公开(公告)号：US20190298908A1

公开(公告)日：2019-10-03

申请号：US16438437

申请日：2019-06-11

Applicant: Yan Chen ,  Gang G. Xu ,  Juanjuan Jiang ,  Juan Sheng

Inventor： Yan Chen ,  Gang G. Xu ,  Juanjuan Jiang ,  Juan Sheng

IPC: A61M1/36 ,  A61M1/34

Abstract: This invention is directed to a process for depleting one or more targeted substances such as toxins, proteins such as one or more immune checkpoint inhibitors (ICI), or a combination thereof from a subject. Immune checkpoint inhibitors (ICI), such as PD-1 protein, PD-1 ligand (PD-L1), CTLA-4, LAG-3, TIM3 and others are known to be involved in inhibition of T-cell activation in tumor patients. This invention is also directed to a device for depleting ICI such as PD-1 protein, PD-1 ligand (PD-L1) including soluble PD-L1 (sPD-L1), PD-L2, CTLA-4 including soluble form sCTLA-4, LAG-3, TIM3, or toxins from a subject. This invention is further directed to the use of the process and the devices for treating medical conditions such as cancers, other diseases and substance overdose.

公开(公告)号：USD1031281S1

公开(公告)日：2024-06-18

申请号：US29871125

申请日：2023-02-13

Applicant: Yan Chen

Designer： Yan Chen

Abstract: FIG. 1 is a front perspective view of a clothes hanger hook, showing my new design;
FIG. 2 is a rear perspective view thereof;
FIG. 3 is a front view thereof;
FIG. 4 is a rear view thereof;
FIG. 5 is a left side view thereof;
FIG. 6 is a right side view thereof;
FIG. 7 is a top view thereof; and,
FIG. 8 is a bottom view thereof.

公开(公告)号：US20240075955A1

公开(公告)日：2024-03-07

申请号：US18242240

申请日：2023-09-05

Applicant: Yan Chen ,  Yiwen Huang

Inventor： Yan Chen ,  Yiwen Huang

IPC: B60W60/00

CPC classification number: B60W60/0015 ,  B60W2520/06 ,  B60W2520/14 ,  B60W2552/53

Abstract: A safety-guaranteed control system for automated vehicles (AVs) considers both vehicle and tire stabilities on varying road conditions. Conventional AV control systems may not be sufficient to adequately handle control-dependent and time-varying safety constraints. The system integrates control-dependent barrier functions (CDBF) and time-varying CBFs (TCBFs) with control Lyapunov functions (CLFs) in a quadratic programming problem.

公开(公告)号：USD1015954S1

公开(公告)日：2024-02-27

申请号：US29819754

申请日：2021-12-17

Applicant: Yan Chen

Designer： Yan Chen

Abstract: FIG. 1 is a front perspective view of bike trailer hitch arm, showing my new design;
FIG. 2 is a front elevational view thereof;
FIG. 3 is a rear elevational view thereof;
FIG. 4 is a left side elevational view thereof;
FIG. 5 is a right side elevational view thereof;
FIG. 6 is a top plan view thereof; and,
FIG. 7 is a bottom plan view thereof.

公开(公告)号：US11012285B2

公开(公告)日：2021-05-18

申请号：US16127151

申请日：2018-09-10

Applicant: Chen Chen ,  Beibei Wang ,  Yi Han ,  Feng Zhang ,  Hung-Quoc Duc Lai ,  Yan Chen ,  K. J. Ray Liu ,  Oscar Chi-Lim Au

Inventor： Chen Chen ,  Beibei Wang ,  Yi Han ,  Feng Zhang ,  Hung-Quoc Duc Lai ,  Yan Chen ,  K. J. Ray Liu ,  Oscar Chi-Lim Au

IPC: H04L27/36 ,  H04W72/04 ,  H04B1/38 ,  H04L5/00

Abstract: The present teaching relates to vital sign detection and monitoring based on channel state information (CSI). In one example, an apparatus for vital sign detection is disclosed. The apparatus comprises a receiver, a processor and a memory communicatively coupled with the processor. The receiver is configured for receiving at least one wireless signal from a multipath channel that can be impacted by a vital sign of at least one living being. The processor is configured for: extracting a time series of channel state information (CSI) for the multipath channel from the at least one wireless signal, obtaining one or more periodic fluctuations based on a spectral analysis of the time series of CSI, and determining whether the vital sign is present based on the one or more periodic fluctuations.

