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    Microfluidic chip system integrated with nano-electrospray interface and method using thereof
    3.
    发明授权
    Microfluidic chip system integrated with nano-electrospray interface and method using thereof 有权
    集成纳米电喷雾界面的微流控芯片系统及其使用方法

    公开(公告)号：US07387765B2

    公开(公告)日：2008-06-17

    申请号：US10822650

    申请日：2004-04-13

    申请人： Shu-Hui Chen ,  Wang-Chou Sung ,  Pao-Chi Liao ,  Gwo-Bin Lee

    发明人： Shu-Hui Chen ,  Wang-Chou Sung ,  Pao-Chi Liao ,  Gwo-Bin Lee

    IPC分类号： B01L3/02 ,  G01N1/10

    CPC分类号： H01J49/04 ,  G01N27/44717 ,  Y10T436/24 ,  Y10T436/2575

    摘要： The present invention provides an integrated microfluidic electrospray chip system and analytical method thereof, characterized in which the proteinase reaction, solid-phase extraction mechanism, electrophoresis and mass spectrometry are integrated into one system. This system allows continuous, fast and on-line detection and identification of a sample, where the sample is firstly hydrolyzed and desalted, and then introduced into the microfluidic electrospray chip to undergo electrophoresis. Finally, the separated sample is introduced into a mass spectrometer by means of electrospray for continuous detection and identification. This system applies mainly in the identification of biochemical substances, such as proteins.

    摘要翻译： 本发明提供了一种集成微流体电喷雾芯片系统及其分析方法，其特征在于将蛋白酶反应，固相萃取机理，电泳和质谱法整合到一个体系中。 该系统允许连续，快速和在线检测和鉴定样品，样品首先水解和脱盐，然后引入微流控电喷雾芯片进行电泳。 最后，通过电喷雾将分离的样品引入质谱仪进行连续检测和鉴定。 该系统主要适用于生物化学物质如蛋白质的鉴定。

    SPLITTER
    4.
    发明申请
    SPLITTER 有权
    分机

    公开(公告)号：US20090267719A1

    公开(公告)日：2009-10-29

    申请号：US12191778

    申请日：2008-08-14

    申请人： Hung-Chieh Tseng ,  Ying-Chian Kang ,  Tsung-Hsien Lee ,  Shu-Hui Chen ,  Hua-Sheng Shih

    发明人： Hung-Chieh Tseng ,  Ying-Chian Kang ,  Tsung-Hsien Lee ,  Shu-Hui Chen ,  Hua-Sheng Shih

    IPC分类号： H01F27/02

    CPC分类号： H01F17/043 ,  H01F3/12 ,  H01F5/02 ,  H01F27/266 ,  H01F2005/043

    摘要： The present invention provides a splitter including a seat, a first inner core, a second inner core, a first coil, an outer core and a second coil. The seat has a bobbin, and the first coil is wound on the bobbin. The first inner core and the second inner core, disposed on the bobbin, are assembled with each other to cover the bobbin. The outer core and the first inner core are assembled with each other. The second coil is disposed between the outer core and the first inner core.

    摘要翻译： 本发明提供了一种分离器，包括座，第一内芯，第二内芯，第一线圈，外芯和第二线圈。 座椅具有线轴，第一线圈缠绕在线轴上。 设置在线轴上的第一内芯和第二内芯彼此组装以覆盖线轴。 外芯和第一内芯彼此组装。 第二线圈设置在外芯和第一内芯之间。

    Sample analysis system with chip-based electrophoresis device
    5.
    发明授权
    Sample analysis system with chip-based electrophoresis device 失效
    带芯片电泳装置的样品分析系统

    公开(公告)号：US06942777B2

    公开(公告)日：2005-09-13

    申请号：US09880801

    申请日：2001-06-15

    申请人： Shu-Hui Chen ,  Gwo-Bin Lee ,  Chung-Shi Yang ,  Yi-Hung Lin ,  Wan-Chou Sung ,  Guan-Ruey Huang

