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    Packaging bag
    4.
    外观设计
    Packaging bag 有权

    公开(公告)号：USD1041321S1

    公开(公告)日：2024-09-10

    申请号：US35516618

    申请日：2022-03-15

    Applicant: OTSUKA PHARMACEUTICAL CO., LTD.

    Designer： Mutsumi Ajichi

    Abstract: The file of this patent contains at least one figure executed in color. Copies of this patent with color figures will be provided by the United States Patent and Trademark Office upon request and payment of the necessary fee.
    Fig. 1.1 is a front, top, and right side perspective view of a packaging bag showing my new design;
    Fig. 1.2 is a front view thereof;
    Fig. 1.3 is a rear view thereof; and
    Fig. 1.4 is a front, bottom, and left side perspective view thereof, and showing the packaging bag in an expanded configuration.
    The dash-dash broken lines and the part painted in dark gray form no part of the claimed design. The dot-dash broken lines show boundaries and form no part of the claimed design. The orange crescent-shaped area is translucent.

    Injectable preparation
    7.
    发明授权
    Injectable preparation 有权

    公开(公告)号：US12016927B2

    公开(公告)日：2024-06-25

    申请号：US18148860

    申请日：2022-12-30

    Applicant: OTSUKA PHARMACEUTICAL CO., LTD.

    Inventor： Daiki Kaneko ,  Takakuni Matsuda ,  Yusuke Hoshika

    IPC: A61K47/32 ,  A61K9/00 ,  A61K9/06 ,  A61K31/496 ,  A61K47/10 ,  A61K47/38

    CPC classification number: A61K47/32 ,  A61K9/0019 ,  A61K9/06 ,  A61K31/496 ,  A61K47/10 ,  A61K47/38 ,  A61K9/0024

    Abstract: An object of the present invention is to provide a storage-stable injectable preparation comprising a composition comprising a poorly soluble drug as an active ingredient and a dispersion medium. Another object of the present invention is to provide a compact, lightweight prefilled syringe by filling a syringe with the injectable preparation. The present invention provides an injectable preparation comprising a composition comprising a poorly soluble drug, a dispersion medium, and a specific suspending agent, the composition having a viscosity of 40 pascal-seconds or more in at least one point in the shear rate range of 0.01 to 0.02 s−1 end having a viscosity of 0.2 pascal-seconds or less in at least one point in the shear rate range of 900 to 1.000 s−1, as measured.

    METHOD FOR PRODUCING CENTANAFADINE
    10.
    发明公开
    METHOD FOR PRODUCING CENTANAFADINE 审中-公开

    公开(公告)号：US20240140910A1

    公开(公告)日：2024-05-02

    申请号：US17769250

    申请日：2020-10-15

    Applicant: OTSUKA PHARMACEUTICAL CO., LTD.

    Inventor： Rei Otsuka ,  Kimiyoshi Annaka ,  Hikaru Mitani

    IPC: C07D209/52

    CPC classification number: C07D209/52

    Abstract: The present invention addresses the problem of finding a method for reliably producing (1R,5S)-1-(naphthalen-2-yl)-3-azabicyclo[3.1.0]hexane hydrochloride, wherein crystalline polymorphs can be controlled with industrially easy operations. Provided is a method for producing a crystalline form of (1R,5S)-1-(naphthalen-2-yl)-3-azabicyclo[3.1.0]hexane hydrochloride, the method comprising: step (a) for heating and dissolving (1R,5S)-1-(naphthalen-2-yl)-3-azabicyclo[3.1.0]hexane hydrochloride in a solvent including an alcohol-based solvent; step (b) for cooling the dissolved product of step (a) to a temperature, at which crystals of (1R,5S)-1-(naphthalen-2-yl)-3-azabicyclo[3.1.0]hexane hydrochloride precipitate, to nucleate the crystals; step (c) for heating a mixture containing the crystals obtained by nucleation to a temperature at which only a specific crystalline form selectively remains; and step (d) for cooling the mixture heated in step (c) to obtain the crystalline form.

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