公开(公告)号：US20210317532A1

公开(公告)日：2021-10-14

申请号：US17091658

申请日：2020-11-06

Applicant: The Johns Hopkins University ,  Duke University

Inventor： Bert Vogelstein ,  Kenneth W. Kinzler ,  D. Williams Parsons ,  Xiaosong Zhang ,  Jimmy Cheng-Ho Lin ,  Rebecca J. Leary ,  Philipp Angenendt ,  Nickolas Papadopoulos ,  Victor Velculescu ,  Giovanni Parmigiani ,  Rachel Karchin ,  Sian Jones ,  Hai Yan ,  Darell Bigner ,  Chien-Tsun Kuan ,  Gregory J. Riggins

IPC: C12Q1/6886

Abstract: We found mutations of the R132 residue of isocitrate dehydrogenase 1 (IDH1) in the majority of grade II and III astrocytomas and oligodendrogliomas as well as in gliblastomas that develop from these lower grade lesions. Those tumors without mutations in IDH1 often had mutations at the analogous R172 residue of the closely related IDH2 gene. These findings have important implications for the pathogenesis and diagnosis of malignant gliomas.

公开(公告)号：US20180282821A1

公开(公告)日：2018-10-04

申请号：US15928811

申请日：2018-03-22

Applicant: The Johns Hopkins University ,  Duke University

Inventor： Bert Vogelstein ,  Kenneth W. Kinzler ,  D. Williams Parsons ,  Xiaosong Zhang ,  Jimmy Cheng-Ho Lin ,  Rebecca J. Leary ,  Philipp Angenendt ,  Nickolas Papadopoulos ,  Victor Velculescu ,  Giovanni Parmigiani ,  Rachel Karchin ,  Sian Jones ,  Hai Yan ,  Darell Bigner ,  Chien-Tsun Kuan ,  Gregory J. Riggins

IPC: C12Q1/6886

Abstract: We found mutations of the R132 residue of isocitrate dehydrogenase 1 (IDH1) in the majority of grade II and III astrocytomas and oligodendrogliomas as well as in gliblastomas that develop from these lower grade lesions. Those tumors without mutations in IDH1 often had mutations at the analogous R172 residue of the closely related IDH2 gene. These findings have important implications for the pathogenesis and diagnosis of malignant gliomas.

公开(公告)号：US20190106752A1

公开(公告)日：2019-04-11

申请号：US16132928

申请日：2018-09-17

Applicant: The Johns Hopkins University ,  Duke University

Inventor： Bert Vogelstein ,  Kenneth W. Kinzler ,  D. Williams Parsons ,  Xiaosong Zhang ,  Jimmy Cheng-Ho Lin ,  Rebecca J. Leary ,  Philipp Angenendt ,  Nickolas Papadopoulos ,  Victor Velculescu ,  Giovanni Parmigiani ,  Rachel Karchin ,  Sian Jones ,  Hai Yan ,  Darell Bigner ,  Chien-Tsun Kuan ,  Gregory J. Riggins

IPC: C12Q1/6886

Abstract: We found mutations of the R132 residue of isocitrate dehydrogenase 1 (IDH1) in the majority of grade II and III astrocytomas and oligodendrogliomas as well as in gliblastomas that develop from these lower grade lesions. Those tumors without mutations in IDH1 often had mutations at the analogous R172 residue of the closely related IDH2 gene. These findings have important implications for the pathogenesis and diagnosis of malignant gliomas.

公开(公告)号：US09926606B2

公开(公告)日：2018-03-27

申请号：US14960681

申请日：2015-12-07

Applicant: The Johns Hopkins University

Inventor： Alberto Bardelli ,  D. Williams Parsons ,  Victor Velculescu ,  Kenneth W. Kinzler ,  Bert Vogelstein

IPC: C12Q1/00 ,  C12Q1/68 ,  C12N9/12 ,  C12Q1/48 ,  G01N33/574 ,  C12Q1/02 ,  A61K31/506

CPC classification number: C12Q1/6886 ,  A61K31/506 ,  C12N9/1205 ,  C12Q1/025 ,  C12Q1/485 ,  C12Q1/6809 ,  C12Q1/6827 ,  C12Q2600/136 ,  C12Q2600/156 ,  G01N33/574

Abstract: Protein kinases are important signaling molecules involved in tumorigenesis. Mutational analysis of the human tyrosine kinase gene family (98 genes) identified somatic alterations in ˜20% of colorectal cancers, with the majority of mutations occurring in NTRK3, FES, GUCY2F and a previously uncharacterized tyrosine kinase gene called MCCK/MLK4. Most alterations were in conserved residues affecting key regions of the kinase domain. These data represent a paradigm for the unbiased analysis of signal transducing genes in cancer and provide useful targets for therapeutic intervention.

