公开(公告)号：US08242113B2

公开(公告)日：2012-08-14

申请号：US13120568

申请日：2009-09-22

申请人： Young Lag Cho ,  Sang Eun Chae ,  Sung Yoon Baek ,  Yeon Ok Kim ,  Seong Jin Kim ,  Hyang Sook Lee ,  Ju Hyun Park ,  Tae Kyo Park ,  Sung Ho Woo ,  Yong Zu Kim

发明人： Young Lag Cho ,  Sang Eun Chae ,  Sung Yoon Baek ,  Yeon Ok Kim ,  Seong Jin Kim ,  Hyang Sook Lee ,  Ju Hyun Park ,  Tae Kyo Park ,  Sung Ho Woo ,  Yong Zu Kim

IPC分类号： C07D403/08 ,  A61K31/5377

CPC分类号： C07D403/08

摘要： Disclosed is a novel oxazolidinone derivative, particularly a novel oxazolidinone compound with a cyclic amidoxime or cyclic amidrazone group. Also disclosed is a pharmaceutical antibiotic composition including a novel oxazolidinone derivative, in vivo hydrolysable ester thereof, in vivo hydrolysable phosphate ester thereof, an isomer thereof or a pharmaceutically acceptable salt thereof as an effective ingredient. Because the novel oxazolidinone derivative, in vivo hydrolysable ester thereof, in vivo hydrolysable phosphate ester thereof, an isomer thereof or a pharmaceutically acceptable salt thereof exhibits a wide antibacterial spectrum against resistant bacteria, a low toxicity, and a strong antibacterial activity against Gram-positive and Gram-negative bacteria, it can be usefully used as an antibiotic.

摘要翻译： 公开了一种新的恶唑烷酮衍生物，特别是具有环偕胺肟或环状氨基腙基团的新型恶唑烷酮化合物。 还公开了包含新的恶唑烷酮衍生物，其体内可水解的酯，其体内可水解的磷酸酯，其异构体或其药学上可接受的盐作为有效成分的药物抗生素组合物。 因为新的恶唑烷酮衍生物，其体内可水解的酯，其体内可水解的磷酸酯，其异构体或其药学上可接受的盐，表现出对抗细菌的抗菌谱广，毒性低，抗革兰氏阳性 和革兰阴性菌，可以有效地用作抗生素。

公开(公告)号：US20110178293A1

公开(公告)日：2011-07-21

申请号：US13120568

申请日：2009-09-22

申请人： Young Lag Cho ,  Sang Eun Chae ,  Sung Yoon Baek ,  Yeon Ok Kim ,  Seong Jin Kim ,  Hyang Sook Lee ,  Ju Hyun Park ,  Tae Kyo Park ,  Sung Ho Woo ,  Yong Zu Kim

发明人： Young Lag Cho ,  Sang Eun Chae ,  Sung Yoon Baek ,  Yeon Ok Kim ,  Seong Jin Kim ,  Hyang Sook Lee ,  Ju Hyun Park ,  Tae Kyo Park ,  Sung Ho Woo ,  Yong Zu Kim

IPC分类号： C07D413/10 ,  C07D403/10 ,  C07D403/14

CPC分类号： C07D403/08

摘要： Disclosed is a novel oxazolidinone derivative, particularly a novel oxazolidinone compound with a cyclic amidoxime or cyclic amidrazone group. Also disclosed is a pharmaceutical antibiotic composition including a novel oxazolidinone derivative, a prodrug thereof, a hydrate thereof, a solvate thereof, an isomer thereof or a pharmaceutically acceptable salt thereof as an effective ingredient. Because the novel oxazolidinone derivative, a prodrug thereof, a hydrate thereof, a solvate thereof, an isomer thereof or a pharmaceutically acceptable salt thereof exhibits a wide antibacterial spectrum against resistant bacteria, a low toxicity, and a strong antibacterial activity against Gram-positive and Gram-negative bacteria, it can be usefully used as an antibiotic.

摘要翻译： 公开了一种新的恶唑烷酮衍生物，特别是具有环偕胺肟或环状氨基腙基团的新型恶唑烷酮化合物。 还公开了包含新型恶唑烷酮衍生物，其前药，其水合物，其溶剂合物，其异构体或其药学上可接受的盐作为有效成分的药物抗生素组合物。 由于新的恶唑烷酮衍生物，其前体药物，其水合物，其溶剂化物，其异构体或其药学上可接受的盐对抗菌细菌具有广泛的抗菌谱，低毒性和抗革兰氏阳性和 革兰氏阴性菌，可有效地用作抗生素。

