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公开(公告)号：US11970506B2
公开(公告)日：2024-04-30
申请号：US16758980
申请日：2018-12-10
Inventor： Jiaqiang Cai , Shuai Song , Tongtong Xue , Liang Xiao , Hanwen Deng , Qiang Tian , Guoqing Zhong , Lichun Wang , Jingyi Wang
IPC: C07D491/22 , A61K45/06 , A61K47/68 , A61P35/00 , C07D401/14 , C07D403/12 , C07D403/14 , C07K5/062 , C07K16/30 , C07K16/32
CPC classification number: C07D491/22 , A61K47/6803 , A61K47/6851 , A61K47/6885 , A61P35/00 , C07D401/14 , C07D403/12 , C07D403/14 , C07K5/06052 , C07K16/30 , C07K16/32 , A61K45/06
Abstract: Provided herein are bioactive molecule conjugates, preparation methods and use thereof, particularly bioactive molecule conjugates (such as antibody-drug conjugates and small molecule drug conjugates) obtained by improved coupling of a drug and a targeting moiety, as well as their preparation method and use for the treatment of a disease associated with an abnormal cell activity.
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公开(公告)号：US20200253971A1
公开(公告)日：2020-08-13
申请号：US16859910
申请日：2020-04-27
Inventor： Shuai Song , Jiaqiang Cai , Qiang Tian , Hong Zeng , Hongmei Song , Hanwen Deng , Zujian Tang , Xiaofan Duan , Rongrong Long , Yao Liu , Lichun Wang , Jingyi Wang
IPC: A61K31/506 , A61K31/5377 , A61P31/16
Abstract: The present invention relates to a method for prophylactically treating or treating a viral disease, comprising administering to a subject in need thereof a dihydropyrimidine compound, and the viral diseases include, but are not limited to, Hepatitis A, Hepatitis B, Hepatitis C, influenza, herpes and acquired immunodeficiency syndrome (AIDS).
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公开(公告)号：US11292785B2
公开(公告)日：2022-04-05
申请号：US16959691
申请日：2019-01-18
Inventor： Shuai Song , Qiang Tian , Yongyong Wu , Mingliang Zhao , Chaolei Wang , Jiaqiang Cai , Lichun Wang , Jingyi Wang
IPC: C07D403/12 , A61P1/16
Abstract: Related is a nitrogen-containing benzoheterocycle compound containing a carboxylic acid group as shown in general formula (I), or a stereoisomer or pharmaceutically acceptable salt thereof. The compound has excellent pharmacokinetic properties and extremely remarkable liver targeting properties, and a pharmaceutical composition comprising the same may be used as a CCR antagonist, in particular a CCR2 and/or CCR5 antagonist and can be used in mediated disease, including, but not limited to, nonalcoholic fatty liver disease (NAFLD) or the like.
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Patent Agency Ranking
公开(公告)号：US10696669B2
公开(公告)日：2020-06-30
申请号：US16334237
申请日：2017-11-09
Inventor： Shuai Song , Jiaqiang Cai , Qiang Tian , Hong Zeng , Hongmei Song , Hanwen Deng , Zujian Tang , Xiaofan Duan , Rongrong Long , Yao Liu , Lichun Wang , Jingyi Wang
IPC: C07D417/14 , C07D413/14 , C07D403/14 , C07D401/14 , C07D417/04 , A61P31/16 , A61P31/22 , A61P31/12 , A61K31/506 , A61K9/00
Abstract: The present invention relates to a dihydropyrimidine compound having an antiviral activity, a pharmaceutical composition comprising same, a preparation method therefor and the uses thereof in the prevention or treatment of viral diseases including, but not limited to, Hepatitis A, Hepatitis B, Hepatitis C, influenza, herpes and acquired immunodeficiency syndrome (AIDS).
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公开(公告)号：US11434235B2
公开(公告)日：2022-09-06
申请号：US16981430
申请日：2019-05-06
Inventor： Tianming Wang , Chengxi Yang , Jiaqiang Cai , Wei Liu , Baolei Zhang , Qiang Tian , Shuai Song , Hao Hu , Weibiao Han , Youqiang Li , Xing Chen , Lichun Wang , Jingyi Wang
IPC: C07D417/14 , A61K45/06
Abstract: Disclosed are a solid form of (E)-3-((R)-4-(((R)-6-(2-chloro-4-fluorophenyl)-5-(methoxycarbonyl)-2-(thiazol-2-yl)-3,6-dihydropyrimidin-4-yl)methyl)morpholin-2-yl)acrylic acid, a preparation method therefor, a pharmaceutical composition comprising same, and the use thereof in the preparation of drugs for preventing or treating viral diseases.
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公开(公告)号：US11207420B2
公开(公告)日：2021-12-28
申请号：US16497415
申请日：2018-04-12
Inventor： Jiaqiang Cai , Tongtong Xue , Shuai Song , Jing Wang , Qiang Tian , Liang Xiao , Hanwen Deng , Liping Liu , Zujian Tang , Hong Zeng , Rongrong Long , Hongmei Song , Qiang Zhang , Guoqing Zhong , Dengnian Liu , Haitao Huang , Ruibin Hu , Lichun Wang , Jingyi Wang
Abstract: Provided is a method for modifying a chimeric antigen receptor-modified T cell (CAR-T cell). The method comprises expressing an SCFV-CDS TM-4-1BB-CD3ζ molecule in a T cell. The CAR-T cell prepared using the method can specifically recognize and bind to a tumor cell with elevated expression of a ROBO1 protein, and can be used to prevent and treat a corresponding tumor-related disease.
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公开(公告)号：US11166954B2
公开(公告)日：2021-11-09
申请号：US16859910
申请日：2020-04-27
Inventor： Shuai Song , Jiaqiang Cai , Qiang Tian , Hong Zeng , Hongmei Song , Hanwen Deng , Zujian Tang , Xiaofan Duan , Rongrong Long , Yao Liu , Lichun Wang , Jingyi Wang
IPC: A61K31/506 , A61K31/5377 , A61P31/16
Abstract: The present invention relates to a method for prophylactically treating or treating a viral disease, comprising administering to a subject in need thereof a dihydropyrimidine compound, and the viral diseases include, but are not limited to, Hepatitis A, Hepatitis B, Hepatitis C, influenza, herpes and acquired immunodeficiency syndrome (AIDS).
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公开(公告)号：US10899786B2
公开(公告)日：2021-01-26
申请号：US16344317
申请日：2017-12-19
Inventor： Jiaqiang Cai , Shuai Song , Qiang Tian , Yitao Zhang , Haitao Huang , Guoqing Zhong , Wei Zhong , Yongjia Hao , Mingliang Zhao , Hong Zeng , Hongmei Song , Xin Zhou , Yao Liu , Yuting Tan , Lichun Wang , Jingyi Wang
Abstract: Provided in the present invention are a compound of Formula (I), a pharmaceutical composition comprising the same, a method for preparing the same, and use thereof as a NS5B polymerase inhibitor, a DNA polymerase inhibitor or a reverse transcriptase inhibitor for the prevention or treatment of viral diseases or cancers.
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