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    Injectable preparation
    2.
    发明授权
    Injectable preparation 有权

    公开(公告)号：US11097007B2

    公开(公告)日：2021-08-24

    申请号：US17108939

    申请日：2020-12-01

    Applicant: OTSUKA PHARMACEUTICAL CO., LTD.

    Inventor： Daiki Kaneko ,  Takakuni Matsuda ,  Yusuke Hoshika

    IPC: A61K47/32 ,  A61K9/00 ,  A61K47/10 ,  A61K9/06 ,  A61K47/38 ,  A61K31/496

    Abstract: An object of the present invention is to provide a storage-stable injectable preparation comprising a composition comprising a poorly soluble drug as an active ingredient and a dispersion medium. Another object of the present invention is to provide a compact, lightweight prefilled syringe by filling a syringe with the injectable preparation. The present invention provides an injectable preparation comprising a composition comprising a poorly soluble drug, a dispersion medium, and a specific suspending agent, the composition having a viscosity of 40 pascal-seconds or more in at least one point in the shear rate range of 0.01 to 0.02 s−1 and having a viscosity of 0.2 pascal-seconds or less in at least one point in the shear rate range of 900 to 1,000 s−1, as measured.

    Injectable preparation
    4.
    发明授权
    Injectable preparation 有权

    公开(公告)号：US10517951B2

    公开(公告)日：2019-12-31

    申请号：US16156958

    申请日：2018-10-10

    Applicant: OTSUKA PHARMACEUTICAL CO., LTD.

    Inventor： Daiki Kaneko ,  Takakuni Matsuda ,  Yusuke Hoshika

    IPC: A61K47/32 ,  A61K31/496 ,  A61K47/38 ,  A61K9/00 ,  A61K47/10 ,  A61K9/06

    Abstract: An object of the present invention is to provide a storage-stable injectable preparation comprising a composition comprising a poorly soluble drug as an active ingredient and a dispersion medium. Another object of the present invention is to provide a compact, lightweight prefilled syringe by filling a syringe with the injectable preparation. The present invention provides an injectable preparation comprising a composition comprising a poorly soluble drug, a dispersion medium, and a specific suspending agent, the composition having a viscosity of 40 pascal-seconds or more in at least one point in the shear rate range of 0.01 to 0.02 s−1 and having a viscosity of 0.2 pascal-seconds or less in at least one point in the shear rate range of 900 to 1,000 s−1, as measured.

    Injectable Formulation
    6.
    发明申请
    Injectable Formulation 审中-公开
    注射剂

    公开(公告)号：US20150086632A1

    公开(公告)日：2015-03-26

    申请号：US14395681

    申请日：2013-04-23

    Applicant: OTSUKA PHARMACEUTICAL CO., LTD.

    Inventor： Tetsuya Sato ,  Takuya Minowa ,  Yusuke Hoshika ,  Hidekazu Toyofuku

    IPC: A61K31/496 ,  A61K9/10 ,  A61K47/24 ,  A61K47/02 ,  A61K47/26 ,  A61K47/20 ,  A61K9/00 ,  A61K47/34

    CPC classification number: A61K31/496 ,  A61K9/0019 ,  A61K9/10 ,  A61K47/02 ,  A61K47/10 ,  A61K47/183 ,  A61K47/20 ,  A61K47/24 ,  A61K47/26 ,  A61K47/34

    Abstract: An object of the present invention is to provide a sustained-release injectable preparation which is in a medication administration form that can provide the effect of 7-[4-(4-benzo[b]thiophen-4-yl-piperazin-1-yl)butoxy]-1H-quinolin-2-one for a prolonged period of time, the preparation releasing a therapeutically effective amount of 7-[4-(4-benzo[b]thiophen-4-yl-piperazin-1-yl)butoxy]-1H-quinolin-2-one for at least one week. The present invention provides an injectable preparation containing 7-[4-(4-benzo[b]thiophen-4-yl-piperazin-1-yl)butoxy]-3H-quinolin-2-one or a salt thereof as an active ingredient, which releases the active ingredient in such a manner that its blood concentration is maintained for at least one week.

    Abstract translation: 本发明的目的是提供一种药物给药形式的缓释可注射制剂，其可以提供7- [4-（4-苯并[b]噻吩-4-基 - 哌嗪-1-基] 吡啶-2-基）丁氧基] -1H-喹啉-2-酮，该制剂释放治疗有效量的7- [4-（4-苯并[b]噻吩-4-基 - 哌嗪-1-基 ）丁氧基] -1H-喹啉-2-酮至少一周。 本发明提供含有7- [4-（4-苯并[b]噻吩-4-基 - 哌嗪-1-基）丁氧基] -3H-喹啉-2-酮或其盐作为活性成分的可注射制剂 ，其以使其血液浓度保持至少一周的方式释放活性成分。

    Injectable preparation
    7.
    发明授权
    Injectable preparation 有权

    公开(公告)号：US12016927B2

    公开(公告)日：2024-06-25

    申请号：US18148860

    申请日：2022-12-30

    Applicant: OTSUKA PHARMACEUTICAL CO., LTD.

