公开(公告)号：US10100939B2

公开(公告)日：2018-10-16

申请号：US15172453

申请日：2016-06-03

Applicant: The University of Tokyo ,  Nikon Corporation

Inventor： Takanori Ichiki ,  Masashi Kobayashi ,  Shotaro Terane ,  Kuno Suzuki

IPC: B01L99/00 ,  B01L3/00 ,  F16K7/12 ,  F16K7/17 ,  B23P15/00 ,  F04B43/02 ,  F16K99/00

Abstract: A valve disposed at a flow path includes: a substrate having a first surface in which a hole having an opening section is formed; and a diaphragm member fixed to at least part of a wall surface of the hole and in which at least a central portion has a thin film shape, wherein a flow of a fluid in the flow path is controlled by deforming the diaphragm member.

公开(公告)号：US11642636B2

公开(公告)日：2023-05-09

申请号：US16216299

申请日：2018-12-11

Applicant: The University of Tokyo ,  Nikon Corporation

Inventor： Takanori Ichiki ,  Taro Ueno ,  Shoichi Tsuchiya ,  Masashi Kobayashi ,  Kenji Miyamoto

IPC: B01F25/54 ,  B01F23/451 ,  B01F25/51 ,  B01F33/30 ,  B01F35/75 ,  G01N1/38 ,  G01N35/00 ,  B01L3/00

CPC classification number: B01F25/54 ,  B01F23/451 ,  B01F25/51 ,  B01F33/30 ,  B01F35/7547 ,  B01L3/5027 ,  B01L2300/0867 ,  G01N2001/386 ,  G01N2035/00158

Abstract: A solution mixer comprising: a main flow path in which a solution circulates; at least one solution introduction flow path connected to the main flow path; and at least one solution discharge flow path connected to the main flow path, wherein the solution discharge flow path has at least one solution discharge flow path valve, and wherein the main flow path has at least one main flow path valve.

公开(公告)号：US10301682B2

公开(公告)日：2019-05-28

申请号：US15080266

申请日：2016-03-24

Applicant: The University of Tokyo ,  Nikon Corporation

Inventor： Takanori Ichiki ,  Masashi Kobayashi ,  Ayako Hayashi ,  Shoichi Tsuchiya ,  Takanori Akagi ,  Taro Ueno ,  Takashi Funatsu ,  Kenji Miyamoto

IPC: C12Q1/6886 ,  G01N33/53 ,  B01L3/00 ,  C12Q1/6806

Abstract: The present invention provides a fluidic device, an exosome analysis method, a biomolecule analysis method, and a biomolecule detection method, which can analyze even the content of an exosome in a series of flows by introducing a sample into the device. A fluidic device of the present invention is a fluidic device which detects a biomolecule contained in an exosome in a sample, and includes: an exosome purification unit which has a layer modified with a compound having a hydrophobic chain and a hydrophilic chain; a biomolecule purification unit; a biomolecule detection unit; a first flow path which connects the exosome purification unit to the biomolecule purification unit; and a second flow path which connects the biomolecule purification unit to the biomolecule detection unit.