公开(公告)号：USD873991S1

公开(公告)日：2020-01-28

申请号：US29662479

申请日：2018-09-05

Applicant: Yan Chen

Designer： Yan Chen

公开(公告)号：US10010552B2

公开(公告)日：2018-07-03

申请号：US15003860

申请日：2016-01-22

Applicant: Sunkyu Kim ,  Shivang Doshi ,  Kristy Haas ,  Steven Kovats ,  Alan Xizhong Huang ,  Yan Chen

Inventor： Sunkyu Kim ,  Shivang Doshi ,  Kristy Haas ,  Steven Kovats ,  Alan Xizhong Huang ,  Yan Chen

IPC: A61K31/519 ,  C07D487/02 ,  A61K31/4439 ,  A61K45/06 ,  A61K31/5377

CPC classification number: A61K31/519 ,  A61K31/4439 ,  A61K31/5377 ,  A61K45/06 ,  A61K2300/00

Abstract: A combination of a CDK4/6 inhibitor and a P3Kinase inhibitor for the treatment of cancer.

公开(公告)号：US09815667B2

公开(公告)日：2017-11-14

申请号：US14401378

申请日：2012-05-16

Applicant: Xiaomei Yu ,  Yan Chen ,  David R. Polak ,  Daniel V. Viens ,  John P. Wesson

Inventor： Xiaomei Yu ,  Yan Chen ,  David R. Polak ,  Daniel V. Viens ,  John P. Wesson

IPC: B05D3/12 ,  B66B15/02 ,  B66B15/04 ,  B05D3/10 ,  F16H55/36 ,  B05D5/08 ,  B05D3/00

CPC classification number: B66B15/02 ,  B05D3/002 ,  B05D3/10 ,  B05D3/12 ,  B05D5/083 ,  B66B15/04 ,  F16H2055/366

Abstract: A method for applying a coating to a substrate includes obtaining a fluorinated polymer compound, where the fluorine is chemically or covalently bonded to the polymer molecule; and coating the surface of the substrate with the fluorinated polymer compound.

公开(公告)号：US20160184311A1

公开(公告)日：2016-06-30

申请号：US14911160

申请日：2014-08-07

Applicant: Yan Chen ,  Xizhong Huang ,  Sunkyu Kim

Inventor： Yan Chen ,  Xizhong Huang ,  Sunkyu Kim

IPC: A61K31/519 ,  A61K31/4439 ,  A61K31/5377 ,  A61K31/138 ,  A61K31/565 ,  A61K31/5685 ,  A61K31/551 ,  A61K31/4196 ,  A61K31/436

CPC classification number: A61K31/519 ,  A61K31/138 ,  A61K31/4196 ,  A61K31/436 ,  A61K31/4439 ,  A61K31/5377 ,  A61K31/551 ,  A61K31/5513 ,  A61K31/565 ,  A61K31/5685 ,  A61K45/06 ,  A61K2300/00

Abstract: The present disclosure relates to a pharmaceutical combination comprising (1) a first agent which is a CDK inhibitor or a pharmaceutically acceptable salt thereof and (2) a second agent which is an anti-hormonal agent or a pharmaceutically acceptable salt thereof. The present disclosure also relates to a pharmaceutical combination comprising (1) a first agent which is a CDK inhibitor or a pharmaceutically acceptable salt thereof, (2) a second agent which is an anti-hormonal agent or a pharmaceutically acceptable salt thereof, and (3) a third agent which is an agent that regulates the PI3K/Akt/mTOR pathway or a pharmaceutically acceptable salt thereof.

Abstract translation: 本公开涉及药物组合，其包含（1）第一药剂，其是CDK抑制剂或其药学上可接受的盐，和（2）第二药剂，其是抗激素剂或其药学上可接受的盐。 本公开还涉及药物组合，其包含（1）第一药剂，其是CDK抑制剂或其药学上可接受的盐，（2）第二药剂，其是抗激素剂或其药学上可接受的盐，和 3）作为调节PI3K / Akt / mTOR途径的药剂的第三药剂或其药学上可接受的盐。

公开(公告)号：US09134304B2

公开(公告)日：2015-09-15

申请号：US13009500

申请日：2011-01-19

Applicant: Richard W. Wagner ,  Alexander Litovchick ,  Yan Chen

Inventor： Richard W. Wagner ,  Alexander Litovchick ,  Yan Chen

IPC: C12N15/10 ,  G01N33/53 ,  G01N33/543 ,  G01N33/68

CPC classification number: C12N15/1086 ,  C07K19/00 ,  C07K2317/10 ,  C07K2317/40 ,  C07K2317/56 ,  C12N15/1062 ,  C12N15/1075 ,  G01N33/5308 ,  G01N33/54366 ,  G01N33/6845

Abstract: The invention provides methods and compositions useful for identifying polypeptides with desired characteristics in vitro.

Abstract translation: 本发明提供了可用于在体外鉴定具有所需特征的多肽的方法和组合物。