公开(公告)号：US08242113B2

公开(公告)日：2012-08-14

申请号：US13120568

申请日：2009-09-22

申请人： Young Lag Cho ,  Sang Eun Chae ,  Sung Yoon Baek ,  Yeon Ok Kim ,  Seong Jin Kim ,  Hyang Sook Lee ,  Ju Hyun Park ,  Tae Kyo Park ,  Sung Ho Woo ,  Yong Zu Kim

发明人： Young Lag Cho ,  Sang Eun Chae ,  Sung Yoon Baek ,  Yeon Ok Kim ,  Seong Jin Kim ,  Hyang Sook Lee ,  Ju Hyun Park ,  Tae Kyo Park ,  Sung Ho Woo ,  Yong Zu Kim

IPC分类号： C07D403/08 ,  A61K31/5377

CPC分类号： C07D403/08

摘要： Disclosed is a novel oxazolidinone derivative, particularly a novel oxazolidinone compound with a cyclic amidoxime or cyclic amidrazone group. Also disclosed is a pharmaceutical antibiotic composition including a novel oxazolidinone derivative, in vivo hydrolysable ester thereof, in vivo hydrolysable phosphate ester thereof, an isomer thereof or a pharmaceutically acceptable salt thereof as an effective ingredient. Because the novel oxazolidinone derivative, in vivo hydrolysable ester thereof, in vivo hydrolysable phosphate ester thereof, an isomer thereof or a pharmaceutically acceptable salt thereof exhibits a wide antibacterial spectrum against resistant bacteria, a low toxicity, and a strong antibacterial activity against Gram-positive and Gram-negative bacteria, it can be usefully used as an antibiotic.

摘要翻译： 公开了一种新的恶唑烷酮衍生物，特别是具有环偕胺肟或环状氨基腙基团的新型恶唑烷酮化合物。 还公开了包含新的恶唑烷酮衍生物，其体内可水解的酯，其体内可水解的磷酸酯，其异构体或其药学上可接受的盐作为有效成分的药物抗生素组合物。 因为新的恶唑烷酮衍生物，其体内可水解的酯，其体内可水解的磷酸酯，其异构体或其药学上可接受的盐，表现出对抗细菌的抗菌谱广，毒性低，抗革兰氏阳性 和革兰阴性菌，可以有效地用作抗生素。

公开(公告)号：US20110178293A1

公开(公告)日：2011-07-21

申请号：US13120568

申请日：2009-09-22

申请人： Young Lag Cho ,  Sang Eun Chae ,  Sung Yoon Baek ,  Yeon Ok Kim ,  Seong Jin Kim ,  Hyang Sook Lee ,  Ju Hyun Park ,  Tae Kyo Park ,  Sung Ho Woo ,  Yong Zu Kim

发明人： Young Lag Cho ,  Sang Eun Chae ,  Sung Yoon Baek ,  Yeon Ok Kim ,  Seong Jin Kim ,  Hyang Sook Lee ,  Ju Hyun Park ,  Tae Kyo Park ,  Sung Ho Woo ,  Yong Zu Kim

IPC分类号： C07D413/10 ,  C07D403/10 ,  C07D403/14

CPC分类号： C07D403/08

摘要： Disclosed is a novel oxazolidinone derivative, particularly a novel oxazolidinone compound with a cyclic amidoxime or cyclic amidrazone group. Also disclosed is a pharmaceutical antibiotic composition including a novel oxazolidinone derivative, a prodrug thereof, a hydrate thereof, a solvate thereof, an isomer thereof or a pharmaceutically acceptable salt thereof as an effective ingredient. Because the novel oxazolidinone derivative, a prodrug thereof, a hydrate thereof, a solvate thereof, an isomer thereof or a pharmaceutically acceptable salt thereof exhibits a wide antibacterial spectrum against resistant bacteria, a low toxicity, and a strong antibacterial activity against Gram-positive and Gram-negative bacteria, it can be usefully used as an antibiotic.

摘要翻译： 公开了一种新的恶唑烷酮衍生物，特别是具有环偕胺肟或环状氨基腙基团的新型恶唑烷酮化合物。 还公开了包含新型恶唑烷酮衍生物，其前药，其水合物，其溶剂合物，其异构体或其药学上可接受的盐作为有效成分的药物抗生素组合物。 由于新的恶唑烷酮衍生物，其前体药物，其水合物，其溶剂化物，其异构体或其药学上可接受的盐对抗菌细菌具有广泛的抗菌谱，低毒性和抗革兰氏阳性和 革兰氏阴性菌，可有效地用作抗生素。

