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公开(公告)号：US11097267B2
公开(公告)日：2021-08-24
申请号：US16062724
申请日：2016-12-14
发明人： Sagar Yadavali , David Issadore , Daeyeon Lee
摘要： A microfluidic device includes at least one substrate formed of one or more silicon wafers. The substrate includes an inlet for receiving a continuous phase fluid; an inlet for receiving a dispersed phase fluid; and a plurality of channels. The plurality of channels are in fluid communication with both the inlet of the continuous phase fluid and the inlet of the dispersed phase fluid. The substrate further includes a plurality of droplet generators configured to produce microdroplets. Each of the droplet generators are in fluid communication with the plurality of channels. Additionally, the substrate includes one or more outlets for delivery of the microdroplets. The number of the plurality of droplet generators is more than two greater than a number of the one or more outlets for delivery of the microdroplets.
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公开(公告)号：US20190275523A1
公开(公告)日：2019-09-12
申请号：US16359368
申请日：2019-03-20
摘要： A microfluidic device contains a first layer having a plurality of channels, a second layer having a plurality of droplet makers, and a third layer having a plurality of through-holes connecting the plurality of channels to the plurality of droplet makers. The channels have a height of at least 4 times greater than the height of the droplet makers. The microfluidic device has at least 500 droplet makers in an area less than 10 cm2. The channels are formed by direct laser-micromachining and the droplet makers are formed by soft lithography molding.
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公开(公告)号：US11794187B2
公开(公告)日：2023-10-24
申请号：US16359368
申请日：2019-03-20
CPC分类号： B01L3/502784 , B01F23/41 , B01F33/3011 , B01F33/813 , B01F35/10 , B01L3/502707 , B01L2200/027 , B01L2200/0673 , B01L2200/12 , B01L2300/0887 , B01L2300/0893
摘要： A microfluidic device contains a first layer having a plurality of channels, a second layer having a plurality of droplet makers, and a third layer having a plurality of through-holes connecting the plurality of channels to the plurality of droplet makers. The channels have a height of at least 4 times greater than the height of the droplet makers. The microfluidic device has at least 500 droplet makers in an area less than 10 cm2. The channels are formed by direct laser-micromachining and the droplet makers are formed by soft lithography molding.
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公开(公告)号：US11786914B2
公开(公告)日：2023-10-17
申请号：US15768286
申请日：2016-10-04
发明人： David Issadore , Venkata Yelleswarapu , Jina Ko
IPC分类号： B03C1/28 , B03C1/01 , G01N33/574 , B03C1/032 , B03C1/034 , G01N33/543
CPC分类号： B03C1/288 , B03C1/01 , B03C1/032 , B03C1/034 , G01N33/5434 , G01N33/54333 , G01N33/574 , B01L2300/0681 , B03C2201/18 , B03C2201/26
摘要： A magnetic separation filter has an unsupported magnetically soft material layer having a plurality of pores, and, optionally, a passivation layer disposed on the magnetically soft material layer. The magnetic separation filter may be part of a microfluidic device having a lateral flow channel and a vertical flow magnetic separation filter. The magnetic separation device may be used to separate magnetically tagged particles, such as cells.
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公开(公告)号：US20220184613A1
公开(公告)日：2022-06-16
申请号：US17380486
申请日：2021-07-20
发明人： Sagar Yadavali , David Issadore , Daeyeon Lee
IPC分类号： B01L3/00 , B05B1/08 , B01F23/41 , B01F25/314 , B01F33/81 , B01F33/3011
摘要： A microfluidic device includes at least one substrate formed of one or more silicon wafers. The substrate includes an inlet for receiving a continuous phase fluid; an inlet for receiving a dispersed phase fluid; and a plurality of channels. The plurality of channels are in fluid communication with both the inlet of the continuous phase fluid and the inlet of the dispersed phase fluid. The substrate further includes a plurality of droplet generators configured to produce microdroplets. Each of the droplet generators are in fluid communication with the plurality of channels. Additionally, the substrate includes one or more outlets for delivery of the microdroplets. The number of the plurality of droplet generators is more than two greater than a number of the one or more outlets for delivery of the microdroplets.
