公开(公告)号：US07135540B2

公开(公告)日：2006-11-14

申请号：US10359600

申请日：2003-02-07

申请人： Tsutomu Honma ,  Shinya Kozaki ,  Takeshi Imamura ,  Takashi Kenmoku ,  Tatsuki Fukui ,  Etsuko Sugawa ,  Tetsuya Yano

发明人： Tsutomu Honma ,  Shinya Kozaki ,  Takeshi Imamura ,  Takashi Kenmoku ,  Tatsuki Fukui ,  Etsuko Sugawa ,  Tetsuya Yano

IPC分类号： C08G63/02

CPC分类号： C12P7/625 ,  C08G63/6822 ,  C08G63/6882 ,  C12P11/00

摘要： The invention provides a polyhydroxyalkanoate having a bromo group in a unit and being thermally stable and capable of arbitrarily controlling physical properties, and a producing method thereof. According to the invention, there are provided a polyhydroxyalkanoate copolymer including a 3-hydroxy-ω-bromoalkanoic acid unit represented by a formula—[OCH((CH2)nBr)CH2C(O)]— (n=1 to 8) (1) and a unit represented by a formula —[OCH((CH2)mR)CH2C(O)]— (2) within a same molecule, and a method for producing a polyhydroxyalkanoate copolymer by microorganisms, utilizing a ω-bromoalkanoic acid represented by a formula Br(CH2)pCH2CH2COOH (p=1 to 8) (20) and a compound represented by a formula R(CH2)qCH2CH2COOH (21) as raw materials.

摘要翻译： 本发明提供一种具有溴基团并且是热稳定的并能够任意控制物理性能的聚羟基链烷酸酯及其制备方法。 根据本发明，提供了一种包含由式 - [OCH（（CH 2）n）n Br表示的3-羟基-ω-溴代链烷酸单元的聚羟基链烷酸酯共聚物 ）CH 2 C（O）] - （n = 1-8）（1）和由式 - [OCH（（CH 2）2） （O）] - （2），以及通过微生物制备聚羟基链烷酸酯共聚物的方法，使用由以下化合物表示的ω-溴烷酸： 式（Br 2 CH 2 CH 2 CH 2 CH 2 CH 2 CH 2 CH 2 COOH（p = 1〜8）（20 ）和由式R（CH 2 CH 2）q CH 2 CH 2 COOH（21）表示的化合物 作为原料。

公开(公告)号：US20060211100A1

公开(公告)日：2006-09-21

申请号：US10531689

申请日：2003-10-23

申请人： Takashi Kenmoku ,  Tetsuya Yano ,  Chieko Mihara ,  Shinya Kozaki ,  Tsutomu Honma ,  Tatsuki Fukui ,  Takeshi Imamura ,  Etsuko Sugawa

发明人： Takashi Kenmoku ,  Tetsuya Yano ,  Chieko Mihara ,  Shinya Kozaki ,  Tsutomu Honma ,  Tatsuki Fukui ,  Takeshi Imamura ,  Etsuko Sugawa

IPC分类号： C12P7/62 ,  C08G63/87

CPC分类号： C08G63/06 ,  C08G63/6882 ,  C12P7/625

摘要： The invention provides a PHA copolymer including at least a 3-hydroxy-ω-carboxyalkanoic acid represented by a formula (19) or (32) and simultaneously at least a unit represented by a formula (2) or a formula (3) in a molecule, a precursor PHA copolymer having a corresponding vinyl group or a corresponding alkoxycarbonyl group, a biosynthesis method thereof by microorganisms, and a method of producing a desired PHA copolymer from the precursor PHA copolymer: (wherein k, m, n are integers; R18 represents H, Na, K, R27? represents (A); R1 represents a substituent on a cyclohexyl group and represents H, CN, NO2, a halogen atom, CH3, C2H5, C3H7, CF3, C2F5, or C3F7; R includes a residue including a phenyl structure or a thienyl structure; these being independent for each unit).

