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公开(公告)号：US20170153254A1
公开(公告)日：2017-06-01
申请号：US15319186
申请日：2015-06-22
发明人： Tie Quan Wei , Zhu Teng , Tatiana Mareeva , Jie Li , Martin A. Drinan , Izak Bahar , Manoj Sharma
CPC分类号： G01N33/82 , A61K39/385 , C07C401/00 , C07K16/44 , G01N21/76 , G01N33/532
摘要： Methods include determining an amount of an epimeric vitamin D analyte in a sample suspected of containing the epimeric vitamin D analyte. A combination is provided in an assay medium that includes the sample and a vitamin D epimer antibody that is specific for the epimeric vitamin D analyte. The assay medium is incubated under conditions for binding of the vitamin D epimer antibody to the epimeric vitamin D analyte to form an epimeric vitamin D antibody-bound complex. The amount of the epimeric vitamin D antibody-bound complex is determined and related to the amount of epimeric vitamin D analyte in the sample.
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公开(公告)号：US20220332803A1
公开(公告)日：2022-10-20
申请号：US17633131
申请日：2020-08-07
发明人： Manoj Sharma , Tatiana Mareeva , Yuriy Smirnov , Pratap Singh , William Bedzyk
摘要： Anti-hog TCN1 monoclonal antibodies are disclosed, along with epitopes recognized by same. Also disclosed are kits containing the monoclonal antibodies and methods of producing the antibodies. Further disclosed are methods of using the monoclonal antibodies, such as (but not limited to) in methods of estimating and/or removing TCN1 from hog intrinsic factor preparations.
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公开(公告)号：US20170121426A1
公开(公告)日：2017-05-04
申请号：US15319221
申请日：2015-06-22
发明人： Manoj Sharma , Tatiana Mareeva , Yuriy Smirnov , William D. Bedzyk , Zhu Teng , Tie Quan Wei
CPC分类号： C07K16/44 , B01D15/3809 , C07K16/26 , C07K2317/33 , G01N33/82
摘要： Antibodies are raised against compounds of Formula (I) where Z is an immunogenic carrier. These compounds are capable of binding specifically to corresponding antibodies. The antibodies are specific for epimers of vitamin D. Antibodies in accordance with the principles described herein may be employed to minimize or eliminate 3-epimer cross-reactivity in assays for non-epimeric forms of vitamin D analytes. Over-estimation of total non-epimeric vitamin D analyte caused by the cross-reactivity of 3-epimer vitamin D with an antibody for vitamin D analyte can be substantially avoided employing, as blocking agents, antibodies prepared against immunogens that are a compound of the Formula (I) wherein Z is an immunogenic carrier.
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公开(公告)号：US09815907B2
公开(公告)日：2017-11-14
申请号：US15319221
申请日：2015-06-22
发明人： Manoj Sharma , Tatiana Mareeva , Yuriy Smirnov , William D. Bedzyk , Zhu Teng , Tie Quan Wei
IPC分类号： G01N33/82 , G01N33/532 , C07K16/44 , B01D15/38
CPC分类号： C07K16/44 , B01D15/3809 , C07K16/26 , C07K2317/33 , G01N33/82
摘要： Antibodies are raised against compounds of Formula (I) where Z is an immunogenic carrier. These compounds are capable of binding specifically to corresponding antibodies. The antibodies are specific for epimers of vitamin D. Antibodies in accordance with the principles described herein may be employed to minimize or eliminate 3-epimer cross-reactivity in assays for non-epimeric forms of vitamin D analytes. Over-estimation of total non-epimeric vitamin D analyte caused by the cross-reactivity of 3-epimer vitamin D with an antibody for vitamin D analyte can be substantially avoided employing, as blocking agents, antibodies prepared against immunogens that are a compound of the Formula (I) wherein Z is an immunogenic carrier.
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公开(公告)号：US09804176B2
公开(公告)日：2017-10-31
申请号：US15319186
申请日：2015-06-22
发明人： Tie Quan Wei , Zhu Teng , Tatiana Mareeva , Jie Li , Martin A. Drinan , Izak Bahar , Manoj Sharma
IPC分类号： G01N33/82 , G01N33/532 , C07K16/44 , A61K39/385 , G01N21/76 , C07C401/00
CPC分类号： G01N33/82 , A61K39/385 , C07C401/00 , C07K16/44 , G01N21/76 , G01N33/532
摘要： Methods include determining an amount of an epimeric vitamin D analyte in a sample suspected of containing the epimeric vitamin D analyte. A combination is provided in an assay medium that includes the sample and a vitamin D epimer antibody that is specific for the epimeric vitamin D analyte. The assay medium is incubated under conditions for binding of the vitamin D epimer antibody to the epimeric vitamin D analyte to form an epimeric vitamin D antibody-bound complex. The amount of the epimeric vitamin D antibody-bound complex is determined and related to the amount of epimeric vitamin D analyte in the sample.
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