公开(公告)号：US20110112083A1

公开(公告)日：2011-05-12

申请号：US13002271

申请日：2009-06-05

申请人： Ho Young Song ,  Young Lag Cho ,  Dae Yon Lee ,  Hee Sock Park ,  Sung Yoon Baek ,  Sang Eun Chae ,  Sang Hui Jo ,  Yeon Ok Kim ,  Hyang Sook Lee ,  Ju Hyun Park ,  Tae Kyo Park ,  Sung Ho Woo ,  Yong Zu Kim

发明人： Ho Young Song ,  Young Lag Cho ,  Dae Yon Lee ,  Hee Sock Park ,  Sung Yoon Baek ,  Sang Eun Chae ,  Sang Hui Jo ,  Yeon Ok Kim ,  Hyang Sook Lee ,  Ju Hyun Park ,  Tae Kyo Park ,  Sung Ho Woo ,  Yong Zu Kim

IPC分类号： A61K31/5395 ,  C07D413/14 ,  C07D487/04 ,  A61K31/53 ,  A61P7/02 ,  A61P9/10 ,  A61P29/00 ,  A61P25/00 ,  A61P9/00 ,  A61P11/00

CPC分类号： C07D413/14 ,  C07D487/04

摘要： The present invention relates to novel oxazolidinone derivatives with cyclic amidoxime or cyclic amidrazone group, pharmaceutically acceptable salts thereof, methods for preparing the same and pharmaceutical compositions comprising the same. The oxazolidinone derivatives with cyclic amidoxime or cyclic amidrazone group or the pharmaceutically acceptable salts thereof can be effectively used for the treatment of thromboembolism and tumor as an anticoagulant based on the inhibition of factor Xa.

摘要翻译： 本发明涉及具有环状偕胺肟或环状氨基腙基的新的恶唑烷酮衍生物，其药学上可接受的盐，其制备方法和包含其的药物组合物。 具有环偕胺肟或环状氨基腙基的恶唑烷酮衍生物或其药学上可接受的盐可以有效地用于基于对因子Xa的抑制作为抗凝血剂治疗血栓栓塞和肿瘤。

公开(公告)号：US08178525B2

公开(公告)日：2012-05-15

申请号：US13002271

申请日：2009-06-05

申请人： Ho Young Song ,  Young Lag Cho ,  Dae Yon Lee ,  Hee Sock Park ,  Sung Yoon Baek ,  Sang Eun Chae ,  Sang Hui Jo ,  Yeon Ok Kim ,  Hyang Sook Lee ,  Ju Hyun Park ,  Tae Kyo Park ,  Sung Ho Woo ,  Yong Zu Kim

发明人： Ho Young Song ,  Young Lag Cho ,  Dae Yon Lee ,  Hee Sock Park ,  Sung Yoon Baek ,  Sang Eun Chae ,  Sang Hui Jo ,  Yeon Ok Kim ,  Hyang Sook Lee ,  Ju Hyun Park ,  Tae Kyo Park ,  Sung Ho Woo ,  Yong Zu Kim

IPC分类号： C07D413/12 ,  C07D413/14 ,  C07D487/04 ,  A61K31/5395 ,  A61K31/53

CPC分类号： C07D413/14 ,  C07D487/04

摘要： Disclosed are novel oxazolidinone derivatives with cyclic amidoxime or cyclic amidrazone group, pharmaceutically acceptable salts thereof, methods for preparing the same and pharmaceutical compositions containing the same. The oxazolidinone derivatives with cyclic amidoxime or cyclic amidrazone group or the pharmaceutically acceptable salts thereof can be effectively used for the treatment of thromboembolism and tumor as an anticoagulant based on the inhibition of factor Xa.

摘要翻译： 公开了具有环状偕胺肟或环状氨基腙基团的新型恶唑烷酮衍生物，其药学上可接受的盐，其制备方法和含有它们的药物组合物。 具有环偕胺肟或环状氨基腙基的恶唑烷酮衍生物或其药学上可接受的盐可以有效地用于基于对因子Xa的抑制作为抗凝血剂治疗血栓栓塞和肿瘤。

公开(公告)号：US08288423B2

公开(公告)日：2012-10-16

申请号：US12598010

申请日：2008-05-09

申请人： Young Lag Cho ,  Ho Young Song ,  Dae Yon Lee ,  Sung Yoon Baek ,  Sang Eun Chae ,  Sang Hui Jo ,  Yeon Ok Kim ,  Hyang Sook Lee ,  Ju Hyun Park ,  Tae Kyo Park ,  Sung Ho Woo ,  Yong Zu Kim

