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    System and method for uniaxial compression of an article, such as a three-dimensionally printed dosage form
    2.
    发明申请
    System and method for uniaxial compression of an article, such as a three-dimensionally printed dosage form 有权
    用于单轴压缩制品的系统和方法，例如三维印刷的剂型

    公开(公告)号：US20030143268A1

    公开(公告)日：2003-07-31

    申请号：US10284430

    申请日：2002-10-29

    申请人： Therics, Inc.

    发明人： Wendy E. Pryce Lewis ,  Charles William Rowe ,  Michael J. Cima ,  Peter A. Materna

    IPC分类号： A61K009/20 ,  B27N003/00

    CPC分类号： A61K9/20 ,  A61J3/10 ,  A61K9/2095 ,  B29C64/00 ,  B29C64/165 ,  B29C67/0051 ,  B29C67/0081 ,  B29L2031/753 ,  B33Y70/00 ,  B33Y80/00

    摘要： A uniaxially compressed dosage form manufactured by three-dimensional printing that preserves the predetermined internal architecture of the dosage form while producing an improved surface finish. The compression compacts the dosage form, eliminating at least some of the void space that remains at the end of conventional three-dimensional printing. Surface finish obtained as a result of the uniaxial compression process can be essentially equal to that obtained from conventional tablet pressing. Additionally, the internal structure or spatial variation of composition of the dosage form is preserved during the pressing operation, with geometric shrinkage occurring mostly in the direction of the axis of pressing. Further, as a result of compression, a greater quantity of API can be packed into a given final volume of dosage form.

    摘要翻译： 通过三维印刷制造的单轴压缩剂型，其保持了剂型的预定内部结构，同时产生改进的表面光洁度。 压缩压缩剂型，消除了在传统三维印刷结束时保留的至少一些空隙空间。 作为单轴压缩方法的结果获得的表面光洁度可以基本上等于从常规压片获得的表面光洁度。 此外，在压制操作期间保留了剂型的组成的内部结构或空间变化，几何收缩主要发生在按压轴的方向上。 此外，作为压缩的结果，可以将更大量的API包装在给定的最终体积的剂型中。

    Method and system for controlling the temperature of a dispensed liquid
    3.
    发明申请
    Method and system for controlling the temperature of a dispensed liquid 有权
    用于控制分配液体的温度的方法和系统

    公开(公告)号：US20030128267A1

    公开(公告)日：2003-07-10

    申请号：US10284425

    申请日：2002-10-29

    申请人： Therics, Inc.

    发明人： Patrick Teung ,  Michael J. Cima ,  Timothy J. Pryor ,  Peter A. Materna

    IPC分类号： B41J002/41

    CPC分类号： B01L3/0268 ,  B01L3/0265 ,  B01L2200/147 ,  B01L2300/1805 ,  B01L2300/1827 ,  B01L2400/0439 ,  B01L2400/0487 ,  B01L2400/0633 ,  B33Y40/00 ,  B41J2/02 ,  B41J2/04528 ,  B41J2/04563 ,  B41J29/377 ,  B41J2002/022 ,  G05D23/1919

    摘要： A device for controlling or altering the temperature of a liquid at the point of dispensing. A temperature-altering device is thermally coupled to a dispensing device to compensate for heat dissipated into the liquid as it passes through the dispensing device during dispensing. The dispensing device may be for example, a miniature solenoid valve (microvalve), a piezoelectric printhead, or the like. According to aspects of the invention, a temperature-altering device provides or reduces heat at the point of dispensing in order to alter, control or maintain a constant temperature of the dispensed liquid. As a result, improvement is obtained in the consistency of the fluid regime of the dispensed droplet stream. The temperature-altering device may be a thermoelectric device capable of moving heat either from or to the dispensing structure, or may be a heater. This device may be used beneficially even when the dispensing is performed near room temperature and the liquid does not require heating to maintain its liquid state.

    摘要翻译： 用于在分配点控制或改变液体的温度的装置。 温度改变装置热耦合到分配装置以补偿在分配期间通过分配装置时散失到液体中的热量。 分配装置可以是例如微型电磁阀（微型阀），压电打印头等。 根据本发明的方面，改变温度的装置在分配点处提供或减少热量，以便改变，控制或维持所分配液体的恒定温度。 结果，在分配的液滴流的流体状态的一致性方面获得了改进。 温度改变装置可以是能够从分配结构移动热量的热电装置，也可以是加热器。 即使当在室温附近进行分配并且液体不需要加热以保持其液体状态时，该装置也可以有利地使用。

    Method and apparatus for dispensing small volume of liquid, such as with a weting-resistant nozzle
    6.
    发明申请
    Method and apparatus for dispensing small volume of liquid, such as with a weting-resistant nozzle 审中-公开
    用于分配小体积液体的方法和装置，例如具有耐弯曲喷嘴

    公开(公告)号：US20020084290A1

    公开(公告)日：2002-07-04

    申请号：US10012102

    申请日：2001-11-13

    申请人： Therics, Inc.

