公开(公告)号：US08590710B2

公开(公告)日：2013-11-26

申请号：US13156630

申请日：2011-06-09

申请人： Tae-seok Sim ,  Jeong-gun Lee ,  Hyo-il Jung ,  Ki-ho Kwon

发明人： Tae-seok Sim ,  Jeong-gun Lee ,  Hyo-il Jung ,  Ki-ho Kwon

IPC分类号： B07C5/00

CPC分类号： B01L3/502761 ,  B01L3/502753 ,  B01L2200/0652 ,  B01L2300/087 ,  B01L2400/0487

摘要： A device separating target particles in a fluid sample includes first through third multi-orifice flow fractionation (“MOFF”) channels, each including a multi-orifice segment with an inlet and an outlet at opposite ends, and an alternating series of contraction channels and expansion chambers interconnected in a lengthwise direction; a first separation unit including a first separation channel which is interconnected in fluid communication with a center region of the outlet of the first MOFF channel, and first branch channels which are interconnected in fluid communication with sidewall regions of the outlet of the first MOFF channel, and respectively with inlets of the second and third MOFF channels; and buffer inlets which are connected to the inlets of the second and third MOFF channels and through which a buffer flows into the second and third MOFF channels.

摘要翻译： 分离流体样品中的目标颗粒的装置包括第一至第三多孔流动分馏（“MOFF”）通道，每个通道包括具有相对端的入口和出口的多孔段，以及交替的一系列收缩通道和 膨胀室沿长度方向互相连接; 第一分离单元，其包括与第一MOFF通道的出口的中心区域流体连通的第一分离通道和与第一MOFF通道的出口的侧壁区域流体连通地互连的第一分支通道， 并分别具有第二和第三MOFF通道的入口; 以及连接到第二和第三MOFF通道的入口并且缓冲器通过其流入第二和第三MOFF通道的缓冲器入口。

公开(公告)号：US08993340B2

公开(公告)日：2015-03-31

申请号：US13051251

申请日：2011-03-18

申请人： Hun-joo Lee ,  Jeong-gun Lee ,  Mi-jeong Song ,  Jong-myeon Park ,  Tae-seok Sim ,  Min-seok S. Kim

发明人： Hun-joo Lee ,  Jeong-gun Lee ,  Mi-jeong Song ,  Jong-myeon Park ,  Tae-seok Sim ,  Min-seok S. Kim

IPC分类号： G01N1/28 ,  C12N5/00 ,  C12M1/00 ,  B01L3/00 ,  B03C1/14 ,  G01N1/40 ,  C12M1/26 ,  B03C1/02

CPC分类号： C12M47/04 ,  B01L3/502753 ,  B01L3/502761 ,  B01L2300/0864 ,  B03C1/02 ,  B03C1/14 ,  B03C1/145 ,  C12M1/266 ,  G01N1/4077 ,  Y10T436/25

摘要： A cell separation device includes a channel or chamber in which a sample flows or moves, the sample including target cells marked with magnetic particles, and non-target cells, and a magnet which generates a magnetic first force in a first direction with respect to the sample within the channel or chamber. The channel or chamber of the cell separation device is applied with a second force in a second direction opposite to the first direction of the magnetic force. According to the cell separation device and a method of separating cells, the target cells move in the first direction by the magnetic force, and the non-target cells move in the second direction by the second force, by simultaneously applying the magnetic force and the second force in opposing directions, thereby separating the target cells from the non-target cells.

摘要翻译： 细胞分离装置包括样品流动或移动的通道或室，包括标记有磁性颗粒的靶细胞的样品和非靶细胞，以及相对于第一方向产生第一方向的磁性第一力的磁体 样品在通道或室内。 细胞分离装置的通道或腔室以与磁力的第一方向相反的第二方向施加第二力。 根据细胞分离装置和分离细胞的方法，靶细胞通过磁力在第一方向上移动，非靶细胞通过第二力在第二方向上移动，同时施加磁力和 从而将目标细胞与非靶细胞分离。

公开(公告)号：US09421543B2

公开(公告)日：2016-08-23

申请号：US13434252

申请日：2012-03-29

申请人： Minseok S. Kim ,  Won-ho Lee ,  Sun-soo Kim ,  Jin-hoon Kim ,  Jeong-gun Lee ,  Tae-seok Sim

发明人： Minseok S. Kim ,  Won-ho Lee ,  Sun-soo Kim ,  Jin-hoon Kim ,  Jeong-gun Lee ,  Tae-seok Sim

IPC分类号： B01D33/00 ,  B01D15/00 ,  B01D33/41 ,  B01D37/00 ,  B82Y99/00 ,  B01L3/00

CPC分类号： B01L3/502753 ,  B01L3/502761 ,  B01L2200/0652 ,  B01L2300/0816 ,  B01L2400/086

摘要： A hydrodynamic filter unit includes an inlet channel connected to a fluid chamber, into which a fluid including a target material is introduced, and a plurality of outlet channels connected to the fluid chamber, through which the fluid is discharged. A filtering method includes introducing a fluid including a target material into the hydrodynamic filter unit through the inlet channel, capturing the target material in the hydrodynamic filter unit, and discharging a remaining part of the fluid outside of the hydrodynamic filter unit through an outlet channel.