摘要翻译： 本发明提供一种PHA共聚物，其包含至少一种由式（19）或（32）表示的3-羟基-ω-羧基烷酸，同时至少由式（2）或式（3）表示的单元在 分子，具有相应的乙烯基或相应的烷氧基羰基的前体PHA共聚物，微生物的生物合成方法以及由前体PHA共聚物制备所需PHA共聚物的方法（其中k，m，n为整数; R 表示H，Na，K，R 27？表示（A）; R 1表示环己基上的取代基，代表H，CN ，NO 2 2，卤素原子，CH 3，C 2 H 5，C 3， H 3，CF 3，C 2 H 5，或C 3 H 3， R> R包括残基 e包括苯基结构或噻吩基结构; 这些对于每个单元是独立的）。

公开(公告)号：US07425432B2

公开(公告)日：2008-09-16

申请号：US10531689

申请日：2003-10-23

申请人： Takashi Kenmoku ,  Tetsuya Yano ,  Chieko Mihara ,  Shinya Kozaki ,  Tsutomu Honma ,  Tatsuki Fukui ,  Takeshi Imamura ,  Etsuko Sugawa

发明人： Takashi Kenmoku ,  Tetsuya Yano ,  Chieko Mihara ,  Shinya Kozaki ,  Tsutomu Honma ,  Tatsuki Fukui ,  Takeshi Imamura ,  Etsuko Sugawa

IPC分类号： C12P11/00 ,  C12P7/72 ,  C08G63/00 ,  C08G63/02 ,  C08G63/68

CPC分类号： C08G63/06 ,  C08G63/6882 ,  C12P7/625

摘要： The invention provides a PHA copolymer including at least a 3-hydroxy-ω-carboxyalkanoic acid represented by a formula (19) or (32) and simultaneously at least a unit represented by a formula (2) or a formula (3) in a molecule, a precursor PHA copolymer having a corresponding vinyl group or a corresponding alkoxycarbonyl group, a biosynthesis method thereof by microorganisms, and a method of producing a desired PHA copolymer from the precursor PHA copolymer: (wherein k, m, n are integers; R18 represents H, Na, K, R27? represents (A); R1 represents a substituent on a cyclohexyl group and represents H, CN, NO2, a halogen atom, CH3, C2H5, C3H7, CF3, C2F5, or C3F7; R includes a residue including a phenyl structure or a thienyl structure; these being independent for each unit).

摘要翻译： 本发明提供一种PHA共聚物，其包含至少一种由式（19）或（32）表示的3-羟基-ω-羧基烷酸，同时至少由式（2）或式（3）表示的单元在 分子，具有相应的乙烯基或相应的烷氧基羰基的前体PHA共聚物，微生物的生物合成方法以及由前体PHA共聚物制备所需PHA共聚物的方法（其中k，m，n为整数; R ＆lt; 18＆gt;＆gt;代表H，Na，K，R 27？表示（A）; R 1表示环己基上的取代基，代表H，CN ，NO 2 2，卤素原子，CH 3，C 2 H 5，C 3， H 3，CF 3，C 2 H 5，或C 3 H 3， R> R包括残基inc 提出苯基结构或噻吩基结构; 这些对于每个单元是独立的）。

公开(公告)号：US07045321B2

公开(公告)日：2006-05-16

申请号：US10084172

申请日：2002-02-28

申请人： Takeshi Imamura ,  Etsuko Sugawa ,  Tetsuya Yano ,  Tsuyoshi Nomoto ,  Tomohiro Suzuki ,  Tsutomu Honma ,  Takashi Kenmoku ,  Tatsuki Fukui

发明人： Takeshi Imamura ,  Etsuko Sugawa ,  Tetsuya Yano ,  Tsuyoshi Nomoto ,  Tomohiro Suzuki ,  Tsutomu Honma ,  Takashi Kenmoku ,  Tatsuki Fukui

IPC分类号： C12P11/00 ,  C12P13/00 ,  C08G63/02

CPC分类号： G03G9/08755 ,  C08G63/6882 ,  C12P7/625 ,  C12P11/00 ,  G03G9/08791 ,  G03G9/09733 ,  G03G9/09775

摘要： A polyhydroxyalkanoate characterized by having in the molecule a unit represented by Chemical Formula (1): wherein n may assume any one integral value within the range of from 1 to 8. Also disclosed are a process for producing the polyhydroxyalkanoate by the use of a microorganism having the ability to produce the polyhydroxyalkanoate and accumulate it in the bacterial body; a charge control agent, a toner binder and a toner which contain this polyhydroxyalkanoate; and an image-forming method and an image-forming apparatus which make use of the toner.