公开(公告)号：US20170081730A1

公开(公告)日：2017-03-23

申请号：US15353002

申请日：2016-11-16

Applicant: The Johns Hopkins University ,  Duke University

Inventor： Bert Vogelstein ,  Kenneth W. Kinzler ,  D. Williams Parsons ,  Xiaosong Zhang ,  Jimmy Cheng-Ho Lin ,  Rebecca J. Leary ,  Philipp Angenendt ,  Nickolas Papadopoulos ,  Victor Velculescu ,  Giovanni Parmigiani ,  Rachel Karchin ,  Sian Jones ,  Hai Yan ,  Darell D. Bigner ,  Chien-Tsun Kuan ,  Gregory J. Riggins

IPC: C12Q1/68

CPC classification number: C12Q1/6886 ,  C12Q2600/112 ,  C12Q2600/118 ,  C12Q2600/136 ,  C12Q2600/156

Abstract: We found mutations of the R132 residue of isocitrate dehydrogenase 1 (IDH1) in the majority of grade II and III astrocytomas and oligodendrogliomas as well as in glioblastomas that develop from these lower grade lesions. Those tumors without mutations in IDH1 often had mutations at the analogous R172 residue of the closely related IDH2 gene. These findings have important implications for the pathogenesis and diagnosis of malignant gliomas.

公开(公告)号：US09353418B2

公开(公告)日：2016-05-31

申请号：US14102730

申请日：2013-12-11

Applicant: The Johns Hopkins University ,  Duke University

Inventor： Bert Vogelstein ,  Kenneth W. Kinzler ,  D. Williams Parsons ,  Xiaosong Zhang ,  Jimmy Cheng-Ho Lin ,  Rebecca J. Leary ,  Philipp Angenendt ,  Nickolas Papadopoulos ,  Victor Velculescu ,  Giovanni Parmigiani ,  Rachel Karchin ,  Sian Jones ,  Hai Yan ,  Darell Bigner ,  Chien-Tsun Kuan ,  Gregory J. Riggins

IPC: C07H21/04 ,  C12Q1/68

CPC classification number: C12Q1/6886 ,  C12Q2600/112 ,  C12Q2600/118 ,  C12Q2600/136 ,  C12Q2600/156

Abstract: We found mutations of the R132 residue of isocitrate dehydrogenase 1 (IDH1) in the majority of grade II and III astrocytomas and oligodendrogliomas as well as in glioblastomas that develop from these lower grade lesions. Those tumors without mutations in IDH1 often had mutations at the analogous R172 residue of the closely related IDH2 gene. These findings have important implications for the pathogenesis and diagnosis of malignant gliomas.

Abstract translation: 我们发现大多数II级和III级星形细胞瘤和少突胶质细胞瘤中异柠檬酸脱氢酶1（IDH1）的R132残基突变以及从这些较低级别病变发展的成胶质细胞瘤。 那些没有IDH1突变的肿瘤在紧密相关的IDH2基因的类似R172残基中经常具有突变。 这些发现对恶性胶质瘤的发病机制和诊断具有重要意义。

公开(公告)号：US09206467B2

公开(公告)日：2015-12-08

申请号：US13746376

申请日：2013-01-22

Applicant: The Johns Hopkins University

Inventor： Alberto Bardelli ,  D. Williams Parsons ,  Victor Velculescu ,  Kenneth W. Kinzler ,  Bert Vogelstein

IPC: G01N33/15 ,  C12Q1/48 ,  C12N9/12 ,  C12Q1/68 ,  G01N33/574 ,  C12Q1/02

CPC classification number: C12Q1/6886 ,  A61K31/506 ,  C12N9/1205 ,  C12Q1/025 ,  C12Q1/485 ,  C12Q1/6809 ,  C12Q1/6827 ,  C12Q2600/136 ,  C12Q2600/156 ,  G01N33/574

Abstract: Protein kinases are important signaling molecules involved in tumorigenesis. Mutational analysis of the human tyrosine kinase gene family (98 genes) identified somatic alterations in −20% of colorectal cancers, with the majority of mutations occurring in NTRK3, FES, GUCY2F and a previously uncharacterized tyrosine kinase gene called MCCK/MLK4. Most alterations were in conserved residues affecting key regions of the kinase domain. These data represent a paradigm for the unbiased analysis of signal transducing genes in cancer and provide useful targets for therapeutic intervention.