    发明人： Peter A. Materna

    IPC分类号： B65D047/18

    CPC分类号： B01L3/0241 ,  B01L2300/166 ,  B05B1/00 ,  B05B13/0228 ,  B05C5/0212 ,  B05C13/025 ,  B41J2/14

    摘要： A wetting-resistant nozzle for accurately and precisely dispensing small volumes of liquids. The nozzle comprises an internal flowpath, and an external surface that recedes from the discharge point at an angle greater than 90 degrees, and an exceptionally low surface energy for the external surface. The low surface energy material may exist as a coating on top of a shaped substrate. A flat land region may be included and may have sharp edges, one of which may define the boundary of the low surface energy region. Another embodiment includes the low surface energy material as a bulk material through which a hole is drilled. The internal flowpath inside the nozzle may be smoothly tapered. Liquid being dispensed tends not to advance past the edge of the low surface energy region, which may coincide with a geometrically sharp edge. Such nozzles provide improved dispensing of liquids that have both low surface tension and low viscosity, such as organic solvents.

    摘要翻译： 一种防湿喷嘴，用于精确和精确地分配少量液体。 喷嘴包括内部流路，以及以大于90度的角度从排出点后退的外表面，以及外表面的极低的表面能。 低表面能材料可以作为成形基底顶部的涂层存在。 可以包括平坦的区域区域并且可以具有尖锐的边缘，其中一个可以限定低表面能区域的边界。 另一个实施例包括作为大量材料的低表面能材料，通过该材料钻出孔。 喷嘴内的内部流路可以平滑地渐缩。 分配的液体往往不会超过低表面能区域的边缘，这可能与几何锋利的边缘重合。 这种喷嘴提供了具有低表面张力和低粘度的液体的改进分配，例如有机溶剂。

    System for manufacturing controlled release dosage forms, such as a zero-order release profile dosage form manufactured by three-dimensional printing
    8.
    发明申请
    System for manufacturing controlled release dosage forms, such as a zero-order release profile dosage form manufactured by three-dimensional printing 有权
    用于制造控制释放剂型的系统，例如通过三维印刷制造的零级释放曲线剂型

    公开(公告)号：US20030198677A1

    公开(公告)日：2003-10-23

    申请号：US10284039

    申请日：2002-10-29

    申请人： Therics, Inc.

    发明人： Wendy E. Pryce Lewis ,  Charles William Rowe ,  Michael J. Cima ,  Peter A. Materna

    IPC分类号： A61K009/24

    CPC分类号： A61K9/2893 ,  A61J3/10 ,  A61K9/2018 ,  A61K9/2027 ,  A61K9/2054 ,  A61K9/209 ,  A61K9/2095 ,  B33Y70/00 ,  B33Y80/00

    摘要： The present invention includes controlled release dosage forms and methods of designing and manufacturing dosage forms to obtain specific release profiles, for example, zero-order release profiles, escalating release profiles or decreasing release profiles. The dosage forms of the present invention can include spatial variation of API concentration in the dosage form and can include nested regions. Dosage forms according to the present invention may be manufactured by any appropriate method for obtaining the internal structure as disclosed herein for producing zero-order release profiles and increasing or decreasing release profiles. The invention further includes methods of manufacturing such dosage forms, such as by three-dimensional printing, possibly also including compression of the dosage form after three-dimensional printing. The invention further includes methods of designing such dosage forms. Release profiles from non-uniform distributions of API concentration may be predicted based on simple experiments with uniform-concentration dosage forms.

    摘要翻译： 本发明包括控制释放剂型和设计和制造剂型以获得特定释放特征的方法，例如零级释放曲线，升级释放曲线或减少释放曲线。 本发明的剂型可以包括剂型中API浓度的空间变化，并且可以包括嵌套区域。 根据本发明的剂型可以通过用于获得本文公开的用于产生零级释放曲线和增加或减少释放曲线的内部结构的任何适当方法来制造。 本发明还包括制造这种剂型的方法，例如通过三维印刷，可能还包括在三维印刷后压制剂型。 本发明还包括设计这种剂型的方法。 可以基于使用均匀浓度剂型的简单实验来预测API浓度不均匀分布的释放曲线。