    发明人： Shu-Hui Chen ,  Gwo-Bin Lee ,  Chung-Shi Yang ,  Yi-Hung Lin ,  Wan-Chou Sung ,  Guan-Ruey Huang

    IPC分类号： G01N27/447 ,  C25B11/00 ,  G01N27/453

    CPC分类号： G01N27/44743 ,  G01N27/44721 ,  G01N27/44791

    摘要： The present invention relates to a sample analysis system with chip-based electrophoresis device, particularly, the chip electrophoresis is connected to the dynamic flow-based auto-sampling device to introduce the sample into the chip-based electrophoresis device. By utilizing the derivatization biochemistry method to have a surface modification on the sample loading channel, it prevents the sample from being adhered to the wall of the sample loading channel, and hence increases the sample loading rate, reduces cross-contamination of samples and performs specific bio-reaction by using the immobilization of matter including antigen, antibody, protein, or enzyme. This invention makes use of the continuous split flow and electric voltage control to work with the detecting unit, signal collecting unit, and signal processing unit so that the sample undergoes a timely, fast, continuous analysis without having interference from the sample of other time.

    摘要翻译： 本发明涉及一种具有基于芯片的电泳装置的样品分析系统，特别地，芯片电泳连接到基于动态流量的自动采样装置，以将样品引入基于芯片的电泳装置。 通过利用衍生生物化学方法在样品加载通道上进行表面改性，可以防止样品粘附到样品加载通道的壁上，从而增加样品加载速率，减少样品的交叉污染，并执行特定的 通过使用固定化物质（包括抗原，抗体，蛋白质或酶）进行生物反应。 本发明利用连续分流和电压控制与检测单元，信号采集单元和信号处理单元一起工作，使得样品经过及时，快速，连续的分析，而不会受到其他时间样品的干扰。

    Layout structure and method for supporting two different package techniques of CPU
    6.
    发明授权
    Layout structure and method for supporting two different package techniques of CPU 有权
    支持CPU的两种不同封装技术的布局结构和方法

    公开(公告)号：US06794744B2

    公开(公告)日：2004-09-21

    申请号：US10064426

    申请日：2002-07-12

    申请人： Nai-Shung Chang ,  Tsai-Sheng Chen ,  Shu-Hui Chen

    发明人： Nai-Shung Chang ,  Tsai-Sheng Chen ,  Shu-Hui Chen

    IPC分类号： H01L2352

    CPC分类号： H05K1/0295 ,  H05K1/0298 ,  H05K1/18 ,  H05K2201/09345 ,  H05K2201/09954 ,  H05K2201/10522 ,  H05K2201/10704 ,  H05K2201/10734

    摘要： A layout structure of a central processing unit (CPU) that supports two different package techniques, having a motherboard that comprising the layout structure and a layout method. The layout structure of the preferred embodiment according to the present invention from up to down sequentially placed a top signal layer, a grounded layer, a power layer having an operating potential area and a grounded potential area, and a bottom solder layer in the area where the signals of the CPU are coupled to the signals of the control chip, so that the signals that are placed on the bottom solder layer can refer to a grounded potential area of the power layer.

    摘要翻译： 中央处理单元（CPU）的布局结构，其支持两种不同的封装技术，具有包括布局结构的主板和布局方法。 根据本发明的优选实施例的布局结构从上到下顺序地放置了顶部信号层，接地层，具有工作电位区域的功率层和接地电位区域，以及底部焊料层， CPU的信号耦合到控制芯片的信号，使得放置在底部焊料层上的信号可以指功率层的接地电位区域。

    Prodrug forms of ribonucleotide reductase inhibitors 3-AP and 3-AMP
    8.
    发明授权
    Prodrug forms of ribonucleotide reductase inhibitors 3-AP and 3-AMP 失效
    核苷酸还原酶抑制剂3-AP和3-AMP的前药形式