Abstract translation: 蛋白激酶是参与肿瘤发生的重要信号分子。 人类酪氨酸激酶基因家族（98个基因）的突变分析鉴定了-20％的结肠直肠癌的体细胞变化，大部分突变发生在NTRK3，FES，GUCY2F和以前称为MCCK / MLK4的未表征的酪氨酸激酶基因。 大多数改变是保守的残基影响激酶结构域的关键区域。 这些数据代表了癌症中信号转导基因的无偏见分析的范例，并为治疗干预提供了有用的目标。

公开(公告)号：US20240344137A1

公开(公告)日：2024-10-17

申请号：US18518055

申请日：2023-11-22

Applicant: The Johns Hopkins University

Inventor： Tobias Sjoblom ,  Sian Jones ,  D. Williams Parsons ,  Laura D. Wood ,  Jimmy Cheng-Ho Lin ,  Thomas Barber ,  Diana Mandelker ,  Bert Vogelstein ,  Kenneth W. Kinzler ,  Victor E. Velculesu

IPC: C12Q1/6886

CPC classification number: C12Q1/6886 ,  C12Q2600/106 ,  C12Q2600/156

Abstract: Analysis of 13,023 genes in 11 breast and 11 colorectal cancers revealed that individual tumors accumulate an average of ˜90 mutant genes but that only a subset of these contribute to the neoplastic process. Using stringent criteria to delineate this subset, we identified 189 genes (average of 11 per tumor) that were mutated at significant frequency. The vast majority of these genes were not known to be genetically altered in tumors and are predicted to affect a wide range of cellular functions, including transcription, adhesion, and invasion. These data define the genetic landscape of two human cancer types, provide new targets for diagnostic and therapeutic intervention and monitoring.

公开(公告)号：US10704108B2

公开(公告)日：2020-07-07

申请号：US16132928

申请日：2018-09-17

Applicant: The Johns Hopkins University ,  Duke University

Inventor： Bert Vogelstein ,  Kenneth W. Kinzler ,  D. Williams Parsons ,  Xiaosong Zhang ,  Jimmy Cheng-Ho Lin ,  Rebecca J. Leary ,  Philipp Angenendt ,  Nickolas Papadopoulos ,  Victor Velculescu ,  Giovanni Parmigiani ,  Rachel Karchin ,  Sian Jones ,  Hai Yan ,  Darell Bigner ,  Chien-Tsun Kuan ,  Gregory J. Riggins

IPC: C12Q1/68 ,  A61K31/00 ,  C12Q1/6886

Abstract: We found mutations of the R132 residue of isocitrate dehydrogenase 1 (IDH1) in the majority of grade II and III astrocytomas and oligodendrogliomas as well as in gliblastomas that develop from these lower grade lesions. Those tumors without mutations in IDH1 often had mutations at the analogous R172 residue of the closely related IDH2 gene. These findings have important implications for the pathogenesis and diagnosis of malignant gliomas.

公开(公告)号：US20240392381A1

公开(公告)日：2024-11-28

申请号：US18629488

申请日：2024-04-08

Applicant: The Johns Hopkins University ,  Duke University

Inventor： Bert Vogelstein ,  Kenneth W. Kinzler ,  D. Williams Parsons ,  Xiaosong Zhang ,  Jimmy Cheng-Ho Lin ,  Rebecca J. Leary ,  Philipp Angenendt ,  Nickolas Papadopoulos ,  Victor Velculescu ,  Giovanni Parmigiani ,  Rachel Karchin ,  Sian Jones ,  Hai Yan ,  Darell Bigner ,  Chien-Tsun Kuan ,  Gregory J. Riggins

IPC: C12Q1/6886 ,  G16B20/20 ,  G16B40/20

Abstract: We found mutations of the R132 residue of isocitrate dehydrogenase 1 (IDH1) in the majority of grade II and III astrocytomas and oligodendrogliomas as well as in gliblastomas that develop from these lower grade lesions. Those tumors without mutations in IDH1 often had mutations at the analogous R172 residue of the closely related IDH2 gene. These findings have important implications for the pathogenesis and diagnosis of malignant gliomas.