公开(公告)号：US20090093865A1

公开(公告)日：2009-04-09

申请号：US11946287

申请日：2007-11-28

Applicant: Yosef Krespi ,  Abraham Kometz

Inventor： Yosef Krespi ,  Abraham Kometz

IPC: A61N5/06

CPC classification number: A61N5/0603 ,  A61N5/0601 ,  A61N5/062 ,  A61N2005/0607 ,  A61N2005/063 ,  A61N2005/0644 ,  A61N2005/0659

Abstract: A method of controlling the spread of an infectious microorganism, for example methicillin-resistant Staphylococcus aureus (“MRSA”) in a group of subjects including people asymptomatic for infection with the microorganism. A dose of microorganism-reducing light can be applied to each anterior nasal cavity of each subject in the group. Optionally a colorant can be applied to the anterior nasal cavity to sensitize any infectious microorganisms present to the microorganism-reducing light. A light applicator system having a hollow light-transmissive nasal dilator insertable into a nostril and a light output member accommodatable in the hollow interior of the nasal dilator can be employed, optionally with a light diffuser around the light output member. One example of light applicator system comprises a hand piece removably attachable to an optical fiber coupled to a light source, the optical fiber constituting the light member.

Abstract translation: 控制感染性微生物（例如耐甲氧西林金黄色葡萄球菌（MRSA））在一组受试者中的扩散的方法，包括无症状感染微生物的人群。 可以对组中每个受试者的每个前鼻腔施用一定剂量的微生物减少光。 任选地，可以将着色剂施加到前鼻腔，以使存在于微生物减少光中的任何感染性微生物致敏。 可以使用具有可插入鼻孔的中空透光鼻扩张器和可容纳在鼻扩张器的中空内部的光输出构件的光施加器系统，可选地在光输出构件周围具有光漫射器。 光施加器系统的一个示例包括可移除地附接到耦合到光源的光纤的手部件，构成光部件的光纤。

公开(公告)号：US11419601B2

公开(公告)日：2022-08-23

申请号：US15912517

申请日：2018-03-05

Applicant: Yosef Krespi ,  Ron Hadani

Inventor： Yosef Krespi ,  Ron Hadani

IPC: A61B17/04 ,  A61B17/29 ,  A61B17/06 ,  A61B34/30 ,  A61B90/00 ,  A61B34/20 ,  A61B17/24

Abstract: There is provided a suture passer device used in procedures of robotic assisted minimally invasive suspension of the hyoid and tongue base in treatment of sleep apnea. The suture passer device is a dual use suture passer, having both suture insertor and extractor functionality on a single unitary instrument section of the device by means of insertion and extraction hooks positioned on an elongated needlelike body which is connected to a handle grip. The insertion and extraction hooks receive a suture via an opening in the body of the instrument, with the suture capable of removal and fastening to the extraction hook by robotic forceps. Procedures for using the device are disclosed which include a single point of entry on a patient and the device moved to first and second positions above and below the hyoid bone during robotic assisted surgery.

公开(公告)号：US07544204B2

公开(公告)日：2009-06-09

申请号：US11066729

申请日：2005-02-25

Applicant: Yosef Krespi ,  Ashutosh Kacker

Inventor： Yosef Krespi ,  Ashutosh Kacker

IPC: A61N5/06

CPC classification number: A61N5/0603 ,  A61N1/403 ,  A61N5/0601 ,  A61N5/062 ,  A61N2005/0606 ,  A61N2005/0607 ,  A61N2005/0644 ,  A61N2005/0651 ,  A61N2005/0654