    公开(公告)号：US5767134A

    公开(公告)日：1998-06-16

    申请号：US856568

    申请日：1997-05-15

    申请人： Jun Li ,  Chuan-Sheng Niu ,  Xiuyan Li ,  Terrence W. Doyle ,  Shu-Hui Chen

    发明人： Jun Li ,  Chuan-Sheng Niu ,  Xiuyan Li ,  Terrence W. Doyle ,  Shu-Hui Chen

    IPC分类号： C07D213/74 ,  A61K31/44 ,  A61K31/4409 ,  A61P35/00 ,  A61P43/00 ,  C07D213/75 ,  C07F9/09 ,  C07F9/58 ,  C07D213/02

    CPC分类号： C07D213/75 ,  C07F9/588

    摘要： The present invention relates to novel prodrug forms of ribonucleoside diphosphate reductase inhibitors 3-aminopyridine-2-carboxaldehyde thiosemicarbazone (3-AP) 3-amino-4-methylpyridine-2-carboxaldehyde thiosemicarbazone (3-AMP) which have increased water solubility, bioavailablity and resistance to in vivo acetylation of their amino functions. Novel compounds according to the present invention relate to those of the formula: ##STR1## where R.sup.4 is H or CH.sub.3 and R.sup.5 is CHR, benzyl or ortho or para substituted benzyl; R is H, CH.sub.3, CH.sub.2 CH.sub.3, CH.sub.2 CH.sub.2 CH.sub.3 or ##STR2## R' is a free acid phosphate, phosphate salt or an --S--S--R" group; R" is CH.sub.2 CH.sub.2 NHR.sup.6, CH.sub.2 CH.sub.2 OH, CH.sub.2 COOR.sup.7, an ortho or para substituted alkylphenyl and ortho or para substituted nitro-phenyl; R.sup.6 is H, C.sub.1 -C.sub.4 acyl group, trifluoroacetyl, benzoyl or substituted benzoyl group, and R.sup.7 is H, C.sub.1 -C.sub.4 alkyl or a benzyl or substituted benzyl.

    摘要翻译： 本发明涉及核糖核苷二磷酸还原酶抑制剂3-氨基吡啶-2-甲醛缩氨基硫脲（3-AP）3-氨基-4-甲基吡啶-2-甲醛缩氨基硫脲（3-AMP）的新型前药形式，其具有增加的水溶性，生物可利用性 和其对氨基功能的体内乙酰化的抗性。 根据本发明的新化合物涉及下式的化合物：其中R 4是H或CH 3且R 5是CHR，苄基或邻位或对位取代的苄基; R是H，CH 3，CH 2 CH 3，CH 2 CH 2 CH 3或R 3是游离酸式磷酸酯，磷酸盐或-S-S-R“基团; R“是CH 2 CH 2 NHR 6，CH 2 CH 2 OH，CH 2 COOR 7，邻或对位取代的烷基苯基和邻位或对位取代的硝基苯基; R6是H，C1-C4酰基，三氟乙酰基，苯甲酰基或取代的苯甲酰基，R7是H，C1-C4烷基或苄基或取代的苄基。

    Fluoro taxols
    9.
    发明授权
    Fluoro taxols 失效
    氟紫杉醇

    公开(公告)号：US5294637A

    公开(公告)日：1994-03-15

    申请号：US62687

    申请日：1993-05-20

    申请人： Shu-Hui Chen ,  Vittorio Farina ,  Joydeep Kant ,  Dolatrai M. Vyas

    发明人： Shu-Hui Chen ,  Vittorio Farina ,  Joydeep Kant ,  Dolatrai M. Vyas

    IPC分类号： C07D305/14 ,  C07D407/12 ,  C07D409/12 ,  C07F7/18 ,  C07F9/655 ,  C07F9/6558 ,  H01L21/48 ,  H05K1/03 ,  H05K1/09 ,  H05K1/16 ,  H05K3/40 ,  A01N43/02 ,  C07D305/00

