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公开(公告)号：US07432110B2
公开(公告)日：2008-10-07
申请号：US11659952
申请日：2005-08-04
Applicant: Yuji Kikuchi , Mitsutoshi Nakajima , Taiji Nishi , Motohiro Fukuda
Inventor： Yuji Kikuchi , Mitsutoshi Nakajima , Taiji Nishi , Motohiro Fukuda
IPC: G01N1/18
CPC classification number: B01L3/502761 , B01F3/0807 , B01F5/0453 , B01F5/0456 , B01F13/0059 , B01L3/502707 , B01L2200/0668 , B01L2300/0816 , C12M23/16 , Y10T436/25375
Abstract: A microchannel array according to the present invention includes a first substrate 1, and a second substrate 11 bonded to the first substrate 1. Two sets, that is, a set of a first through-hole 9, a first recess 7, and a first groove 8 and a set of a second through-hole 4, a second recess 2, and a second groove 3 are formed on the first substrate 1. The different sets are separated by a partition 5. A cell differentation/proliferation speed after micro-injection can be increased by using such microchannel array.
Abstract translation: 根据本发明的微通道阵列包括第一基板1和结合到第一基板1的第二基板11。 两组，即一组第一通孔9，第一凹槽7和第一凹槽8以及一组第二通孔4，第二凹槽2和第二凹槽3形成在 第一基板1。 不同的集合由分区5分隔。 通过使用这种微通道阵列可以增加微注射后的细胞分化/增殖速度。
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公开(公告)号：US08435782B2
公开(公告)日：2013-05-07
申请号：US12280607
申请日：2007-02-19
Applicant: Taiji Nishi , Go Tazaki , Motohiro Fukuda , Michio Yazawa , Masayuki Takahashi
Inventor： Taiji Nishi , Go Tazaki , Motohiro Fukuda , Michio Yazawa , Masayuki Takahashi
IPC: C12M1/14
CPC classification number: C12M23/12 , B01L3/5085 , B01L3/5088 , B01L2300/0829 , B01L2300/0851 , B01L2300/0858 , B01L2300/0893 , C12M25/00
Abstract: An object of the present invention is to provide a cell culture chamber with which the survival rate of cells to be cultured can be increased, and a method of producing the same. A cell culture chamber according to the present invention includes a mass of projections formed of a plurality of microprojections 1 formed on a surface on which cells are cultured. The width or diameter of each of the microprojections 1 is in a range of 20 nm to 3 μm, and the aspect ratio of each of the microprojections is in a range of 0.2 to 3.0. Thus, there can be provided a cell culture chamber most suitable for the adhesion and differentiation/proliferation of cells to be cultured.
Abstract translation: 本发明的目的是提供一种能够提高培养细胞存活率的细胞培养室及其制造方法。 根据本发明的细胞培养室包括由在其上培养细胞的表面上形成的多个微突出物1形成的突起体。 每个微喷射体1的宽度或直径在20nm至3μm的范围内，并且每个微喷射体的纵横比在0.2至3.0的范围内。 因此，可以提供最适合于待培养细胞的粘附和分化/增殖的细胞培养室。
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3.发明申请MICROCHANNEL ARRAY AND METHOD FOR PRODUCING THE SAME, AND BLOOD MEASURING METHOD EMPLOYING IT 审中-公开MICROCHANNEL ARRAY AND METHOD FOR PRODUCTION THE SAME，和BLOOD MEASURING METHODWORKING IT公开(公告)号：US20090149345A1
公开(公告)日：2009-06-11
申请号：US11908047
申请日：2006-03-01
Applicant: Taiji Nishi , Motohiro Fukuda , Go Tazaki , Seiichi Kanai , Takenori Kitani , Naoto Fukuhara
Inventor： Taiji Nishi , Motohiro Fukuda , Go Tazaki , Seiichi Kanai , Takenori Kitani , Naoto Fukuhara
CPC classification number: G01N33/80 , B01L3/502707 , B01L3/502746 , B01L2300/0681 , B01L2300/0816 , G01N33/56972
Abstract: A microchannel array, a method of manufacturing the same, and a blood test method. The microchannel array is formed by joining first and second substrates, each including a fluid inlet and outlet on their surfaces. An internal space structure connects the fluid inlet and outlet, and includes an upstream flow channel connected with the fluid inlet, a downstream flow channel connected with the fluid outlet with a gap therebetween, and a micro flow channel connecting the upstream and downstream flow channels. A minimum distance from a center of a sectional surface of the micro flow channel to a side wall of the micro flow channel is smaller than that of the upstream and downstream flow channels. Each surface of the first and second substrates includes grooves for creating the upstream and downstream flow channels, and the surface of the second substrate has grooves for creating the micro flow channel.
