Synthetic method of optically pure (S)-3-hydroxypyrrolidine
    8.
    发明授权
    Synthetic method of optically pure (S)-3-hydroxypyrrolidine 失效
    光学纯(S)-3-羟基吡咯烷的合成方法

    公开(公告)号:US07652152B2

    公开(公告)日:2010-01-26

    申请号:US11996011

    申请日:2006-07-19

    IPC分类号: C07D207/12

    CPC分类号: C07D207/12 Y02P20/55

    摘要: A method of preparing optically pure (S)-3-hydroxypyrrolidine is disclosed. The present invention provides a method of economically and industrially preparing optically and chemically pure (S)-3-hydroxypyrrolidine, through a process comprising introducing an amine protecting group by using optically pure 4-amino-(S)-2-hydroxybutylic acid as a starting material, reducing a carboxylic acid group into a primary alcohol, removing the amine protecting group to form an amine salt, halogenating the primary alcohol, and amine cyclization; and through a simple purification process, i.e., distillation under reduced pressure. As another method, the present invention provides a method of preparing optically and chemically pure (S)-3-hydroxypyrrolidine, through a process comprising esterifying optically pure 4-amino-(S)-2-hydroxybutylic acid as a starting material, lactam cyclization, and reduction.

    摘要翻译: 公开了制备光学纯的(S)-3-羟基吡咯烷的方法。 本发明提供了经济和工业上制备光学和化学纯的(S)-3-羟基吡咯烷的方法,其包括通过使用光学纯的4-氨基 - (S)-2-羟基丁酸作为 将羧酸基团还原成伯醇,除去胺保护基以形成胺盐,卤化伯醇和胺环化; 并通过简单的纯化方法,即减压蒸馏。 作为另一种方法,本发明提供了一种通过包括酯化光学纯的4-氨基 - (S)-2-羟基丁酸作为起始原料的方法制备光学和化学纯的(S)-3-羟基吡咯烷的方法,内酰胺环化 ,并减少。

    Synthetic Method of Optically Pure (S)-3-Hydroxypyrrolidine
    9.
    发明申请
    Synthetic Method of Optically Pure (S)-3-Hydroxypyrrolidine 失效
    光学纯(S)-3-羟基吡咯烷的合成方法

    公开(公告)号:US20080214837A1

    公开(公告)日:2008-09-04

    申请号:US11996011

    申请日:2006-07-19

    IPC分类号: C07D207/12

    CPC分类号: C07D207/12 Y02P20/55

    摘要: A method of preparing optically pure (S)-3-hydroxypyrrolidine is disclosed. The present invention provides a method of economically and industrially preparing optically and chemically pure (S)-3-hydroxypyrrolidine, through a process comprising introducing an amine protecting group by using optically pure 4-amino-(S)-2-hydroxybutylic acid as a starting material, reducing a carboxylic acid group into a primary alcohol, removing the amine protecting group to form an amine salt, halogenating the primary alcohol, and amine cyclization; and through a simple purification process, i.e., distillation under reduced pressure. As another method, the present invention provides a method of preparing optically and chemically pure (S)-3-hydroxypyrrolidine, through a process comprising esterifying optically pure 4-amino-(S)-2-hydroxybutylic acid as a starting material, lactam cyclization, and reduction.

    摘要翻译: 公开了制备光学纯的(S)-3-羟基吡咯烷的方法。 本发明提供了经济和工业上制备光学和化学纯的(S)-3-羟基吡咯烷的方法,其包括通过使用光学纯的4-氨基 - (S)-2-羟基丁酸作为 将羧酸基团还原成伯醇,除去胺保护基以形成胺盐,卤化伯醇和胺环化; 并通过简单的纯化方法,即减压蒸馏。 作为另一种方法,本发明提供了一种通过包括酯化光学纯的4-氨基 - (S)-2-羟基丁酸作为起始原料的方法制备光学和化学纯的(S)-3-羟基吡咯烷的方法,内酰胺环化 ,并减少。

    Method for preparing ketones
    10.
    发明授权
    Method for preparing ketones 失效
    制备酮的方法

    公开(公告)号:US06353139B1

    公开(公告)日:2002-03-05

    申请号:US09792240

    申请日:2001-02-26

    IPC分类号: C07C4569

    CPC分类号: C07C45/00 C07F7/083

    摘要: A method for preparing ketones has advantages of improving yields and reducing the time of the reactions due to high efficiency of catalysts. Ketones are prepared by reacting an aliphatic or an aromatic aldehyde with a vinyl olefin having an aliphatic or aromatic alkyl moiety in the presence of a transition metal catalyst, 2-aminopyridine catalyst, a primary amine and an acid, as catalysts and additives.

    摘要翻译: 制备酮的方法具有提高产率和减少催化剂效率高的反应时间的优点。 酮是通过在过渡金属催化剂,2-氨基吡啶催化剂,伯胺和酸作为催化剂和添加剂的存在下使脂族或芳族醛与具有脂族或芳族烷基部分的乙烯基烯烃反应来制备的。