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    Bicycle frame and method of converting to electronic shifting system
    2.
    发明授权
    Bicycle frame and method of converting to electronic shifting system 有权
    自行车架和转换为电子换档系统的方法

    公开(公告)号：US09545975B2

    公开(公告)日：2017-01-17

    申请号：US14623355

    申请日：2015-02-16

    申请人： David Rosen

    发明人： David Rosen

    IPC分类号： B62M25/08 ,  F16L3/12 ,  B62M25/04

    CPC分类号： B62M9/127 ,  B62J99/00 ,  B62J2099/0046 ,  B62K23/02 ,  B62K23/06 ,  B62M25/04 ,  B62M25/045 ,  B62M25/08 ,  F16L3/1218 ,  Y10T74/20462

    摘要： The present disclosure relates to devices and methods of converting a bicycle frame from a mechanical gear-shifting configuration to an electronic gear-shifting configuration and vice versa. In a representative embodiment, a method of converting a bicycle frame from a mechanical gear-shifting configuration to an electronic gear-shifting configuration comprises removing a mechanical cable extending between a mechanical gear-shift actuator and a mechanical gear shifter via a cable stop of a removable bracket member secured to a down tube member of the bicycle frame, and removing the removable bracket member from the down tube member of the bicycle frame. The method further comprises mounting an electronically-actuated gear shifter to the bicycle frame in electrical communication with an electronic gear-shift actuator such that actuation of the electronic gear-shift actuator causes the electronically-actuated gear shifter to shift gears.

    摘要翻译： 本公开涉及将自行车车架从机械变速结构转换为电子换档配置的装置和方法，反之亦然。 在代表性的实施例中，一种将自行车车架从机械换档构型转换成电子变速构型的方法包括：经机械齿轮换档致动器和机械变速器之间延伸的机械缆索经由 可移动支架构件固定到自行车车架的下管构件，并且从自行车车架的下管构件移除可移除的支架构件。 该方法还包括将电子致动的换档器安装到与电子换档致动器电连通的自行车车架，使得电子变速执行器的致动使得电子致动的换档器移动齿轮。

    VALVELESS PUMP
    3.
    发明申请
    VALVELESS PUMP 审中-公开
    气动泵

    公开(公告)号：US20130071271A1

    公开(公告)日：2013-03-21

    申请号：US13635582

    申请日：2011-03-17

    申请人： David Rosen ,  David Ku ,  Jane Kang

    发明人： David Rosen ,  David Ku ,  Jane Kang

    IPC分类号： F04B43/08 ,  F04B43/09

    CPC分类号： F04B43/086 ,  F04B43/09 ,  F04B43/123 ,  F04B43/1292 ,  Y10T29/4924

    摘要： A valveless, pulsatile, non-contact, positive displacement, finger-pump for pumping one or more fluids is disclosed. The pump can include one or more channels for holding one or more lengths of flexible tubing. The channels can include an adjustment mechanism and/or a resilient backing plate to reduce over compression of the tubing. The pump can utilize a plurality of profiled, pivoting fingers to sequentially occlude a length of tubing causing a pumping action. The fingers can be moved from the first position to the second position by a motor driven camshaft. Cam lobes disposed on the camshaft can be a modified eccentric design to improve tube occlusion and pump efficiency. At least one cam lobe can completely occlude the tubing at all times during operation to prevent backflow. The fingers can alternatively be moved from the first position to the second position by a variety of linear actuators.

    摘要翻译： 公开了用于泵送一种或多种流体的无阀，脉动，非接触，正位移，指泵。 泵可以包括用于保持一段或多段柔性管的一个或多个通道。 通道可以包括调节机构和/或弹性背板，以减少管道的过度压缩。 泵可以利用多个成型的，枢转的指状物来顺序地封闭一段导管泵送作用的管道。 手指可以通过马达驱动的凸轮轴从第一位置移动到第二位置。 设置在凸轮轴上的凸轮凸角可以是改进的偏心设计，以改善管堵塞和泵效率。 在操作过程中，至少有一个凸轮凸起可以在任何时候完全堵塞管道，以防止回流。 手指可以通过各种线性致动器从第一位置移动到第二位置。

    Kits for multiparametric phospho analysis
    8.
    发明授权
    Kits for multiparametric phospho analysis 有权
    多参数磷酸分析试剂盒

    公开(公告)号：US08242248B2

    公开(公告)日：2012-08-14

    申请号：US12730170

    申请日：2010-03-23

    申请人： David Soper ,  David Rosen ,  Ying-Wen Huang ,  Wendy Fantl

    发明人： David Soper ,  David Rosen ,  Ying-Wen Huang ,  Wendy Fantl

    IPC分类号： C07K16/00

    CPC分类号： G01N33/6842 ,  G01N33/5011 ,  G01N33/5041 ,  G01N33/5094 ,  G01N33/6845 ,  G01N33/80 ,  G01N2440/14 ,  G01N2510/00

    摘要： As disclosed herein, the present invention provides for kits and a composition for diagnosis, prognosis, drug discovery, drug development, and patient stratification. The kits can comprise a plurality of binding elements for cell surface markers, and a plurality of binding elements for state-specific intracellular markers. The kits can further comprise a plurality of modulators directed for the particular cell function or signaling pathways. The kits can further include fixatives, permeabilizing agent, buffers, containers, instructions, and software for data analysis/compilation.

    摘要翻译： 如本文所公开的，本发明提供用于诊断，预后，药物发现，药物开发和患者分层的试剂盒和组合物。 试剂盒可以包含用于细胞表面标记的多个结合元件，以及用于状态特异性细胞内标记物的多个结合元件。 试剂盒还可以包含针对特定细胞功能或信号传导途径的多个调节剂。 试剂盒还可以包括固定剂，渗透剂，缓冲液，容器，说明书和用于数据分析/汇编的软件。