例如为保留在其中的材料（例如活细胞）提供免疫隔离。
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公开(公告)号：US20150164664A1
公开(公告)日：2015-06-18
申请号：US14533979
申请日：2014-11-05
IPC分类号： A61F2/89
CPC分类号： A61F2/915 , A61F2/82 , A61F2/844 , A61F2/86 , A61F2002/91558 , A61F2002/91575 , A61F2002/91583 , A61F2210/0014 , A61F2250/0036 , A61L31/122 , A61L31/146 , A61L2400/12 , B29C59/007 , B82Y40/00
摘要： A vascular stent assembly includes at least a first and a second strut, each including a thickness and a depth. The assembly includes a pair of end radii, with each of the first and second struts extending from one of the pair of end radii. A thickness of at least one of the first and second struts includes a tapering profile extending from one of the end radii to another of the end radii, the tapering profile following a continuously increasing or decreasing function through at least half a length of the at least one strut.
摘要翻译： 血管支架组件包括至少第一和第二支柱，每个支柱包括厚度和深度。 组件包括一对端部半径，第一和第二支柱中的每一个从一对端部半径中的一个延伸。 所述第一和第二支柱中的至少一个的厚度包括从所述端部半径之一延伸到所述端部半径中的另一个的锥形轮廓，所述锥形轮廓沿连续增加或减小的功能通过所述至少一半的长度 一个支柱
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公开(公告)号：US20140276843A1
公开(公告)日：2014-09-18
申请号：US14193317
申请日：2014-02-28
发明人： Kenny KOAY , Rod McMILLAN , Rene HAAG
CPC分类号： A61B17/1615 , A61B17/16 , A61B17/1604 , A61B2017/00831 , A61B2017/1651 , A61B2090/062 , A61L31/122
摘要： A bone cutting device extends from a proximal end to a distal end and has a sharpened cutting surface adjacent the distal end, the cutting surface being dimensioned to permit cutting of bone, the bone cutting device being formed of an implant grade material and an outer surface of the bone cutting device is one of carburized and nitrided.
摘要翻译： 骨切割装置从近端延伸到远端并且具有邻近远端的锐化切割表面，切割表面的尺寸被设计成允许切割骨骼，骨切割装置由植入物级材料和外表面形成 的骨切割装置是渗碳和氮化之一。
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10.发明授权Medical drainage devices with carbon-based structures for inhibiting growth of fibroblasts 有权具有抑制成纤维细胞生长的碳基结构的医疗引流装置公开(公告)号：US08764696B2
公开(公告)日：2014-07-01
申请号：US12816840
申请日：2010-06-16
申请人： Khalid Lafdi , Edward J. Timm
发明人： Khalid Lafdi , Edward J. Timm
IPC分类号： A61M5/00
CPC分类号： A61L31/122 , A61F9/00781 , A61L29/02 , A61L29/123 , A61L29/126 , A61L31/125 , A61L31/14 , A61L2400/12 , A61M1/008 , A61M1/3653 , A61M1/3655 , A61M25/0009 , A61M25/001 , A61M25/0012 , A61M25/0026 , A61M25/0043 , A61M27/002 , A61M27/006 , A61M2025/0037 , A61M2025/006 , A61M2210/101 , B82Y5/00 , Y10T428/1369 , Y10T428/23993
摘要： Drainage devices for draining a fluid from a patient during treatment of a medical condition body are disclosed. The drainage devices comprise a body defining at least one conduit through the body from a distal end of the body to a proximal end of the body. The body comprises at least one carbon-based structure configured to inhibit growth of fibroblasts in the conduit when the fluid flows through the conduit. Example embodiments of the drainage device may include an ophthalmic shunt, a hydrocephalus shunt, an artificial mesh, an arteriovenous shunt, a thoracic catheter, and a central venous access device.
摘要翻译： 公开了用于在治疗医疗状况体内从患者排出流体的排水装置。 引流装置包括：主体，其限定穿过主体的至少一个导管，其从主体的远端到主体的近端。 身体包括至少一个碳基结构，其被配置为当流体流过导管时抑制导管中成纤维细胞的生长。 排水装置的示例性实施例可以包括眼科分流术，脑积水分流术，人造网，动静脉分流术，胸导管和中心静脉通路装置。
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