公开(公告)号：US20070293678A1

公开(公告)日：2007-12-20

申请号：US11574255

申请日：2005-09-12

申请人： Xinglong Jiang ,  Prasad Kapa ,  George Lee ,  Edwin Villhauer

发明人： Xinglong Jiang ,  Prasad Kapa ,  George Lee ,  Edwin Villhauer

IPC分类号： C07D471/04 ,  C07D213/81

CPC分类号： C07D213/81 ,  C07D471/04

摘要： A process for the manufacture of isoquinoline and 1,7-naphthyridine derivatives of formula wherein R1, R2, R3, R4 and X have the meanings as indicated in the specification. The process utilizes readily available starting materials of the formulae or compounds prepared from such starting materials wherein R1, R2, R3 and X have meanings as defined for formula (I); and R and R5 are independently C1-C7-alkyl.

摘要翻译： 制备下式的异喹啉和1,7-萘啶衍生物的方法其中R 1，R 2，R 3，R 3， > 4＆gt;和X具有如说明书中所示的含义。 该方法利用容易获得的由这些起始物质制备的式或化合物的起始原料，其中R 1，R 2，R 3和X具有 对于式（I）定义的含义; 且R和R 5独立地为C 1 -C 7 - 烷基。

公开(公告)号：US20050261504A1

公开(公告)日：2005-11-24

申请号：US10527628

申请日：2003-09-18

申请人： Prasad Kapa ,  Xinglong Jiang ,  Eric Loeser ,  Joel Slade ,  Mahavir Prashad ,  George Lee

发明人： Prasad Kapa ,  Xinglong Jiang ,  Eric Loeser ,  Joel Slade ,  Mahavir Prashad ,  George Lee

IPC分类号： C07C259/06 ,  C07D205/08 ,  C07D207/16 ,  C07D277/04

CPC分类号： C07D401/12 ,  C07C259/06 ,  C07D205/08 ,  C07D207/16 ,  Y02P20/55

摘要： The present invention is directed to a process for preparing intermediates that are useful to prepare certain antibacterial N-formyl hydroxylamine compounds which are peptide deformylase inhibitors. The process makes use a β-lactarn intermediate. Certain optically pure intermediates are also claimed.

摘要翻译： 本发明涉及一种制备中间体的方法，其可用于制备作为肽去甲酰化酶抑制剂的某些抗菌N-甲酰基羟胺化合物。 该过程使用β-内酰胺中间体。 还要求某些光学纯中间体。

公开(公告)号：US20070135502A1

公开(公告)日：2007-06-14

申请号：US11619936

申请日：2007-01-04

申请人： Andrew Bach ,  Prasad Kapa ,  George Lee ,  Eric Loeser ,  Michael Sabio ,  James Stanton ,  Thalaththani Vedananda

发明人： Andrew Bach ,  Prasad Kapa ,  George Lee ,  Eric Loeser ,  Michael Sabio ,  James Stanton ,  Thalaththani Vedananda

IPC分类号： A61K31/42 ,  A61K31/404 ,  A61K31/4025 ,  A61K31/401 ,  C07D413/02 ,  C07D411/02

CPC分类号： C07D205/04 ,  C07D207/16 ,  C07D209/42 ,  C07D401/12 ,  C07D403/12 ,  C07D405/12 ,  C07D413/12 ,  C07D417/12

摘要： Compounds of the formula provide pharmacological agents which are potent agonists of Peroxisome Proliferator-Activated Receptors (PPARs). Accordingly, the compounds of the instant invention are useful for the treatment of conditions mediated by the PPAR receptor activity in mammals. Such conditions include dyslipidemia, hyperlipidemia, hypercholesteremia, atherosclerosis, hypertriglyceridemia, heart failure, myocardial infarction, vascular diseases, cardiovascular diseases, hypertension, obesity, inflammation, arthritis, cancer, Alzheimer's disease, skin disorders, respiratory diseases, ophthalmic disorders, inflammatory bowel diseases, ulcerative colitis and Crohn's disease. The compounds of the present invention are particularly useful in mammals as hypoglycemic agents for the treatment and prevention of conditions in which impaired glucose tolerance, hyperglycemia and insulin resistance are implicated, such as type-1 and type-2 diabetes, and Syndrome X. Preferred are the compounds of the invention which are dual agonists of PPARα and PPARγ receptors.