发明人： Young Lag Cho ,  Ho Young Song ,  Dae Yon Lee ,  Sung Yoon Baek ,  Sang Eun Chae ,  Sang Hui Jo ,  Yeon Ok Kim ,  Hyang Sook Lee ,  Ju Hyun Park ,  Tae Kyo Park ,  Sung Ho Woo ,  Yong Zu Kim

IPC分类号： A01N43/64 ,  A01N43/76 ,  A01N43/50 ,  A01N43/02 ,  A01N43/06 ,  A61K31/41 ,  A61K31/42 ,  A61K31/415 ,  A61K31/38

CPC分类号： C07D413/14

摘要： The present invention relates to novel oxazolidinone derivatives with cyclic amidines, and prodrugs, hydrates, solvates, isomers and pharmaceutically acceptable salts thereof, and processes for preparing the same, and pharmaceutical compositions comprising the same. The oxazolidinone derivatives with cyclic amidines, and prodrugs, hydrates, solvates, isomers and pharmaceutically acceptable salts thereof can be usefully employed as an anticoagulant for treating thromboembolism and tumors via inhibition of coagulation factor Xa.

摘要翻译： 本发明涉及具有环脒的新的恶唑烷酮衍生物及其前体药物，水合物，溶剂合物，异构体和药学上可接受的盐及其制备方法，以及包含其的药物组合物。 具有环脒的恶唑烷酮衍生物及其前体药物，水合物，溶剂合物，异构体和药学上可接受的盐可有效地用作通过抑制凝血因子Xa治疗血栓栓塞和肿瘤的抗凝血剂。

公开(公告)号：US20100184781A1

公开(公告)日：2010-07-22

申请号：US12598010

申请日：2008-05-09

申请人： Young Lag Cho ,  Ho Young Song ,  Dae Yon Lee ,  Sung Yoon Baek ,  Sang Eun Chae ,  Sang Hui Jo ,  Yeon Ok Kim ,  Hyang Sook Lee ,  Ju Hyun Park ,  Tae Kyo Park ,  Sung Ho Woo ,  Yong Zu Kim

发明人： Young Lag Cho ,  Ho Young Song ,  Dae Yon Lee ,  Sung Yoon Baek ,  Sang Eun Chae ,  Sang Hui Jo ,  Yeon Ok Kim ,  Hyang Sook Lee ,  Ju Hyun Park ,  Tae Kyo Park ,  Sung Ho Woo ,  Yong Zu Kim

IPC分类号： A61K31/506 ,  C07D413/14 ,  A61K31/422 ,  C07D409/14 ,  A61K31/4439 ,  A61P9/10 ,  A61P29/00 ,  A61P9/00

CPC分类号： C07D413/14

摘要： The present invention relates to novel oxazolidinone derivatives with cyclic amidines, and prodrugs, hydrates, solvates, isomers and pharmaceutically acceptable salts thereof, and processes for preparing the same, and pharmaceutical compositions comprising the same. The oxazolidinone derivatives with cyclic amidines, and prodrugs, hydrates, solvates, isomers and pharmaceutically acceptable salts thereof can be usefully employed as an anticoagulant for treating thromboembolism and tumors via inhibition of coagulation factor Xa.

摘要翻译： 本发明涉及具有环脒的新的恶唑烷酮衍生物及其前体药物，水合物，溶剂合物，异构体和药学上可接受的盐及其制备方法，以及包含其的药物组合物。 具有环脒的恶唑烷酮衍生物及其前体药物，水合物，溶剂合物，异构体和药学上可接受的盐可有效地用作通过抑制凝血因子Xa治疗血栓栓塞和肿瘤的抗凝血剂。

公开(公告)号：US06636938B1

公开(公告)日：2003-10-21

申请号：US09132677

申请日：1998-08-12

申请人： Yeon Ok Kim

发明人： Yeon Ok Kim

IPC分类号： G06F1200

CPC分类号： G10H7/002

摘要： A sound generator, capable of improving a DRAM download speed and reducing power consumption when operating a DRAM download by applying a dedicated download logic, may increase the download speed up to 8 times at the minimum to 62 times at the maximum, and reduce power consumption by decreasing unnecessary clockings. In addition, since the sound generator according to the present invention does not access a parameter memory when downloading, previously processed data is not erroneously handled, and there is no need to rewrite new data to an internal memory after the download operation is completed.

摘要翻译： 通过应用专用的下载逻辑，能够提高DRAM下载速度并降低功耗的声音发生器可以将下载速度最多最多提高8倍至最多62倍，并降低功耗 通过减少不必要的时钟。 此外，由于根据本发明的声音发生器在下载时不访问参数存储器，所以先前处理的数据未被错误地处理，并且在下载操作完成之后不需要将新数据重写到内部存储器。