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1.发明授权公开(公告)号：US12195496B2
公开(公告)日：2025-01-14
申请号：US18309435
申请日：2023-04-28
Applicant: Otsuka Pharmaceutical Co., Ltd.
Inventor： Gemma Zuend , Ian Scott , Nipun Davar , Kimiyoshi Annaka , Masahiro Miyake , Motoshi Matsui
Abstract: The invention relates to methods of synthesizing 2′-deoxy-2′,2′-difluorotetrahydrouridine with increased purity and uniform particle size distribution. In particular, methods of the invention include crystallization and isolation procedures rendering synthetic reaction intermediates. The invention further includes compositions comprising the final compound in highly pure form, including lower number of impurities and lower levels of individual and total impurities.
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2.发明授权公开(公告)号：US12187757B2
公开(公告)日：2025-01-07
申请号：US17766074
申请日：2020-10-07
Applicant: OTSUKA PHARMACEUTICAL CO., LTD.
Inventor： Gemma Zuend , Ian Scott , Nipun Davar , Kimiyoshi Annaka , Masahiro Miyake , Motoshi Matsui
Abstract: The invention relates to methods of synthesizing 2′-deoxy-2′,2′-difluorotetrahydrouridine with increased purity and uniform particle size distribution. In particular, methods of the invention include crystallization and isolation procedures rendering synthetic reaction intermediates. The invention further includes compositions comprising the final compound in highly pure form, including lower number of impurities and lower levels of individual and total impurities.
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3.发明公开公开(公告)号：US20230303609A1
公开(公告)日：2023-09-28
申请号：US18309435
申请日：2023-04-28
Applicant: Otsuka Pharmaceutical Co., Ltd.
Inventor： Gemma Zuend , Ian Scott , Nipun Davar , Kimiyoshi Anaka , Masahiro Miyake , Motoshi Matsui
Abstract: The invention relates to methods of synthesizing 2′-deoxy-2′,2′-difluorotetrahydrouridine with increased purity and uniform particle size distribution. In particular, methods of the invention include crystallization and isolation procedures rendering synthetic reaction intermediates. The invention further includes compositions comprising the final compound in highly pure form, including lower number of impurities and lower levels of individual and total impurities.
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4.发明申请公开(公告)号：US20220411457A1
公开(公告)日：2022-12-29
申请号：US17766074
申请日：2020-10-07
Applicant: Otsuka Pharmaceutical Co., Ltd.
Inventor： Gemma Zuend , Ian Scott , Nipun Davar , Kimiyoshi Anaka , Masahiro Miyake , Motoshi Matsui
Abstract: The invention relates to methods of synthesizing 2′-deoxy-2′,2′-difluorotetrahydrouridine with increased purity and uniform particle size distribution. In particular, methods of the invention include crystallization and isolation procedures rendering synthetic reaction intermediates. The invention further includes compositions comprising the final compound in highly pure form, including lower number of impurities and lower levels of individual and total impurities.
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