Abstract translation: 微通道阵列，其制造方法和血液检查方法。 微通道阵列通过接合第一和第二基底而形成，每个基底在其表面上包括流体入口和出口。 内部空间结构连接流体入口和出口，并且包括与流体入口连接的上游流动通道，与流体出口连接的下游流动通道，其间具有间隙，以及连接上游和下游流动通道的微流动通道。 从微流动通道的截面的中心到微流动通道的侧壁的最小距离小于上游和下游流动通道的最小距离。 第一和第二基板的每个表面包括用于产生上游和下游流动通道的槽，并且第二基板的表面具有用于产生微流动通道的凹槽。
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公开(公告)号：US20070202589A1
公开(公告)日：2007-08-30
申请号：US11360535
申请日：2006-02-24
Applicant: Yuji Kikuchi , Hiroko Kikuchi , Taiji Nishi , Takenori Kitani , Yukihiro Yanagawa , Motohiro Fukuda
Inventor： Yuji Kikuchi , Hiroko Kikuchi , Taiji Nishi , Takenori Kitani , Yukihiro Yanagawa , Motohiro Fukuda
IPC: C12M3/00
CPC classification number: C12M23/16 , B01L3/5027
Abstract: A cell culture plate has a plurality of flow channels, uneven pattern areas and through holes. The flow channels are formed between the uneven pattern areas, and culture solution flows from the flow channels into the uneven pattern areas or from the uneven pattern areas into the flow channels. The uneven pattern area has uneven patterns that create a cell culture space.
Abstract translation: 细胞培养板具有多个流路，不均匀图案区域和通孔。 流动通道形成在不均匀图案区域之间，培养液从流动通道流入不均匀图案区域或从凹凸图案区域流入流动通道。 不均匀图案区域具有形成细胞培养空间的不均匀图案。
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5.发明授权Member for ink recording, ink recording body, and laminated body for ink recording 有权油墨记录用构件，油墨记录体和油墨记录层压体公开(公告)号：US09399340B2
公开(公告)日：2016-07-26
申请号：US14356066
申请日：2012-09-05
Applicant: Taiji Nishi
Inventor： Taiji Nishi
CPC classification number: B41J2/01 , B41J2/0057 , B41M5/50 , B41M5/506 , B41M5/508 , B41M5/52 , B41M5/5209 , B41M5/5236 , B41M5/5245 , B41M5/5254
Abstract: The present invention provides a resin-based ink recorded body having high transparency, high definition, free from bleeding and having a high film strength of an ink. An ink recording member of the present invention includes a substrate containing an acrylic resin and a plant oil derived from a fatty acid having hydroxyl and carboxyl group blended to the acrylic resin, and an ink fixing film composed of a hydrophilic resin and provided on at least one main face of the substrate. An ink printed pattern is provided on the film.