公开(公告)号：US20110112083A1

公开(公告)日：2011-05-12

申请号：US13002271

申请日：2009-06-05

申请人： Ho Young Song ,  Young Lag Cho ,  Dae Yon Lee ,  Hee Sock Park ,  Sung Yoon Baek ,  Sang Eun Chae ,  Sang Hui Jo ,  Yeon Ok Kim ,  Hyang Sook Lee ,  Ju Hyun Park ,  Tae Kyo Park ,  Sung Ho Woo ,  Yong Zu Kim

发明人： Ho Young Song ,  Young Lag Cho ,  Dae Yon Lee ,  Hee Sock Park ,  Sung Yoon Baek ,  Sang Eun Chae ,  Sang Hui Jo ,  Yeon Ok Kim ,  Hyang Sook Lee ,  Ju Hyun Park ,  Tae Kyo Park ,  Sung Ho Woo ,  Yong Zu Kim

IPC分类号： A61K31/5395 ,  C07D413/14 ,  C07D487/04 ,  A61K31/53 ,  A61P7/02 ,  A61P9/10 ,  A61P29/00 ,  A61P25/00 ,  A61P9/00 ,  A61P11/00

CPC分类号： C07D413/14 ,  C07D487/04

摘要： The present invention relates to novel oxazolidinone derivatives with cyclic amidoxime or cyclic amidrazone group, pharmaceutically acceptable salts thereof, methods for preparing the same and pharmaceutical compositions comprising the same. The oxazolidinone derivatives with cyclic amidoxime or cyclic amidrazone group or the pharmaceutically acceptable salts thereof can be effectively used for the treatment of thromboembolism and tumor as an anticoagulant based on the inhibition of factor Xa.

摘要翻译： 本发明涉及具有环状偕胺肟或环状氨基腙基的新的恶唑烷酮衍生物，其药学上可接受的盐，其制备方法和包含其的药物组合物。 具有环偕胺肟或环状氨基腙基的恶唑烷酮衍生物或其药学上可接受的盐可以有效地用于基于对因子Xa的抑制作为抗凝血剂治疗血栓栓塞和肿瘤。

公开(公告)号：US08288423B2

公开(公告)日：2012-10-16

申请号：US12598010

申请日：2008-05-09

申请人： Young Lag Cho ,  Ho Young Song ,  Dae Yon Lee ,  Sung Yoon Baek ,  Sang Eun Chae ,  Sang Hui Jo ,  Yeon Ok Kim ,  Hyang Sook Lee ,  Ju Hyun Park ,  Tae Kyo Park ,  Sung Ho Woo ,  Yong Zu Kim

发明人： Young Lag Cho ,  Ho Young Song ,  Dae Yon Lee ,  Sung Yoon Baek ,  Sang Eun Chae ,  Sang Hui Jo ,  Yeon Ok Kim ,  Hyang Sook Lee ,  Ju Hyun Park ,  Tae Kyo Park ,  Sung Ho Woo ,  Yong Zu Kim

IPC分类号： A01N43/64 ,  A01N43/76 ,  A01N43/50 ,  A01N43/02 ,  A01N43/06 ,  A61K31/41 ,  A61K31/42 ,  A61K31/415 ,  A61K31/38

CPC分类号： C07D413/14

摘要： The present invention relates to novel oxazolidinone derivatives with cyclic amidines, and prodrugs, hydrates, solvates, isomers and pharmaceutically acceptable salts thereof, and processes for preparing the same, and pharmaceutical compositions comprising the same. The oxazolidinone derivatives with cyclic amidines, and prodrugs, hydrates, solvates, isomers and pharmaceutically acceptable salts thereof can be usefully employed as an anticoagulant for treating thromboembolism and tumors via inhibition of coagulation factor Xa.

摘要翻译： 本发明涉及具有环脒的新的恶唑烷酮衍生物及其前体药物，水合物，溶剂合物，异构体和药学上可接受的盐及其制备方法，以及包含其的药物组合物。 具有环脒的恶唑烷酮衍生物及其前体药物，水合物，溶剂合物，异构体和药学上可接受的盐可有效地用作通过抑制凝血因子Xa治疗血栓栓塞和肿瘤的抗凝血剂。

公开(公告)号：US20100184781A1

公开(公告)日：2010-07-22

申请号：US12598010

申请日：2008-05-09

申请人： Young Lag Cho ,  Ho Young Song ,  Dae Yon Lee ,  Sung Yoon Baek ,  Sang Eun Chae ,  Sang Hui Jo ,  Yeon Ok Kim ,  Hyang Sook Lee ,  Ju Hyun Park ,  Tae Kyo Park ,  Sung Ho Woo ,  Yong Zu Kim

发明人： Young Lag Cho ,  Ho Young Song ,  Dae Yon Lee ,  Sung Yoon Baek ,  Sang Eun Chae ,  Sang Hui Jo ,  Yeon Ok Kim ,  Hyang Sook Lee ,  Ju Hyun Park ,  Tae Kyo Park ,  Sung Ho Woo ,  Yong Zu Kim

