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公开(公告)号：US20220152069A1
公开(公告)日：2022-05-19
申请号：US17590771
申请日：2022-02-01
发明人： Guochuan Emil Tsai , Yi-Wen Mao , Lu-Ping Lu , Wei-Hua Chang , Han-Yi Hsieh , Jhe Wei Hu , Tsai-Miao Shih , ChanHui Huang
IPC分类号： A61K31/7032 , A61P31/14 , A61K9/00 , A61K45/06
摘要： A method of treating coronavirus infection, comprising administering to a subject in need thereof an effective amount of a composition, wherein the composition comprises one or more compounds of Formula (I): or a pharmaceutically acceptable salt thereof.
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公开(公告)号：US20190201427A1
公开(公告)日：2019-07-04
申请号：US16298804
申请日：2019-03-11
IPC分类号： A61K31/7024 , C07H13/08 , A61P11/00 , A61P25/16 , C07H1/08 , A23L33/105 , A61K36/49 , A61K36/48 , A61K36/22 , A61K36/185 , A61K45/06 , A61K38/26 , A61K36/87 , A61K36/82 , A61P1/16 , A23L33/10 , A23L33/00 , A61P5/50 , A61P25/28 , A61P25/30 , A61P9/00 , A61P11/06 , A61P25/18 , A61P25/24
CPC分类号： A61K31/7024 , A23L33/10 , A23L33/105 , A23L33/30 , A23V2002/00 , A61K31/00 , A61K36/185 , A61K36/22 , A61K36/48 , A61K36/49 , A61K36/82 , A61K36/87 , A61K38/26 , A61K45/06 , A61P1/16 , A61P5/50 , A61P9/00 , A61P11/00 , A61P11/06 , A61P25/16 , A61P25/18 , A61P25/24 , A61P25/28 , A61P25/30 , C07H1/08 , C07H13/08 , Y02A50/411 , A61K2300/00
摘要： Compositions (e.g., pharmaceutical compositions, nutraceutical compositions or medical food compositions) comprising tannic acids, particularly tannic acids which are D-amino acid oxidase inhibitor with superior potency, purity and safety profile; and uses thereof for treating CNS disorder and obesity disorders including diabetes, hyperglycemia, hyperlipidemia or hypercholesterolemia.
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公开(公告)号：US20220218730A1
公开(公告)日：2022-07-14
申请号：US17699784
申请日：2022-03-21
发明人： Guochuan Emil Tsai , Yi-Wen Mao , Lu-Ping Lu , Wei-Hua Chang , Han-Yi Hsieh , Jhe Wei Hu , Tsai-Miao Shih , ChanHui Huang
IPC分类号： A61K31/7048 , A61P25/18 , C07D317/68 , C07C69/90 , C07D207/34 , C07D231/14 , C07H15/22 , C07H15/26 , A61K31/36 , A61K31/235 , A61K31/40 , A61K31/415 , A61K31/7034 , A23L33/10 , A23L33/00
摘要： A compound of Formula (I): or a pharmaceutically acceptable salt thereof, in which Ring X is a 3 to 7 membered monocyclic ring, at least one of R1, R2, R3, and R4 is OR5 or CH2OR5 and the other R1, R2, R3, and R4 each independently are halogen, OH, OR5, CH2OR5, CO2H, OC═OR6, (C═O)R6, R6, C1-10 alkyl, C2-10 alkenyl, C2-10 alkynyl, H, or absent. Also provided herein are therapeutic uses of the compound of Formula (I).
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公开(公告)号：US11382924B2
公开(公告)日：2022-07-12
申请号：US17377829
申请日：2021-07-16
发明人： Guochuan Emil Tsai , Yi-Wen Mao , Lu-Ping Lu , Wei-Hua Chang , Han-Yi Hsieh , Jhe Wei Hu , Tsai-Miao Shih , ChanHui Huang
IPC分类号： A61K31/7032 , A61K9/00 , A61P31/14 , A61K45/06
摘要： A method of treating coronavirus infection, comprising administering to a subject in need thereof an effective amount of a composition, wherein the composition comprises one or more compounds of Formula (I): or a pharmaceutically acceptable salt thereof.
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公开(公告)号：US20220054516A1
公开(公告)日：2022-02-24
申请号：US17377829
申请日：2021-07-16
发明人： Guochuan Emil Tsai , Yi-Wen Mao , Lu-Ping Lu , Wei-Hua Chang , Han-Yi Hsieh , Jhe Wei Hu , Tsai-Miao Shih , ChanHui Huang
IPC分类号： A61K31/7032 , A61K45/06 , A61P31/14 , A61K9/00
摘要： A method of treating coronavirus infection, comprising administering to a subject in need thereof an effective amount of a composition, wherein the composition comprises one or more compounds of Formula (I): or a pharmaceutically acceptable salt thereof.
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公开(公告)号：US20180092935A1
公开(公告)日：2018-04-05
申请号：US15834428
申请日：2017-12-07
IPC分类号： A61K31/7024 , A61P25/28 , A61P25/18 , A61P25/24 , A61P25/30 , A61P25/16 , A61P9/00 , A61P1/16 , A61P5/50 , A61P11/06 , A61P11/00 , A23L33/10 , A23L33/00
CPC分类号： A61K31/7024 , A23L33/10 , A23L33/105 , A23L33/30 , A23V2002/00 , A61K36/185 , A61K36/22 , A61K36/48 , A61K36/49 , A61K36/82 , A61K36/87 , A61K38/26 , A61K45/06 , A61P1/16 , A61P5/50 , A61P9/00 , A61P11/00 , A61P11/06 , A61P25/16 , A61P25/18 , A61P25/24 , A61P25/28 , A61P25/30 , C07H1/08 , C07H13/08 , Y02A50/411 , A61K2300/00
摘要： Compositions (e.g., pharmaceutical compositions, nutraceutical compositions or medical food compositions) comprising tannic acids, particularly tannic acids which are D-amino acid oxidase inhibitor with superior potency, purity and safety profile; and uses thereof for treating CNS disorder and obesity disorders including diabetes, hyperglycemia, hyperlipidemia or hypercholesterolemia.