Abstract: Disclosed are safe, simple and effective broad-spectrum treatments for halitosis and other microbial infections of the nondental upper respiratory tract useful to treat bacterial and other microorganism species, including anaerobic bacteria. Electromagnetic radiative energy including visible, and optionally, thermal, RF and/or microwave wavelengths, is topically applied to internal surfaces of the upper respiratory tract to destroy or incapacitate superficial microorganisms without the use of antibiotics. One useful apparatus is a handheld energy applicator having a light output head suitable for treating the back of the tongue and the tonsils and which may be interchangeably provided with extensions to reach the sinuses. The energy applicator can be supported and guided by a mounting device held between the subject's teeth, if desired. Useful embodiments of the invention include preparative treatment of the target surfaces with a photosensitizing agent such as an oxidizing agent or a complementary stain. Optionally a pre-treament procedure may be employed to remove detritus and microfloral overgrowths that may mask more deeply resident target microorganisms. Novel treatments include treatment of halitosis by destruction of bacterial species associated with halitosis, such as Atopobium parvulum, by application of non-ionizing radiative energy to the tonsils and the back of the tongue. Another embodiment comprises a candy bar incorporating a halitosis treatment lamp disposed within the candy.

Abstract translation: 公开了用于治疗细菌和其他微生物物种（包括厌氧细菌）的非上皮性上呼吸道的口臭和其他微生物感染的安全，简单和有效的广谱治疗。 电磁辐射能包括可见光，以及任选的热，射频和/或微波波长，被局部施用于上呼吸道的内表面，以破坏或失去表面微生物而不使用抗生素。 一种有用的装置是具有适于治疗舌头和扁桃体背部的光输出头的手持式能量施用器，并且可以互换地设置有延伸部以达到鼻窦。 如果需要，能量施加器可以被保持在被检者牙齿之间的安装装置支撑和引导。 本发明的有用实施方案包括用光敏剂如氧化剂或互补染色剂对目标表面进行制备处理。 任选地，可以采用预处理方法来去除可能掩盖更深层次的靶微生物的碎屑和微生物过度生长。 新型治疗方法包括通过对扁桃体和舌头后部施加非电离辐射能来破坏与口臭相关的细菌种类，例如Atopobium parvulum来治疗口臭。 另一个实施方案包括装配在糖果中的口臭治疗灯的糖果棒。

公开(公告)号：US12201848B2

公开(公告)日：2025-01-21

申请号：US15666566

申请日：2017-08-02

Applicant: Yosef Krespi

Inventor： Yosef Krespi

IPC: A61N5/00 ,  A61N5/02 ,  A61N5/06 ,  A61N1/05 ,  A61N5/067

Abstract: A device for removal of bio-film without cutting or injury to tissue is provided which is an elongated, thin and flexible member which encases a fiber optic piece and having a downward curved section at or near one end. The fiber optic protrudes from the end of the member and is covered by a diffuser to create a light emitting head, which can be used to direct light energy to a selected treatment site. Disclosed are safe, simple and effective broad-spectrum treatments for bio-film removal, such as halitosis and other microbial infections of the non-dental upper respiratory tract useful to treat bacterial and other microorganism species, including anaerobic bacteria. Electromagnetic radiative energy including visible, and optionally, thermal, RF and/or microwave wavelengths, is topically applied to internal surfaces of the upper respiratory tract to destroy or incapacitate superficial microorganisms without the use of antibiotics.

公开(公告)号：US20100076526A1

公开(公告)日：2010-03-25

申请号：US12480281

申请日：2009-06-08

Applicant: Yosef Krespi ,  Ashutosh Kacker

Inventor： Yosef Krespi ,  Ashutosh Kacker

IPC: A61N5/06

CPC classification number: A61N5/0603 ,  A61N1/403 ,  A61N5/0601 ,  A61N5/062 ,  A61N2005/0606 ,  A61N2005/0607 ,  A61N2005/0644 ,  A61N2005/0651 ,  A61N2005/0654

