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公开(公告)号：US20230256139A1
公开(公告)日：2023-08-17
申请号：US18138588
申请日：2023-04-24
发明人： Jeremy V. Suhardi , Ebru Oral , Orhun K. Muratoglu , Hany Bedair
IPC分类号： A61L27/54 , A61L27/34 , A61K31/167 , A61K31/451 , A61L27/48
CPC分类号： A61L27/54 , A61L27/34 , A61K31/167 , A61K31/451 , A61L27/48 , A61L2300/402 , A61L2300/428 , A61L2300/602
摘要： The invention related to therapeutic polymeric materials and medical implants containing additives and/or analgesic agents. The invention also relates to methods of making therapeutic polymeric materials and medical implants containing additives and/or analgesic agents. Methods of spatially controlling additive concentrations and release as well as polymeric material morphology are also provided.
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公开(公告)号：US20220143053A1
公开(公告)日：2022-05-12
申请号：US17437912
申请日：2020-03-24
发明人： Orhun K. Muratoglu , Ebru Oral , Dmitry Gil
IPC分类号： A61K31/702 , A61K47/32 , A61K31/445 , A61K31/407 , A61K31/196 , A61K31/245 , A61K31/065 , A61K31/121 , A61K31/167 , A61K38/14
摘要： The present invention provides methods for making and using antibacterial polymeric materials loaded with additives, as well as antibacterial materials comprising additives. Certain additives or combinations of additives show unexpected combinatorial or synergistic antibacterial activity. The invention also provides medical devices comprised of antibacterial polymeric materials, and methods of making and using such devices, which can have unexpected combinatorial or synergistic antibacterial activity.
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公开(公告)号：US09889224B2
公开(公告)日：2018-02-13
申请号：US14420005
申请日：2013-08-02
发明人： Ebru Oral , Chhavi Gupta , Orhun Muratoglu
IPC分类号： A61F2/02 , A61F2/30 , B29C43/52 , B29C45/72 , B29C35/08 , A61L27/16 , C08J3/28 , C08K5/1545 , C08J3/20 , A61L27/50 , A61L29/04 , A61L29/14 , A61L31/04 , A61L31/14 , A61L17/04 , A61L17/14 , C08F10/02 , B29C35/16 , C08K9/08 , B29L31/00
CPC分类号： A61L27/16 , A61F2/30 , A61F2/3094 , A61L17/04 , A61L17/14 , A61L27/50 , A61L27/505 , A61L29/041 , A61L29/14 , A61L31/048 , A61L31/14 , A61L2430/24 , B29C35/16 , B29C43/52 , B29C45/7207 , B29C2035/0827 , B29C2035/0844 , B29C2035/085 , B29C2035/0877 , B29L2031/00 , C08F10/02 , C08J3/203 , C08J3/28 , C08K5/1545 , C08K9/08 , C08L23/06
摘要： Provided is a method of making a polymeric material with a spatially controlled distribution of one or more additives including the steps of blending the one or more additives with a polymeric material, consolidating the polymeric material, heating at least a portion of at least one surface of the consolidated additive-blended polymeric material, and cooling the heated consolidated additive-blended polymeric material, thereby forming a polymeric material with a spatially controlled distribution of additive.
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公开(公告)号：US09168683B2
公开(公告)日：2015-10-27
申请号：US13826636
申请日：2013-03-14
发明人： Orhun K. Muratoglu , Ebru Oral
IPC分类号： A61F2/02 , B29C35/08 , A61L27/16 , A61L27/50 , B29C43/00 , C08J3/28 , A61F2/30 , B29K23/00 , B29L31/00
CPC分类号： B29C35/08 , A61F2/30 , A61L27/16 , A61L27/50 , B29C43/003 , B29K2023/0683 , B29K2023/083 , B29L2031/7532 , C08J3/28 , C08J2323/06 , Y10T29/4998 , C08L23/06
摘要： The present invention relates to methods for making highly crystalline cross-linked polymeric material, for example, highly crystalline cross-linked ultra-high molecular weight polyethylene (UHMWPE). The invention also provides methods of making antioxidant-doped highly crystalline cross-linked polymeric material using high pressure and high temperature crystallization processes, medical implants made thereof, and materials used therein.
摘要翻译： 本发明涉及制备高度结晶的交联聚合物材料的方法，例如高度结晶的交联超高分子量聚乙烯（UHMWPE）。 本发明还提供使用高压和高温结晶方法制备抗氧化剂掺杂的高结晶交联聚合物材料的方法，由其制成的医用植入物及其中使用的材料。
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公开(公告)号：US20240240005A1
公开(公告)日：2024-07-18
申请号：US18618523
申请日：2024-03-27
发明人： Orhun K. Muratoglu , Ebru Oral
CPC分类号： C08L23/06 , A61L31/048 , C08J3/24 , C08J2323/06
摘要： The inventions provide methods of manufacturing peroxide cross-linked and high temperature melted polymeric material, for example ultra-high molecular weight polyethylene (UHMWPE) containing vitamin E, total joint implants with high wear resistance, high oxidation resistance, and very low concentration of residual by-products, as well as products made thereby.