摘要翻译： 配方的化合物提供作为过氧化物酶体增殖物激活受体（PPARs）的有效激动剂的药理学试剂。 因此，本发明的化合物可用于治疗由哺乳动物中的PPAR受体活性介导的病症。 这些病症包括血脂异常，高脂血症，高胆固醇血症，动脉粥样硬化，高甘油三酯血症，心力衰竭，心肌梗死，血管疾病，心血管疾病，高血压，肥胖症，炎症，关节炎，癌症，阿尔茨海默病，皮肤病，呼吸系统疾病，眼科疾病，炎症性肠病 ，溃疡性结肠炎和克罗恩病。 本发明的化合物在哺乳动物中特别可用作降血糖药，用于治疗和预防葡萄糖耐量降低，高血糖症和胰岛素抵抗等疾病，如1型和2型糖尿病，以及X综合征。 是本发明的化合物，它们是PPARα和PPARγ受体的双重激动剂。

公开(公告)号：US09659300B2

公开(公告)日：2017-05-23

申请号：US13215991

申请日：2011-08-23

申请人： George Lee ,  Hugo Olliphant

发明人： George Lee ,  Hugo Olliphant

IPC分类号： G06Q30/00 ,  G06Q30/02 ,  G06Q30/06

CPC分类号： G06Q30/02 ,  G06Q30/0601 ,  G06Q30/0641

摘要： A system and method for conducting a gift value transaction is described herein. The method includes receiving a request for payment for a gift, wherein the request includes buyer-imposed conditions on use of the gift; notifying a gift recipient of the gift; and tracking the gift recipient's account balances at the different merchants with the buyer-imposed conditions.

公开(公告)号：US09469627B2

公开(公告)日：2016-10-18

申请号：US13439511

申请日：2012-04-04

申请人： Christopher L. Vandeusen ,  Franz J. Weiberth ,  Harpal S. Gill ,  George Lee ,  Andrea Hillegass

发明人： Christopher L. Vandeusen ,  Franz J. Weiberth ,  Harpal S. Gill ,  George Lee ,  Andrea Hillegass

IPC分类号： C07D413/14 ,  A61K31/506 ,  C07D271/06

CPC分类号： A61K31/506 ,  C07D217/06 ,  C07D271/06 ,  C07D413/14

摘要： This invention is directed to a compound of formula (I): wherein R1, R2 and R3 are as defined herein, a pharmaceutical composition comprising the compound, intermediates and processes for making said compounds, and the use of the compound to treat allergic and/or inflammatory disorders, particularly disorders such as allergic rhinitis, asthma, chronic obstructive pulmonary disease (COPD) and age-related macular degeneration (AMD).

公开(公告)号：US09307034B1

公开(公告)日：2016-04-05

申请号：US12759676

申请日：2010-04-13

申请人： Pedram Keyani ,  George Lee ,  Joel Benjamin Seligstein

发明人： Pedram Keyani ,  George Lee ,  Joel Benjamin Seligstein

IPC分类号： G06F15/16 ,  H04L29/08 ,  G06Q20/20

CPC分类号： H04L67/146 ,  G06Q20/0655 ,  G06Q20/20 ,  G06Q20/204 ,  G06Q20/34 ,  G06Q50/01 ,  H04L67/10 ,  H04L67/20 ,  H04L67/28 ,  H04L67/306 ,  H04W4/21 ,  H04W12/02

摘要： Methods, apparatuses and systems directed to federated access to social networking information of a user initiated upon activation of a physical access token. A user may initiate a workflow, by activating a physical token, that establishes a federated access session between a third-party system and a social networking system to allow the third-party system to augment the user's experience with social networking information without the user directly accessing either the third-party system or the social networking system.

摘要翻译： 针对在物理访问令牌激活时发起的用户对社交网络信息进行联合访问的方法，装置和系统。 用户可以通过激活建立第三方系统和社交网络系统之间的联合访问会话的物理令牌来启动工作流，以允许第三方系统在没有用户直接的情况下增加用户的社交网络信息的体验 访问第三方系统或社交网络系统。

公开(公告)号：US20140218899A1

公开(公告)日：2014-08-07

申请号：US13757801

申请日：2013-02-03

申请人： Calvin Chuen Kam Law ,  George Lee

发明人： Calvin Chuen Kam Law ,  George Lee

IPC分类号： F21L4/04

CPC分类号： F21L4/027 ,  F21L4/08 ,  F21S8/04 ,  F21S8/06 ,  F21S9/024 ,  F21V21/406 ,  F21V23/0464

摘要： A modular lighting system for mounting in the garage, under a cabinet, or on a wall area includes a LED light mounted in the housing and two battery operated detachable, removable flashlight assemblies mounted in the housing. The flashlight assembly includes a rechargeable battery; an electrical device, such as a male plug for interconnecting the battery and power source; and an electrical device for sensing power loss. The lighting system also includes a flashlight electrical connection in the housing, such as a plug receptacle, for connection to the male plug for supplying power from the power source to the detachable flashlight assembly.