Abstract: Disclosed are safe, simple and effective broad-spectrum treatments for halitosis and other microbial infections of the nondental upper respiratory tract useful to treat bacterial and other microorganism species, including anaerobic bacteria. Electromagnetic radiative energy including visible, and optionally, thermal, RF and/or microwave wavelengths, is topically applied to internal surfaces of the upper respiratory tract to destroy or incapacitate superficial microorganisms without the use of antibiotics. One useful apparatus is a handheld energy applicator having a light output head suitable for treating the back of the tongue and the tonsils and which may be interchangeably provided with extensions to reach the sinuses. The energy applicator can be supported and guided by a mounting device held between the subject's teeth, if desired. Useful embodiments of the invention include preparative treatment of the target surfaces with a photosensitizing agent such as an oxidizing agent or a complementary stain. Optionally a pre-treatment procedure may be employed to remove detritus and microfloral overgrowths that may mask more deeply resident target microorganisms. Novel treatments include treatment of halitosis by destruction of bacterial species associated with halitosis, such as Atopobium parvulum, by application of non-ionizing radiative energy to the tonsils and the back of the tongue. Another embodiment comprises a candy bar incorporating a halitosis treatment lamp disposed within the candy.

Abstract translation: 公开了用于治疗细菌和其他微生物物种（包括厌氧细菌）的非上皮性上呼吸道的口臭和其他微生物感染的安全，简单和有效的广谱治疗。 电磁辐射能包括可见光，以及任选的热，射频和/或微波波长，被局部施用于上呼吸道的内表面，以破坏或失去表面微生物而不使用抗生素。 一种有用的装置是具有适于治疗舌头和扁桃体背部的光输出头的手持式能量施用器，并且可以互换地设置有延伸部以达到鼻窦。 如果需要，能量施加器可以被保持在被检者牙齿之间的安装装置支撑和引导。 本发明的有用实施方案包括用光敏剂如氧化剂或互补染色剂对目标表面进行制备处理。 任选地，可以采用预处理程序来去除可能掩盖更深层次的靶微生物的碎屑和微生物过度生长。 新型治疗方法包括通过对扁桃体和舌头后部施加非电离辐射能来破坏与口臭相关的细菌种类，例如Atopobium parvulum来治疗口臭。 另一个实施方案包括装配在糖果中的口臭治疗灯的糖果棒。

公开(公告)号：US07435252B2

公开(公告)日：2008-10-14

申请号：US10929696

申请日：2004-08-30

Applicant: Yosef Krespi ,  Ashutosh Kacker

Inventor： Yosef Krespi ,  Ashutosh Kacker

IPC: A61N5/06

CPC classification number: A61N5/062 ,  A61B18/18 ,  A61B18/1815 ,  A61N5/0601 ,  A61N5/0624 ,  A61N2005/0606 ,  A61N2005/0607 ,  A61N2005/0644 ,  A61N2005/0654

Abstract: Disclosed are methods and apparatus for safe, simple and effective broad-spectrum treatments of chronic rhinosinusitis and other common and less common infections of the sino-nasal tract which may implicate not only a wide range of bacterial species but also fungi and viruses. Electromagnetic radiative energy including visible, and optionally, thermal RF, microwave or other longer wavelengths, is applied to target internal surfaces of the sino-nasal tract to destroy or incapacitate superficial microorganisms without the use of antibiotics. The treatment can be controlled to permit regrowth of healthy microflora. A handheld energy applicator has a light output head receivable into, or engageable with, the treatment subject's nostril which may be provided with extensions to reach the sinuses. Useful embodiments of the invention include pretreatment of target sino-nasal surfaces with a photosensitizing agent such as an oxidizing agent or a complementary stain. For example methylene blue can be used with orange or red light. The combination treatment of photosensitizer and application of visual wavelength energy provides a flexible treatment regimen which enables low concentrations of stains to be employed, minimizing aesthetic problems.