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公开(公告)号：US11779561B2
公开(公告)日：2023-10-10
申请号：US17590771
申请日：2022-02-01
发明人： Guochuan Emil Tsai , Yi-Wen Mao , Lu-Ping Lu , Wei-Hua Chang , Han-Yi Hsieh , Jhe Wei Hu , Tsai-Miao Shih , ChanHui Huang
IPC分类号： A61K31/351 , A61K31/235 , A61K9/00 , A61K31/513 , A61K31/427 , A61K31/4709 , A61K31/472 , A61K31/4433 , A61K31/685 , A61K38/21 , A61K31/46 , A61K38/16 , A61K39/395 , A61K31/675 , A61K31/395 , A61K31/353 , A61K31/499 , A61K31/16 , A61K31/426 , A61K31/4045 , A61K31/343 , A61K31/13 , A61K31/4245 , A61K31/7072 , A61K31/708 , A61K31/506 , A61K31/52 , A61K31/551 , A61K31/4985 , A61K31/553 , A23L33/00 , A23L33/10 , A61P31/14 , A61K31/7032 , A61K45/06
CPC分类号： A61K31/351 , A23L33/10 , A23L33/40 , A61K9/008 , A61K9/0056 , A61K9/0078 , A61K31/13 , A61K31/16 , A61K31/235 , A61K31/343 , A61K31/353 , A61K31/395 , A61K31/4045 , A61K31/426 , A61K31/427 , A61K31/4245 , A61K31/4433 , A61K31/46 , A61K31/472 , A61K31/4709 , A61K31/499 , A61K31/4985 , A61K31/506 , A61K31/513 , A61K31/52 , A61K31/551 , A61K31/553 , A61K31/675 , A61K31/685 , A61K31/708 , A61K31/7032 , A61K31/7072 , A61K38/16 , A61K38/21 , A61K38/212 , A61K38/217 , A61K39/3955 , A61K45/06 , A61P31/14 , A23V2002/00
摘要： A method of treating coronavirus infection, comprising administering to a subject in need thereof an effective amount of a composition, wherein the composition comprises one or more compounds of Formula (I):
or a pharmaceutically acceptable salt thereof.-
公开(公告)号：US11202791B2
公开(公告)日：2021-12-21
申请号：US16883815
申请日：2020-05-26
IPC分类号： A61K31/7024 , A23L33/105 , A23L33/10 , A23L33/00 , A61P5/50 , A61P25/28 , A61P25/30 , A61P1/16 , A61P9/00 , A61P11/06 , C07H1/08 , C07H13/08 , A61K36/82 , A61K36/87 , A61K38/26 , A61K45/06 , A61K36/185 , A61K36/22 , A61K36/48 , A61K36/49 , A61P25/18 , A61P25/24 , A61P11/00 , A61P25/16 , A61K31/00
摘要： Compositions (e.g., pharmaceutical compositions, nutraceutical compositions or medical food compositions) comprising tannic acids, particularly tannic acids which are D-amino acid oxidase inhibitor with superior potency, purity and safety profile; and uses thereof for treating CNS disorder and obesity disorders including diabetes, hyperglycemia, hyperlipidemia or hypercholesterolemia.
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公开(公告)号：US20210162316A1
公开(公告)日：2021-06-03
申请号：US16770530
申请日：2017-12-07
IPC分类号： B01D11/02 , A61K31/7032
摘要： Improved enrichment methods for preparing tannic acid compositions that have superior potency in inhibiting D-amino acid oxidase, and superior purity and safety profiles. The tannic acid compositions (e.g., pharmaceutical compositions, nutraceutical compositions or medical food compositions) can be used for treating CNS disorder and obesity disorders including diabetes, hyperglycemia, hyperlipidemia or hypercholesterolemia.
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公开(公告)号：US11793823B2
公开(公告)日：2023-10-24
申请号：US17699784
申请日：2022-03-21
发明人： Guochuan Emil Tsai , Yi-Wen Mao , Lu-Ping Lu , Wei-Hua Chang , Han-Yi Hsieh , Jhe Wei Hu , Tsai-Miao Shih , ChanHui Huang
IPC分类号： C07D207/34 , A61K31/7048 , A23L33/10 , A23L33/00 , A61P25/18 , A61K31/235 , A61K31/36 , A61K31/40 , A61K31/415 , A61K31/7034 , C07C69/90 , C07D231/14 , C07D317/68 , C07H15/22 , C07H15/26
CPC分类号： A61K31/7048 , A23L33/10 , A23L33/40 , A61K31/235 , A61K31/36 , A61K31/40 , A61K31/415 , A61K31/7034 , A61P25/18 , C07C69/90 , C07D207/34 , C07D231/14 , C07D317/68 , C07H15/22 , C07H15/26 , A23V2002/00
摘要： A compound of Formula (I):
or a pharmaceutically acceptable salt thereof, in which Ring X is a 3 to 7 membered monocyclic ring, at least one of R1, R2, R3, and R4 is OR5 or CH2OR5 and the other R1, R2, R3, and R4 each independently are halogen, OH, OR5, CH2OR5, CO2H, OC═OR6, (C═O)R6, R6, C1-10 alkyl, C2-10 alkenyl, C2-10 alkynyl, H, or absent. Also provided herein are therapeutic uses of the compound of Formula (I).
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