公开(公告)号：US20240344137A1

公开(公告)日：2024-10-17

申请号：US18518055

申请日：2023-11-22

Applicant: The Johns Hopkins University

Inventor： Tobias Sjoblom ,  Sian Jones ,  D. Williams Parsons ,  Laura D. Wood ,  Jimmy Cheng-Ho Lin ,  Thomas Barber ,  Diana Mandelker ,  Bert Vogelstein ,  Kenneth W. Kinzler ,  Victor E. Velculesu

IPC: C12Q1/6886

CPC classification number: C12Q1/6886 ,  C12Q2600/106 ,  C12Q2600/156

Abstract: Analysis of 13,023 genes in 11 breast and 11 colorectal cancers revealed that individual tumors accumulate an average of ˜90 mutant genes but that only a subset of these contribute to the neoplastic process. Using stringent criteria to delineate this subset, we identified 189 genes (average of 11 per tumor) that were mutated at significant frequency. The vast majority of these genes were not known to be genetically altered in tumors and are predicted to affect a wide range of cellular functions, including transcription, adhesion, and invasion. These data define the genetic landscape of two human cancer types, provide new targets for diagnostic and therapeutic intervention and monitoring.