Abstract translation: 公开了用于安全，简单和有效地广泛治疗慢性鼻鼻窦炎和其他常见且不太常见的中鼻道感染的方法和装置，其可能不仅涉及广泛的细菌种类，而且还涉及真菌和病毒。 将包括可见光和可选的RF，微波或其他较长波长的电磁辐射能量施加到中鼻道的目标内表面，以破坏或消除表面微生物而不使用抗生素。 可以控制治疗以允许健康微生物群落的再生长。 手持式能量施加器具有可以接收到治疗对象的鼻孔中或与受治疗者的鼻孔接合的光输出头，其可以设置有延伸部以达到鼻窦。 本发明的有用实施方案包括用光敏剂如氧化剂或互补染色剂预处理靶鼻鼻表面。 例如亚甲基蓝可以与橙色或红色的光一起使用。 光敏剂的组合治疗和视觉波长能量的应用提供了灵活的治疗方案，其使得能够使用低浓度的污渍，从而最小化审美问题。

公开(公告)号：US20180036554A1

公开(公告)日：2018-02-08

申请号：US15666566

申请日：2017-08-02

Applicant: Yosef Krespi

Inventor： Yosef Krespi

IPC: A61N5/06 ,  A61N1/05 ,  A61N5/02

CPC classification number: A61N5/0624 ,  A61N1/0548 ,  A61N5/022 ,  A61N5/0603 ,  A61N5/0625 ,  A61N2005/0606 ,  A61N2005/0626 ,  A61N2005/063 ,  A61N2005/0644 ,  A61N2005/0651 ,  A61N2005/0659 ,  A61N2005/0661 ,  A61N2005/0662 ,  A61N2005/067

Abstract: A device for removal of bio-film without cutting or injury to tissue is provided which is an elongated, thin and flexible member which encases a fiber optic piece and having a downward curved section at or near one end. The fiber optic protrudes from the end of the member and is covered by a diffuser to create a light emitting head, which can be used to direct light energy to a selected treatment site. Disclosed are safe, simple and effective broad-spectrum treatments for bio-film removal, such as halitosis and other microbial infections of the non-dental upper respiratory tract useful to treat bacterial and other microorganism species, including anaerobic bacteria. Electromagnetic radiative energy including visible, and optionally, thermal, RF and/or microwave wavelengths, is topically applied to internal surfaces of the upper respiratory tract to destroy or incapacitate superficial microorganisms without the use of antibiotics.

公开(公告)号：US09402686B2

公开(公告)日：2016-08-02

申请号：US12716561

申请日：2010-03-03

Applicant: Yosef Krespi ,  Victor Z. Kizhner

Inventor： Yosef Krespi ,  Victor Z. Kizhner

IPC: A61B18/22 ,  A61M25/00 ,  A61N5/06 ,  A61B17/24 ,  A61M25/01 ,  A61M25/10

CPC classification number: A61B18/22 ,  A61B17/24 ,  A61M25/00 ,  A61M25/01 ,  A61M25/10 ,  A61M2025/105 ,  A61N5/0624 ,  A61N2005/0607

Abstract: A method for sinus surgery includes piercing first and second access openings into the anatomy of a human subject to access an inaccessible sinus site for cooperatively manipulating respective first and second surgical instruments inserted through the openings. One instrument, for example an endoscope, can permit viewing of the sinus site while the other instrument is manipulated to effect a treatment at the sinus site. The maxillary and other sinuses can be accessed and anti-inflammatory and other treatments can be applied. Systems and instruments for performing such sinus surgery methods are also disclosed.

Abstract translation: 一种用于鼻窦手术的方法包括将第一和第二进入孔穿入人体受试者的解剖结构，以进入不可接近的窦部位，以协同操作通过开口插入的相应的第一和第二手术器械。 一个仪器，例如内窥镜，可以允许观察窦位，而另一个仪器被操纵以在窦位处进行治疗。 可以接触上颌骨和其他鼻窦，并可应用抗炎和其他治疗。 还公开了用于执行这种鼻窦手术方法的系统和仪器。

公开(公告)号：US20060047329A1

公开(公告)日：2006-03-02

申请号：US11066729

申请日：2005-02-25

Applicant: Yosef Krespi ,  Ashutosh Kacker

Inventor： Yosef Krespi ,  Ashutosh Kacker

IPC: A61H33/00

CPC classification number: A61N5/0603 ,  A61N1/403 ,  A61N5/0601 ,  A61N5/062 ,  A61N2005/0606 ,  A61N2005/0607 ,  A61N2005/0644 ,  A61N2005/0651 ,  A61N2005/0654