摘要翻译： 流体动力过滤器单元包括连接到流体室的入口通道，包括目标材料的流体被引入到该流体室中，以及连接到流体室的多个出口通道，流体被排出。 过滤方法包括通过入口通道将包括目标材料的流体引入到流体动力过滤器单元中，捕获流体动力过滤器单元中的目标材料，以及通过出口通道将流体动力过滤器单元外剩余部分排出。

公开(公告)号：US09238225B2

公开(公告)日：2016-01-19

申请号：US13571202

申请日：2012-08-09

申请人： June-young Lee ,  Sang-hyun Baek ,  Hyo-young Jeong ,  Tae-seok Sim ,  Jeong-gun Lee

发明人： June-young Lee ,  Sang-hyun Baek ,  Hyo-young Jeong ,  Tae-seok Sim ,  Jeong-gun Lee

IPC分类号： G01N1/20 ,  B01L3/00 ,  G01N35/00 ,  G01N35/04

CPC分类号： B01L3/502753 ,  B01L3/5027 ,  B01L2200/0621 ,  B01L2200/141 ,  B01L2300/0681 ,  B01L2300/0861 ,  B01L2300/0867 ,  B01L2300/087 ,  B01L2400/0487 ,  G01N2035/00237 ,  G01N2035/0437 ,  Y10T137/4259

摘要： A fluid controlling apparatus including at least one sample chamber for holding a fluid containing target materials; a cleaning chamber for holding a cleaning solution; a first multi-port connected to the at least one sample chamber through a first channel and connected to the cleaning chamber through a second channel; a filter portion, connected to the first multi-port through a third channel, for filtering the target materials; and a first pump, connected to the filter portion, for applying a pressure; and a method of controlling a fluid using the fluid controlling apparatus, which comprises passing the fluid containing the target materials from the at least one sample chamber to the filter portion; and cleaning a path of the fluid by passing the cleaning solution through the path.

摘要翻译： 一种流体控制装置，包括用于保持含有目标材料的流体的至少一个样品室; 用于保持清洁溶液的清洁室; 第一多端口，其通过第一通道连接到所述至少一个样品室，并通过第二通道连接到所述清洁室; 过滤器部分，通过第三通道连接到第一多端口，用于过滤目标材料; 以及连接到过滤器部分的用于施加压力的第一泵; 以及使用所述流体控制装置控制流体的方法，所述方法包括将包含所述目标材料的流体从所述至少一个样品室传送到所述过滤器部分; 以及通过使清洁溶液通过路径来清洁流体的路径。

公开(公告)号：US09089843B2

公开(公告)日：2015-07-28

申请号：US13584552

申请日：2012-08-13

申请人： Minseok S. Kim ,  Sun-soo Kim ,  Jin-hoon Kim ,  Won-ho Lee ,  Jeong-gun Lee ,  Tae-seok Sim ,  Sang-hyun Baek ,  Hyo-young Jeong

发明人： Minseok S. Kim ,  Sun-soo Kim ,  Jin-hoon Kim ,  Won-ho Lee ,  Jeong-gun Lee ,  Tae-seok Sim ,  Sang-hyun Baek ,  Hyo-young Jeong

IPC分类号： B01D29/50 ,  C40B40/00 ,  C40B40/06 ,  C40B40/10 ,  C40B40/12 ,  C40B60/00 ,  B01L3/00 ,  G01N21/05 ,  G01N21/03 ,  G01N1/40

CPC分类号： B01L3/502753 ,  B01L3/502746 ,  B01L2200/10 ,  B01L2300/0816 ,  B01L2300/0819 ,  B01L2300/0877 ,  B01L2300/0887 ,  B01L2400/0487 ,  B01L2400/086 ,  G01N21/05 ,  G01N2001/4088 ,  G01N2021/0325 ,  G01N2021/0346

摘要： A fluid controlling apparatus including an inlet through which a fluid is introduced, a channel portion connected to the inlet, an outlet that is connected to the channel portion and through which the fluid is discharged, and at least one fluid resisting portion disposed between the inlet and the outlet, as well as a filter and a biochip including the fluid controlling apparatus.

摘要翻译： 一种流体控制装置，其包括入口，流体通过该入口，与入口连接的通道部分，连接到通道部分并且流体被排出的出口以及设置在入口之间的至少一个流体阻力部分 和出口，以及包括流体控制装置的过滤器和生物芯片。

公开(公告)号：US08459299B2

公开(公告)日：2013-06-11

申请号：US12555120

申请日：2009-09-08

申请人： Tae-seok Sim ,  Chin-sung Park

发明人： Tae-seok Sim ,  Chin-sung Park

IPC分类号： F04F3/00

CPC分类号： F04B19/006 ,  B01L3/502715 ,  B01L3/50273 ,  B01L2200/027 ,  F04B19/04 ,  G01N1/2035 ,  G01N2001/205 ,  Y10T137/86035 ,  Y10T137/86083 ,  Y10T137/86163

摘要： A fluid control apparatus includes a fluid system, a pump and valve array, which selectively provides a pressure or a vacuum of various degrees, and an intermediate bin, which is connected between the pump and valve array and the fluid system, the intermediate bin including a reservoir unit, which stores a fluid discharged from the fluid system.

摘要翻译： 流体控制装置包括选择性地提供各种程度的压力或真空的流体系统，泵和阀阵列，以及连接在泵与阀阵列和流体系统之间的中间仓，中间仓包括 存储单元，其存储从流体系统排出的流体。