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公开(公告)号：US20160001290A1
公开(公告)日：2016-01-07
申请号：US14790083
申请日：2015-07-02
发明人： David Issadore , Jin A. Ko
CPC分类号： B01J13/06
摘要： A microfluidic device includes a substrate and a microfluidic channel embedded in the substrate. The microfluidic channel includes a plurality of fluid inlets, at least one waste outlet, at least one vesicle outlet, a flow junction joining the at least one vesicle outlet and the at least one waste outlet in fluid communication, the flow junction having a fluid flow path that is orthogonal to the plane of the substrate, and at least one membrane between the at least one vesicle outlet and the at least one waste outlet configured to intercept a portion of the fluid flow path.
摘要翻译： 微流体装置包括衬底和嵌入衬底中的微流体通道。 微流体通道包括多个流体入口，至少一个废物出口，至少一个囊泡出口，连接至少一个囊泡出口的流动连接点和流体连通的至少一个废物出口，该流动接头具有流体流动 所述至少一个囊泡出口与所述至少一个废物出口之间的至少一个膜被构造成拦截所述流体流动路径的一部分。
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7.发明公开公开(公告)号：US20240238802A1
公开(公告)日：2024-07-18
申请号：US18365318
申请日：2023-08-04
发明人： David Issadore , Venkata Yelleswarapu , Jina Ko
IPC分类号： B03C1/28 , B03C1/01 , B03C1/032 , B03C1/034 , G01N33/543 , G01N33/574
CPC分类号： B03C1/288 , B03C1/01 , B03C1/032 , B03C1/034 , G01N33/54333 , G01N33/5434 , G01N33/574 , B01L2300/0681 , B03C2201/18 , B03C2201/26
摘要： A magnetic separation filter has an unsupported magnetically soft material layer having a plurality of pores, and, optionally, a passivation layer disposed on the magnetically soft material layer. The magnetic separation filter may be part of a microfluidic device having a lateral flow channel and a vertical flow magnetic separation filter. The magnetic separation device may be used to separate magnetically tagged particles, such as cells.
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公开(公告)号：US10473590B2
公开(公告)日：2019-11-12
申请号：US15503592
申请日：2015-08-14
摘要： Microfluidic devices for analyzing droplets are disclosed. A described microfluidic device includes a substrate and a microfluidic channel formed on the substrate. The microfluidic channel includes passages where each passage has a mask pattern configured to modulate a signal of a droplet passing through that passage, such that droplets passing through the passages produce signals. The microfluidic device also includes a detector configured to detect the signals. Methods of analyzing droplets with a microfluidic device having a microfluidic channel formed on a substrate are disclosed. A described method includes passing droplets through the passages, modulating signals from the droplets using mask patterns, formed on the passages; and detecting the signals.
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公开(公告)号：US10335789B2
公开(公告)日：2019-07-02
申请号：US14907720
申请日：2014-07-23
IPC分类号： B03C1/00 , B01L99/00 , B01L3/00 , B03C1/035 , B03C1/28 , G01N33/569 , G01N33/574
摘要： A magnetic separation device has a membrane having a plurality of pores, a magnetically soft material layer disposed on the membrane, and a passivation layer disposed on the magnetically soft material layer. The magnetic separation device may be part of a microfluidic device having a lateral flow channel and a vertical flow magnetic separation filter. The magnetic separation device may be used to separate magnetically tagged particles, such as cells.
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10.发明授权公开(公告)号：US11498070B2
公开(公告)日：2022-11-15
申请号：US17040120
申请日：2019-03-21
IPC分类号： B01L3/00
摘要： Microfluidic devices having a construct formed from perfluoropolyether and poly(ethylene glycol) diacrylate. The construct includes an inlet for receiving a continuous phase fluid, an inlet for receiving a dispersed phase fluid, and a plurality of channels extending through the construct. The plurality of channels are in fluid communication with both the inlet of the continuous phase fluid and the inlet of the dispersed phase fluid. The construct further includes a plurality of microdroplet generators configured to produce microdroplets, each of the microdroplet generators in fluid communication with the plurality of channels. Additionally, the construct includes an outlet formed in the construct and in fluid connection with the plurality of microdroplet generators.
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