    CPC分类号： C07D407/12 ,  C07D305/14 ,  C07D409/12 ,  C07F7/1856 ,  C07F9/65512 ,  C07F9/65586 ,  H01L21/4839 ,  H05K1/16 ,  H05K1/0306 ,  H05K1/092 ,  H05K3/403

    摘要： This invention relates to a fluorinated taxol of formula I ##STR1## in which R.sup.1 is --COR.sup.z in which R.sup.z is RO-- or R;R.sup.g is C.sub.1-6 alkyl, C.sub.2-6 alkenyl, C.sub.2-6 alkynyl, C.sub.3-6 cycloalkyl, or a radical of the formula --W--R.sup.x in which W is a bond, C.sub.2-6 alkenediyl, or --(CH.sub.2).sub.t --, in which t is one to six; and R.sup.x is naphthyl, furyl, thienyl or phenyl, and furthermore R.sup.x can be optionally substituted with one to three same or different C.sub.1-6 alkyl, C.sub.1-6 alkoxy, halogen or --CF.sub.3 groups;R.sup.2 is --OCOR, H, OH, --OR, --OSO.sub.2 R, --OCONR.sup.o R, --OCONHR, --OCOO(CH.sub.2).sub.t R, or --OCOOR; andR and R.sup.o are independently C.sub.1-6 alkyl, C.sub.2-6 alkenyl, C.sub.3-6 cycloalkyl, C.sub.2-6 alkynyl, or phenyl, optionally substituted with one to three same or different C.sub.1-6 alkyl, C.sub.1-6 alkoxy, halogen or --CF.sub.3 groups.Further provided by this invention are pharmaceutical formulations and useful intermediates for the fluorinated taxols of formula I. A method of treating mammalian tumors using a compound of formula I is also provided.

    摘要翻译： 本发明涉及式I的氟化紫杉醇，其中R 1是-COR 3，其中R z是RO-或R; R 8为C 1-6烷基，C 2-6烯基，C 2-6炔基，C 3-6环烷基或W-Rx基团，W为键，C 2-6亚烯基或 - （CH 2）t - 其中t为1至6; 并且Rx是萘基，呋喃基，噻吩基或苯基，此外Rx可以任选地被一至三个相同或不同的C 1-6烷基，C 1-6烷氧基，卤素或-CF 3基团取代; R2是-OCOR，H，OH，-OR，-OSO2R，-OCONRoR，-OCONHR，-OCOO（CH2）tR或-OCOOR; 并且R和R 4独立地是C 1-6烷基，C 2-6烯基，C 3-6环烷基，C 2-6炔基或苯基，任选地被一至三个相同或不同的C 1-6烷基，C 1-6烷氧基，卤素或 -CF3组。 本发明进一步提供了用于式I的氟化紫杉醇的药物制剂和有用的中间体。还提供了使用式I化合物治疗哺乳动物肿瘤的方法。

    Wheel cylinder adjuster
    10.
    发明授权
    Wheel cylinder adjuster 有权

    公开(公告)号：US09657792B2

    公开(公告)日：2017-05-23

    申请号：US14803134

    申请日：2015-07-20

    申请人： Shu-Hui Chen

    发明人： Shu-Hui Chen

    IPC分类号： B25B27/00 ,  B25B27/02 ,  F16D65/00

    CPC分类号： F16D65/0043 ,  B25B27/0035 ,  B25B27/023

    摘要： A caliper piston adjuster includes a body defining a passage, a push rod, a resilient member, a holding rod, a positioning stop plate, and a positioning member. The push rod is fixedly connected with a positioning cart, and mounted with the resilient member, and inserted through the passage of the body, such that one end of the resilient member contacts the positioning part fixed at the push rod. The push rod is connected with a connector and an activating disc respectively at two ends thereof. The connector is connected with the holding rod. The positioning member is inserted through an opening of the positioning stop plate to be connected to the body. With the aid of the resilient member, the caliper piston adjuster can adjust the piston of a caliper cylinder more easily by rotating the holding rod.