    Inventor： Daiki Kaneko ,  Takakuni Matsuda ,  Yusuke Hoshika

    IPC: A61K47/32 ,  A61K9/00 ,  A61K9/06 ,  A61K31/496 ,  A61K47/10 ,  A61K47/38

    CPC classification number: A61K47/32 ,  A61K9/0019 ,  A61K9/06 ,  A61K31/496 ,  A61K47/10 ,  A61K47/38 ,  A61K9/0024

    Abstract: An object of the present invention is to provide a storage-stable injectable preparation comprising a composition comprising a poorly soluble drug as an active ingredient and a dispersion medium. Another object of the present invention is to provide a compact, lightweight prefilled syringe by filling a syringe with the injectable preparation. The present invention provides an injectable preparation comprising a composition comprising a poorly soluble drug, a dispersion medium, and a specific suspending agent, the composition having a viscosity of 40 pascal-seconds or more in at least one point in the shear rate range of 0.01 to 0.02 s−1 end having a viscosity of 0.2 pascal-seconds or less in at least one point in the shear rate range of 900 to 1.000 s−1, as measured.

    Injectable preparation
    8.
    发明授权
    Injectable preparation 有权

    公开(公告)号：US11638757B2

    公开(公告)日：2023-05-02

    申请号：US17444469

    申请日：2021-08-04

    Applicant: OTSUKA PHARMACEUTICAL CO., LTD.

    Inventor： Daiki Kaneko ,  Takakuni Matsuda ,  Yusuke Hoshika

    IPC: A61K47/32 ,  A61K9/00 ,  A61K47/10 ,  A61K9/06 ,  A61K47/38 ,  A61K31/496

    Abstract: An object of the present invention is to provide a storage-stable injectable preparation comprising a composition comprising a poorly soluble drug as an active ingredient and a dispersion medium. Another object of the present invention is to provide a compact, lightweight prefilled syringe by filling a syringe with the injectable preparation. The present invention provides an injectable preparation comprising a composition comprising a poorly soluble drug, a dispersion medium, and a specific suspending agent, the composition having a viscosity of 40 pascal-seconds or more in at least one point in the shear rate range of 0.01 to 0.02 s−1 and having a viscosity of 0.2 pascal-seconds or less in at least one point in the shear rate range of 900 to 1,000 s−1, as measured.

    INJECTABLE PREPARATION
    9.
    发明申请
    INJECTABLE PREPARATION 审中-公开
    注意事项

    公开(公告)号：US20150093442A1

    公开(公告)日：2015-04-02

    申请号：US14396380

    申请日：2013-04-23

    Applicant: OTSUKA PHARMACEUTICAL CO., LTD.

    Inventor： Daiki Kaneko ,  Takakuni Matsuda ,  Yusuke Hoshika

    IPC: A61K47/32 ,  A61K47/10 ,  A61K9/06 ,  A61K31/496 ,  A61K9/00

    Abstract: An object of the present invention is to provide a storage-stable injectable preparation comprising a composition comprising a poorly soluble drug as an active ingredient and a dispersion medium. Another object of the present invention is to provide a compact, lightweight prefilled syringe by filling a syringe with the injectable preparation. The present invention provides an injectable preparation comprising a composition comprising a poorly soluble drug, a dispersion medium, and a specific suspending agent, the composition having a viscosity of 40 pascal-seconds or more in at least one point in the shear rate range of 0.01 to 0.02 s−1 and having a viscosity of 0.2 pascal-seconds or less in at least one point in the shear rate range of 900 to 1,000 s−1, as measured.

    Abstract translation: 本发明的目的是提供一种储存稳定的可注射制剂，其包含包含难溶性药物作为活性成分和分散介质的组合物。 本发明的另一个目的是通过用可注射制剂填充注射器来提供一种紧凑，重量轻的预填充注射器。 本发明提供一种包含难溶性药物，分散介质和特定悬浮剂的组合物的可注射制剂，该组合物在剪切速率范围为0.01以上的至少一点粘度为40帕斯卡秒以上 至0.02s -1，并且在900至1,000s -1的剪切速率范围内的至少一个点中具有0.2帕斯卡 - 秒以下的粘度。

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