公开(公告)号：US20190298908A1

公开(公告)日：2019-10-03

申请号：US16438437

申请日：2019-06-11

Applicant: Yan Chen ,  Gang G. Xu ,  Juanjuan Jiang ,  Juan Sheng

Inventor： Yan Chen ,  Gang G. Xu ,  Juanjuan Jiang ,  Juan Sheng

IPC: A61M1/36 ,  A61M1/34

Abstract: This invention is directed to a process for depleting one or more targeted substances such as toxins, proteins such as one or more immune checkpoint inhibitors (ICI), or a combination thereof from a subject. Immune checkpoint inhibitors (ICI), such as PD-1 protein, PD-1 ligand (PD-L1), CTLA-4, LAG-3, TIM3 and others are known to be involved in inhibition of T-cell activation in tumor patients. This invention is also directed to a device for depleting ICI such as PD-1 protein, PD-1 ligand (PD-L1) including soluble PD-L1 (sPD-L1), PD-L2, CTLA-4 including soluble form sCTLA-4, LAG-3, TIM3, or toxins from a subject. This invention is further directed to the use of the process and the devices for treating medical conditions such as cancers, other diseases and substance overdose.