Abstract translation: 本发明提供一种树脂系墨水记录体，其具有高透明度，高清晰度，无渗色性，并具有高的油墨强度。 本发明的墨水记录元件包括含有丙烯酸树脂的基材和衍生自与丙烯酸树脂共混的具有羟基和羧基的脂肪酸的植物油，以及由亲水性树脂构成并至少提供至少 衬底的一个主要面。 在薄膜上设置油墨印刷图案。
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Patent Agency Ranking
公开(公告)号：US09005970B2
公开(公告)日：2015-04-14
申请号：US11813720
申请日：2006-01-11
Applicant: Ryosuke Nishio , Taiji Nishi , Motohiro Fukuda , Yasuzo Kirita , Seiichi Kanai , Takenori Kitani
Inventor： Ryosuke Nishio , Taiji Nishi , Motohiro Fukuda , Yasuzo Kirita , Seiichi Kanai , Takenori Kitani
CPC classification number: C12M25/06 , C12M23/12 , C12N5/0657 , C12N2533/30 , C12N2535/00
Abstract: [PROBLEMS] Relating to a bioassay method with the use of cultured cells and cell culture for a therapeutic purpose in the case of determining the efficacy of a drug or the like or examining the toxicity thereof, it is intended to provide a method of culturing cells under regulation in the extension direction and a cell culture plate. [MEANS FOR SOLVING PROBLEMS] A cell culture plate having a plural number of side walls (1) and a plural number of space structures (3) for providing cultured cells which are formed by the side walls (1), wherein the side walls (1) are provided with openings (2) so that the space structures (3) are linked together. By using this cell culture plate, a method of culturing cells under regulation in the extension direction can be provided.
Abstract translation: [问题]关于在确定药物等的功效或检查其毒性的情况下使用培养细胞和细胞培养物进行生物测定方法的目的是提供培养细胞的方法 在延伸方向调节和细胞培养板。 解决问题的手段具有多个侧壁（1）和多个用于提供由侧壁（1）形成的培养细胞的多个空间结构（3）的细胞培养板，其中侧壁 1）设置有开口（2），使得空间结构（3）连接在一起。 通过使用该细胞培养板，可以提供在延伸方向的调节下培养细胞的方法。
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公开(公告)号：US08980625B2
公开(公告)日：2015-03-17
申请号：US11360535
申请日：2006-02-24
Applicant: Yuji Kikuchi , Hiroko Kikuchi , Taiji Nishi , Takenori Kitani , Yukihiro Yanagawa , Motohiro Fukuda
Inventor： Yuji Kikuchi , Hiroko Kikuchi , Taiji Nishi , Takenori Kitani , Yukihiro Yanagawa , Motohiro Fukuda
CPC classification number: C12M23/16 , B01L3/5027
Abstract: A cell culture plate has a plurality of flow channels, uneven pattern areas and through holes. The flow channels are formed between the uneven pattern areas, and culture solution flows from the flow channels into the uneven pattern areas or from the uneven pattern areas into the flow channels. The uneven pattern area has uneven patterns that create a cell culture space.
Abstract translation: 细胞培养板具有多个流路，不均匀图案区域和通孔。 流动通道形成在不均匀图案区域之间，培养液从流动通道流入不均匀图案区域或从凹凸图案区域流入流动通道。 不均匀图案区域具有形成细胞培养空间的不均匀图案。
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公开(公告)号：US20090170190A1
公开(公告)日：2009-07-02
申请号：US12280607
申请日：2007-02-19
Applicant: Taiji Nishi , Go Tazaki , Motohiro Fukuda , Michio Yazawa , Masayuki Takahashi
Inventor： Taiji Nishi , Go Tazaki , Motohiro Fukuda , Michio Yazawa , Masayuki Takahashi
CPC classification number: C12M23/12 , B01L3/5085 , B01L3/5088 , B01L2300/0829 , B01L2300/0851 , B01L2300/0858 , B01L2300/0893 , C12M25/00
Abstract: An object of the present invention is to provide a cell culture chamber with which the survival rate of cells to be cultured can be increased, and a method of producing the same. A cell culture chamber according to the present invention includes a mass of projections formed of a plurality of microprojections 1 formed on a surface on which cells are cultured. The width or diameter of each of the microprojections 1 is in a range of 20 nm to 3 μm, and the aspect ratio of each of the microprojections is in a range of 0.2 to 3.0. Thus, there can be provided a cell culture chamber most suitable for the adhesion and differentiation/proliferation of cells to be cultured.