Abstract: Disclosed are safe, simple and effective broad-spectrum treatments for halitosis and other microbial infections of the nondental upper respiratory tract useful to treat bacterial and other microorganism species, including anaerobic bacteria. Electromagnetic radiative energy including visible, and optionally, thermal, RF and/or microwave wavelengths, is topically applied to internal surfaces of the upper respiratory tract to destroy or incapacitate superficial microorganisms without the use of antibiotics. One useful apparatus is a handheld energy applicator having a light output head suitable for treating the back of the tongue and the tonsils and which may be interchangeably provided with extensions to reach the sinuses. The energy applicator can be supported and guided by a mounting device held between the subject's teeth, if desired. Useful embodiments of the invention include preparative treatment of the target surfaces with a photosensitizing agent such as an oxidizing agent or a complementary stain. Optionally a pre-treament procedure may be employed to remove detritus and microfloral overgrowths that may mask more deeply resident target microorganisms. Novel treatments include treatment of halitosis by destruction of bacterial species associated with halitosis, such as Atopobium parvulum, by application of non-ionizing radiative energy to the tonsils and the back of the tongue. Another embodiment comprises a candy bar incorporating a halitosis treatment lamp disposed within the candy.

公开(公告)号：US20050107853A1

公开(公告)日：2005-05-19

申请号：US10929696

申请日：2004-08-30

Applicant: Yosef Krespi ,  Ashutosh Kacker

Inventor： Yosef Krespi ,  Ashutosh Kacker

IPC: A61B18/18 ,  A61N5/06 ,  A61N1/00

CPC classification number: A61N5/062 ,  A61B18/18 ,  A61B18/1815 ,  A61N5/0601 ,  A61N5/0624 ,  A61N2005/0606 ,  A61N2005/0607 ,  A61N2005/0644 ,  A61N2005/0654

Abstract: Disclosed are methods and apparatus for safe, simple and effective broad-spectrum treatments of chronic rhinosinusitis and other common and less common infections of the sino-nasal tract which may implicate not only a wide range of bacterial species but also fungi and viruses. Electromagnetic radiative energy including visible, and optionally, thermal RF, microwave or other longer wavelengths, is applied to target internal surfaces of the sino-nasal tract to destroy or incapacitate superficial microorganisms without the use of antibiotics. The treatment can be controlled to permit regrowth of healthy microflora. A handheld energy applicator has a light output head receivable into, or engageable with, the treatment subject's nostril which may be provided with extensions to reach the sinuses. Useful embodiments of the invention include pretreatment of target sino-nasal surfaces with a photosensitizing agent such as an oxidizing agent or a complementary stain. For example methylene blue can be used with orange or red light. The combination treatment of photosensitizer and application of visual wavelength energy provides a flexible treatment regimen which enables low concentrations of stains to be employed, minimizing aesthetic problems.

Abstract translation: 公开了用于安全，简单和有效地广泛治疗慢性鼻鼻窦炎和其他常见且不太常见的中鼻道感染的方法和装置，其可能不仅涉及广泛的细菌种类，而且还涉及真菌和病毒。 将包括可见光和可选的RF，微波或其他较长波长的电磁辐射能量施加到中鼻道的目标内表面，以破坏或消除表面微生物而不使用抗生素。 可以控制治疗以允许健康微生物群落的再生长。 手持式能量施加器具有可以接收到治疗对象的鼻孔中或与受治疗者的鼻孔接合的光输出头，其可以设置有延伸部以达到鼻窦。 本发明的有用实施方案包括用光敏剂如氧化剂或互补染色剂预处理靶鼻鼻表面。 例如亚甲基蓝可以与橙色或红色的光一起使用。 光敏剂的组合治疗和视觉波长能量的应用提供了灵活的治疗方案，其使得能够使用低浓度的污渍，从而最小化审美问题。