摘要翻译： 公开了在分子中具有由化学式（1）表示的单元的聚羟基链烷酸酯。 其中R选自氢原子，卤原子，CN，NO 2，COOR'，SO 2 R“，CH 3，C 2 H 5，C 3 H 7，C（CH 3）2 H和C（CH 3）3; 其中R'是H，Na，K，CH3或C2H5，R“是OH，ONa，OK，卤素原子，OCH3或OC2H5; x是任意选自1至8的整数; 条件是排除了具有氢原子作为R的聚羟基链烷酸酯，并且所有单元中的x均为2或4.还公开了通过使用具有生产聚羟基链烷酸酯的能力的微生物来生产聚羟基链烷酸酯并累积 它在细菌体内

公开(公告)号：US06645743B1

公开(公告)日：2003-11-11

申请号：US10372285

申请日：2003-02-25

申请人： Tsutomu Honma ,  Etsuko Sugawa ,  Tetsuya Yano ,  Takeshi Imamura ,  Takashi Kenmoku ,  Tatsuki Fukui

发明人： Tsutomu Honma ,  Etsuko Sugawa ,  Tetsuya Yano ,  Takeshi Imamura ,  Takashi Kenmoku ,  Tatsuki Fukui

IPC分类号： C12P742

CPC分类号： C08G63/06 ,  C08G63/6882 ,  C12P7/625 ,  C12P11/00 ,  Y10S435/874 ,  Y10S435/877

摘要： A polyhydroxyalkanoate (PHA) having a desired configuration is produced using a raw material containing &ohgr;-(4-vinylphenyl)-alkanoic acid and (&ohgr;-substituted alkanoic acid in which a group having a ring structure selected from phenyl, thienyl, and cyclohexyl structures substitutes therefor on the end thereof by producing a PHA copolymer containing the corresponding 3-hydroxy-&ohgr;-(4-vinylphenyl)-alkanoate unit and the corresponding 3-hydroxy-&ohgr;-substituted alkanoate unit by making use of a microorganism capable of producing the PHA or by oxidizing a predetermined portion of the corresponding PHA.

摘要翻译： 使用含有ω-（4-乙烯基苯基） - 链烷酸的原料和（其中具有选自苯基，噻吩基和环己基结构的环结构的基团的（ω-取代的链烷酸）制备具有所需构型的聚羟基链烷酸酯（PHA） 通过制备含有相应的3-羟基-ω-（4-乙烯基苯基） - 烷酸酯单元和相应的3-羟基-ω-取代的链烷酸酯单元的PHA共聚物，通过使用能够产生 或通过氧化相应PHA的预定部分。

公开(公告)号：US06649380B1

公开(公告)日：2003-11-18

申请号：US10373038

申请日：2003-02-26

申请人： Tetsuya Yano ,  Takashi Kenmoku ,  Tsutomu Honma ,  Etsuko Sugawa ,  Tatsuki Fukui ,  Takeshi Imamura

发明人： Tetsuya Yano ,  Takashi Kenmoku ,  Tsutomu Honma ,  Etsuko Sugawa ,  Tatsuki Fukui ,  Takeshi Imamura

IPC分类号： C12P762

CPC分类号： C12P7/625 ,  C08G63/06 ,  C08G63/6882 ,  Y10S435/874

摘要： A method is provided for controlling the molecular weight of a polyhydroxyalkanoate containing at least one of a unit: —[OCH((CH2)mR1)CH2C(O)]— (m=1-8; R1 is a residue having a ring structure of any of phenyl and thienyl structure), and a unit: —[OCH((CH2)kC6H1)R2)CH2C(O)]— (k=0-8; R2 denotes a substituent on the cyclohexyl group including H, CN, NO2, halogen atom, CH3, C2H5, C3H7, CF3, C2F5 or C3F7), wherein a microorganism is cultivated in the presence of a hydroxyl group-containing compound, which is capable of producing the polyhydroxyalkanoate from R3(CH2)qCH2CH2COOH (q=1-8; R3 contains a residue having a ring structure of phenyl or thienyl) or R4C6H10(CH2)rCH2CH2COOH (r=0-8; R4 denotes a substituent on the cyclohexyl group including H, CN, NO2, halogen, CH3, C2H5, C3H7, CF3, C2F5, or C3F7).

摘要翻译： 提供一种控制含有至少一个单元的聚羟基链烷酸酯的分子量的方法： - [OCH（（CH 2）m R 1）CH 2 C（O）] - （m = 1-8; R 1是具有环结构 苯基和噻吩基结构中的任一个取代基）和单位： - [OCH（（CH 2）k C 6 H 1）R 2）CH 2 C（O）] - （k = 0-8; R 2表示环己基上的取代基， NO 2，卤素原子，CH 3，C 2 H 5，C 3 H 7，CF 3，C 2 F 5或C 3 F 7），其中微生物在含羟基化合物存在下培养，其能够由R3（CH2）qCH2CH2COOH（q = 1-8; R3包含具有苯基或噻吩基的环结构的残基）或R4C6H10（CH2）rCH2CH2COOH（r = 0-8; R4表示环己基上的取代基，包括H，CN，NO2，卤素，CH3，C2H5 ，C3H7，CF3，C2F5或C3F7）。

