公开(公告)号：US20200061056A1

公开(公告)日：2020-02-27

申请号：US16666546

申请日：2019-10-29

Applicant: OTSUKA PHARMACEUTICAL CO., LTD.

Inventor： Hiroshi YAMASHITA ,  Yohji SAKURAI ,  Motoyuki MIYAMOTO ,  Yuichi NAKAMURA ,  Hideaki KURODA ,  Takuya MINOWA

IPC: A61K31/496 ,  A61K31/695 ,  A61K31/675 ,  A61K31/541 ,  A61K31/5377 ,  A61K31/506 ,  A61K31/501 ,  C07D409/14 ,  C07D409/12

Abstract: Provided is a superior, novel heterocyclic compound with improved solubility in oil such as sesame oil and benzyl benzoate, which has a broader treatment spectrum, causes less side effects, and is superior in tolerability and safety, and use thereof. A heterocyclic compound represented by the formula (I) wherein each symbol is as defined in the specification, or a salt thereof.

公开(公告)号：US20210052575A1

公开(公告)日：2021-02-25

申请号：US16896329

申请日：2020-06-09

Applicant: OTSUKA PHARMACEUTICAL CO., LTD.

Inventor： Hiroshi YAMASHITA ,  Yohji SAKURAI ,  Motoyuki MIYAMOTO ,  Yuichi NAKAMURA ,  Hideaki KURODA ,  Takuya MINOWA

IPC: A61K31/496 ,  C07D409/12 ,  C07D409/14 ,  A61K31/501 ,  A61K31/506 ,  A61K31/5377 ,  A61K31/541 ,  A61K31/675 ,  A61K31/695

Abstract: Provided is a superior, novel hetrocyclic compound with improved solubility in oil such as sesame oil and benzyl benzoate, which has a broader treatment spectrum, causes side effects, and is superior in tolerability and safety, and use thereof. A heterocyclic compound represented by the formula (I) wherein each symbol is as defined in the specification, or a salt thereof.

公开(公告)号：US20200163960A1

公开(公告)日：2020-05-28

申请号：US16775222

申请日：2020-01-28

Applicant: OTSUKA PHARMACEUTICAL CO., LTD.

Inventor： Tetsuya SATO ,  Takuya MINOWA ,  Yusuke HOSHIKA ,  Hidekazu TOYOFUKU

IPC: A61K31/496 ,  A61K47/24 ,  A61K47/20 ,  A61K9/10 ,  A61K47/34 ,  A61K47/02 ,  A61K47/26 ,  A61K47/18 ,  A61K9/00 ,  A61K47/10

Abstract: An object of the present invention is to provide a sustained-release injectable preparation which is in a medication administration form that can provide the effect of 7-[4-(4-benzo[b]thiophen-4-yl-piperazin-1-yl)butoxy]-1H-quinolin-2-one for a prolonged period of time, the preparation releasing a therapeutically effective amount of 7-[4-(4-benzo[b]thiophen-4-yl-piperazin-1-yl)butoxy]-1H-quinolin-2-one for at least one week. The present invention provides an injectable preparation containing 7-[4-(4-benzo[b]thiophen-4-yl-piperazin-1-yl)butoxy]-1H-quinolin-2-one or a salt thereof as an active ingredient, which releases the active ingredient in such a manner that its blood concentration is maintained for at least one week.

公开(公告)号：US20180318294A1

公开(公告)日：2018-11-08

申请号：US16033749

申请日：2018-07-12

Applicant: Otsuka Pharmaceutical Co., Ltd.

