Immunosuppressive effects of administration of a cyclooxygenase-2 inhibitor and a 5-lipoxygenase inhibitor
    1.
    发明授权
    Immunosuppressive effects of administration of a cyclooxygenase-2 inhibitor and a 5-lipoxygenase inhibitor 失效
    施用环氧合酶-2抑制剂和5-脂肪氧合酶抑制剂的免疫抑制作用

    公开(公告)号:US07132441B2

    公开(公告)日:2006-11-07

    申请号:US10098644

    申请日:2002-03-15

    IPC分类号: A61K31/415 A61K31/34

    摘要: This invention is in the field of a combination comprising a therapeutically-effective amount of a cyclooxygenase-2 inhibitor, a 5-lipoxygenase inhibitor and an immunosuppressive drug selected from antiproliferative agents, antiinflammatory-acting compounds and inhibitors of leukocyte activation. This combination may be used, for example, to suppress the immune response associated with organ transplantation, graft versus host disease, and conditions with underlying autoimmune or inflammatory reactivities or responses.

    摘要翻译: 本发明涉及包含治疗有效量的环加氧酶-2抑制剂,5-脂氧合酶抑制剂和选自抗增生剂,抗炎作用化合物和白细胞活化抑制剂的免疫抑制药物的组合领域。 这种组合可以用于例如抑制与器官移植相关的免疫应答,移植物抗宿主病和具有潜在的自身免疫或炎性反应性或反应的病症。