公开(公告)号：US07408017B2

公开(公告)日：2008-08-05

申请号：US11155599

申请日：2005-06-20

申请人： Takeshi Imamura ,  Etsuko Sugawa ,  Tetsuya Yano ,  Tsuyoshi Nomoto ,  Tomohiro Suzuki ,  Tsutomu Honma ,  Takashi Kenmoku ,  Tatsuki Fukui

发明人： Takeshi Imamura ,  Etsuko Sugawa ,  Tetsuya Yano ,  Tsuyoshi Nomoto ,  Tomohiro Suzuki ,  Tsutomu Honma ,  Takashi Kenmoku ,  Tatsuki Fukui

IPC分类号： C08G63/688

CPC分类号： G03G9/08755 ,  C08G63/6882 ,  C12P7/625 ,  C12P11/00 ,  G03G9/08791 ,  G03G9/09733 ,  G03G9/09775

摘要： A polyhydroxyalkanoate is disclosed which has in the molecule a unit represented by Chemical Formula (1). wherein R is arbitrarily selected from a hydrogen atom, a halogen atom, CN, NO2, COOR′, SO2R″, CH3, C2H5, C3H7, C(CH3)2H and C(CH3)3; where R′ is H, Na, K, CH3 or C2H5, and R″ is OH, ONa, OK, a halogen atom, OCH3 or OC2H5; and x is an integer arbitrarily selected from 1 to 8; with the proviso that a polyhydroxyalkanoate is excluded which has a hydrogen atom as R and x in all the units is 2 or 4. Also disclosed is a process for producing the polyhydroxyalkanoate by the use of a microorganism having the ability to produce the polyhydroxyalkanoate and accumulate it in the bacterial body.

摘要翻译： 公开了在分子中具有由化学式（1）表示的单元的聚羟基链烷酸酯。 其中R可以任选地选自氢原子，卤原子，CN，NO 2，COOR'，SO 2 R“，CH 3 C 2 H 3，C 3 H 3，C（CH 3）3 H 3，C 3 H 3， 2）H和C（CH 3 3）3。 其中R'是H，Na，K，CH 3或C 2 H 5，并且R“是OH，ONa，OK， 卤素原子，OCH 3或OC 2 H 5; x是任意选自1至8的整数; 条件是排除了具有氢原子作为R的聚羟基链烷酸酯，并且所有单元中的x均为2或4.还公开了通过使用具有生产聚羟基链烷酸酯的能力的微生物来生产聚羟基链烷酸酯并累积 它在细菌体内。

公开(公告)号：US20050250191A1

公开(公告)日：2005-11-10

申请号：US11155599

申请日：2005-06-20

申请人： Takeshi Imamura ,  Etsuko Sugawa ,  Tetsuya Yano ,  Tsuyoshi Nomoto ,  Tomohiro Suzuki ,  Tsutomu Honma ,  Takashi Kenmoku ,  Tatsuki Fukui

发明人： Takeshi Imamura ,  Etsuko Sugawa ,  Tetsuya Yano ,  Tsuyoshi Nomoto ,  Tomohiro Suzuki ,  Tsutomu Honma ,  Takashi Kenmoku ,  Tatsuki Fukui

IPC分类号： C08G63/688 ,  C12P7/62 ,  C12P11/00 ,  G03G9/087 ,  G03G9/097 ,  C08G63/68

CPC分类号： G03G9/08755 ,  C08G63/6882 ,  C12P7/625 ,  C12P11/00 ,  G03G9/08791 ,  G03G9/09733 ,  G03G9/09775

摘要： A polyhydroxyalkanoate is disclosed which has in the molecule a unit represented by Chemical Formula (1). wherein R is arbitrarily selected from a hydrogen atom, a halogen atom, CN, NO2, COOR′, SO2R″, CH3, C2H5, C3H7, C(CH3)2H and C(CH3)3; where R′ is H, Na, K, CH3 or C2H5, and R″ is OH, ONa, OK, a halogen atom, OCH3 or OC2H5; and x is an integer arbitrarily selected from 1 to 8; with the proviso that a polyhydroxyalkanoate is excluded which has a hydrogen atom as R and x in all the units is 2 or 4. Also disclosed is a process for producing the polyhydroxyalkanoate by the use of a microorganism having the ability to produce the polyhydroxyalkanoate and accumulate it in the bacterial body.