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公开(公告)号：US20180207315A1
公开(公告)日：2018-07-26
申请号：US15883970
申请日：2018-01-30
发明人： Ebru Oral , Chhavi Gupta , Orhun Muratoglu
IPC分类号： A61L27/16 , C08K5/1545 , A61L17/04 , A61L17/14 , A61L27/50 , A61L29/04 , A61L29/14 , A61L31/04 , A61L31/14 , B29C43/52 , A61F2/30 , C08J3/28 , C08J3/20 , B29C45/72 , B29C35/08 , C08K9/08 , C08F10/02 , B29C35/16 , B29L31/00
CPC分类号： A61L27/16 , A61F2/30 , A61F2/3094 , A61L17/04 , A61L17/14 , A61L27/50 , A61L27/505 , A61L29/041 , A61L29/14 , A61L31/048 , A61L31/14 , A61L2430/24 , B29C35/16 , B29C43/52 , B29C45/7207 , B29C71/0009 , B29C71/02 , B29C71/04 , B29C2035/0827 , B29C2035/0844 , B29C2035/085 , B29C2035/0877 , B29C2071/0027 , B29C2071/022 , B29L2031/00 , C08F10/02 , C08J3/203 , C08J3/28 , C08K5/1545 , C08K9/08 , C08L23/06
摘要： Provided is a method of making a polymeric material with a spatially controlled distribution of one or more additives including the steps of blending the one or more additives with a polymeric material, consolidating the polymeric material, heating at least a portion of at least one surface of the consolidated additive-blended polymeric material, and cooling the heated consolidated additive-blended polymeric material, thereby forming a polymeric material with a spatially controlled distribution of additive.
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公开(公告)号：US09731047B2
公开(公告)日：2017-08-15
申请号：US14584519
申请日：2014-12-29
发明人： Ebru Oral , Orhun K. Muratoglu
IPC分类号： C08F2/46 , C08G61/04 , A61L27/50 , C08J3/20 , C08J3/24 , C08J3/28 , B65B55/08 , B65B55/10 , B65B55/16 , B65B55/18 , A61L27/16 , A61L29/04 , A61L29/14 , A61L31/04 , A61L31/14 , C08K5/134
CPC分类号： A61L27/50 , A61L27/16 , A61L27/505 , A61L29/041 , A61L29/14 , A61L29/143 , A61L31/048 , A61L31/14 , A61L31/143 , B65B55/08 , B65B55/10 , B65B55/16 , B65B55/18 , C08J3/203 , C08J3/247 , C08J3/28 , C08J2323/06 , C08K5/134 , C08L23/06
摘要： The present invention relates to methods for making wear and oxidation resistant polymeric materials by high temperature melting. The invention also provides methods of making medical implants containing cross-linked antioxidant-containing tough and ductile polymers and materials used therewith also are provided.
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公开(公告)号：US20160250779A1
公开(公告)日：2016-09-01
申请号：US15030206
申请日：2014-10-16
发明人： Orhun K. Muratoglu , Ebru Oral
IPC分类号： B29C35/08 , B29B11/12 , B29B11/06 , B29B13/02 , B29B13/04 , B29C43/00 , B29C43/10 , B65B55/08 , B65B55/10 , B65B55/16 , B65B55/18 , B65B31/00 , A61F2/00 , C08J3/20 , C08J3/24 , C08J7/12 , B29B7/88
CPC分类号： B29C35/0805 , A61F2/0095 , B29B7/88 , B29B11/06 , B29B11/12 , B29B13/022 , B29B13/045 , B29B2013/002 , B29C35/02 , B29C35/0866 , B29C43/006 , B29C43/10 , B29C2035/085 , B29C2035/0877 , B29C2071/022 , B29C2791/001 , B29C2791/002 , B29K2023/0683 , B29K2105/0035 , B29K2995/0087 , B29L2009/00 , B29L2031/7532 , B65B31/00 , B65B55/08 , B65B55/10 , B65B55/16 , B65B55/18 , C08J3/203 , C08J3/24 , C08J7/12 , C08J7/123 , C08J2323/06
摘要： Methods of making oxidation and wear resistant polymeric materials using peroxide cross-linking and high temperature melting process are disclosed. A multiple step procedure for enabling the manufacturing of such material without size limitations is also disclosed.
摘要翻译： 公开了使用过氧化物交联和高温熔融方法制备氧化和耐磨聚合材料的方法。 还公开了能够制造这种材料而没有尺寸限制的多步骤程序。
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公开(公告)号：US20150151866A1
公开(公告)日：2015-06-04
申请号：US14400375
申请日：2013-05-09
发明人： Ebru Oral , Orhun Muratoglu
CPC分类号： B65B55/16 , A61F2/30 , A61F2240/001 , A61L27/16 , A61L27/50 , A61L2300/428 , C08J7/123 , C08J2323/06 , C08L23/06 , C08L2207/068
摘要： Methods of making a wear and oxidation resistant medical implant are disclosed.
摘要翻译： 公开了制造耐磨损和抗氧化的植入物的方法。
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公开(公告)号：US11970600B2
公开(公告)日：2024-04-30
申请号：US17703288
申请日：2022-03-24
发明人： Orhun K. Muratoglu , Ebru Oral
CPC分类号： C08L23/06 , A61L31/048 , C08J3/24 , C08J2323/06
摘要： The inventions provide methods of manufacturing peroxide cross-linked and high temperature melted polymeric material, for example ultra-high molecular weight polyethylene (UHMWPE) containing vitamin E, total joint implants with high wear resistance, high oxidation resistance, and very low concentration of residual by-products, as well as products made thereby.
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