Inventor： Hiroshi YAMASHITA ,  Yohji SAKURAI ,  Motoyuki MIYAMOTO ,  Yuichi NAKAMURA ,  Hideaki KURODA ,  Takuya MINOWA

IPC: A61K31/496 ,  A61K31/695 ,  A61K31/675 ,  A61K31/541 ,  A61K31/5377 ,  C07D409/12 ,  A61K31/501 ,  C07D409/14 ,  A61K31/506

CPC classification number: A61K31/496 ,  A61K31/501 ,  A61K31/506 ,  A61K31/5377 ,  A61K31/541 ,  A61K31/675 ,  A61K31/695 ,  C07D409/12 ,  C07D409/14

Abstract: Provided is a superior, novel heterocyclic compound with improved solubility in oil such as sesame oil and benzyl benzoate, which has a broader treatment spectrum, causes less side effects, and is superior in tolerability and safety, and use thereof. A heterocyclic compound represented by the formula (I) wherein each symbol is as defined in the specification, or a salt thereof.

公开(公告)号：US20170066752A1

公开(公告)日：2017-03-09

申请号：US15294644

申请日：2016-10-14

Applicant: OTSUKA PHARMACEUTICAL CO., LTD.

Inventor： Hiroshi YAMASHITA ,  Tetsuya SATO ,  Takuya MINOWA ,  Yusuke HOSHIKA ,  Hidekazu TOYOFUKU ,  Tetsuya YAMAGUCHI ,  Masahiro SOTA ,  Shuuji KAWANO ,  Takayuki NAKAMURA ,  Ryohei ETO ,  Takuma IKEBUCHI ,  Kei MORIYAMA ,  Nobuaki ITO

IPC: C07D409/12

CPC classification number: C07D409/12 ,  A61K9/0019

Abstract: An object of the present invention is to provide a compound that can be used as a more superior therapeutic agent for central nervous system diseases. The present invention provides a dihydrate of 7-[4-(4-benzo[b]thiophen-4-yl-piperazin-1-yl)butoxy]-1H-quinolin-2-one or of a salt thereof, and a process for producing the same.

Abstract translation: 本发明的目的是提供可用作中枢神经系统疾病的更优异的治疗剂的化合物。 本发明提供了7- [4-（4-苯并[b]噻吩-4-基 - 哌嗪-1-基）丁氧基] -1H-喹啉-2-酮或其盐的二水合物和方法 为了生产相同。

公开(公告)号：US20240277702A1

公开(公告)日：2024-08-22

申请号：US18541083

申请日：2023-12-15

Applicant: OTSUKA PHARMACEUTICAL CO., LTD.

Inventor： Tetsuya SATO ,  Takuya MINOWA ,  Yusuke HOSHIKA ,  Hidekazu TOYOFUKU

IPC: A61K31/496 ,  A61K9/00 ,  A61K9/10 ,  A61K47/02 ,  A61K47/10 ,  A61K47/20 ,  A61K47/24 ,  A61K47/26 ,  A61K47/34

CPC classification number: A61K31/496 ,  A61K9/0019 ,  A61K9/10 ,  A61K47/02 ,  A61K47/10 ,  A61K47/20 ,  A61K47/24 ,  A61K47/26 ,  A61K47/34

Abstract: An object of the present invention is to provide a sustained-release injectable preparation which is in a medication administration form that can provide the effect of 7-[4-(4-benzo[b]thiophen-4-yl-piperazin-1-yl)butoxy]-1H-quinolin-2-one for a prolonged period of time, the preparation releasing a therapeutically effective amount of 7-[4-(4-benzo[b]thiophen-4-yl-piperazin-1-yl)butoxy]-1H-quinolin-2-one for at least one week. The present invention provides an injectable preparation containing 7-[4-(4-benzo[b]thiophen-4-yl-piperazin-1-yl)butoxy]-1H-quinolin-2-one or a salt thereof as an active ingredient, which releases the active ingredient in such a manner that its blood concentration is maintained for at least one week.

公开(公告)号：US20190167672A1

公开(公告)日：2019-06-06

申请号：US16268827

申请日：2019-02-06

Applicant: OTSUKA PHARMACEUTICAL CO., LTD.