Abstract translation: 本发明的目的是提供一种能够提高培养细胞存活率的细胞培养室及其制造方法。 根据本发明的细胞培养室包括由在其上培养细胞的表面上形成的多个微突出物1形成的突起体。 每个微喷射体1的宽度或直径在20nm至3μm的范围内，并且每个微喷射体的纵横比在0.2至3.0的范围内。 因此，可以提供最适合于待培养细胞的粘附和分化/增殖的细胞培养室。
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公开(公告)号：US20090075363A1
公开(公告)日：2009-03-19
申请号：US12298803
申请日：2007-04-25
Applicant: Yuji Morimoto , Taiji Nishi , Taisuke Kamada , Go Tazaki , Motohiro Fukuda
Inventor： Yuji Morimoto , Taiji Nishi , Taisuke Kamada , Go Tazaki , Motohiro Fukuda
Abstract: To provide a cell culture chamber capable of reproducing a cell function in vivo, and a method of producing the same. The cell culture chamber according to the present invention has a concave-convex pattern formed on the surface on which cells are cultured. A concave portion of the concave-convex pattern includes cell culture portions and micro flow channels communicating with the cell culture portions. The bottom surface of each of the cell culture portions has a width 1.0 to 20 times an equivalent diameter of each of the cultured cells. A cell adhesion-inducing substance is formed only on the bottom surface and the side walls of the concave portion.
Abstract translation: 提供能够在体内再现细胞功能的细胞培养室及其制造方法。 根据本发明的细胞培养室具有形成在其上培养细胞的表面上的凹凸图案。 凹凸图案的凹部包括与细胞培养部连通的细胞培养部和微流路。 每个细胞培养部分的底表面具有每个培养细胞的当量直径的1.0至20倍的宽度。 细胞粘附诱导物质仅形成在凹部的底面和侧壁上。
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10.发明申请Process for Producing Microsphere with Use of Metal Substrate having Through-Hole 有权使用具有通孔的金属基板生产微球的方法公开(公告)号：US20080061459A1
公开(公告)日：2008-03-13
申请号：US11577474
申请日：2005-10-11
Applicant: Mitsutoshi Nakajima , Taiji Nishi , Seiichi Kanai , Takenori Kitani , Motohiro Fukuda
Inventor： Mitsutoshi Nakajima , Taiji Nishi , Seiichi Kanai , Takenori Kitani , Motohiro Fukuda
CPC classification number: B01J13/04 , A23P10/25 , A61K9/1682 , B01F3/0807 , B01F5/0475 , B01F13/0059 , B01F2215/0014 , B01F2215/0016 , B01F2215/0019 , B01F2215/0031 , B01F2215/0034 , B01J13/02 , C25D1/08 , Y10T428/24273
Abstract: An object of the present invention is to provide a process for producing microspheres that are solid microparticles or liquid microparticles for use as an emulsion employed in the food industry, production of medicine and cosmetic etc. or an emulsion for DDS (drug delivery system). The object is attained by a process for producing a microsphere including: separating a disperse phase from a continuous phase by a substrate 1 having a through-hole 7; and extruding the disperse phase into the continuous phase through the through-hole 7, in which the substrate having the through-hole 7 with a width of 0.5 to 500 μm, a depth of 10 μm to 6000 μm and a ratio of the width to the depth of the through-hole 7 of 1 to 1/30 is a metal substrate.
Abstract translation: 本发明的目的是提供一种制备用作食品工业中使用的乳液的固体微粒或液体微粒的微球的制造方法，药物和化妆品的制造等，或用于DDS（药物输送系统）的乳液。 该目的通过一种制备微球体的方法来实现，包括：通过具有通孔7的基底1将分散相与连续相分离; 并通过通孔7将分散相挤出到连续相中，其中具有宽度为0.5-500μm的通孔7的基底，深度为10μm至6000μm，宽度与 通孔7的深度为1〜1/30是金属基板。
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