摘要翻译： 用于安装在车库，柜体或墙壁区域的模块化照明系统包括安装在壳体中的LED灯和安装在壳体中的两个电池操作的可拆卸的可拆卸手电筒组件。 手电筒组件包括可充电电池; 用于互连电池和电源的电气设备，例如公插头; 以及用于感测功率损耗的电气设备。 照明系统还包括壳体中的手电筒电连接，例如插头插座，用于连接到阳插头，用于从电源向可拆卸的手电筒组件供电。

公开(公告)号：US08669709B2

公开(公告)日：2014-03-11

申请号：US13216763

申请日：2011-08-24

申请人： George Lee ,  Arthur Young ,  Jing-Bo Mo

发明人： George Lee ,  Arthur Young ,  Jing-Bo Mo

IPC分类号： H05B37/02

CPC分类号： H05B33/0809 ,  H05B33/0812 ,  Y02B20/343

摘要： A solid state lighting driver and system having a total harmonic distortion (“THDi”) bypass circuit is disclosed. The solid state driver energizes a solid state lamp having a first lighting segment serially connected to a second lighting segment. The THDi bypass circuit bypasses a first lighting segment and energizes a second lighting segment of LEDs when the driving voltage is low. As a result, the solid state lamp will emit light over a larger portion of the power cycle and will decrease the THDi.

摘要翻译： 公开了具有总谐波失真（“THDi”）旁路电路的固态照明驱动器和系统。 固态驱动器激励具有串联连接到第二照明段的第一点亮段的固态灯。 当驱动电压低时，THDi旁路电路绕过第一个照明段并激励第二个LED点亮段。 结果，固态灯将在功率循环的较大部分发光，并将减少THDi。

公开(公告)号：US20130155713A1

公开(公告)日：2013-06-20

申请号：US13331911

申请日：2011-12-20

申请人： Calvin Chuen Kam Law ,  George Lee

发明人： Calvin Chuen Kam Law ,  George Lee

IPC分类号： F21S8/10 ,  B29C65/48

CPC分类号： B60Q1/34 ,  B29C65/483 ,  B29C65/485 ,  B29C65/542 ,  B29C66/112 ,  B29C66/114 ,  B29C66/542 ,  B29C66/73365 ,  B29L2031/3055 ,  B29L2031/747 ,  B60Q1/22 ,  B60Q1/2696 ,  F21S43/14 ,  F21S43/195 ,  F21S45/10

摘要： A light bar apparatus is disclosed. The light bar apparatus is attached to a vehicle and comprises a plurality of LED lights capable of illuminating in patterns signaled by the vehicle. The light bar is made at least in part of thermosetting polymer material such that the curing of the thermosetting polymer results in a protective layer for the LED lights by shielding the LED lights from excessive vibration from a vehicle in motion.

摘要翻译： 公开了一种灯条装置。 灯条装置附接到车辆并且包括能够以由车辆发信号的图案照明的多个LED灯。 光棒至少部分地由热固性聚合物材料制成，使得热固性聚合物的固化通过屏蔽LED灯免于运动中的车辆的过度振动而导致用于LED灯的保护层。

公开(公告)号：US08442016B1

公开(公告)日：2013-05-14

申请号：US12435707

申请日：2009-05-05

申请人： George Lee ,  Zhenyu Zhang ,  Gladys Yuen Yan Wong

发明人： George Lee ,  Zhenyu Zhang ,  Gladys Yuen Yan Wong

IPC分类号： H04W4/00 ,  G06F15/16 ,  H04B7/00

CPC分类号： H04W72/1215 ,  H04B1/0475 ,  H04W16/14 ,  H04W84/18 ,  H04W88/06

摘要： A method for transmitting one or more first wireless local area network (WLAN) packets and one or more first Bluetooth (BT) packets. The method includes: prior to transmission of the one or more first wireless local area network (WLAN) packets, predicting a first time at which the transmission of the one or more first wireless local area network (WLAN) packets is going to end, and predicting a second time at which reception of one or more second Bluetooth (BT) packets is going to start; and simultaneously transmitting the one or more first wireless local area network (WLAN) packets and the one or more first Bluetooth (BT) packets in response to the first time being predicted to occur prior to the second time.

摘要翻译： 一种用于发送一个或多个第一无线局域网（WLAN）分组和一个或多个第一蓝牙（BT）分组的方法。 该方法包括：在发送一个或多个第一无线局域网（WLAN）分组之前，预测一个或多个第一无线局域网（WLAN）分组的传输将要结束的第一时间，以及 预测一个或多个第二蓝牙（BT）分组的接收将要开始的第二时间; 并且响应于第一次被预测在第二时间之前发生，同时发送一个或多个第一无线局域网（WLAN）分组和一个或多个第一蓝牙（BT）分组。