Inventor： Hiroshi YAMASHITA ,  Yohji SAKURAI ,  Motoyuki MIYAMOTO ,  Yuichi NAKAMURA ,  Hideaki KURODA ,  Takuya MINOWA

IPC: A61K31/496 ,  A61K31/695 ,  A61K31/675 ,  A61K31/541 ,  C07D409/12 ,  A61K31/506 ,  A61K31/501 ,  C07D409/14 ,  A61K31/5377

Abstract: Provided is a superior, novel heterocyclic compound with improved solubility in oil such as sesame oil and benzyl benzoate, which has a broader treatment spectrum, causes less side effects, and is superior in tolerability and safety, and use thereof. A heterocyclic compound represented by the formula (I) wherein each symbol is as defined in the specification, or a salt thereof.

公开(公告)号：US20180092907A1

公开(公告)日：2018-04-05

申请号：US15643969

申请日：2017-07-07

Applicant: Otsuka Pharmaceutical Co., Ltd.

Inventor： Hiroshi YAMASHITA ,  Yohji SAKURAI ,  Motoyuki MIYAMOTO ,  Yuichi NAKAMURA ,  Hideaki KURODA ,  Takuya MINOWA

IPC: A61K31/496 ,  A61K31/695 ,  A61K31/675 ,  A61K31/541 ,  A61K31/5377 ,  C07D409/12 ,  A61K31/501 ,  C07D409/14 ,  A61K31/506

CPC classification number: A61K31/496 ,  A61K31/501 ,  A61K31/506 ,  A61K31/5377 ,  A61K31/541 ,  A61K31/675 ,  A61K31/695 ,  C07D409/12 ,  C07D409/14

Abstract: Provided is a superior, novel heterocyclic compound with improved solubility in oil such as sesame oil and benzyl benzoate, which has a broader treatment spectrum, causes less side effects, and is superior in tolerability and Safety, and use thereof. A heterocyclic compound represented by the formula (I) wherein each symbol is as defined in the specification, or a salt thereof.

公开(公告)号：US20230099694A1

公开(公告)日：2023-03-30

申请号：US17577465

申请日：2022-01-18

Applicant: OTSUKA PHARMACEUTICAL CO., LTD.

Inventor： Hiroshi YAMASHITA ,  Yohji SAKURAI ,  Motoyuki MIYAMOTO ,  Yuichi NAKAMURA ,  Hideaki KURODA ,  Takuya MINOWA

IPC: A61K31/496 ,  C07D409/12 ,  C07D409/14 ,  A61K31/501 ,  A61K31/506 ,  A61K31/5377 ,  A61K31/541 ,  A61K31/675 ,  A61K31/695

Abstract: Provided is a superior, novel heterocyclic compound with improved solubility in oil such as sesame oil and benzyl benzoate, which has a broader treatment spectrum, causes less side effects, and is superior in tolerability and safety, and use thereof. A heterocyclic compound represented by the formula (I) wherein each symbol is as defined in the specification, or a salt thereof.

公开(公告)号：US20230049327A1

公开(公告)日：2023-02-16

申请号：US17651042

申请日：2022-02-14

Applicant: OTSUKA PHARMACEUTICAL CO., LTD.

Inventor： Hiroshi YAMASHITA ,  Tetsuya SATO ,  Takuya MINOWA ,  Yusuke HOSHIKA ,  Hidekazu TOYOFUKU ,  Tatsuya YAMAGUCHI ,  Masahiro SOTA ,  Shuuji KAWANO ,  Takayuki NAKAMURA ,  Ryohei ETO ,  Takuma IKEBUCHI ,  Kei MORIYAMA ,  Nobuaki ITO

IPC: C07D409/12 ,  A61K9/00

Abstract: An object of the present invention is to provide a compound that can be used as a more superior therapeutic agent for central nervous system diseases. The present invention provides a dihydrate of 7-[4-(4-benzo[b]thiophen-4-yl-piperazin-1-yl)butoxy]-1H-quinolin-2-one or of a salt thereof, and a process for producing the same