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    Immunoassays employing non-particulate chemiluminescent reagent
    1.
    发明授权
    Immunoassays employing non-particulate chemiluminescent reagent 有权

    公开(公告)号：US09720004B2

    公开(公告)日：2017-08-01

    申请号：US15131120

    申请日：2016-04-18

    申请人： Siemens Healthcare Diagnostics Inc.

    发明人： Pratap Singh ,  Yi Feng Zheng ,  Liping Geng ,  Roland Janzen ,  Carsten Schelp

    IPC分类号： G01N33/78 ,  G01N33/58

    CPC分类号： G01N33/78 ,  G01N33/582 ,  G01N2333/59

    摘要： Methods and reagents are disclosed for conducting assays. Embodiments of the present methods and reagents are concerned with chemiluminescent reagents for determining the presence and/or amount of an analyte in a sample suspected of containing the analyte. The reagent is non-particulate and comprises a binding partner for the analyte and a chemiluminescent composition comprising an olefinic compound and a metal chelate. In embodiments of an assay, a combination is provided that comprises a sample suspected of containing the analyte, a chemiluminescent reagent as described above and a sensitizer reagent capable of generating singlet oxygen. The combination is subjected to conditions for binding of the analyte to the binding partner for the analyte. The sensitizer is activated and the amount of luminescence generated by the chemiluminescent composition is detected wherein the amount of luminescence is related to the amount of the analyte in the sample.

    IMMUNOASSAYS EMPLOYING NON-PARTICULATE CHEMILUMINESCENT REAGENT
    2.
    发明申请
    IMMUNOASSAYS EMPLOYING NON-PARTICULATE CHEMILUMINESCENT REAGENT 有权
    免费使用非颗粒性发光试剂

    公开(公告)号：US20160231336A1

    公开(公告)日：2016-08-11

    申请号：US15131120

    申请日：2016-04-18

    申请人： Siemens Healthcare Diagnostics Inc.

    发明人： Pratap Singh ,  Yi Feng Zheng ,  Liping Geng ,  Roland Janzen ,  Carsten Schelp

    IPC分类号： G01N33/78 ,  G01N33/58

    CPC分类号： G01N33/78 ,  G01N33/582 ,  G01N2333/59

    摘要： Methods and reagents are disclosed for conducting assays. Embodiments of the present methods and reagents are concerned with chemiluminescent reagents for determining the presence and/or amount of an analyte in a sample suspected of containing the analyte. The reagent is non-particulate and comprises a binding partner for the analyte and a chemiluminescent composition comprising an olefinic compound and a metal chelate. In embodiments of an assay, a combination is provided that comprises a sample suspected of containing the analyte, a chemiluminescent reagent as described above and a sensitizer reagent capable of generating singlet oxygen. The combination is subjected to conditions for binding of the analyte to the binding partner for the analyte. The sensitizer is activated and the amount of luminescence generated by the chemiluminescent composition is detected wherein the amount of luminescence is related to the amount of the analyte in the sample.

    摘要翻译： 公开了用于进行测定的方法和试剂。 本发明方法和试剂的实施方案涉及用于确定怀疑含有分析物的样品中分析物的存在和/或量的化学发光试剂。 试剂是非颗粒的并且包含用于分析物的结合配偶体和包含烯属化合物和金属螯合物的化学发光组合物。 在测定的实施方案中，提供了包含疑似含有分析物的样品，如上所述的化学发光试剂和能够产生单线态氧的敏化剂的组合。 该组合经受用于将分析物与分析物的结合配偶体结合的条件。 敏化剂被激活，并且检测由化学发光组合物产生的发光量，其中发光量与样品中分析物的量相关。

    COMPOSITION FOR USE AS AN ASSAY REAGENT
    4.
    发明申请
    COMPOSITION FOR USE AS AN ASSAY REAGENT 审中-公开
    用作测定试剂的组合物

    公开(公告)号：US20160376464A1

    公开(公告)日：2016-12-29

    申请号：US15259768

    申请日：2016-09-08

    申请人： Siemens Healthcare Diagnostics Inc.

    发明人： Bhalchandra Lele ,  Pratap Singh ,  Raphael Bartz ,  Jason A. Kellogg

    IPC分类号： C09D133/26 ,  G01N33/533 ,  C09D139/06 ,  C08F120/60 ,  C08F126/10

    CPC分类号： C09D133/26 ,  C08F120/60 ,  C08F126/10 ,  C08F220/06 ,  C08F220/26 ,  C08F220/38 ,  C08F220/58 ,  C08F2800/20 ,  C09D139/06 ,  C09D177/06 ,  C09D179/04 ,  C09D181/00 ,  G01N33/533 ,  G01N33/582

    摘要： A composition for use as an assay reagent comprises a solid support comprising a member of a signal producing system and a coating of a synthetic copolymer. The synthetic copolymer comprises a first polymerized monomer comprising a pendant moiety comprising a reactive functionality or a derivative of a reactive functionality and a second polymerized monomer comprising a pendant moiety comprising at least 1 carbon atoms and at least 2 heteroatoms. In some embodiments the copolymer comprises a polyethylenic backbone comprising the pendant moiety comprising a reactive functionality or a derivative of a reactive functionality and the pendant moiety comprising at least 1 carbon atom and at least 2 heteroatoms.

    摘要翻译： 用作测定试剂的组合物包括固体支持物，其包括信号产生系统的成员和合成共聚物的涂层。 合成共聚物包含第一聚合单体，其包括包含反应性官能团或反应性官能团的衍生物的侧基部分和包含至少包含1个碳原子和至少2个杂原子的侧链部分的第二聚合单体。 在一些实施方案中，共聚物包含包含侧链部分的聚乙烯主链，其包含反应性官能团或反应性官能团的衍生物，并且所述侧链部分包含至少1个碳原子和至少2个杂原子。