IPC分类号： A61K31/506 ,  C07D413/14 ,  A61K31/422 ,  C07D409/14 ,  A61K31/4439 ,  A61P9/10 ,  A61P29/00 ,  A61P9/00

CPC分类号： C07D413/14

摘要： The present invention relates to novel oxazolidinone derivatives with cyclic amidines, and prodrugs, hydrates, solvates, isomers and pharmaceutically acceptable salts thereof, and processes for preparing the same, and pharmaceutical compositions comprising the same. The oxazolidinone derivatives with cyclic amidines, and prodrugs, hydrates, solvates, isomers and pharmaceutically acceptable salts thereof can be usefully employed as an anticoagulant for treating thromboembolism and tumors via inhibition of coagulation factor Xa.

摘要翻译： 本发明涉及具有环脒的新的恶唑烷酮衍生物及其前体药物，水合物，溶剂合物，异构体和药学上可接受的盐及其制备方法，以及包含其的药物组合物。 具有环脒的恶唑烷酮衍生物及其前体药物，水合物，溶剂合物，异构体和药学上可接受的盐可有效地用作通过抑制凝血因子Xa治疗血栓栓塞和肿瘤的抗凝血剂。

公开(公告)号：US08178525B2

公开(公告)日：2012-05-15

申请号：US13002271

申请日：2009-06-05

申请人： Ho Young Song ,  Young Lag Cho ,  Dae Yon Lee ,  Hee Sock Park ,  Sung Yoon Baek ,  Sang Eun Chae ,  Sang Hui Jo ,  Yeon Ok Kim ,  Hyang Sook Lee ,  Ju Hyun Park ,  Tae Kyo Park ,  Sung Ho Woo ,  Yong Zu Kim

发明人： Ho Young Song ,  Young Lag Cho ,  Dae Yon Lee ,  Hee Sock Park ,  Sung Yoon Baek ,  Sang Eun Chae ,  Sang Hui Jo ,  Yeon Ok Kim ,  Hyang Sook Lee ,  Ju Hyun Park ,  Tae Kyo Park ,  Sung Ho Woo ,  Yong Zu Kim

IPC分类号： C07D413/12 ,  C07D413/14 ,  C07D487/04 ,  A61K31/5395 ,  A61K31/53

CPC分类号： C07D413/14 ,  C07D487/04

摘要： Disclosed are novel oxazolidinone derivatives with cyclic amidoxime or cyclic amidrazone group, pharmaceutically acceptable salts thereof, methods for preparing the same and pharmaceutical compositions containing the same. The oxazolidinone derivatives with cyclic amidoxime or cyclic amidrazone group or the pharmaceutically acceptable salts thereof can be effectively used for the treatment of thromboembolism and tumor as an anticoagulant based on the inhibition of factor Xa.

摘要翻译： 公开了具有环状偕胺肟或环状氨基腙基团的新型恶唑烷酮衍生物，其药学上可接受的盐，其制备方法和含有它们的药物组合物。 具有环偕胺肟或环状氨基腙基的恶唑烷酮衍生物或其药学上可接受的盐可以有效地用于基于对因子Xa的抑制作为抗凝血剂治疗血栓栓塞和肿瘤。

公开(公告)号：US20090285910A1

公开(公告)日：2009-11-19

申请号：US11915373

申请日：2006-05-23

申请人： Sang Il Nam ,  Ju Hyun Park ,  Jin Woong Kim ,  Kee Dong Yoon

发明人： Sang Il Nam ,  Ju Hyun Park ,  Jin Woong Kim ,  Kee Dong Yoon

IPC分类号： A61K36/8945 ,  A61P25/00

CPC分类号： A61K36/8945 ,  A23L33/105 ,  A23V2002/00 ,  A23V2250/21 ,  A23V2200/322

摘要： The present invention relates to a composition comprising an extract of Dioscorea opposita having neuron-protective activity for preventing and treating brain disease. The extracts from Dioscorea opposita show potent neuronal cell protective activity by inhibiting neuronal cell death caused by neuro-toxicity of glutamate and H2O2 therefore it can be used as the therapeutics or health food for treating and preventing brain diseases.

