公开(公告)号：US11292785B2

公开(公告)日：2022-04-05

申请号：US16959691

申请日：2019-01-18

Applicant: Sichuan Kelun-Biotech Biopharmaceutical Co., Ltd.

Inventor： Shuai Song ,  Qiang Tian ,  Yongyong Wu ,  Mingliang Zhao ,  Chaolei Wang ,  Jiaqiang Cai ,  Lichun Wang ,  Jingyi Wang

IPC: C07D403/12 ,  A61P1/16

Abstract: Related is a nitrogen-containing benzoheterocycle compound containing a carboxylic acid group as shown in general formula (I), or a stereoisomer or pharmaceutically acceptable salt thereof. The compound has excellent pharmacokinetic properties and extremely remarkable liver targeting properties, and a pharmaceutical composition comprising the same may be used as a CCR antagonist, in particular a CCR2 and/or CCR5 antagonist and can be used in mediated disease, including, but not limited to, nonalcoholic fatty liver disease (NAFLD) or the like.

公开(公告)号：US11541049B2

公开(公告)日：2023-01-03

申请号：US16965450

申请日：2019-03-18

Applicant: SICHUAN KELUN-BIOTECH BIOPHARMACEUTICAL CO., LTD.

Inventor： Yongyong Wu ,  Jiaqiang Cai ,  Guangchao Zhang ,  Shuangshuang Duan ,  Chaolei Wang ,  Lichun Wang ,  Jingyi Wang

IPC: C07D403/14 ,  A61K31/496 ,  A61P7/02 ,  A61K31/4725 ,  A61K45/06 ,  C07D401/14 ,  C07D413/14 ,  C07D401/10

Abstract: Provided are tetrahydroisoquinoline derivatives, the preparation and use thereof. More specifically, provided are the tetrahydroisoquinoline derivatives or a pharmaceutically acceptable salt, ester, stereoisomer, tautomer, polymorph, solvate, isotopically labeled compound, metabolite or prodrug thereof. Further provided are a preparation process of the compound, the intermediates, a pharmaceutical composition comprising the compound and the use thereof in the treatment or prevention of a thromboembolic disorder.