摘要翻译： 公开了在分子中具有由化学式（1）表示的单元的聚羟基链烷酸酯。 其中R可以任选地选自氢原子，卤原子，CN，NO 2，COOR'，SO 2 R“，CH 3 C 2 H 3，C 3 H 3，C（CH 3）3 H 3，C 3 H 3， 2）H和C（CH 3 3）3。 其中R'是H，Na，K，CH 3或C 2 H 5，并且R“是OH，ONa，OK， 卤原子，OCH 3或OC 2 H 5; x是任意选自1至8的整数; 条件是排除了具有氢原子作为R的聚羟基链烷酸酯，并且所有单元中的x均为2或4.还公开了通过使用具有生产聚羟基链烷酸酯的能力的微生物来生产聚羟基链烷酸酯并累积 它在细菌体内。

公开(公告)号：US06911520B2

公开(公告)日：2005-06-28

申请号：US10373851

申请日：2003-02-27

申请人： Tatsuki Fukui ,  Etsuko Sugawa ,  Tetsuya Yano ,  Chieko Mihara ,  Takeshi Imamura ,  Takashi Kenmoku

发明人： Tatsuki Fukui ,  Etsuko Sugawa ,  Tetsuya Yano ,  Chieko Mihara ,  Takeshi Imamura ,  Takashi Kenmoku

IPC分类号： C08G63/06 ,  C08G63/688 ,  C08G63/91 ,  C08L101/16 ,  G03G9/087 ,  G03G9/097 ,  C08G63/02

CPC分类号： C08G63/912 ,  C08G63/06 ,  C08G63/6882 ,  G03G9/08791 ,  G03G9/097 ,  G03G9/09733

摘要： Provided is a polyhydroxyalkanoate containing in a molecule thereof one or more units each selected from the following formulae (1) (2), (3) and (4): wherein R1 and R6 are each OH, halogen, ONa, OK, OCH3 or OC2H5; A1 and J6 are each a substituted or unsubstituted aliphatic hydrocarbon; m and n are each 0 to 7; r is 1 to 500; and R1′ to R5′ are each hydrogen or halogen.

摘要翻译： 提供一种分子中含有一个或多个选自下式（1）（3）和（4）中的单元的聚羟基链烷酸酯：其中R 1和R 6 每个OH，卤素，ONa，OK，OCH 3或OC 2 H 5; A 1和J 6各自为取代或未取代的脂族烃; m和n各自为0至7; r为1〜500; R 1至R 5'各自为氢或卤素。

公开(公告)号：US06908721B2

公开(公告)日：2005-06-21

申请号：US10367951

申请日：2003-02-19

申请人： Takashi Kenmoku ,  Etsuko Sugawa ,  Tetsuya Yano ,  Chieko Mihara ,  Takeshi Imamura ,  Tatsuki Fukui

发明人： Takashi Kenmoku ,  Etsuko Sugawa ,  Tetsuya Yano ,  Chieko Mihara ,  Takeshi Imamura ,  Tatsuki Fukui

IPC分类号： G03G9/097 ,  C08G63/688 ,  C08G63/91 ,  C08L101/16 ,  C12P7/62 ,  C12P11/00 ,  G03G9/087 ,  C08G63/02

CPC分类号： G03G9/08755 ,  C08G63/6882 ,  C08G63/912 ,  C12P7/625 ,  C12P11/00 ,  G03G9/08791

摘要： A polyhydroxyalkanoate comprises a unit of formula (1): —(O—CH((CH2)mSASO2R)CH2C(═O))— wherein R is selected from the group consisting of OH, a halogen atom, ONa, OK, OCH3 and OC2H5; A represents a substituted or unsubstituted aliphatic hydrocarbon structure; m is an integer number selected from 1 to 8; and in the case where a plurality of units exist in the same molecule, R, A and m in one unit can be different from them in another unit respectively. A method of producing the polyhydroxyalkanoate comprises the step of reacting a polyhydroxyalkanoate comprising a unit of formula (18): —(O—CH((CH2)mBr)CH2C(═O))—, wherein m is an integer number selected from 1 to 8, and in the case where a plurality of units exist in the same molecule, m in one unit can be different from that in another unit, with at least one type of compounds of formula (19): HS-A1-SO2R15 wherein R15 is selected from the group consisting of OH, a halogen atom, ONa, OK, OCH3 and OC2H5 and A1 is a substituted or unsubstituted aliphatic hydrocarbon structure, and in the case where a plurality of types of compounds exist in the same molecule, R15 and A1 in one unit can be different from them in another unit respectively.

摘要翻译： 聚羟基链烷酸酯包含式（1）的单元： - （O-CH（（CH 2）2）NH 2 R 2 CH 2 （O）） - 其中R选自OH，卤素原子，ONa，OK，OCH 3和OC 2 可以分别与另一个单元中的不同。