摘要翻译： 本发明涉及包含具有用于预防和治疗脑部疾病的神经元保护活性的薯Di皂甙提取物的组合物。 薯a皂苷提取物通过抑制由谷氨酸和H 2 O 2的神经毒性引起的神经元细胞死亡，显示出有效的神经元细胞保护活性，因此可用作治疗和预防脑疾病的治疗剂或保健食品。

公开(公告)号：US08106933B2

公开(公告)日：2012-01-31

申请号：US11863848

申请日：2007-09-28

申请人： Ju Hyun Park ,  Do Hyung Kweon

发明人： Ju Hyun Park ,  Do Hyung Kweon

IPC分类号： B41J2/32

CPC分类号： B41J2/325 ,  B41J11/20 ,  B41J29/02 ,  B41J2202/31

摘要： An image forming apparatus includes a frame that has a first side frame and a second side frame facing each other, a platen which is rotatably supported by the first side frame and the second side frame, a head to move in first or second directions to press against or separate from the platen, a head supporting member connected to the head to support the head, and an adjusting member to pivotally support opposite ends of the head supporting member, wherein one of the two ends is fixed to the first side frame, and the other of the two ends is movably coupled to the second side frame so as to be able to move relative to the fixed end in the first and second directions.

摘要翻译： 图像形成装置包括具有第一侧框架和彼此面对的第二侧框架的框架，由第一侧框架和第二侧框架可旋转地支撑的压板，在第一或第二方向上移动以按压的头部 连接到头部以支撑头部的头部支撑构件和用于枢转地支撑头部支撑构件的相对端的调节构件，其中两个端部中的一个固定到第一侧框架，以及 两个端部中的另一个可移动地联接到第二侧框架，以便能够在第一和第二方向上相对于固定端部移动。

公开(公告)号：US07824718B2

公开(公告)日：2010-11-02

申请号：US11915373

申请日：2006-05-23

申请人： Sang Il Nam ,  Ju Hyun Park ,  Jin Woong Kim ,  Kee Dong Yoon

发明人： Sang Il Nam ,  Ju Hyun Park ,  Jin Woong Kim ,  Kee Dong Yoon

IPC分类号： A61K36/00

CPC分类号： A61K36/8945 ,  A23L33/105 ,  A23V2002/00 ,  A23V2250/21 ,  A23V2200/322

摘要： The present invention relates to a composition comprising an extract of Dioscorea opposita having neuron-protective activity for preventing and treating brain disease. The extracts from Dioscorea opposita show potent neuronal cell protective activity by inhibiting neuronal cell death caused by neuro-toxicity of glutamate and H2O2 therefore it can be used as the therapeutics or health food for treating and preventing brain diseases.

摘要翻译： 本发明涉及包含具有用于预防和治疗脑部疾病的神经元保护活性的薯Di皂甙提取物的组合物。 薯a皂苷提取物通过抑制由谷氨酸和H 2 O 2的神经毒性引起的神经元细胞死亡，显示出有效的神经元细胞保护活性，因此可用作治疗和预防脑疾病的治疗剂或保健食品。

公开(公告)号：US07420269B2

公开(公告)日：2008-09-02

申请号：US11379097

申请日：2006-04-18

申请人： Jong-Woo Ha ,  Gwang Kim, Jr. ,  Ju Hyun Park

发明人： Jong-Woo Ha ,  Gwang Kim, Jr. ,  Ju Hyun Park

IPC分类号： H01L23/02 ,  H01L23/34 ,  H01L23/48 ,  H01L23/52 ,  H01L29/40

CPC分类号： H01L25/0657 ,  H01L23/3135 ,  H01L24/73 ,  H01L25/03 ,  H01L25/105 ,  H01L25/162 ,  H01L25/165 ,  H01L2224/16225 ,  H01L2224/32225 ,  H01L2224/48091 ,  H01L2224/48225 ,  H01L2224/48227 ,  H01L2224/73204 ,  H01L2224/73265 ,  H01L2225/0651 ,  H01L2225/06562 ,  H01L2225/1023 ,  H01L2225/1052 ,  H01L2924/14 ,  H01L2924/15311 ,  H01L2924/19107 ,  H01L2924/00014 ,  H01L2924/00 ,  H01L2924/00012

摘要： A stacked integrated circuit package-in-package system is provided forming a first integrated circuit package having a first peripheral contact, forming a second integrated circuit package having a second peripheral contact, stacking the second integrated circuit package on the first integrated circuit package in an offset configuration with the first peripheral contact exposed, the offset configuration provides a second package overhang with the second integrated circuit package above the first integrated circuit package, electrically connecting the first peripheral contact and a package substrate top contact, and electrically connecting the second peripheral contact and the package substrate top contact.

摘要翻译： 提供一种堆叠式集成电路封装封装系统，其形成具有第一外围触点的第一集成电路封装，形成具有第二外围触点的第二集成电路封装，将第二集成电路封装堆叠在第一集成电路封装上 第一外围触点暴露的偏移构造，偏移构造提供第二封装突出端与第一集成电路封装之上的第二集成电路封装，电连接第一周边触点和封装衬底顶部触点，并电连接第二周边触点 和封装衬底顶部接触。